DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and ybt1

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_594585.1	Gene:	ybt1 / 2542640	PomBaseID:	SPAC9E9.12c	Length:	1427	Species:	Schizosaccharomyces pombe

Alignment Length:	1354	Identity:	380/1354 - (28%)
Similarity:	638/1354 - (47%)	Gaps:	205/1354 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 IPI-FRKGYRKTLDSTDLYRPLEEQKSDI---------LGNRLCASWEREL-------------- 146
            ||: |.:.:..|:..:.:.||..||...|         |...:..||::.:
pombe   171 IPLFFPRAWSPTVKFSKVARPSPEQTCSIFSLIFTYGWLNGIIWKSWKKPITLTDVPALPDTECT 235

  Fly   147 --------KNDGRS------PSLVRALLRVFGWQLGFPGLAIFVVELGLRTL--QPIFLVKLISY 195
                    |||.:|      .||...:|           |.:|:..|...||  .|:.:.||:.|
pombe   236 QIWYSRFAKNDRKSLMHTILLSLKSTIL-----------LMVFLSVLVSSTLFVTPLAIKKLLQY 289

  Fly   196 FSG-EPDAANAGFYYAVAQIVISALTVMILTPTTFGIHHVCFKMRVAMGSMIFRKALRLTKGALG 259
            ... :.|..|:.|.:....::...|..::.............:::.|:..||::|.  ||...|.
pombe   290 LQNPKSDEGNSPFLWVFVLLIGPYLASVVKELYVHVSRRFMLRIKAAITQMIYKKV--LTSKTLF 352

  Fly   260 DTTSG------HVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLL 318
            ....|      :|.||::.|:..:......:..:...||::.|..|.:||.:|.||..|:|..:|
pombe   353 VAVDGSKINLDYVYNLLAKDVDNIGEMREFIGIIARAPLEMGVSMYFLYQLLGWSAYVGLLLAIL 417

  Fly   319 FMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTI- 382
            .....:.:.::.|.:...|...:|.|||:..|::.:|::.|::.||:|....:...|..|:|.:
pombe   418 SSSFPLLVASKISRLTSIANTSSDERIRLTTELLKSIKITKLFGWERPMLSRIQEKRSFEVNNMY 482

  Fly   383 ---------RQGQYIRGFDFARRIVLSRVAIFLSLVGYV-ILGKVFTPEIAFMITAYYNVLLAAM 437
                     :.|..|..|          :::|::...|. |:|...||..||...:.:. ||...
pombe   483 SLTLFDIIFKSGMKIAPF----------ISMFITFAIYTKIMGHQLTPATAFTSISMFG-LLRYQ 536

  Fly   438 SIYVPSAIIQTAQFLTSIRRVEQFMQSEELGSSDKSEGPSKDTVPGNPPSNNNEADLLKSAISIR 502
            .|::.|...|..||..|::||:.|:....:..|......|                     ....
pombe   537 FIWLASVSRQFIQFKVSLKRVDNFVYGNMVNDSSIESSDS---------------------FVFE 580

  Fly   503 DLKAKWDPNSPD---YTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQL---QVN 561
            :....|.| :|.   :.|..:|..|.......|:|.||||||:|..|:||||...||::   .::
pombe   581 NTSLSWSP-TPSTALFQLKNLNFTIPRNQFTLVVGSTGSGKSTLAMALLGELHVISGKMTTPSIS 644

  Fly   562 GSLSYTSQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSG 626
            ..::|..|.:||.:||:|.|||||:|.|.:||.:::|.|.|:.|.:.:...|.|.:...|::|||
pombe   645 QRIAYVPQAAWLRNGTIRSNILFGEPYDEERYFQIIKACCLDSDLNSMNDGDLTYIHSNGSSLSG 709

  Fly   627 GQKARISLARSVYRKASIYLLDDPLSAVDASVARHLFDQC-VRGHLRGSTVVLVTHQEQF-LPHV 689
            |||.|:||||::|..|.:|:.||..||:|.|.:|.:::.| :...|:..|::|.||.... ||..
pombe   710 GQKQRVSLARALYSNAEVYIFDDIFSALDVSTSRKIYESCFLSTLLQHKTIILFTHNVSLCLPIA 774

  Fly   690 DQIVILAN--GQIKALGDYESLLKTGLITGLGSLSKTDKAKTEEQEPLNLNSPDNKNEVTPIKEN 752
            :.:::|.|  .|:.:....:.|:.:   |...|.:|.|..:.|..||.:.              :
pombe   775 ENVIVLKNSTAQLVSPDSIQELVPS---TFFSSNTKKDNIEEENLEPHSF--------------S 822

