DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)03659 and Tap2

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_114445.2	Gene:	Tap2 / 24812	RGDID:	3818	Length:	703	Species:	Rattus norvegicus

Alignment Length:	640	Identity:	161/640 - (25%)
Similarity:	292/640 - (45%)	Gaps:	105/640 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   772 SGGISLALYRKYFQAGG-----------GLVAFLVMLSSSVLAQVAVTGGDYFLTYWVKKESTAA 825
            :..:|||::.....||.           .|:..|:.||...|..:.|......:..|   ..|..
  Rat   108 AAALSLAVWAVLSPAGAQEKEPGQENNRALMIRLLRLSKPDLPFLIVAFIFLAMAVW---GETLI 169

  Fly   826 GH--GEMEDMESKSMDVYKYTLIIILSVIMNLSSSF--------LLFNIAKKASIRLHNTIFNRV 880
            .|  |.:.|:.....|...:...|....:.::.||.        .||.:: :.::|:...:|:.:
  Rat   170 PHYSGRVIDILGGDFDPDAFASAIFFMCLFSVGSSLSAGCRGGSFLFTMS-RINLRIREQLFSSL 233

  Fly   881 TRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNP------LL 939
            .|.|:.||...|.|.:.:|.:.|.|.:...||.....:::..:.:.|:...:..|:|      ||
  Rat   234 LRQDLAFFQETKTGELNSRLSSDTSLMSRWLPFNANILLRSLVKVVGLYYFMLQVSPRLTFLSLL 298

  Fly   940 LVPTLMLSVIFYHLRN-LYLKTSRDL--KRVEAINRSPVYSHLAASLNGLTTIRALDAQRVLEKE 1001
            .:|..:.:...|:.|: ..||..:|:  |..:.:..         ::.||.|:|:..|:   |:|
  Rat   299 DLPLTIAAEKVYNPRHQAVLKEIQDVVAKAGQVVRE---------AVGGLQTVRSFGAE---EQE 351

  Fly  1002 FDSYQDA------------HSSAFFMYISTSQAFG---YCMNC-ICVIYISIIT----LSFFAFP 1046
            ...|::|            .....::.|....|.|   ..:|| :..|....:|    |||..:.
  Rat   352 VSRYKEALERCRQLWWRRDLEKELYLVIRRVMALGMQVLILNCGVQQILAGEVTRGGLLSFLLYQ 416

  Fly  1047 PGNGADVGLVITQAMGLIDMVQWGVRQTAELENTMTAVERVVEYESIEPEGMLEAPDDKKPPKTW 1111
            ...|..|       ..|:.|.       .::.:.:.|.|:|..|....|.  |..|....||:.
  Rat   417 EEVGHHV-------RNLVYMY-------GDMLSNVGAAEKVFSYLDRRPN--LPKPGTLAPPRV- 464

  Fly  1112 PEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFRLSY--TDG 1174
              :|.:.|::::..| |:...:.||:.|:|.:.|.:...:||..|:|||: :.||.:..|  |.|
  Rat   465 --EGRVEFQDVSFSY-PSRPEKPVLQGLTFTLHPGKVTALVGPNGSGKST-VAALLQNLYQPTGG 525

  Fly  1175 SVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEY-----SDEKLWGCLEEVKLK 1234
            .||:|.....|...|.|.||:.::.||||||||:::.|:    .|     .|.::....:.....
  Rat   526 KVLLDGEPLVQYDHHYLHRQVVLVGQEPVLFSGSVKDNI----AYGLRNCEDAQVMAAAQAACAD 586

  Fly  1235 EVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQATIRS 1299
            :.:.::.:|:.::|.|.|:..:|||:|.:.:|||::|..|:|::||||:.:|.:.:..:| |.||
  Rat   587 DFIGEMTNGINTEIGERGSQLAVGQKQRLAIARALVRNPRVLILDEATSALDAECEQALQ-TWRS 650

  Fly  1300 KFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLVNQ 1354
            : .|.|:|.|||||||:.::|:|:|:..|::||..     ..:.:..|:.:||.|
  Rat   651 Q-EDRTMLVIAHRLHTVQNADQVLVLKQGQLVEHD-----QLRDEQDVYAHLVQQ 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	157/627 (25%)
		ABC_membrane	171..437	CDD:294371
		ABCC_MRP_domain1	499..699	CDD:213217
		ABC_membrane	799..1045	CDD:294371	57/284 (20%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	78/227 (34%)
Tap2	NP_114445.2	3a01208	1..697	CDD:273363	158/636 (25%)
		ABC_membrane	156..416	CDD:279056	55/275 (20%)
		P-loop_NTPase	457..680	CDD:304359	78/233 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000