DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and Abcc1

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_071617.2	Gene:	Abcc1 / 24565	RGDID:	3112	Length:	1532	Species:	Rattus norvegicus

Alignment Length:	1404	Identity:	457/1404 - (32%)
Similarity:	754/1404 - (53%)	Gaps:	173/1404 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 KLTVNSENNSAQNEKEKVLPEN--PRARSNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQK 130
            :|.::..::|:....|.|...|  |.:.::|:|.:.||:...:..:|||:.|.|:||:...:|..
  Rat   185 QLVLSCFSDSSPLFSETVRDPNPCPESSASFLSRITFWWITGMMVQGYRQPLKSSDLWSLNKEDT 249

  Fly   131 SDILGNRLCASWEREL----------------------------------------KNDGRSPSL 155
            |:.:...|..:|::|.                                        .:..|.|||
  Rat   250 SEEVVPVLVNNWKKECVKSRKQPVRIVYAPPKDPTKPKGSSQLDVNEEVEALIVKSSHKDRDPSL 314

  Fly   156 VRALLRVFGWQLGFPGLAIFVVELGLRTLQPIF------LVKLISYFSGEPDAANAGFYYAVAQI 214
            .:.|.:.||        ..|::....:.|..:.      :::||..|..:.:|.:...|...|.:
  Rat   315 FKVLYKTFG--------PYFLMSFLYKALHDLMMFAGPEILELIINFVNDREAPDWQGYLYTALL 371

  Fly   215 VISALTVMILTPTTFGIH---HVCF----KMRVAMGSMIFRKALRLTKGALGDTTSGHVVNLISN 272
            .:||..      .|..:|   |:||    :::.|:...::||||.:|..|...:|.|.:|||:|.
  Rat   372 FVSACL------QTLALHQYFHICFVTGMRIKTAVVGAVYRKALVITNSARKSSTVGEIVNLMSV 430

  Fly   273 DIPR-LDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLK 336
            |..| :|.|.| ::.:|..||||.:..|.::..:|.|.:.||..|:|.:|....:..:|...|:.
  Rat   431 DAQRFMDLATY-INMIWSAPLQVTLALYFLWLNLGPSVLAGVAVMILMVPFNAVMAMKTKTYQVA 494

  Fly   337 AAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQYIRG---FDFARR-- 396
            ..:..||||:::|||::.|:|||:||||..|:..|.:.|::|:..:::..|:..   |.:...
  Rat   495 HMKSKDNRIKLMNEILNGIKVLKLYAWELAFQDKVMNIRQEELKVLKKSAYLAAVGTFTWVCTPF 559

  Fly   397 -IVLSRVAIFLSLVGYVILGKVFTPEIAFMITAYYNVLLAAMSIYVPSAIIQTAQFLTSIRRVEQ 460
             :.||..|:|::    |....:...:.||:..|.:|:|...::| :|..|....|...|::|:..
  Rat   560 LVALSTFAVFVT----VDEKNILDAKKAFVSLALFNILRFPLNI-LPMVISSIVQASVSLKRLRI 619

  Fly   461 FMQSEELGSSDKSEGPSKDTVPGNPPSNNNEADLLKSAISIRDLKAKWDPNSPDYTLSGINLEIK 525
            |:..|||..........||....|             :|::::....|..:.|. ||:||...|.
  Rat   620 FLSHEELEPDSIERWSIKDGGGMN-------------SITVKNATFTWARDEPP-TLNGITFAIP 670

  Fly   526 PGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGSLSYTSQESWLFSGTVRQNILFGQPMDS 590
            .|::|||:|..|.|||||:.|:|.|:....|.:.:.||::|..|::|:.:.::|:|||||:|:..
  Rat   671 DGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGRPLQE 735

  Fly   591 QRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVYRKASIYLLDDPLSAVD 655
            ..|:.|::.|||..|.::||..|.|.:||:|..||||||.|:||||:||..:.||||||||||||
  Rat   736 HCYKAVMEACALLPDLEILPSGDLTEIGEKGVNLSGGQKQRVSLARAVYCNSDIYLLDDPLSAVD 800

