Protein Alignment l(2)03659 and Sur

DIOPT Version :10

• Sequence 1: NP_610482.3
• Gene: l(2)03659 / 47905
• FlyBaseID: FBgn0010549
• Length: 1374
• Species: Drosophila melanogaster
• Sequence 2: XP_061511301.1
• Gene: Sur / 3292067
• VectorBaseID: AGAMI1_003204
• Length: 2282
• Species: Anopheles gambiae
• Alignment Length: 1584
• Identity: 402/1584 - (25%)
• Similarity: 644/1584 - (40%)
• Gaps: 522/1584 - (32%)

  Fly   263 SGHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFG-VLFMLLFMPIQMYL 326
            :|.:.||:|:|...:.|....|||:|..||::.|:.||:|:::|||.|.| |:.::...|:|:.:
Mosquito   698 AGTITNLMSDDAFNVMSFVKMVHYVWAIPLKIAVVMYLLYRQLGISTVIGSVVCIVTMTPLQLLI 762

  Fly   327 GTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQYIRGF 391
            |...:|...|.:|.||.|:|.:||::..|:::|:.|||..|:..::.||::|         :|..
Mosquito   763 GKLMAANSKKVSECTDERLRRINEVLLGIKLIKLNAWETVFKDKISQARQQE---------LRHL 818

  Fly   392 DF---------------ARRIVLSRVAIFLSLVGYVI---LGKVFTPEIAFMITAYYNVLLAAMS 438
            |.               :..|.:..:|:||:|....|   .|::|..      .|.:|.|...:.
Mosquito   819 DLDSIYWTLMMLLTHISSVLITIVTIAVFLALENNPIELTAGRLFAS------LALFNQLTVPLF 877

  Fly   439 IYVPSAIIQTAQFLTSIRRVEQFMQSEE---------------LGSSDKS--------------- 473
            |: |..|..|...:.|..|:|.|:...|               |..||.|
Mosquito   878 IF-PITIPITLSAIVSTGRLEAFLGQPEVERSSLEGIRTMARILSKSDASLDMDEAGDPQYGDDA 941

  Fly   474 --------------------EG--------PSKDTVPGNPPSNNNEAD----------------- 493
                                ||        .|.|.|.|:|.:....||
Mosquito   942 AAAQEQCPGVPVVAPPDQVEEGQQLQQPGIKSSDNVTGSPQTERKAADNAGPLPLVEDVGGKSCS 1006

  Fly   494 ---------------------------------------LLK----------------------- 496
                                                   |.|
Mosquito  1007 QHSSMSSDRSIRCEQVDRAPMARQRPAKYQKTVPSPRVKLKKHSQLSVSARLEKCRQKQKHLARE 1071

  Fly   497 --------SAISIRDLKAKWDPNSPDYTLSGINLEIK-----PGSVVAVIGLTGSGKSSLIQAIL 548
                    :|:.::|.:.:|:....|.|::...|.|:     ...:..::|.:|||||||:.|:|
Mosquito  1072 MRFGLPDHAAVFLKDARFRWNDTGADDTMAHCALHIEQLTVPKAKLTVIVGRSGSGKSSLLAALL 1136

  Fly   549 GELKANSGQLQVN--GSLSYTSQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPL 611
            .|:...||:|..|  .|::|..|:.||.:.|:|:|:|||:....:||:.|::.|||:.|.||:|.
Mosquito  1137 KEINHLSGELIWNKYSSIAYVPQKPWLQNATIRENVLFGESFRPKRYDRVLRACALKPDLDLMPA 1201

  Fly   612 RDNTIVGERGATLSGGQKARISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCVRGHL--RGS 674
            .|.|.:||||..|||||:.||::||::|..|::.:|||||||:|..||..:|:..|...|  :..
Mosquito  1202 GDGTEIGERGLKLSGGQRQRIAIARALYSSANVVILDDPLSALDNEVAMDVFENGVHRMLARQKR 1266

  Fly   675 TVVLVTHQEQFLPHVDQIVILANGQIKALG-------DYESLLKT-------------------- 712
            |::|||.:.|.:...|.||::..|.:.|.|       :|..:|:.
Mosquito  1267 TIILVTQKVQLVHRADNIVVMEGGTVSATGSLTEIENNYPHILREWNAIIAKEQQQSSEAQSSPG 1331

  Fly   713 -------GLITGLGSLSKTDKAKTEE------------------------------------QEP 734
                   .|...:..:|......|||                                    .||
Mosquito  1332 RTARERWKLFKNISRISFQRNHATEENDFMERTFYFPRTMANRALFGSRFSAHDFPLPIEDCHEP 1396

  Fly   735 -----------LNLNSPDNKNEVT----PIKE------NSEQTV-------------GGSSSGKE 765
                       |..:||.:...|.    |:.:      ...|:|             ..||:..:
Mosquito  1397 NVALRRHYSNRLRKDSPPSSTAVVLRRPPLGQIEHPPGTGHQSVFRALSLQLGTNATTSSSTVNQ 1461

