DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and abc2

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_593943.3	Gene:	abc2 / 2543193	PomBaseID:	SPAC3F10.11c	Length:	1478	Species:	Schizosaccharomyces pombe

Alignment Length:	1325	Identity:	417/1325 - (31%)
Similarity:	688/1325 - (51%)	Gaps:	105/1325 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 SNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNRLCASWERELKNDGRSPSLVRA 158
            :|..|.:.|.:..|:.:.|||..|..:|.:.....::|..|......:|....|.. :|...:..
pombe   195 ANIFSRISFGWLSPLMKFGYRNYLTESDAWSLPPAERSSNLTIVFEKNWISHAKKK-KSSLYMWG 258

  Fly   159 LLRVFGWQLGFPGLAIFVVELGLRTLQPIFLVKLI----SYFSGEPDAANAGFYYAVAQIVISAL 219
            :|.:..|:|....:.:.:|:..:..:||..:.|::    ||.|..|.....||..|:|..:.:.:
pombe   259 VLFLNHWKLTVVIIVLKLVQDVVAFIQPNLIRKIVIFVSSYSSEHPQPPQVGFSLAIAMFLTNVV 323

  Fly   220 TVMILTPTTFGIHHVCFKMRVAMG--------SMIFRKALRLTKGALGDTTSGHVVNLISNDIPR 276
            ...:|        ...|::.:.:|        :.|:||:|||:..|....:.|.:||.:|.|..:
pombe   324 QTALL--------QQYFQLGMVLGMRWRSELITAIYRKSLRLSSAARQSRSVGDIVNYMSVDTQK 380

  Fly   277 LDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLKAAERT 341
            :......:..:..||.|:::....:|..:|..|:.|.....|..|..:.:.:.....|.:..:..
pombe   381 VCDLTMFLFVIVSGPFQIVLALTNLYHLVGYGALSGAFVTFLLFPCNVVIASIFKRFQNRQMKNK 445

  Fly   342 DNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHARE-KEMNTIRQ---GQYIRGFDFARRIVLSRV 402
            |.|.:.:.|||:.|:.:|:||||..|.|.:...|. :|:..:::   ...|..|.:....:|...
pombe   446 DARSQFMTEIINNIRSIKLYAWENIFLQKLLQLRNTRELRMLKKIGIVNTIGNFTWLFAPILVSA 510

  Fly   403 AIFLSLVGYVILGK--VFTPEIAFMITAYYNVLLAAMSIYVPSAIIQTAQFLTSIRRVEQFMQSE 465
            |.|.:.:  |:.||  |.:.:|.|...:.:|:|...::: :|..:....:...:|.|:..|:.:.
pombe   511 ATFGTFI--VLYGKTRVLSVDIVFACLSLFNLLQFPLTM-LPIVVSSVLEASVAISRIYGFLTAG 572

  Fly   466 ELGSSDKSEGPSKDTVPGNPPSNNNEADLLKSAISIRDLKAKWD---PNSPDYTLSGINLEIKPG 527
            ||.|:      :....|.|...:....::.|...|       |.   .|:.:.||..|:...:.|
pombe   573 ELDSN------AVQRYPANKEPSGVCLEIKKGTFS-------WSGPGQNAAEPTLRDIDFVARRG 624

  Fly   528 SVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGSLSYTSQESWLFSGTVRQNILFGQPMDSQR 592
            .:..::|..|.|||||::|.||.::.:||.:...||::|.:|:.|:.:.|:::|||||..:|.:.
pombe   625 ELCCIVGKVGMGKSSLLEACLGNMQKHSGSVFRCGSIAYAAQQPWILNATIQENILFGLELDPEF 689

  Fly   593 YEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVYRKASIYLLDDPLSAVDAS 657
            ||:.::.|.|.|||::|...|.|.|||:|.:|||||||||||||:||.::.||||||.|||||..
pombe   690 YEKTIRACCLLRDFEILADGDQTEVGEKGISLSGGQKARISLARAVYSRSDIYLLDDILSAVDQH 754

  Fly   658 VARHLFDQCV--RGHLRGSTVVLVTHQEQFLPHVDQIVILANGQIKALGDYESLLK---TGLITG 717
            |.|.|....:  :|.||...|:|.|:....|.....|.:|.||:|...|.:..|..   :.|...
pombe   755 VNRDLVRNLLGSKGLLRSRCVILSTNSLTVLKEASMIYMLRNGKIIESGSFTQLSSSPDSQLFQL 819

  Fly   718 LGSLSKTDKA-KTEEQEPLNLNSP--DNKNEVTPIKENSEQTVGG------SSSGK--------- 764
            |...||.|.| .|....||:.:..  .:..:||.....|..||..      ..:|:
pombe   820 LSEFSKKDTASSTGADTPLSRSQSVITSSTDVTSSASRSSDTVSNYPKATIKGTGRIRKRLTDED 884

