DRSC/TRiP Functional Genomics Resources

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Protein Alignment l(2)03659 and Tap1

DIOPT Version :9

Sequence 1:NP_001260823.1 Gene:l(2)03659 / 47905 FlyBaseID:FBgn0010549 Length:1374 Species:Drosophila melanogaster
Sequence 2:NP_114444.2 Gene:Tap1 / 24811 RGDID:3817 Length:725 Species:Rattus norvegicus


Alignment Length:596 Identity:150/596 - (25%)
Similarity:265/596 - (44%) Gaps:89/596 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   788 GGLVAFLVMLSSSVLAQVAV---TGGDYFLTYWVKKESTAAGHGEMEDMESKSMDVYKYTLIIIL 849
            |.|...||:|..|.|.::|:   ||.   :|.|:.::.||         .|.:.:::...::.:.
  Rat   162 GRLHLVLVLLILSCLGEMAIPFFTGR---ITDWILQDKTA---------PSFARNMWLMCILTVA 214

  Fly   850 SVIMNLSSSFLLFNIAK-KASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPV 913
            |..:..:... ::||.. ....|:|..:|..|...:..||..|..|||.:|.|:|.|.|.|.:. 
  Rat   215 STALEFAGDG-IYNITMGHMHSRVHGEVFRAVLHQETGFFLKNPTGSITSRVTEDTSNVCESIS- 277

  Fly   914 VLVDVMQIALWLAG-----IIIVIANVNPLLLVPTLMLSVIFYHLRNL-YLKTSRDLKRVEAINR 972
               |.:.:.||..|     :..:|.....|.:|..|.|.::|...|.| .:..|..:|..|::.:
  Rat   278 ---DKLNLFLWYLGRGLCLLAFMIWGSFYLTVVTLLSLPLLFLLPRRLGKVYQSLAVKVQESLAK 339

  Fly   973 SPVYSHLAASLNGLTTIRAL-----DAQRVLEK--EFDSYQDAHSSAFFMYISTSQAFGYCMNCI 1030
            |...:  ..:|:.:.|:|:.     :||:..:|  |........:.|:...:.|....|..:. :
  Rat   340 STQVA--LEALSAMPTVRSFANEEGEAQKFRQKLEEMKPLNKKEALAYVTEVWTMSVSGMLLK-V 401

  Fly  1031 CVIYISIITLSFFAFPPGNGADVGLVITQAMGLIDMVQWGVRQTAELE----------NTMTAVE 1085
            .::|:....:...|...||             |:..|.:.::.|..:|          .::.|.|
  Rat   402 GILYLGGQLVVRGAVSSGN-------------LVSFVLYQLQFTRAVEVLLSIYPSMQKSVGASE 453

  Fly  1086 RVVEYESIEP----EGMLEAPDDKKPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPR 1146
            ::.||....|    .|.| ||.:.|        |.:.|::::..| ||.....||:.|:|.:.|.
  Rat   454 KIFEYLDRTPCSPLSGSL-APLNMK--------GLVKFQDVSFAY-PNHPNVQVLQGLTFTLYPG 508

  Fly  1147 EKVGIVGRTGAGKSSLINALFRLSY--TDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTM 1209
            :...:||..|:|||: :.||.:..|  |.|.||:|.....|...|.|..|::.:.|||:||..:.
  Rat   509 KVTALVGPNGSGKST-VAALLQNLYQPTGGKVLLDGELLVQYDHHYLHTQVAAVGQEPLLFGRSF 572

  Fly  1210 RYNL------DPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARA 1268
            |.|:      .|    :.|::.....|....:.:|..|.|..:::.|.|...|.||||.|.||||
  Rat   573 RENIAYGLTRTP----TMEEITAVAMESGAHDFISGFPQGYDTEVGETGNQLSGGQRQAVALARA 633

  Fly  1269 ILRENRILVMDEATANVDPQTDGLIQATI--RSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVV 1331
            ::|:.|:|::|:||:.:|......:|..:  ..::...|||.|..:|.....:..::.:..|.|.
  Rat   634 LIRKPRLLILDDATSALDAGNQLRVQRLLYESPEWASRTVLLITQQLSLAERAHHILFLKEGSVC 698

  Fly  1332 EFGSPYELMTK 1342
            |.|:..:||.:
  Rat   699 EQGTHLQLMER 709

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)03659NP_001260823.1 CFTR_protein 89..1343 CDD:273530 150/596 (25%)
ABC_membrane 171..437 CDD:294371
ABCC_MRP_domain1 499..699 CDD:213217
ABC_membrane 799..1045 CDD:294371 56/262 (21%)
ABCC_MRP_domain2 1115..1336 CDD:213211 70/230 (30%)
Tap1NP_114444.2 3a01208 2..717 CDD:273363 150/596 (25%)
ABC_membrane 177..435 CDD:279056 60/290 (21%)
Part of the peptide-binding site. /evidence=ECO:0000250|UniProtKB:Q03518 352..397 8/44 (18%)
Part of the peptide-binding site. /evidence=ECO:0000250|UniProtKB:Q03518 430..464 6/33 (18%)
P-loop_NTPase 469..697 CDD:304359 72/242 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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