DRSC/TRiP Functional Genomics Resources

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Protein Alignment l(2)03659 and Abcb4

DIOPT Version :9

Sequence 1:NP_001260823.1 Gene:l(2)03659 / 47905 FlyBaseID:FBgn0010549 Length:1374 Species:Drosophila melanogaster
Sequence 2:NP_036822.1 Gene:Abcb4 / 24891 RGDID:620248 Length:1278 Species:Rattus norvegicus


Alignment Length:1463 Identity:325/1463 - (22%)
Similarity:581/1463 - (39%) Gaps:368/1463 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 FELGHQTENCKQKLTVNSENNSAQNEKEKVLPENPRARSNFISSLCFWYTIPIFRKGYRKTLDST 120
            ||||             |.:|.::.:|:||         |.|..|      .:||          
  Rat    18 FELG-------------SISNQSREKKKKV---------NLIGPL------TLFR---------- 44

  Fly   121 DLYRPLEEQKSDILGNRLCASWERELKNDGRSPSLVRALLRVFGWQLGFPGLAIFVVELGLRTLQ 185
              |...:::...:||..:..:          ..|.:..::.|||....     .||...|..:|.
  Rat    45 --YSDWQDKLFMLLGTAMAIA----------HGSGLPLMMIVFGEMTD-----KFVDNAGNFSLP 92

  Fly   186 PIFLVKLISYFSG---EPDAANAGFYYA--------VAQIVISALTVMILTPTTFGIHHVCFKMR 239
            ..|.:.:::  .|   |.:.....:||:        .|.|.:|..|                   
  Rat    93 VNFSLSMLN--PGRILEEEMTRYAYYYSGLGGGVLLAAYIQVSFWT------------------- 136

  Fly   240 VAMGSMI-------FRKALRLTKGALGDTTSGHVVNLISNDIPRLDS-----------------A 280
            :|.|..|       |...||...|......:..:...:::||.::..                 |
  Rat   137 LAAGRQIRKIRQKFFHAILRQEMGWFDIKGTTELNTRLTDDISKISEGIGDKVGMFFQAIATFFA 201

  Fly   281 PYTVHYL--WVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDN 343
            .:.|.::  |...|.::.||.:    :|:|.......:..|...::....:..|:          
  Rat   202 GFIVGFIRGWKLTLVIMAITAI----LGLSTAVWAKILSTFSDKELAAYAKAGAV---------- 252

  Fly   344 RIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQYIRGFDFARRIVLSR------- 401
                ..|.:.||:.:..:.           .:.||:.     :|.:..:.|::|.:.:       
  Rat   253 ----AEEALGAIRTVIAFG-----------GQNKELE-----RYQKHLENAKKIGIKKAISANIS 297

  Fly   402 --VAIFLSLVGY---------VILGKVFTPEIAFMITAYYNVLLAAMSIYVPSAIIQTAQFLTSI 455
              :|..|....|         :::.|.:|  |...:|.::::|:.|.|:...:..|.        
  Rat   298 MGIAFLLIYASYALAFWYGSTLVISKEYT--IGNAMTVFFSILIGAFSVGQAAPCID-------- 352

  Fly   456 RRVEQFMQSEELGSSDKSEGPSK---DTVPGNP-----PSNNNEADLLKSAISIRDLKAKWDPNS 512
                         :...:.|.:.   |.:..||     ....::.|.:|..:...|:...:...:
  Rat   353 -------------AFPNARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFSDVHFSYPSRA 404

  Fly   513 PDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGS-------------L 564
            ....|.|:||::|.|..||::|.:|.|||:.:|.:........|.:.::|.             :
  Rat   405 NIKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGTISIDGQDIRNFNVRCLREFI 469

  Fly   565 SYTSQESWLFSGTVRQNILFGQ---PMDSQRYEEVVKKCALER---DFDL-LPLRDNTIVGERGA 622
            ...|||..|||.|:.:||.:|:   .||.      :||...|.   ||.: ||.:.:|:||:|||
  Rat   470 GVVSQEPVLFSTTIAENIRYGRGNVTMDE------IKKAVKEANAYDFIMKLPQKFDTLVGDRGA 528

  Fly   623 TLSGGQKARISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCVRGHLR-GSTVVLVTHQEQFL 686
            .||||||.||::||::.|...|.|||:..||:|......:  |......| |.|.:::.|:...:
  Rat   529 QLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV--QAALDKAREGRTTIVIAHRLSTV 591

  Fly   687 PHVDQIVILANGQIKALGDYESLL-KTGLITGLGSLSKTDKAKTEEQEPLNLNSPDNKNEVTP-- 748
            .:.|.|....:|.|...|.:..|: |.|:...|.::..:......|:..:.|:.......|.|  
  Rat   592 RNADVIAGFEDGVIVEQGSHSELIKKEGIYFRLVNMQTSGSQILSEEFEVELSDEKAAGGVAPNG 656

