DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and Abcc9

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_037172.2	Gene:	Abcc9 / 25560	RGDID:	3787	Length:	1545	Species:	Rattus norvegicus

Alignment Length:	1387	Identity:	410/1387 - (29%)
Similarity:	685/1387 - (49%)	Gaps:	195/1387 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 NFISSLCFWYTIPIFRKGYRKTLDSTDLYR-PLEEQKSDILGNRLC--ASWERELK----NDGRS 152
            |.:|...:|:...:....:||.:|...:.: |:..:   .:.|.:|  .::|.:.|    :..|:
  Rat   221 NLLSKATYWWMNTLIISAHRKPIDLKAIGKLPIAMR---AVTNYVCLKEAYEEQKKKAADHPNRT 282

  Fly   153 PSLVRALLRVFGWQLGFPGLAIFVVELGLRTLQPIFLVKLISY------FSG------------E 199
            ||:..|:.|.||                    :||.|.....|      |:|            |
  Rat   283 PSIWLAMYRAFG--------------------RPILLSSTFRYLADLLGFAGPLCISGIVQRVNE 327

  Fly   200 PDAANAGF--------YYAVAQIVISALTVMILTPTTF--GIHHVCFK----MRVAMGSMIFRKA 250
            |......|        :...|.::...|.:.::...||  ..::|..:    :|.|:.:||:.|.
  Rat   328 PKNNTTRFSETLSSKEFLENAHVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKI 392

  Fly   251 LRLTKG--ALGDTTSGHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGV 313
            |||:..  ::|:.|.|.:.||::.:..:|....:....||..|:|:::...|:|..:|.||:.|.
  Rat   393 LRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGA 457

  Fly   314 LFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKE 378
            ..::|..|||.::.|:.:..|....:.:..|::..|||:..|::||:||||..|.:.|...|.||
  Rat   458 AVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKE 522

  Fly   379 MNTIRQGQYIRGFDFARRIVLSRVAIFLSLVGYVIL-GKVFTPEIAFMITAYYNVLLAAMSIYVP 442
            :::::...............:...|:..:.|.:... |....|..||...:.:::|:.  .:::.
  Rat   523 LSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVT--PLFLL 585

  Fly   443 SAIIQTA-QFLTSIRRVEQFMQSEELG--------------SSDKSEG----PSKDTVPGNPPSN 488
            |.:::.| :.:.|::::.:|:.|:|:|              |..|..|    |.....||....:
  Rat   586 STVVRFAVKAIISVQKLNEFLLSDEIGEDSWRTGEGTLPFESCKKHTGVQSKPINRKQPGRYHLD 650

  Fly   489 NNE-------ADLLKSAISIRDLKAKWDPNSPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQA 546
            |.|       |:....||.:.:....|  .|...|||.|::.|..|.:..::|..|.|||||:.|
  Rat   651 NYEQARRLRPAETEDVAIKVTNGYFSW--GSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLA 713

  Fly   547 ILGELKANSGQLQVNG-----------------SLSYTSQESWLFSGTVRQNILFGQPMDSQRYE 594
            ||||::...|::..|.                 |::|.:|:.||.:.||.:||.||...:.|||:
  Rat   714 ILGEMQTLEGKVYWNNVNESEPSFEATRSRSRYSVAYAAQKPWLLNATVEENITFGSSFNRQRYK 778

  Fly   595 EVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVYRKASIYLLDDPLSAVDASVA 659
            .|...|:|:.|.||||..|.|.:||||..|||||:.||.:||::|:..:|..||||.||:|..::
  Rat   779 AVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLS 843

  Fly   660 RHLFDQCVRGHLRGS--TVVLVTHQEQFLPHVDQIVILANGQIKALGDYESLLKTGLITGLGSLS 722
            .||..:.:...|:..  |||||||:.|:|.|.|.|:.:.:|         |:|:.|.:..:
  Rat   844 DHLMQEGILKFLQDDKRTVVLVTHKLQYLTHADWIIAMKDG---------SVLREGTLKDI---- 895