  Fly   753 SEQTVGGSSSGKEHVERQESGGISLAL----YRKYFQAGGGLVAFLVMLSSSVLAQVAVTGGDYF 813
            .:.|:..||...|  :|..:...|:.|    |.|||.:...::..::::   :::||::....::
pombe   823 FDSTLASSSDNDE--QRDFASNSSIVLLGLHYLKYFGSNKYILGSILLV---MMSQVSLASIHFW 882

  Fly   814 LTYWVKKESTAAGHGEME-DMESKSMDVYKYTLIIILSVIMNLSSSFLLFNIAKKASIRLHNTIF 877
            :..|       :|:.... .:.|....::.|.:::.:..:|:||.:.......:.||..:|:.:.
pombe   883 IALW-------SGNSLFSLKLPSSFSFLWGYAILLFIYFLMDLSRAITFAKGGRTASENIHDILS 940

  Fly   878 NRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANVN---PLL 939
            .||..:.:|:|.....|.|||||:|||...|.:|...|..::   |.:..|:|.:.||.   |:.
pombe   941 ERVLYSPLHWFEKTAAGRILNRFSKDMYATDNLLWASLEGML---LCVMAILITMLNVTLVMPIF 1002

  Fly   940 LVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQRVLEKEFDS 1004
            :||...:|::.|.....|.|..:.|..:::...|||::.|..:|.|:|.|||...:::.|.|
pombe  1003 MVPAAFVSLLVYLHGYAYSKAQKQLTSLQSSRTSPVFTMLGETLGGITVIRAFKKEKIFEHE--- 1064

  Fly  1005 YQDAHSSAFF------MYIS-------------TSQAFGYCMNCICVIYISIITLSFFAFPPGNG 1050
                 :.||.      :|||             .|...|:....|.::..:|        |||.
pombe  1065 -----NMAFIDDMIQPLYISFAINRWLAIRTDGISGLVGFSTGLIALLRQNI--------PPGL- 1115

  Fly  1051 ADVGLVITQAMGLIDMVQWGVRQTAELENTMTAVERVVEYESIEPEGMLEAPDDKKPPKTWPEQG 1115
              ||..:..|:|....|...||...|:...:....|:.||..:..|....:...|...|.||..|
pombe  1116 --VGFSLNSAIGFNISVLVFVRANNEILTYINNFRRLYEYMLLPSEKNESSCLTKPMNKEWPTLG 1178

  Fly  1116 EIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFRLS-YTDGSVLID 1179
            .:..|.|.:.|:....|  ||:.::..|.|:||:.||||||:|||::...|.|.: ...|:|.:|
pombe  1179 HVSIKNLTVSYSIGQAA--VLEDINLEILPKEKIAIVGRTGSGKSTMGLTLLRFTMIMSGAVEVD 1241

  Fly  1180 TRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEVV----SDL 1240
            ..|...:.|..||::||:|||:|||.|||:|.|||||:||.|.:|...|:....:.:|    .:.
pombe  1242 GIDINSLDLEVLRQRISLIPQDPVLISGTVRSNLDPFEEYGDGELNEILKTASCESLVQASNKNS 1306

  Fly  1241 PDGLA----SKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQATIRSKF 1301
            .|..|    :.:..||.|||.||||::.||||::|::||:::||:||:||..||..||..:|:.|
pombe  1307 LDAFAIHLDTPVDSGGVNFSSGQRQILALARALVRKSRIVILDESTASVDDTTDRRIQQMLRAAF 1371

  Fly  1302 RDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLVNQS 1355
            :..|||.||||:.||:|.|||:|:|:|:.||||||..|.|:  .:.|..:..:|
pombe  1372 KHATVLCIAHRIKTIVDYDKVLVLDSGKTVEFGSPKSLYTQ--RRAFWKMCKES 1423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	378/1340 (28%)
		ABC_membrane	171..437	CDD:294371	65/285 (23%)
		ABCC_MRP_domain1	499..699	CDD:213217	76/209 (36%)
		ABC_membrane	799..1045	CDD:294371	62/268 (23%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	102/229 (45%)
ybt1	NP_594585.1	CFTR_protein	192..1416	CDD:273530	372/1324 (28%)
		ABC_membrane	266..537	CDD:294371	64/283 (23%)
		ABCC_MRP_domain1	577..782	CDD:213217	75/205 (37%)
		ABC_membrane	866..1094	CDD:294371	58/248 (23%)
		ABCC_MRP_domain2	1178..1406	CDD:213211	102/229 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.900