DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and Abcc2

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_036965.1	Gene:	Abcc2 / 25303	RGDID:	2366	Length:	1541	Species:	Rattus norvegicus

Alignment Length:	1407	Identity:	477/1407 - (33%)
Similarity:	737/1407 - (52%)	Gaps:	203/1407 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 ENPRARSNFISSLCF-WYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNRLCA----------- 140
            :.|...::|:||:.| ||...:. |||:..|...|::...|..|:..:.::..|
  Rat   191 QTPSVTASFLSSITFSWYDRTVL-KGYKHPLTLEDVWDIDEGFKTRSVTSKFEAAMTKDLQKARQ 254

  Fly   141 SWERELKNDGRSPS-------------------------------------LVRALLRVFGWQLG 168
            :::|.|:...|.|.                                     |:::|.:.|...:
  Rat   255 AFQRRLQKSQRKPEATLHGLNKKQSQSQDVLVLEEAKKKSEKTTKDYPKSWLIKSLFKTFHVVI- 318

  Fly   169 FPGLAIFVVEL---GLRTLQPIFLVKLISYFSGEPDAANAGFYYAVAQIVISALTVMILTPTTFG 230
               |..|:::|   .|..|.|..|..||.:..........|:..|:....::.:....|  .::.
  Rat   319 ---LKSFILKLIHDLLVFLNPQLLKLLIGFVKSSNSYVWFGYICAILMFAVTLIQSFCL--QSYF 378

  Fly   231 IHHVCFKM----RVAMGSMIFRKALRLTKGALGDTTSGHVVNLISNDIPRLDSAPYTVHYLWVGP 291
            .|  ||.:    |..:.|.|::|||.|:..|....|.|..|||:|.|..:|..|...:..:|...
  Rat   379 QH--CFVLGMCVRTTVMSSIYKKALTLSNLARKQYTIGETVNLMSVDSQKLMDATNYMQLVWSSV 441

  Fly   292 LQVLVITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQ 356
            :|:.:..:.:::|:|.|.:.||..|:|.:|:...|.|:...||::..:..|.|::::|||:|.|:
  Rat   442 IQITLSIFFLWRELGPSILAGVGVMVLLIPVNGVLATKIRNIQVQNMKNKDKRLKIMNEILSGIK 506

  Fly   357 VLKMYAWEQPFEQMVTHAREKEM-NTIRQGQYIRGFDFARRIVLSRVAIFLSLVG---YVIL--G 415
            :||.:|||..|::.|...|:||: |.:|.||......|    :|....|.:|:|.   ||::  .
  Rat   507 ILKYFAWEPSFQEQVQGIRKKELKNLLRFGQLQSLLIF----ILQITPILVSVVTFSVYVLVDSA 567

  Fly   416 KVFTPEIAFMITAYYNVLLAAMSI--YVPSAIIQTAQFLTSIRRVEQFMQSEELGSSDKSEGPSK 478
            .|...|.||.....:|:|...:|:  .|.|:|:|.:   .|:.|:|:::..::|
  Rat   568 NVLNAEKAFTSITLFNILRFPLSMLPMVTSSILQAS---VSVDRLERYLGGDDL----------- 618

  Fly   479 DTVPGNPPSNNNEADLLKSAISIRDLKAKWDPNSPDYTLSGINLEIKPGSVVAVIGLTGSGKSSL 543
            ||......||      ...|:...:....|||:. :.|:..:||:||||.:|||:|..|||||||
  Rat   619 DTSAIRRVSN------FDKAVKFSEASFTWDPDL-EATIQDVNLDIKPGQLVAVVGTVGSGKSSL 676

  Fly   544 IQAILGELKANSGQLQVNGSLSYTSQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDL 608
            :.|:|||::...|.:.:.||.:|..|:||:.:||::.|||||...:.::|::|:|.|||..|.::
  Rat   677 VSAMLGEMENVHGHITIQGSTAYVPQQSWIQNGTIKDNILFGSEYNEKKYQQVLKACALLPDLEI 741

  Fly   609 LPLRDNTIVGERGATLSGGQKARISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCV--RGHL 671
            ||..|...:||:|..||||||.|:||||:.|:.|.||:||||||||||.|.:|:|::.|  .|.|
  Rat   742 LPGGDMAEIGEKGINLSGGQKQRVSLARAAYQDADIYILDDPLSAVDAHVGKHIFNKVVGPNGLL 806

  Fly   672 RGSTVVLVTHQEQFLPHVDQIVILANGQIKALGDYESLL----------KT-------------- 712
            .|.|.:.|||...|||.||:||:|..|.|...|.|..||          ||
  Rat   807 AGKTRIFVTHGIHFLPQVDEIVVLGKGTILEKGSYRDLLDKKGVFARNWKTFMKHSGPEGEATVN 871

