DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and Abcc5

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_038818.2	Gene:	Abcc5 / 27416	MGIID:	1351644	Length:	1436	Species:	Mus musculus

Alignment Length:	1492	Identity:	455/1492 - (30%)
Similarity:	736/1492 - (49%)	Gaps:	218/1492 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SERENTSIEESSLLENNGFDHRNKDESLSVNTSPPLVCRKCFELGHQTENCKQKLTVNSENNSAQ 79
            |:|:.:::..         .||:.:|.....|. .|.|:...|...:.|.....::|:|......
Mouse    19 SDRDRSAVPG---------QHRDPEEPRFRRTR-SLECQDALETAARVEGLSLDISVHSHLQILD 73

  Fly    80 NEKEK--------VLP--------ENPRARSNFISSLCFWYTIPIFRKGYRK-TLDSTDLYRPLE 127
            .|..|        ||.        ::|...:...|.:.|.:..|:.|..::| .|...|::...:
Mouse    74 EEHSKGKYHHGLSVLKPFRTTTKHQHPVDNAGLFSYMTFSWLSPLARVVHKKGELLMEDVWPLSK 138

  Fly   128 EQKSDILGNRLCASWERELKNDGRSPSLVRALLRVFGWQLGFPGLAIFVVELGLRTLQ----PIF 188
            .:.||:...||...|:.||...|...:.:|.::    |......|.:.:|.|.:..|.    |.|
Mouse   139 YESSDVNSRRLERLWQEELNEVGPDAASLRRVV----WIFCRTRLILSIVCLMITQLAGFSGPAF 199

  Fly   189 LVK-LISYFSGEPDAANAGFYYAVAQIVISALTVMILT---PTTFGIHH-VCFKMRVAMGSMIFR 248
            :|| |:.|    ..|..:...|::..::...||.::.:   ..|:.::: ...::|.|:.:|.|:
Mouse   200 VVKHLLEY----TQATESNLQYSLLLVLGLLLTEVVRSWSLALTWALNYRTGVRLRGAILTMAFK 260

  Fly   249 KALRLTKGALGDTTSGHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEI--GISAVF 311
            |.|:|..  :.:.:.|.::|:.|||..|:..|......|..||  |:.|..::|..|  |.:...
Mouse   261 KILKLKN--IKEKSLGELINICSNDGQRMFEAAAVGSLLAGGP--VVAILGMIYNVIILGPTGFL 321

  Fly   312 GVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHARE 376
            |....:||.|..|::...|:..:.|....||:|::.:||:::.|:.:|||||.:.|.|.|...||
Mouse   322 GSAVFILFYPAMMFVSRLTAYFRRKCVAATDDRVQKMNEVLTYIKFIKMYAWVKAFSQCVQKIRE 386

  Fly   377 KEMNTIRQGQYIRGFDFARRIVLSRVAIFLSLVGYVILGKVFTPEIAFMITAYYNVLLAAMSIYV 441
            :|...:.:..|.:........::..:|..::...::.||...|...||.:...:|.:..|:.: .
Mouse   387 EERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTLGFHLTAAQAFTVVTVFNSMTFALKV-T 450

  Fly   442 PSAIIQTAQFLTSIRRVEQFMQSEELGSSDKSEGPSKDTVPGNPPSNNNEADLLKSAISIRDLKA 506
            |.::...::...::.|.:.....||:           ..:...|.|.:.:.::..:.::
Mouse   451 PFSVKSLSEASVAVDRFKSLFLMEEV-----------HMIKNKPASPHIKIEMKNATLA------ 498

  Fly   507 KWD------PNSP---------------------------------------------------- 513
             ||      .|||
Mouse   499 -WDSSHSSIQNSPKLTPKMKKDKRATRGKKEKSRQLQHTEHQAVLAEQKGHLLLDSDERPSPEEE 562

  Fly   514 ------------DYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGSLSY 566
                        ..||..|:|||:.|.:|.:.|..||||:||:.||||::....|.:.|:|:.:|
Mouse   563 EGKQIHTGSLRLQRTLYNIDLEIEEGKLVGICGSVGSGKTSLVSAILGQMTLLEGSIAVSGTFAY 627

  Fly   567 TSQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKAR 631
            .:|::|:.:.|:|.|||||:..|.:||..|:..|.|..|..:||..|.|.:|||||.|||||:.|
Mouse   628 VAQQAWILNATLRDNILFGKEFDEERYNSVLNSCCLRPDLAILPNSDLTEIGERGANLSGGQRQR 692