  Fly   656 ASVARHLFDQCV--RGHLRGSTVVLVTHQEQFLPHVDQIVILANGQIKALGDYESLL-------- 710
            |.|.:|:|::.|  .|.|:..|.:||||...:||.||.|::::.|:|..:|.|:.||
  Rat   801 AHVGKHIFEKVVGPMGLLKNKTRILVTHGISYLPQVDVIIVMSGGKISEMGSYQELLDRDGAFAE 865

  Fly   711 ------------------KTGLITGLGSLSK--------TDKAKTEEQEPL--NLNSPDNKNEVT 747
                              |.| ::|||..||        ||..    .:||  :|::..:.:.||
  Rat   866 FVRTYANTEQDLASEDDSKNG-VSGLGKESKPVENGILVTDAV----GKPLQRHLSNSSSHSVVT 925

  Fly   748 PIKENSEQTVGGSSSGKE-----HVERQESGGISLALYRKYFQAGGGLVAFLVMLSSSVLAQVAV 807
            ..:.:|...:..|...:|     ..::.::|.:.|::|..|.:|.|..::|| .:...:...|:.
  Rat   926 NQQHSSTAELQKSGVKEETWKLMEADKAQTGQVKLSVYWNYMKAIGLCISFL-SIFLFLCNHVSA 989

  Fly   808 TGGDYFLTYWVKKESTAAGHGEMEDMESK-----SMDVYKYTLIIILSVIMNLSSSFLLFNIAKK 867
            ...:|:|:.|.  :...|.:|..|:...:     ::.:.:...:...|:.:::...|
  Rat   990 LASNYWLSLWT--DDRPAVNGTQENRNFRLSVYGALGILQGVAVFGYSMAVSIGGIF-------- 1044

  Fly   868 ASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVI 932
            ||.|||..:...|.|:.|.||.....|:::|||:|::..||.::|.|:...|.....:.|.:|:|
  Rat  1045 ASRRLHLDLLQNVLRSPMSFFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIII 1109

  Fly   933 ANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQRV 997
            ....|:..|....|.::::.::..|:.:||.|||:|:::|||||||...:|.|::.|||.:.|..
  Rat  1110 LLATPIAAVIIPPLGLVYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQER 1174

  Fly   998 LEKEFDSYQDAHSSAFFMYISTSQAFGYCMNCI--CVIYISII--TLSFFAFPPGNGADVGLVIT 1058
            ..::.|...|.:..|::..|..::.....:.|:  |::..:.:  .:|..:...|.   |||.::
  Rat  1175 FIRQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGL---VGLSVS 1236

  Fly  1059 QAMGLIDMVQWGVRQTAELENTMTAVERVVEYESIEPEGMLEAPDDKKPPKTWPEQGEIIFKELN 1123
            .::.:...:.|.||.::|:|..:.||||:.||...|.|...:. .:..||.|||..|.:.|::..
  Rat  1237 YSLQITAYLNWLVRMSSEMETNIVAVERLKEYSETEKEASWQI-QETAPPSTWPHSGRVEFRDYC 1300

  Fly  1124 LRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFRLSYT-DGSVLIDTRDTRQMG 1187
            |||..:  .:.|||.::..|:..||||||||||||||||...|||::.: :|.::||..:..::|
  Rat  1301 LRYRED--LDLVLKHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIG 1363

  Fly  1188 LHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGG 1252
            ||:||.:|:||||:||||||::|.|||||.:||||::|..||...||..||.|||.|..:.:|||
  Rat  1364 LHNLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGG 1428

  Fly  1253 TNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTII 1317
            .|.|||||||||||||:||:.:|||:|||||.||.:||.|||:|||::|.|.|||||||||:||:
  Rat  1429 ENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDSTVLTIAHRLNTIM 1493

  Fly  1318 DSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLVNQSG 1356
            |..:|:|:|.|.:.|.|:|.||:.:..  ||:::...:|
  Rat  1494 DYTRVIVLDKGEIRECGAPSELLQQRG--VFYSMAKDAG 1530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	450/1368 (33%)
		ABC_membrane	171..437	CDD:294371	79/285 (28%)
		ABCC_MRP_domain1	499..699	CDD:213217	90/201 (45%)
		ABC_membrane	799..1045	CDD:294371	62/254 (24%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	125/221 (57%)
Abcc1	NP_071617.2	MRP_assoc_pro	7..1531	CDD:188098	457/1404 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345027
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.660