  Fly   723 KTDKAKTEEQEPLNLNSPDNKNE------VTPIKENSEQTVGGSSSGK---------EHVERQES 772
            :|...:..|.....:|..|.:.|      .|.::..:.:....|...|         |..|..|.
  Rat   896 QTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDED 960

  Fly   773 GGISLALYRK----------YFQAGGGLVAFLVMLSSSVLAQVAVTGGDYFLTYWVKKESTAAGH 827
            ..:|..:..:          |..:||..:.|| |:.|.:|....:...||:|..|..:.|
  Rat   961 DNMSTVMRLRTKMPWKTCWWYLTSGGFFLLFL-MIFSKLLKHSVIVAIDYWLATWTSEYS----- 1019

  Fly   828 GEMEDMESKSMDVY--KYTLI----IILSVIMNLSSSFLLFNIAKKASIRLHNTIFNRVTRADMH 886
              :.|........|  .::::    |.|.::.:|:..::....||    .||:.:.|::....:.
  Rat  1020 --INDPGKADQTFYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAK----NLHHNLLNKIILGPIR 1078

  Fly   887 FFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFY 951
            ||.....|.|||||:.|.:.:|:.:|..|..:.:..|.....|.:|:...|:.|:....|.|.||
  Rat  1079 FFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLIALAPLGVAFY 1143

  Fly   952 HLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALD-----AQRVLEKEFDSYQDAHSS 1011
            .::..:...|:||:.::...:.|:..|.:.:..|||||||..     .||:||     ..|.::.
  Rat  1144 FIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLE-----LTDTNNI 1203

  Fly  1012 AFFMYISTSQAF-----GYCMNCICVIYISIITLSFFAFPPGNGADVGLVITQAMGLIDMVQWGV 1071
            | ::::|.:..:     .|...|| |:..||.::|    ...|...|||.:..|:.:.:.:.|.|
  Rat  1204 A-YLFLSAANRWLEVRTDYLGACI-VLTASIASIS----GSSNSGLVGLGLLYALTITNYLNWVV 1262

  Fly  1072 RQTAELENTMTAVERVVEYESIEPEGMLEAPDDKKPPKTWPEQGEIIFKELNLRYTPNAKAENVL 1136
            |..|:||..|.||::|..:.::|.|......|..:.|:.||::|||...:|.:||..|.|.  ||
  Rat  1263 RNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKP--VL 1325

  Fly  1137 KSLSFVIQPREKVGIVGRTGAGKSSLINALFRL-SYTDGSVLIDTRDTRQMGLHDLRRQISIIPQ 1200
            |.:...|:|.:||||.||||:|||||..|.||: ...||.::||..|..::.||.||.::|||.|
  Rat  1326 KHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQ 1390

  Fly  1201 EPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCL 1265
            :|:||||::|:||||..:.:|::||..||..:||.:|..||.||.:.::|||.|||||||||.||
  Rat  1391 DPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDATVTEGGENFSVGQRQLFCL 1455

  Fly  1266 ARAILRENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRV 1330
            |||.:|::.||:||||||::|..|:.::|..:.:.|.|.||:|||||:|||:.:|.|:||..|.:
  Rat  1456 ARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILTADLVIVMKRGNI 1520

  Fly  1331 VEFGSPYELMTKSDSKVFHNLV 1352
            :|:.:|..|:.:.|. ||.:.|
  Rat  1521 LEYDTPESLLAQEDG-VFASFV 1541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	406/1376 (30%)
		ABC_membrane	171..437	CDD:294371	67/300 (22%)
		ABCC_MRP_domain1	499..699	CDD:213217	84/218 (39%)
		ABC_membrane	799..1045	CDD:294371	64/261 (25%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	111/221 (50%)
Abcc9	NP_037172.2	MRP_assoc_pro	222..1542	CDD:188098	409/1386 (30%)
Abcc9	NP_037172.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..963		4/22 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345047
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.650