DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and abcc5

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_001182542.1	Gene:	abcc5 / 336147	ZFINID:	ZDB-GENE-050517-17	Length:	1426	Species:	Danio rerio

Alignment Length:	1406	Identity:	450/1406 - (32%)
Similarity:	720/1406 - (51%)	Gaps:	152/1406 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 ENNSAQNEKEKVLPENPRARSNFISSLCF--------------------------WYT---IPIF 109
            :..:|.:.||  |.|:...||.:..|:|.                          |.|   :...
Zfish    56 DRGNAADAKE--LEEDAAGRSKYHHSVCVLKPIRSTSKYQHPVDNAGLFSFMTFNWLTSLAVLAH 118

  Fly   110 RKGYRKTLDSTDLYRPLEEQKSDILGNRLCASWERELKNDGRSPSLVRALLRVFGWQLGFPGLAI 174
            :||   .|...|::...:.:..:|...||...||.|:::.|...||.|.:......:|....|.:
Zfish   119 KKG---QLFLEDIWAVSQFESCEINRRRLAGLWEEEIRSRGNDASLRRVVWHFCRTRLLLSILCL 180

  Fly   175 FVVEL-GLRTLQPIFLV-KLISYFS-GEPDAANAGFYYAVAQIVISALTVMILTPTTFGI----- 231
            .|.:| |..:  |.|:| :|:.|.. .|||..     |.:. :|:..|...::...:..:
Zfish   181 MVTQLAGFSS--PAFVVWRLLEYTQRSEPDLP-----YGLL-LVLGLLATELIRSWSHALTWALN 237

  Fly   232 HHVCFKMRVAMGSMIFRKALRLTKGALGDTTSGHVVNLISNDIPRLDSAPYTVHYLWVGPL-QVL 295
            :....::|.|:.:|.|.|.|||.  :|.:.:.|.::|:.|.|..|:..|......|..||| .||
Zfish   238 YRTGTRLRGAILTMAFHKILRLR--SLREKSMGELINMCSGDGQRMFEAAAVGSLLAGGPLVAVL 300

  Fly   296 VITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKM 360
            .:.|.:: .:|.:::.|....:||.|..|:....|:..:.|....||.|::.:|||::.|:.:||
Zfish   301 GMAYNLF-VLGPTSLLGSAVFILFYPTMMFSSRLTAYFRRKGVAVTDQRVQKMNEILNYIKFIKM 364

  Fly   361 YAWEQPFEQMVTHAREKEMNTIRQGQYIRGFDFARR---IVLSRVAIFLSLVGYVILGKVFTPEI 422
            |||.:.|.|.|...|::|...:.:..|.:.......   :|::.||.|.:   :::||...|...
Zfish   365 YAWVKAFSQAVRRIRDEERQILERTGYFQSITVGVAPIVVVIASVATFST---HMLLGYDLTAAQ 426

  Fly   423 AFMITAYYNVLLAAMSIYVPSAIIQTAQFLTSIRRVEQFMQSEEL-----------------GSS 470
            ||.:...:|.:..|:.: .|.::...::...:|.|.:..:...|:                 |:|
Zfish   427 AFTVVTVFNAMTFALKV-TPFSVKSLSEASVAIDRFKSLLLMAEVKMIRELPRNPSVAVEMSGAS 490

  Fly   471 DKSE--GPSKDTVPGNPP--------SNNNEADLLK-SAI--------SIRDLKAKWDPNSPDY- 515
            ...|  |.|....|...|        ....:.|:.| .||        .:.|:..:...:..|.
Zfish   491 LAWETGGHSAQPSPRGTPHVGTRGCRKKRRQRDVPKHHAILEEETHGQLLNDVSGEMASSPKDQT 555

  Fly   516 ------------TLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGSLSYTS 568
                        ||..|:|.|:.|.:|.|.|..||||:|||.||||::....|.:.|:|..:|.:
Zfish   556 LHVPTISQRLQRTLHCIDLSIQKGKLVGVCGSVGSGKTSLISAILGQMTLLEGTVAVDGDFAYVA 620

  Fly   569 QESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARIS 633
            |::|:.:.:.|.|||||:.|:.:||:.::..|.|..|..:||..|.|.:|||||.|||||:.|||
Zfish   621 QQAWILNASFRDNILFGKEMEEERYQAILSACCLRPDLAMLPSGDLTEIGERGANLSGGQRQRIS 685

  Fly   634 LARSVYRKASIYLLDDPLSAVDASVARHLFDQCVRGHLRGSTVVLVTHQEQFLPHVDQIVILANG 698
            |||::|....||:|||||||:||.|..|:|:..::..|||.||:.||||.|:|...|.::::.:|
Zfish   686 LARALYSNRGIYILDDPLSALDAHVGNHIFNNAIKKQLRGKTVIFVTHQLQYLVDCDDVIVMRDG 750

  Fly   699 QIKALGDYESLLK-----TGLITGLGSLSKTDKAKT-EEQEPLNLNSPDNKNEVTPIKENSEQTV 757
            .|...|.:|.|:.     ..:...| .|.:|...:. .::...:|..|..|::...:|:....|.
Zfish   751 SIAEQGSHEDLMNVNGDYAAMFNNL-QLGETPIIEVPNKKSGSSLKKPLEKSKAGSVKKEKSTTQ 814