  Fly   749 ----IKENSEQTVGGSSSGKEH-----VERQE-SGGISLALYRK----------YFQAG------ 787
                |..||  |.....|.:.|     ||..| ...:....:.|          ||..|      
  Rat   657 WKARIFRNS--TKKSLKSSRAHQNRLDVETNELDANVPPVSFLKVLRLNKTEWPYFVVGTLCAIA 719

  Fly   788 -GGL-VAFLVMLSSSVLAQVAVTG-GDYFLTYWVKKESTAAGHGEMEDMESKSMDVYKYTLIIIL 849
             |.| .||.::||.    .:|:.| ||                   :.::.:..:::.   ::.|
  Rat   720 NGALQPAFSIILSE----MIAIFGPGD-------------------DTVKQQKCNMFS---LVFL 758

  Fly   850 SVIMNLSSSFLL--FNIAKKASI---RLHNTIFNRVTRADMHFFSINKH--GSILNRFTKDMSQV 907
            .:.::...:|.|  |...|...|   ||.:..|..:.|.||.:|..:|:  |::..|...|.:||
  Rat   759 GLGVHSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQV 823

  Fly   908 DEVLPVVLVDVMQIALWL-AGIIIVIANVNPLLLVPTLMLSVI-------FYHLRNLYLKTSRDL 964
            .......|..:.|....| .||||.......|.|   |:|||:       ...::.|.....||.
  Rat   824 QGATGTRLALIAQNTANLGTGIIISFIYGWQLTL---LLLSVVPFIAVAGIVEMKMLAGNAKRDK 885

  Fly   965 KRVEAINRSPVYSHLAASLNGLTTIRALDAQRVLEKEF---------DSYQDAHSSAFFMYISTS 1020
            |.:||..:.     ...::..:.|:.:|..:|..|..:         :|.:.||  .:.:..|.|
  Rat   886 KEMEAAGKI-----ATEAIENIRTVVSLTQERKFESMYVEKLHGPYRNSVRKAH--IYGITFSIS 943

  Fly  1021 QAFGYCMNCICVIYISIITLSFFAFPPGNG----ADVGLVITQAMGLIDMVQWGVRQT------- 1074
            |||.|.....|..:.|.:.:        ||    .||.||.:..  ::..|..|...:       
  Rat   944 QAFMYFSYAGCFRFGSYLIV--------NGHMRFKDVILVFSAI--VLGAVALGHASSFAPDYAK 998

  Fly  1075 AELENT--MTAVERVVEYESIEPEGMLEAPDDKKPPKTWPE--QGEIIFKELNLRYTPNAKAENV 1135
            |:|...  .:..||....:|...|||            ||:  :|.:.|.|:...|...|... |
  Rat   999 AKLSAAYLFSLFERQPLIDSYSREGM------------WPDKFEGSVTFNEVVFNYPTRANVP-V 1050

  Fly  1136 LKSLSFVIQPREKVGIVGRTGAGKSSLINALFRLSYTD---GSVLIDTRDTRQMGLHDLRRQISI 1197
            |:.||..::..:.:.:||.:|.|||:::..|.|  :.|   |:||:|.::.:::.:..||.|:.|
  Rat  1051 LQGLSLEVKKGQTLALVGSSGCGKSTVVQLLER--FYDPMAGTVLLDGQEAKKLNVQWLRAQLGI 1113

  Fly  1198 IPQEPVLFSGTMRYNL---DPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQ 1259
            :.|||:||..::..|:   |.....|.:::....:|..:...:..||....:::.:.||..|.||
  Rat  1114 VSQEPILFDCSIAKNIAYGDNSRVVSQDEIVRAAKEANIHPFIETLPQKYETRVGDKGTQLSGGQ 1178

  Fly  1260 RQLVCLARAILRENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMV 1324
            :|.:.:|||::|:.|:|::||||:.:|.:::.::|..:.......|.:.|||||.||.::|.::|
  Rat  1179 KQRIAIARALIRQPRVLLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVV 1243

  Fly  1325 MDAGRVVEFGSPYELMTKSDSKVFHNLVN-QSG 1356
            :|.|:|.|.|:..:|:.:..  ::.::|| |:|
  Rat  1244 IDNGKVKEHGTHQQLLAQKG--IYFSMVNIQAG 1274

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)03659NP_001260823.1 CFTR_protein 89..1343 CDD:273530 312/1414 (22%)
ABC_membrane 171..437 CDD:294371 48/320 (15%)
ABCC_MRP_domain1 499..699 CDD:213217 67/220 (30%)
ABC_membrane 799..1045 CDD:294371 57/270 (21%)
ABCC_MRP_domain2 1115..1336 CDD:213211 70/226 (31%)
Abcb4NP_036822.1 PTZ00265 29..1271 CDD:240339 316/1434 (22%)
ABC_membrane 58..342 CDD:279056 52/355 (15%)
ABC_MTABC3_MDL1_MDL2 392..628 CDD:213216 74/243 (30%)
Interaction with HAX1. /evidence=ECO:0000269|PubMed:15159385 622..646 3/23 (13%)
ABC_membrane 714..984 CDD:279056 69/315 (22%)
ABC_MTABC3_MDL1_MDL2 1033..1272 CDD:213216 72/243 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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