  Fly   713 ----------GLITGL-------------------GSLSKTDKAKTEEQEPLNLNSPDNKNEVTP 748
                      |||..:                   .:||::.::.:...:.|. ||...|| |..
  Rat   872 NDSEAEDDDDGLIPTMEEIPEDAASLAMRRENSLRRTLSRSSRSSSRRGKSLK-NSLKIKN-VNV 934

  Fly   749 IKENSEQTVGGSSSGKEHVERQESGGISLALYRKYFQA-GGGLVAFLVMLSSSVLAQVAVTGGDY 812
            :||..::..|.....||.|   |:|.:..::|.||.|| |...:.|:::...  |..||..|.:.
  Rat   935 LKEKEKEVEGQKLIKKEFV---ETGKVKFSIYLKYLQAVGWWSILFIILFYG--LNNVAFIGSNL 994

  Fly   813 FLTYWVKKESTAAGHGEMEDMESKSMDVYKYTLIIILSVIMNLSSSFLLFNIAKKASIRLHNTIF 877
            :|:.|.......  :|.......:.|.:..:..:.:...|..|.|:.......:.||..||..:.
  Rat   995 WLSAWTSDSDNL--NGTNNSSSHRDMRIGVFGALGLAQGICLLISTLWSIYACRNASKALHGQLL 1057

  Fly   878 NRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNPLLLVP 942
            ..:.||.|.||.....|.|:|||:.|:|.||::||..|...|.....:||.:::|....|:..:.
  Rat  1058 TNILRAPMRFFDTTPTGRIVNRFSGDISTVDDLLPQTLRSWMMCFFGIAGTLVMICMATPVFAII 1122

  Fly   943 TLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALD-AQRVL---EKEFD 1003
            .:.||:::..::..|:.|||.|:|::::.:||:|||.:.::.||..|||.: .||.|   ||:.|
  Rat  1123 IIPLSILYISVQVFYVATSRQLRRLDSVTKSPIYSHFSETVTGLPIIRAFEHQQRFLAWNEKQID 1187

  Fly  1004 SYQDAHSSAFFMYISTSQAFG-----------YCMNCICVIYISIITLSFFAFPPGNGADVGLVI 1057
            ..|    ...|.:|::::...           :|...:.|||...:|          |..||.|:
  Rat  1188 INQ----KCVFSWITSNRWLAIRLELVGNLVVFCSALLLVIYRKTLT----------GDVVGFVL 1238

  Fly  1058 TQAMGLIDMVQWGVRQTAELENTMTAVERVVEYESIEPEGMLEAP--DDKKPPKTWPEQGEIIFK 1120
            :.|:.:...:.|.||.|:|.|..:.||||:.||.::|.    |||  .||:||..||..|||.|.
  Rat  1239 SNALNITQTLNWLVRMTSEAETNIVAVERISEYINVEN----EAPWVTDKRPPADWPRHGEIQFN 1299

  Fly  1121 ELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFR-LSYTDGSVLIDTRDTR 1184
            ...:||.|  :.:.|||.::..|:..||||:|||||||||||.|.||| |....|.::||..|..
  Rat  1300 NYQVRYRP--ELDLVLKGITCNIKSGEKVGVVGRTGAGKSSLTNCLFRILESAGGQIIIDGIDVA 1362

  Fly  1185 QMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKIS 1249
            .:||||||.:::||||:|:||||::|.|||||::||||::|..||...|:..||.|..||.|:::
  Rat  1363 SIGLHDLRERLTIIPQDPILFSGSLRMNLDPFNKYSDEEVWRALELAHLRSFVSGLQLGLLSEVT 1427

  Fly  1250 EGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLH 1314
            |||.|.|:|||||:||.||:||:::|||:|||||.||.:||.|||.|||.:|..|||:|||||||
  Rat  1428 EGGDNLSIGQRQLLCLGRAVLRKSKILVLDEATAAVDLETDSLIQTTIRKEFSQCTVITIAHRLH 1492

  Fly  1315 TIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLVNQSG 1356
            ||:||||:||:|.|::||:|||.||::...|  |:.:..::|
  Rat  1493 TIMDSDKIMVLDNGKIVEYGSPEELLSNRGS--FYLMAKEAG 1532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	474/1391 (34%)
		ABC_membrane	171..437	CDD:294371	80/278 (29%)
		ABCC_MRP_domain1	499..699	CDD:213217	96/201 (48%)
		ABC_membrane	799..1045	CDD:294371	69/260 (27%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	128/221 (58%)
Abcc2	NP_036965.1	MRP_assoc_pro	7..1533	CDD:188098	477/1407 (34%)
		ABC_membrane	322..589	CDD:279056	79/274 (29%)
		ABCC_MRP_domain1	633..834	CDD:213217	96/201 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	862..881		0/18 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	901..923		2/21 (10%)
		ABC_membrane	979..1245	CDD:279056	74/283 (26%)
		ABCC_MRP_domain2	1294..1514	CDD:213211	128/221 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345109
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.660