DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment l(2)03659 and abc4

DIOPT Version :9

Sequence 1:NP_001260823.1 Gene:l(2)03659 / 47905 FlyBaseID:FBgn0010549 Length:1374 Species:Drosophila melanogaster
Sequence 2:NP_594558.1 Gene:abc4 / 2543059 PomBaseID:SPAC30.04c Length:1469 Species:Schizosaccharomyces pombe


Alignment Length:1339 Identity:380/1339 - (28%)
Similarity:631/1339 - (47%) Gaps:164/1339 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    94 SNFISSLCFWY-------TIPIFRKGYRKTLDSTDLYRPLEEQKSDILG--------NRLCASWE 143
            |::...|.|::       .||:|.......|...|.|:|..||...:..        |.|..:.:
pombe   187 SSYSPFLWFYFFITIVGNFIPLFTPRVWYPLFPEDNYQPSAEQVCSMFNFACSYGYLNPLVLTAK 251

  Fly   144 REL-------------KNDG--------RSPSLVRALLRVFGWQLGFPGLAIFVVELGLRTLQPI 187
            |.:             ||..        ::|||...:.::|..|:...|::.|:|.: .:.|.||
pombe   252 RRVVEVDDTPVIPDYDKNKAWTYRFERMKTPSLFITIHKIFWRQILGMGVSSFMVSV-CQFLSPI 315

  Fly   188 FLVKLISYFSGEPDAANAGFYYAVAQIVISALTVMILTPTTFGIHHVCFKMRVAMGSMIFRKAL- 251
            .|.:|:.:......::.....:.|..:....||.:......|.......:....:...|:.|.: 
pombe   316 ALNRLLKHLESPSSSSVNPLVWIVLLLTGPFLTSLFTQFYLFMSTRYLARSYTTLVQQIYNKVIR 380

  Fly   252 -RLTKGALGDTTSGHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLF 315
             |..:...||:..|...||||.|:..:......:|.:...|:::....||:.:.:|.||..|:..
pombe   381 SRFVQNKSGDSKVGRSNNLISTDVDDIGEIREFIHIIVRAPVEIAGSIYLLQKLLGWSAYVGLAL 445

  Fly   316 MLLFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMN 380
            .:|...:.:.||...:.:.|:|...||:||.:::|::.:|::.|.:.||.|....|...|:.|:|
pombe   446 TVLTCSVPIVLGPLVAKLTLRANRATDSRIELMSELLQSIRITKFFGWELPMLDRVKQRRQVELN 510

  Fly   381 TIRQGQYIRGFDFARRIVLSRVAIFLSLVGYV----ILGKVFTPEIAFMITAYYNVLLAAMSIYV 441
              |..:.:. .:...::::..:.:|.....:|    |:|:..||.|||...:.::.:....| ::
pombe   511 --RTWKLLL-MEICIQVLVESLPVFSMFATFVVFTTIMGQTITPSIAFTSISLFSFIRTQFS-WI 571

  Fly   442 PSAIIQTAQFLTSIRRVEQFMQSEELGSSDKSEGPSKDTVPGNPPSNNNEADLLKSAISIRDLKA 506
            ...:.|..|...||.||..|:       :|..|....:|:    ...:.|.....::::      
pombe   572 AYLMRQIVQIFVSIGRVSDFL-------NDPDEVDPVNTI----EDTSQEIGFFNASLT------ 619

  Fly   507 KW--DPNSPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGS--LSYT 567
             |  :|:..|:.|..:|:......:..|||.|||||||||.|:||||..|.|...:..|  :||.
pombe   620 -WVSNPSPGDFCLRDLNIVFPRNKLSIVIGPTGSGKSSLISALLGELSLNKGSYNLPRSKGVSYV 683

  Fly   568 SQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARI 632
            ||..||.:.|:|.||||..|...:||::|::.|.|..|.......|.|.:||:|.|||||||.||
pombe   684 SQVPWLRNATIRDNILFDYPYIEERYKKVIQACGLLTDLQSFVASDLTEIGEKGVTLSGGQKQRI 748

  Fly   633 SLARSVYRKASIYLLDDPLSAVDASVARHLFDQCVRGHL-RGSTVVLVTHQ-EQFLPHVDQIVIL 695
            :|||:||...||.|:||..||:|...:..::..|.:..| ...||:||||. ..|:.....||.:
pombe   749 ALARAVYSPTSIVLMDDVFSALDIHTSNWIYKHCFQSSLMENRTVILVTHNVHLFMDSAAFIVTV 813

  Fly   696 ANGQIKALGDYESLLKTGLITGLGSLSKTDKAKTEEQEPLNLNSPDNKNEVTPIKENSEQTVGGS 760
            .||....:.|..|.|.        .|::...:.:|...| :|.:....|||...:...|:     
pombe   814 KNGSAFPVTDKSSPLL--------FLAEQAASASEAAAP-DLAAIPIPNEVDDAEAADEK----- 864

