DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and Abcc8

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_037171.2	Gene:	Abcc8 / 25559	RGDID:	3786	Length:	1582	Species:	Rattus norvegicus

Alignment Length:	1386	Identity:	434/1386 - (31%)
Similarity:	714/1386 - (51%)	Gaps:	158/1386 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 NFISSLCFWYTIPIFRKGYRKTLDSTDLYR-PLEEQKSDILGN--RLCASWERELKNDGRSP--- 153
            |.:|...:|:.....:..::|.:|...:.: |:..:   .|.|  |||.:::.:.:.|.:|.
  Rat   223 NLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMR---ALTNYQRLCLAFDAQARKDTQSQQGA 284

  Fly   154 -SLVRALLRVFGWQ-------------LGFPG-LAIF--VVELGL--RTLQPIFLVKLISYFSGE 199
             ::.|||...||.:             |||.| |.||  |..||.  ...||......:.:.|.:
  Rat   285 RAIWRALCHAFGRRLVLSSTFRILADLLGFAGPLCIFGIVDHLGKENHVFQPKTQFLGVYFVSSQ 349

  Fly   200 PDAANAGFYYAVAQIVISALTVMILTPTTF--GIHHVCFK----MRVAMGSMIFRKALRLTKG-- 256
            ....||   |.:|.::..||    |...||  ..::|..:    :|.|:.:.|:.|.:.|:..
  Rat   350 EFLGNA---YVLAVLLFLAL----LLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNL 407

  Fly   257 ALGDTTSGHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMP 321
            ::|:.|:|.:.||::.|..:|....:....||..|:|::|...|:|..:|:||:.|...::|..|
  Rat   408 SMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAP 472

  Fly   322 IQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQ 386
            :|.::.|:.|..|....|.::.|::..||::..|::||:||||..|...|...|.|||.::|...
  Rat   473 VQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFCSRVEKTRRKEMTSLRAFA 537

  Fly   387 YIRGFDFARRIVLSRVAIFLSLVGYVILGKV--FTPEIAFMITAYYNVLLAAMSIYVPSAIIQTA 449
            ............:...|:.::.||:|...|.  |:|.:||...:.:::|:..:.: :.|.:..|.
  Rat   538 VYTSISIFMNTAIPIAAVLITFVGHVSFFKESDFSPSVAFASLSLFHILVTPLFL-LSSVVRSTV 601

  Fly   450 QFLTSIRRVEQFMQSEEL-------------GSSDKSEG----------PSKDTVPG--NP---- 485
            :.|.|::::.:|:.|.|:             |.:.|.:.          |:::.|..  .|
  Rat   602 KALVSVQKLSEFLSSAEIREEQCAPREPAPQGQAGKYQAVPLKVVNRKRPAREEVRDLLGPLQRL 666

  Fly   486 -PSNNNEADLLKSAISIRDLKAKWDPNS-PDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAIL 548
             ||.:.:||  ...:.|......|.|:. |  |||.|.:.|..|.:..::|..|.|||||:.|.|
  Rat   667 TPSTDGDAD--NFCVQIIGGFFTWTPDGIP--TLSNITIRIPRGQLTMIVGQVGCGKSSLLLATL 727

  Fly   549 GELKANSGQLQVNGSL---------------------------SYTSQESWLFSGTVRQNILFGQ 586
            ||::..||.:..|.||                           :|.||:.||.:.||.:||.|..
  Rat   728 GEMQKVSGAVFWNSSLPDSEGEDPSNPERETAADSDARSRGPVAYASQKPWLLNATVEENITFES 792

  Fly   587 PMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVYRKASIYLLDDPL 651
            |.:.|||:.|::.|:|:.|.|:||..|.|.:||||..|||||:.|||:||::|:..::..||||.
  Rat   793 PFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHTNVVFLDDPF 857

  Fly   652 SAVDASVARHLFDQCVRGHLRGS--TVVLVTHQEQFLPHVDQIVILANGQIKALGDYESLLKT-- 712
            ||:|..::.||....:...||..  |||||||:.|:|||.|.|:.:.:|.|:..|..:...::
  Rat   858 SALDVHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSEC 922

  Fly   713 GLITGLGSLSKTDKAKTEEQEPLNLNSPD---------NKNEVTPIKENSEQTVGGSSSGKEHVE 768
            .|.....:|......:.|::..:...:|:         :..:...:.|:.|:        :|..|
  Rat   923 QLFEHWKTLMNRQDQELEKETVMERKAPEPSQGLPRAMSSRDGLLLDEDEEE--------EEAAE 979