  Fly   758 GGSSSGKEHVERQESGGISLALYRKYFQAGGGLVAFLVMLSSSVLAQVAVTGGDYFLTYWVKKES 822
            |...  ...||.:..|.:..|:|:.|.||.||...||.:|:..:|...:....:::|.||:|:.|
Zfish   815 GDGQ--LMQVEERGKGSVPWAVYKVYIQALGGWPVFLFILALFILNVGSTAFSNWWLCYWIKQGS 877

  Fly   823 ----TAAGHGEM--EDM-ESKSMDVYK--YTLIIILSVIMNLSSSFLLFNIAKKASIRLHNTIFN 878
                ...|:..:  |.| ::..|..|.  ||:.:.:.:::.|....:......:||.|||:.:|.
Zfish   878 GNTTVQVGNSSVLSESMRDNPLMQHYAAVYTMSMGVMLLLKLLRGIVFVKGTLRASSRLHDELFQ 942

  Fly   879 RVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNPLLLV-- 941
            ::.|:.|.||.......|||||:|||.:||..||.......|..:.:...:.||.:|.|..||
Zfish   943 KILRSPMKFFDTTPTARILNRFSKDMDEVDTRLPFQAEMFTQNVILVLFCLAVIGSVFPWFLVAV 1007

  Fly   942 -PTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQRVLEKEFDSY 1005
             |.::|..:.:.:..:::   |:|||::.:.:||..||:|:|:.||||:.|...:......:...
Zfish  1008 GPLVLLFTVLHVVSRVFI---RELKRLDNVTQSPFLSHIASSIQGLTTVHAYGKEDEFLHRYQEL 1069

  Fly  1006 QDAHSSAFFMYISTSQAFGYCMNCICVIYISI----ITLSFFAFPPGNGADVGLVITQAMGLIDM 1066
            .|.:.:.|:::....:.....::.|.|..|||    |.|.....||   |..||.|:.|:.|..:
Zfish  1070 LDQNQAPFYLFSCAMRWLAVRLDVISVALISITALMIVLMHGQIPP---AYAGLAISYAVQLTGL 1131

  Fly  1067 VQWGVRQTAELENTMTAVERVVEY-ESIEPEGMLEAP---DDKKPPKTWPEQGEIIFKELNLRYT 1127
            .|:.||..:|.|...|:|||:..| :|:.    ||||   .:|.||..||::|||:|.:..::|.
Zfish  1132 FQFTVRLASETEARFTSVERIHHYIKSLS----LEAPARVKNKAPPSDWPQEGEIVFDQTEMKYR 1192

  Fly  1128 PNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFRL-SYTDGSVLIDTRDTRQMGLHDL 1191
            .|...  :||..||.::|:||:|||||||:|||||...|:|| ....||:.||..:...:||.|:
Zfish  1193 DNLPL--ILKKASFTVRPKEKIGIVGRTGSGKSSLGVVLYRLVEPCGGSIKIDGVNICDIGLADV 1255

  Fly  1192 RRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFS 1256
            |.::|||||||||||||:|.|||||.:||:.::|..||...:||.||.||..|.|::.|.|.|||
Zfish  1256 RSKLSIIPQEPVLFSGTVRSNLDPFSQYSEAQIWDALERTHMKECVSQLPLKLESEVVENGENFS 1320

  Fly  1257 VGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDK 1321
            ||:|||:|:||.:||:.:||::|||||.:..:||.|||.|||:.|:|||.||||||:||::..|:
Zfish  1321 VGERQLLCVARVLLRQCKILILDEATAAMGTETDCLIQETIRNAFQDCTTLTIAHRVHTVLSCDR 1385

  Fly  1322 VMVMDAGRVVEFGSPYELMTKSDSKVFHNLVNQSGRASYEG 1362
            :||::.|:||||..|.:|:...:|:....|.....:.|..|
Zfish  1386 IMVLNQGQVVEFDEPSKLLANENSRFCAMLAAVENKISVRG 1426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	441/1370 (32%)
		ABC_membrane	171..437	CDD:294371	73/277 (26%)
		ABCC_MRP_domain1	499..699	CDD:213217	88/220 (40%)
		ABC_membrane	799..1045	CDD:294371	69/261 (26%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	118/221 (53%)
abcc5	NP_001182542.1	intraplasmic N-terminal	1..59		0/2 (0%)
		transmembrane domain 1	59..149		18/94 (19%)
		CFTR_protein	95..1419	CDD:273530	439/1356 (32%)
		ABC_membrane	177..441	CDD:294371	73/277 (26%)
		nucleotide binding domain 1	188..248		12/67 (18%)
		transmembrane domain 2	279..379		32/100 (32%)
		nucleotide binding domain 2	403..450		12/50 (24%)
		ABCC_MRP_domain1	552..751	CDD:213217	86/198 (43%)
		ABC_membrane	851..1132	CDD:294371	78/286 (27%)
		ABCC_MRP_domain2	1180..1400	CDD:213211	118/221 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585985
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.660