  Fly   765 ------EHVERQESGGISLALYRKYFQAGGGLVAFLVMLSSSVLAQVAV-TGGDYFLTYWVKKES 822
                  :..|:.|.|.:...:|..||:|....:.||..|  .::..:.: .|.:.:|.:| .:.:
pombe   885 NVKATGQAAEKMERGKVKWKVYWTYFKACSLFLIFLYFL--FIIGGIGMNVGTNVWLKHW-SEVN 946

  Fly   823 TAAGHGEMEDMESKSMDVYKYTLIIILS-VIMNLSSSFLLFNIAKKASIRLHNTIFNRVTRADMH 886
            |..|:.     ......:..|||..:|| .:::|||..:....|.|:...||:::...|.||.|.
pombe   947 TQLGYN-----PKPYFYLGIYTLFGLLSCALISLSSLTITVFCAIKSCRYLHDSMVKAVLRAPMS 1006

  Fly   887 FFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFY 951
            ||.....|.|||||:.|:.:||||:..|.:...:....:..::.||...:|:.::..:.|..::.
pombe  1007 FFETTPTGRILNRFSSDVYRVDEVISRVFMFFFRNLFQIVFVLAVICYSSPMFMILIVPLFFLYR 1071

  Fly   952 HLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQRVLEKEFDSYQDAHSSAFFMY 1016
            :.:..|.:|||:|||::::.|||:|:|...||.||:||||.|.:.....|.|...|.:...:|:|
pombe  1072 YNQVYYTQTSRELKRLDSVTRSPLYAHFQESLGGLSTIRAYDMEDTFISENDIRVDTNHRIWFLY 1136

  Fly  1017 ISTS-------QAFGYCMNCICVIYISII--TLSFFAFPPGNGADVGLVITQAMGLIDMVQWGVR 1072
            .|::       :|.|     ..|::.|..  .||.....|.:|. |||.::.|:.:...:.:.||
pombe  1137 FSSNRWQAIRVEAIG-----ALVVFSSAFFGVLSAVRGNPNSGL-VGLSLSYAVQITQSLTFVVR 1195

  Fly  1073 QTAELENTMTAVERVVEYESIEPEGMLEAPDDKKPPKTWPEQGEIIFKELNLRYTPNAKAENVLK 1137
            |:.::|..:.:|||::||..:..|.....| |.:||:.||..|.|.|...::||..|...  ||.
pombe  1196 QSVDVETNIVSVERMLEYIGLPSEAPSIIP-DHRPPEGWPSHGAIKFDHYSVRYRENLPL--VLN 1257

  Fly  1138 SLSFVIQPREKVGIVGRTGAGKSSLINALFRL-SYTDGSVLIDTRDTRQMGLHDLRRQISIIPQE 1201
            .:|..|:|:||:|||||||||||:|..||||| ..|.|.:.:|..:...:||||||.:::|||||
pombe  1258 DISVNIKPQEKIGIVGRTGAGKSTLTLALFRLIEPTSGDIQLDDINITSIGLHDLRSRLAIIPQE 1322

  Fly  1202 PVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLA 1266
            ...|.||:|.||||....:||::|..||...||:.:..|..||.|:::|||.|.|.|||||:||.
pombe  1323 NQAFEGTIRENLDPNANATDEEIWHALEAASLKQFIQTLDGGLYSRVTEGGANLSSGQRQLMCLT 1387

  Fly  1267 RAILRENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVV 1331
            ||:|...|:|::|||||.||.:||.::|.|||.:|.|.|:||||||::|::||::::|:|.|:||
pombe  1388 RALLTPTRVLLLDEATAAVDVETDAIVQRTIRERFNDRTILTIAHRINTVMDSNRILVLDHGKVV 1452

  Fly  1332 EFGSPYELMTKSDSKVFHNLVNQSG 1356
            ||.|..:|: ::.:.:|::|..:||
pombe  1453 EFDSTKKLL-ENKASLFYSLAKESG 1476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	413/1310 (32%)
		ABC_membrane	171..437	CDD:294371	65/283 (23%)
		ABCC_MRP_domain1	499..699	CDD:213217	84/204 (41%)
		ABC_membrane	799..1045	CDD:294371	72/256 (28%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	112/221 (51%)
abc2	NP_593943.3	MRP_assoc_pro	96..1477	CDD:188098	417/1325 (31%)
		ABC_membrane	272..545	CDD:279056	65/282 (23%)
		ABCC_MRP_domain1	593..798	CDD:213217	85/211 (40%)
		ABC_membrane	928..1190	CDD:279056	78/273 (29%)
		ABCC_MRP_domain2	1237..1456	CDD:213211	112/220 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720