DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and Abcc6

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	XP_006541009.1	Gene:	Abcc6 / 27421	MGIID:	1351634	Length:	1500	Species:	Mus musculus

Alignment Length:	1266	Identity:	376/1266 - (29%)
Similarity:	603/1266 - (47%)	Gaps:	139/1266 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 NEKEKVLPENPRARSNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNRLCASWER 144
            :|..:.|...|.|.::|.|...||:...:..:||:|.|...||:....|..|:.|.::|...|.|
Mouse   268 SEDSQPLNPCPEAEASFPSKAMFWWASGLLWRGYKKLLGPKDLWSLGRENSSEELVSQLEREWRR 332

  Fly   145 -----------------------ELKNDGRSPSLVRALLRVF--GWQLGFPGLAIFVVELGLRTL 184
                                   :.:...|.| |:||:.|||  .:.||...|   |:....|..
Mouse   333 SCNGLPGHKGHSSVGAPETEAFLQPERSQRGP-LLRAIWRVFRSTFLLGTLSL---VISDAFRFA 393

  Fly   185 QPIFLVKLISYFSGEPDAANAGFYYAVAQIVISALTVMILTPTTFGIHHVCFKMRVAMGSMIFRK 249
            .|..|...:.:......:|..|:..||.....:.|..:......:....:..::|.|:..:::||
Mouse   394 VPKLLSLFLEFMGDRNSSAWTGWLLAVLMFAAACLQTLFEQQHMYRAKVLQMRLRTAITGLVYRK 458

  Fly   250 ALRLTKGALGDTTSGHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVL 314
            .|.|:.|:...:.:|.||||:|.||.||..:...::.||:..|.:.|....::|.:|.||:..|.
Mouse   459 VLVLSSGSRKSSAAGDVVNLVSVDIQRLAESIIYLNGLWLLFLWIFVCFVYLWQLLGPSALTAVA 523

  Fly   315 FMLLFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEM 379
            ..|..:|:..::..:....|.:...:..:|.|:.:.::..::.:|.:.||..|.:.:.|.|.:|:
Mouse   524 VFLSLLPLNFFITKKRGFHQEEQMRQKASRARLTSSMLRTVRTIKSHGWEHAFLERLLHIRGQEL 588

  Fly   380 NTIRQGQYIRGFDFARRIVLSRVAIFL-SLVGYVILGKV-----FTPEIAFMITAYYNVLLAAMS 438
            :.::....:    |:..:|..:|:.|| :||.:.:...|     ...|.||:.....::|..|.:
Mouse   589 SALKTSTLL----FSVSLVSFQVSTFLVALVVFAVHTLVAEDNAMDAEKAFVTLTVLSILNKAQA 649

  Fly   439 IYVPSAIIQTAQFLTSIRRVEQFMQSEELGSSDKSEGPSKDTVPGNPPSNNNEADLLKSAISIRD 503
             ::|.::....|...|..|:..|:..||:..:            |...||:..:.  |..||:.:
Mouse   650 -FLPFSVHCIVQARVSFDRLAAFLCLEEVDPN------------GMIASNSRRSS--KDRISVHN 699

  Fly   504 LKAKWDPNSPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGSLSYTS 568
            ....|...||. .|.||||.:..|.::||:|..|:|||||:.|:||||....|.:.:.||::|..
Mouse   700 GTFAWSQESPP-CLHGINLTVPQGCLLAVVGPVGAGKSSLLSALLGELLKVEGSVSIEGSVAYVP 763

  Fly   569 QESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARIS 633
            ||:|:.:.:|.:|:.|.|.:|....::|:..|||..|....|...:|.:||:|..||||||.|:|
Mouse   764 QEAWVQNTSVVENVCFRQELDLPWLQKVLDACALGSDVASFPAGVHTPIGEQGMNLSGGQKQRLS 828

  Fly   634 LARSVYRKASIYLLDDPLSAVDASVARHLFDQCV--RGHLRGSTVVLVTHQEQFLPHVDQIVILA 696
            |||:||:||:||||||||:|:||.|::.:|.|.:  .|.|:|:|.:||||....||..|:|::||
Mouse   829 LARAVYKKAAIYLLDDPLAALDAHVSQQVFKQVIGPSGLLQGTTRILVTHTLHVLPQADRILVLA 893

