DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and Abcc10

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_001334325.1	Gene:	Abcc10 / 224814	MGIID:	2386976	Length:	1526	Species:	Mus musculus

Alignment Length:	1396	Identity:	433/1396 - (31%)
Similarity:	696/1396 - (49%)	Gaps:	189/1396 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 SAQNEKEKVLPENPRARSNFISSLCFWYTIPIFRKGYRKTL----DSTDLYRPLEEQKSDILGNR 137
            |:::::.:|..:.    .:::|...:.:..|:..:|.|..|    |:..|.|.|...   .|...
Mouse   206 SSESQETEVAEDG----ESWLSRFSYAWLAPLLARGVRGELQQPRDTCRLPRRLHPA---FLARV 263

  Fly   138 LCASWERELKNDGRSPSLVRALLRVF-------------GWQLGFPGLAIFVVELGLRTLQPIFL 189
            ..|.|:       ....|.|||.|.|             |..|||.|              |:.|
Mouse   264 FQAHWK-------EGAQLWRALYRAFGCCYLALGLLKMVGTMLGFSG--------------PLLL 307

  Fly   190 VKLISYFSGEPDAANAGFYYAVAQIVISALTVMILTPTTFGIHHVCFKMRVAMGSMIFRKALRLT 254
            ..|:.:.....:..:.|..|.:.....:.::.::.....:.:..|..:.|||:.|.::||||:|.
Mouse   308 SLLVGFLEEGQEPLSHGLLYVLGLAGGTVISAVLQNQYGYEVRKVTLQARVAVLSTLYRKALKLG 372

  Fly   255 KGALGDTTSGHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLF 319
            ...   ..:|.|:||:..|..||.:...:.|..|..|||:.:..||:||::|::.:.|::..||.
Mouse   373 PSR---PPTGEVLNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGMAFLAGLVLALLL 434

  Fly   320 MPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQ 384
            :|:...:.||..|...:.....|.|::::.|::|.|:|:|.:.|||.....|...|.||:..:|.
Mouse   435 VPVNKVIATRIMASNQEMLRHKDARVKLMTELLSGIRVIKFFRWEQALGDRVKACRTKELGRLRV 499

  Fly   385 GQYIRG---FDFARRIVLSRVAIFLSLVGYVILGKVFTPEIAFMITAYYNVLLAAMSIYVPSAII 446
            .:|:..   :.:|...|:..:.||::   ||::|...|....|...|...:|:..::.: |..|.
Mouse   500 IKYLDAACVYLWAALPVVICITIFIT---YVLMGHQLTATKVFTALALVRMLILPLNNF-PWVIN 560

  Fly   447 QTAQFLTSIRRVEQFMQSEELGSSDKSEGPSKDTVPGNPPSNNNEADLLKSAISIRDLKAKWDPN 511
            ...:...|:.|:::|:   :|.|.......|.|     ||:..:      :|:.:.:....|||.
Mouse   561 GLLESKVSLDRIQRFL---DLPSYSPEAYYSPD-----PPAEPS------TALELHEALFSWDPI 611

  Fly   512 SPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQL---QVNGSLSYTSQESWL 573
            .........:|::|.|.:|.::|..|.|||||:.||.|||....|.:   :::......:||.|:
Mouse   612 GASQKTFISHLQVKKGMLVGIVGKVGCGKSSLLAAITGELHRLCGWVAVSELSKGFGLATQEPWI 676

  Fly   574 FSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSV 638
            ...|:|.|||||:..|:|.|.||::.|||..|..:||..|.|.|||:|.||||||:|||:|||:|
Mouse   677 QCATIRDNILFGKTFDAQLYREVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAV 741

  Fly   639 YRKASIYLLDDPLSAVDASVARHLFDQCVRGHLRGSTVVLVTHQEQFLPHVDQIVILANGQIKAL 703
            |::.::|||||||:||||.||.||..:|:.|.|..:|.:|.||:.::|...|.::::..||:...
Mouse   742 YQEKALYLLDDPLAAVDADVANHLLHRCILGVLSHTTRLLCTHRTEYLERADVVLLMEAGQLVRT 806

  Fly   704 GDYESLL------------KTGLITGLGSLSKTDKAKTEEQEPLNLNSPDNKNEVTPIKENSEQT 756
            |....:|            |..:.|...|.|..|..:|.|:|          .||       ||:
Mouse   807 GPPSEILPLVQAVPTAWAEKEQVATSGQSPSVCDLERTTEEE----------LEV-------EQS 854