  Fly   761 SSGKEHVERQESGG----ISLALYRKYFQAGGGLVAFLVMLSSSVLAQVAVTGGDYFLTYWVKKE 821
             .||...|.|...|    ..:..|.|:|.:|..:.|.|:...::....:.:   |.::.:|    
pombe   865 -DGKLVEEEQRVTGDVVFSEIFSYMKHFGSGFYVAAVLLFFVTTQATSILI---DLWVAFW---- 921

  Fly   822 STAAGHGEMEDMESKSMDVY-----KYTLIIILSVIMNLSSSFLLFNIAKKASIRLHNTIFNRVT 881
             |.:.....:...:|.:.||     .|:|:..|..:.....::.       ||.:||:::...|.
pombe   922 -TNSSVNSPDVNNNKFLFVYGTMLLAYSLLDFLRTVSYDRGAWW-------ASRKLHDSMLESVF 978

  Fly   882 RADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNPLLLVPTLML 946
            .....:|.....|.|:|||.||:..:|..|...|...:...|.:||.|:.:::..|:.::|.:::
pombe   979 GTFASWFDKTPTGRIVNRFAKDIRSIDMNLSGWLFFSINCFLSVAGGILSVSSAMPIFMIPAVIV 1043

  Fly   947 SVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQRVLEKEFDSYQDAHSS 1011
            .:..|:...||.:....:||:.:|..||::|.|..|:.|::.|||.:.|.:.::.|....|    
pombe  1044 CLAGYYFGLLYTRAQVGVKRLISIYTSPIFSLLGESIVGVSVIRAFNRQTIFKQMFSERLD---- 1104

  Fly  1012 AFFMYISTSQAFGYCMNCICVI-----------YISIITLSFFAFPPGNGADVGLVITQAMGLID 1065
                .:...|:..|.:|....:           ...:|.|......||   .||..:.||:....
pombe  1105 ----NLVRLQSTSYNLNRWVAVRTDGISGLVGAIAGLIALLQKDLSPG---VVGFSLNQAVIFSS 1162

  Fly  1066 MVQWGVRQTAELENTMTAVERVVEYESIEPEGMLEAPDDKKP------PKTWPEQGEIIFKELNL 1124
            .|...||....|:..|.:.|||:||..:        |.:..|      |.|||::|:|:|..:::
pombe  1163 SVLLFVRSCNSLQAEMNSYERVLEYSKL--------PQEPAPTIAGQVPATWPKEGDIVFNHVSV 1219

  Fly  1125 RYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFRLSY-TDGSVLIDTRDTRQMGL 1188
            .|  :|....:||.::..|.|.|||.:|||||:|||:|...|.|.:: ..|.:.|:.|:|:.:.|
pombe  1220 SY--SAAGPTILKDVNLHINPSEKVAVVGRTGSGKSTLGLTLLRFTHRISGEIYINGRETQSVNL 1282

  Fly  1189 HDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDG-------LAS 1246
            :.||::||.|||:|:|||||:|.|||||||..|..|...|:......::....|.       |.:
pombe  1283 NALRQRISFIPQDPILFSGTVRSNLDPFDELEDNFLNEALKTSGASSMIMAHTDDQKPIHITLDT 1347

  Fly  1247 KISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAH 1311
            .::..|:|||.||:|::.|||||:|.::|:::||.||:||...|..||.|:|..|.|.|:|.|||
pombe  1348 HVASEGSNFSQGQKQVLALARAIVRRSKIIILDECTASVDDAMDQKIQKTLREAFGDATMLCIAH 1412

  Fly  1312 RLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHN 1350
            ||.||:|.|||||:|.|.:||:|.|        :.::||
pombe  1413 RLKTIVDYDKVMVLDKGVLVEYGPP--------AVLYHN 1443

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)03659NP_001260823.1 CFTR_protein 89..1343 CDD:273530 378/1330 (28%)
ABC_membrane 171..437 CDD:294371 60/271 (22%)
ABCC_MRP_domain1 499..699 CDD:213217 83/205 (40%)
ABC_membrane 799..1045 CDD:294371 54/261 (21%)
ABCC_MRP_domain2 1115..1336 CDD:213211 101/228 (44%)
abc4NP_594558.1 CFTR_protein 240..1449 CDD:273530 368/1286 (29%)
ABC_membrane 300..568 CDD:294371 60/271 (22%)
ABCC_MRP_domain1 611..817 CDD:213217 83/212 (39%)
ABC_membrane 901..1164 CDD:294371 61/288 (21%)
ABCC_MRP_domain2 1210..1437 CDD:213211 101/228 (44%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 1 1.100 - - O PTHR24223
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.900

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