  Fly   769 RQESGGISLALYR----------KYFQAGGGLVAFLVMLSSSVLAQVAVTGGDYFLTYWVKKE-- 821
            .:|...:|..|::          ||..:.|.|:..|::. |.:|..:.:...||:|..|....
  Rat   980 SEEDDNLSSVLHQRAKIPWRACTKYLSSAGILLLSLLVF-SQLLKHMVLVAIDYWLAKWTDSALV 1043

  Fly   822 -STAAGHGEMEDMESKSMDVYK--YTLIIILSVIMNLSSSFLLFNIAKKASIRLHNTIFNRVTRA 883
             |.||.:..:....:....||.  :|::..|.:.:.|.:|..:.....|.:.|||.::.||:..|
  Rat  1044 LSPAARNCSLSQECALDQSVYAMVFTVLCSLGIALCLVTSVTVEWTGLKVAKRLHRSLLNRIILA 1108

  Fly   884 DMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSV 948
            .|.||.....|||||||:.|.:.:|:.:|..|..:.:..|.....:.||:.|.|:.||..|.|:|
  Rat  1109 PMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYVTPVFLVALLPLAV 1173

  Fly   949 IFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQRVLEKEFDSYQDAHSSAF 1013
            :.|.::..:...||||::::...:.|:.||.|.::.|||||||...:...:::...|.|:::.|.
  Rat  1174 VCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIAS 1238

  Fly  1014 FMYISTSQAFGYCMNCI--CVIYISIIT-LSFFAFPPGNGADVGLVITQAMGLIDMVQWGVRQTA 1075
            ....:.::.....|..|  ||:.|:..| :|.......:...|||.:|.|:.:.:.:.|.||..|
  Rat  1239 LFLTAANRWLEVRMEYIGACVVLIAAATSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLA 1303

  Fly  1076 ELENTMTAVERV---VEYESIEPEGMLEAPDDKKPPKTWPEQGEIIFKELNLRYTPNAKAENVLK 1137
            ::|..:.||:|:   ::.|:...||:| ||  ...||.||:||:|..:.|::||..:.|.  |||
  Rat  1304 DMEIQLGAVKRIHTLLKTEAESYEGLL-AP--SLIPKNWPDQGKIQIQNLSVRYDSSLKP--VLK 1363

  Fly  1138 SLSFVIQPREKVGIVGRTGAGKSSLINALFRL-SYTDGSVLIDTRDTRQMGLHDLRRQISIIPQE 1201
            .::.:|.|.:|:||.||||:||||...|.||: ...:|.::||..|..::.||.||.::|||.|:
  Rat  1364 HVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDMFEGRIIIDGIDIAKLPLHTLRSRLSIILQD 1428

  Fly  1202 PVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLA 1266
            |||||||:|:||||..:.||..||..||..:||.||..||.||.:.|:|||.|||.|||||.|||
  Rat  1429 PVLFSGTIRFNLDPEKKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLA 1493

  Fly  1267 RAILRENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVV 1331
            ||.:|:..|.:||||||::|..|:.::|..:.:.|.|.||:|||||:|||:.:|.|||:..|.::
  Rat  1494 RAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMVLKRGAIL 1558

  Fly  1332 EFGSPYELMTKSDSKVFHNLV 1352
            ||..|.:|:::.|| ||.:.|
  Rat  1559 EFDKPEKLLSQKDS-VFASFV 1578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	429/1375 (31%)
		ABC_membrane	171..437	CDD:294371	77/280 (28%)
		ABCC_MRP_domain1	499..699	CDD:213217	88/229 (38%)
		ABC_membrane	799..1045	CDD:294371	72/253 (28%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	110/221 (50%)
Abcc8	NP_037171.2	CFTR_protein	223..1582	CDD:273530	434/1386 (31%)
		ABC_membrane	<375..590	CDD:279056	58/214 (27%)
		P-loop_NTPase	679..907	CDD:304359	88/229 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	741..768		2/26 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	939..962		2/22 (9%)
		ABC_membrane	1017..1295	CDD:279056	77/278 (28%)
		ABCC_SUR2	1343..1582	CDD:213255	117/239 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345067
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.650