  Fly   757 VGGSSSGKEHVERQESGGISLALYRKYFQA-GGGLVAFLVMLSSSVLAQVAVTGGDYFLTYWVKK 820
            ..|....:   |.:..|.::|.:||.|::| |.||.|  .:|.|.:|.|....|.|::|.:|: .
Mouse   855 TCGCLVQE---ESKSEGAVALHVYRAYWRAMGSGLAA--AILVSLLLMQATRNGADWWLAHWL-S 913

  Fly   821 ESTAAGHGEMEDMESKS------------------------------------MDVYKYTLIIIL 849
            :..|..:|..||..|.|                                    .||:.|  :|:.
Mouse   914 QLKAGRNGSREDPASCSPGSTALFSPRLLLFSPGNLYTPLLSTPLHKAASNGTADVHFY--LIVY 976

  Fly   850 SVIMNLSSSFLLFNI------AKKASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVD 908
            :.|..::|...|...      |.:|:..||:.:.:|:..|.:.|:.....|.:||||:.|::.||
Mouse   977 ATIAGVNSLCTLLRAVLFAAGALQAAASLHHRLLHRLLMAPVTFYDSTPSGRVLNRFSSDVACVD 1041

  Fly   909 EVLPVVLVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRS 973
            :.||.:|..::..::.|.|::.|:.:..|.||:....||.::|.::..|..:.|:|:|:.::..|
Mouse  1042 DSLPFLLNILLANSVGLLGLLAVLGSGLPWLLLLLPPLSFVYYSVQGYYRASFRELRRLGSLTWS 1106

  Fly   974 PVYSHLAASLNGLTTIRALDAQRVLEKEFDSYQDAHSSAFFMYISTSQAFGYCMNCICVIYISII 1038
            |:|||||.:|.||..:||..|....|:|.....:.:....|...:|.|.....:..:....:|.|
Mouse  1107 PLYSHLADTLAGLPVLRAAGATYRFEEENQRLLELNQRCQFASYATMQWLDIRLQLMGAAVVSAI 1171

  Fly  1039 T-LSFFAFPPG--NGADVGLVITQAMGLIDMVQWGVRQTAELENTMTAVERVVEYESIEPE---- 1096
            . ::......|  |...||||::.|:.|..::...|....:.|..|.:|||:.||....|:
Mouse  1172 AGIALVQHQQGLANPGLVGLVLSYALSLTGLLSGLVSSFTQTEAMMVSVERLEEYSCDVPQEPHS 1236

  Fly  1097 GMLEAPDDKKPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSS 1161
            ..|::|..::  .:|..||.:.|:::.|.|.|.  ..|.|..::|.::|.||:|||||||:||||
Mouse  1237 QPLQSPHQQR--ISWLTQGSVEFQDVVLVYRPG--LPNALDGVTFRVEPGEKLGIVGRTGSGKSS 1297

  Fly  1162 LINALFRLSYTD-GSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLW 1225
            |...||||...: |.||:|..||.|:.|.:||.|:::|||||.|||||:|.||||...:.|..||
Mouse  1298 LFLVLFRLLEPNAGRVLLDNVDTSQLELAELRSQLAVIPQEPFLFSGTIRENLDPQGLHEDRALW 1362

  Fly  1226 GCLEEVKLKEVV------------------------SDLPDGLASKISEGGTNFSVGQRQLVCLA 1266
            ..||:..|.||.                        :.|..||..::.|.|.|.|:|||||:|||
Mouse  1363 QALEQCHLSEVAVAMGESQACQRSQREAKNGHWQCSALLTGGLDGELGERGQNLSLGQRQLLCLA 1427

  Fly  1267 RAILRENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVV 1331
            ||:|.:.:||.:|||||:||.:||.|:|.||..:|.:.|||||||||:||::||:|:|:.|||||
Mouse  1428 RALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVV 1492

  Fly  1332 EFGSPYELMTKSDSKVFHNLVNQSGRASYEG 1362
            |..||..|..:..| :|..|:..|.:.::.|
Mouse  1493 ELDSPSALRNQPHS-LFQQLLQSSQQGAHSG 1522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	426/1363 (31%)
		ABC_membrane	171..437	CDD:294371	67/268 (25%)
		ABCC_MRP_domain1	499..699	CDD:213217	85/202 (42%)
		ABC_membrane	799..1045	CDD:294371	71/288 (25%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	116/245 (47%)
Abcc10	NP_001334325.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841745
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.740