  Fly   632 ISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCVRGHLRGSTVVLVTHQEQFLPHVDQIVILA 696
            |||||::|...|||:|||||||:||.|..|:|:..:|..|:..||:.||||.|:|...|:::.:.
Mouse   693 ISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKRLKSKTVLFVTHQLQYLVDCDEVIFMK 757

  Fly   697 NGQIKALGDYESLLK---------TGLITGLGSLSKTDKAKTEEQEPLNLNSPDNKNEVTPIKEN 752
            .|.|...|.:|.|:.         ..|:.|             |..|:.:||   |.|.|..:::
Mouse   758 EGCITERGTHEELMNLNGDYATIFNNLLLG-------------ETPPVEINS---KKEATGSQKS 806

  Fly   753 SEQTVGGSSSGKE-----------HVERQESGGISLALYRKYFQAGGGLVAFLVMLSSSVLAQVA 806
            .::.....|..||           .||.:..|.:..::|..|.||.||.:||||::...:|...:
Mouse   807 QDKGPKPGSVKKEKAVKSEEGQLVQVEEKGQGSVPWSVYWVYIQAAGGPLAFLVIMVLFMLNVGS 871

  Fly   807 VTGGDYFLTYWVKKES--TAAGHG-------EMEDMESKSMDVYK--YTLIIILSVIMNLSSSFL 860
            .....::|:||:|:.|  :....|       .|:|  :..|..|.  |.|.:.:.:|:......:
Mouse   872 TAFSTWWLSYWIKQGSGNSTVYQGNRSFVSDSMKD--NPFMQYYASIYALSMAVMLILKAIRGVV 934

  Fly   861 LFNIAKKASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWL 925
            ......:||.|||:.:|.|:.|:.|.||.....|.|||||:|||.:||..||      .|..:::
Mouse   935 FVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLP------FQAEMFI 993

  Fly   926 AGIIIV------IANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLN 984
            ..:|:|      ||.|.|..||....|.::|..|..:.....|:|||::.|.:||..||:.:|:.
Mouse   994 QNVILVFFCVGMIAGVFPWFLVAVGPLLILFSLLHIVSRVLIRELKRLDNITQSPFLSHITSSIQ 1058

  Fly   985 GLTTIRALDAQRVLEKEFDSYQDAHSSAFFMYISTSQAFGYCMNCICVIYIS----IITLSFFAF 1045
            ||.||.|.:.::.....:....|.:.:.||::....:.....::.|.:..|:    :|.|.....
Mouse  1059 GLATIHAYNKRQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQI 1123

  Fly  1046 PPGNGADVGLVITQAMGLIDMVQWGVRQTAELENTMTAVERVVEY-ESIEPEGMLEAP---DDKK 1106
            |   .|..||.|:.|:.|..:.|:.||..:|.|...|:|||:..| :::.    ||||   .:|.
Mouse  1124 P---SAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLS----LEAPARIKNKA 1181

  Fly  1107 PPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFRL-S 1170
            ||..||::||:.|:...:||..|...  |||.:||.|:|:||:|||||||:|||||..||||| .
Mouse  1182 PPHDWPQEGEVTFENAEMRYRENLPL--VLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVE 1244

  Fly  1171 YTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKE 1235
            .:.|.:.||......:||.|||.:::||||||||||||:|.|||||::|:::::|..||...:||
Mouse  1245 LSGGCIKIDGIRISDIGLADLRSKLAIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKE 1309

  Fly  1236 VVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQATIRSK 1300
            .::.||..|.|::.|.|.|||||:|||:|:|||:||..:||::|||||.:|.:||.|||.|||..
Mouse  1310 CIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREA 1374

  Fly  1301 FRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLVNQSGRASYEG 1362
            |.|||:|||||||||::.||::||:..|:||||.:|..|::...|:.:........:.:.:|
Mouse  1375 FADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAENKVAVKG 1436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	437/1381 (32%)
		ABC_membrane	171..437	CDD:294371	69/276 (25%)
		ABCC_MRP_domain1	499..699	CDD:213217	91/269 (34%)
		ABC_membrane	799..1045	CDD:294371	72/266 (27%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	122/221 (55%)
Abcc5	NP_038818.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41		5/30 (17%)
		PLN03130	100..1424	CDD:215595	438/1387 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..569		3/67 (4%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	798..822		5/23 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841663
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.660