  Fly   766 HVERQ---------------ESGGI-SLALYRKYFQAGG-----GLVAFLVMLSSS--VLAQVAV 807
            ..:||               .||.: ...||||....||     |.:|....||..  :||....
Mosquito  1462 RQQRQPAVVVRHISFPTTLTSSGALDDDTLYRKRLNQGGTAAHPGQLASAGALSGQRRMLASTDD 1526

  Fly   808 TGGD----------------------------------YFLT----------------------- 815
            ||.|                                  .||.
Mosquito  1527 TGMDGIEPNRTGVLLYGQNEGRNSCEDLKRSSIGFRIPEFLRRMSLRGRRFSNPTEFGRPYRERE 1591

  Fly   816 ---------------------YWVKKESTAAGHGEMEDMESKSMD----------VY----KYTL 845
                                 |.:|:..:.... :.||.|..|:|          :|    ||..
Mosquito  1592 DGSRKSSRKTSSLKSIPKERHYSIKRLLSTISR-QSEDTEESSVDYGEAEVSNRLIYDDERKYGR 1655

  Fly   846 I-------IILSVIMNLSSSFLLFNIAKKA----------------------------------- 868
            |       .::|....:.:.|.|..:|::|
Mosquito  1656 IPARMYWLYLISCGPRMVAIFFLSALAQQALKVYTDFWLQEWTDQTATISTIVVPTNGTVADASS 1720

  Fly   869 ---------------------------SI------------RLHNTIFNRVTRADMHFFSINKHG 894
                                       |:            |||..:...|.:..:|||.....|
Mosquito  1721 PTKPLEIRRHFHAYVALSAVCIVLAAISVPAGQRAGSNARRRLHRELIASVLQNSIHFFQSVPLG 1785

  Fly   895 SILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLK 959
            .|:||.:.|::.||:.:......::|..|.....:::.:.|.|..::.|:.:..|:|.::..|..
Mosquito  1786 RIMNRLSIDVAVVDKKIAATSQKLLQFILLCVCAVLINSVVTPYFILLTIPICGIYYMVQKFYRA 1850

  Fly   960 TSRDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQ-RVLEKEFDSYQDAHSSAFFMYISTSQAF 1023
            :||:|:|:|::..|||.:|.:.::.|:|||||...: |.:|..| ...:|::.|......:::..
Mosquito  1851 SSRELQRIESMTYSPVLAHFSETIEGVTTIRAFGQEARFMEVLF-KRMEANNVAQLALNCSNRWL 1914

  Fly  1024 GYCMNCI--CVIYISIITLSFFAF--PPGNGAD-VGLVITQAMGLIDMVQWGVRQTAELENTMTA 1083
            |..::.:  .:::::|:|....|.  |....:. :||.:..||.:...:.|.|:..||:|....|
Mosquito  1915 GIALDYLGAIIVFVAILTALITASLRPQSTSSSLIGLAVNYAMLVPIYLNWVVKLFAEMEMYGGA 1979

  Fly  1084 VERVVEYESIEP-----EGMLEAPDD-------------KKPPKTWPEQGEIIFKELNLRYTPNA 1130
            |||:..:...:.     :|.|.....             |..|.:||.:|.|:::.::||| .|.
Mosquito  1980 VERIQSFIECDVQRRRLDGGLRGRSSRVVQDTGVVPFSYKTVPISWPLRGVIVYEGVSLRY-ENQ 2043

  Fly  1131 KAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALF-RLSYTDGSVLIDTRDTRQMGLH--DLR 1192
            | ||::.:|:..|...:::||.||||:|||||..||| .|..|.|.:|||  |....|||  :||
Mosquito  2044 K-ENIITNLNLTIPAGQRLGICGRTGSGKSSLALALFGALEITAGRILID--DVDIAGLHTDELR 2105

  Fly  1193 RQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSV 1257
            .::||||||.:||.|::|.||||...:||.:||.|||..:||.||..|||||.::||:....||.
Mosquito  2106 SRLSIIPQEVMLFGGSVRENLDPRGHFSDLELWNCLELAQLKNVVMSLPDGLDTQISDDKHYFSS 2170

  Fly  1258 GQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKV 1322
            |||||.||||||||.:..||:||||:::|.:|:.|:....:..|:..||:|||||||:::|.::|
Mosquito  2171 GQRQLFCLARAILRGSVCLVLDEATSSLDTETEKLVLQAAKKAFKGRTVITIAHRLHSLVDYERV 2235

  Fly  1323 MVMDAGRVVEFGSPYELMTKSDSK 1346
            :|::.||:||.|.|.:|..|..||
Mosquito  2236 LVLEQGRIVEDGCPRKLAGKPGSK 2259

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_610482.3	PLN03130	83..1369	CDD:215595	402/1584 (25%)
Sur	XP_061511301.1	None