  Fly   697 NGQIKALGDYESLLK-----TGLITGLGSLSKTDKAKTEEQ--------EPLNLNSPDNKNEVTP 748
            ||.|..:|.|:.||:     .||:.|....:.|..|.|.:.        .|..........|..|
Mouse   894 NGTIAEMGSYQDLLQRNGALVGLLDGARQPAGTHDAATSDDLGGFPGGGRPTCRPDRPRPTEAAP 958

  Fly   749 IKENSEQTV-----------GGSSSGKEHVERQESGGISLALYRKYFQA-GGGLVAFLVMLSSSV 801
            :|..|...|           .|.::.::.|   ..|.:...:|..|.:| |..|..:.:.|  .:
Mouse   959 VKGRSTSEVQMEASLDDPEATGLTAEEDSV---RYGRVKTTIYLSYLRAVGTPLCTYTLFL--FL 1018

  Fly   802 LAQVAVTGGDYFLTYWVK------KESTAAGHGEMEDMESKSMDVYKYTLIIILSVIMNLSSSFL 860
            ..|||.....|:|:.|..      ::..||..|            :.:.|:..|..|...:|...
Mouse  1019 CQQVASFSQGYWLSLWADDPVVDGRQMHAALRG------------WVFGLLGCLQAIGLFASMAA 1071

  Fly   861 LFNIAKKASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWL 925
            :|....:||..|..::...|.|:.:.||.....|::||||:|:...||..:|..|..::..|..|
Mouse  1072 VFLGGARASGLLFRSLLWDVARSPIGFFERTPVGNLLNRFSKETDTVDVDIPDKLRSLLTYAFGL 1136

  Fly   926 AGIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIR 990
            ..:.:.:....||.:|..|.|.|::...::||:.||..|:|:|:...|.|.||:|.:..|...:|
Mouse  1137 LEVGLAVTMATPLAIVAILPLMVLYAGFQSLYVATSCQLRRLESARYSSVCSHMAETFQGSLVVR 1201

  Fly   991 ALDAQRVLEKEFDSYQDAHSSAFF------MYISTS-QAFGYCMNCICVIYISIITLSFFAFPPG 1048
            |..||.....:.|:..|.:....|      .:::|: :..|   |.:..:..:...||......|
Mouse  1202 AFRAQASFTAQHDALMDENQRVSFPKLVADRWLATNLELLG---NGLVFVAATCAVLSKAHLSAG 1263

  Fly  1049 NGADVGLVITQAMGLIDMVQWGVRQTAELENTMTAVERVVEYESIEPEGMLEAPDDKKPPKTWPE 1113
            .   ||..::.|:.:...:||.||...:|||:|.|||||.:|..|..|.....|.....| .||.
Mouse  1264 L---VGFSVSAALQVTQTLQWVVRSWTDLENSMVAVERVQDYARIPKEAPWRLPTCAAQP-LWPC 1324

  Fly  1114 QGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFRL-SYTDGSVL 1177
            .|:|.|::..||:.|....  .::.:|..|...||||||||||||||||...|.|| ...:|::.
Mouse  1325 GGQIEFRDFGLRHRPELPL--AVQGVSLKIHAGEKVGIVGRTGAGKSSLAWGLLRLQEAAEGNIW 1387

  Fly  1178 IDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPD 1242
            ||......:|||.||.:|:||||:||||.|::|.|||...|::||.:|..||.|:||..|:.||
Mouse  1388 IDGVPITHVGLHTLRSRITIIPQDPVLFPGSLRMNLDLLQEHTDEGIWAALETVQLKAFVTSLP- 1451

  Fly  1243 GLASKISEGGTNFSVGQRQLVCLARA-ILRE 1272
                           ||.|..|..:. .|||
Mouse  1452 ---------------GQLQYECAGQGDDLRE 1467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	374/1257 (30%)
		ABC_membrane	171..437	CDD:294371	60/271 (22%)
		ABCC_MRP_domain1	499..699	CDD:213217	91/201 (45%)
		ABC_membrane	799..1045	CDD:294371	64/258 (25%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	68/160 (43%)
Abcc6	XP_006541009.1	MRP_assoc_pro	101..1465	CDD:188098	373/1262 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841725
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1734
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.600