DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and Abcc9

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_035641.1	Gene:	Abcc9 / 20928	MGIID:	1352630	Length:	1546	Species:	Mus musculus

Alignment Length:	1384	Identity:	409/1384 - (29%)
Similarity:	689/1384 - (49%)	Gaps:	188/1384 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 NFISSLCFWYTIPIFRKGYRKTLDSTDLYR-PLEEQKSDILGNRLC--ASWERELK----NDGRS 152
            |.:|...:|:...:....:||.:|...:.: |:..:   .:.|.:|  .::|.:.|    :..|:
Mouse   221 NLLSKATYWWMNTLIISAHRKPIDLKAIGKLPIAMR---AVTNYVCLKEAYEEQKKKAADHPNRT 282

  Fly   153 PSLVRALLRVFGWQLGFPGLAIFVVELGLRTLQPIFLVKLISY------FSGE------------ 199
            ||:..|:.|.||                    :||.|.....|      |:|.
Mouse   283 PSIWLAMYRAFG--------------------RPILLSSTFRYLADLLGFAGPLCISGIVQRVNE 327

  Fly   200 ---------PDAANAGFYYAVAQIVISALTVMILTPTTF--GIHHVCFK----MRVAMGSMIFRK 249
                     |:..::..:...|.::...|.:.::...||  ..::|..:    :|.|:.:||:.|
Mouse   328 KTNTTREMFPETLSSKEFLENAHVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNK 392

  Fly   250 ALRLTKG--ALGDTTSGHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFG 312
            .|||:..  ::|:.|.|.:.||::.:..:|....:....||..|:|:::...|:|..:|.||:.|
Mouse   393 ILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVG 457

  Fly   313 VLFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREK 377
            ...::|..|||.::.|:.:..|....:.:..|::..|||:..|::||:||||..|.:.|...|.|
Mouse   458 AAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMK 522

  Fly   378 EMNTIRQGQYIRGFDFARRIVLSRVAIFLSLVGYVIL-GKVFTPEIAFMITAYYNVLLAAMSIYV 441
            |:::::...............:...|:..:.|.:... |....|..||...:.:::|:.  .:::
Mouse   523 ELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVT--PLFL 585

  Fly   442 PSAIIQTA-QFLTSIRRVEQFMQSEELGSSDKSEGP--------SKDTVPGNPPSNN-------- 489
            .|.:::.| :.:.|::::.:|:.|:|:|......|.        .|.|...:.|.|.
Mouse   586 LSTVVRFAVKAIISVQKLNEFLLSDEIGEDSWRAGEGTLPFESCKKHTGVQSKPINRKQPGRYHL 650

  Fly   490 ---NEADLLKSA----ISIRDLKAKWDPNSPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAI 547
               .:|..|:.|    |:|:.....:...|...|||.|::.|..|.:..::|..|.|||||:.||
Mouse   651 DSYEQARRLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAI 715

  Fly   548 LGELKANSGQLQVNG-----------------SLSYTSQESWLFSGTVRQNILFGQPMDSQRYEE 595
            |||::...|::..|.                 |::|.:|:.||.:.||.:||.||.|.:.|||:.
Mouse   716 LGEMQTLEGKVYWNNVNESEPSFEATRSRSRYSVAYAAQKPWLLNATVEENITFGSPFNRQRYKA 780

  Fly   596 VVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVYRKASIYLLDDPLSAVDASVAR 660
            |...|:|:.|.||||..|.|.:||||..|||||:.||.:||::|:..:|..||||.||:|..::.
Mouse   781 VTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSD 845

  Fly   661 HLFDQCVRGHLRGS--TVVLVTHQEQFLPHVDQIVILANGQIKALGDYESLLKTGLITGLGSLSK 723
            ||..:.:...|:..  |||||||:.|:|.|.|.|:.:.:|         |:|:.|.:..:    :
Mouse   846 HLMQEGILKFLQDDKRTVVLVTHKLQYLTHADWIIAMKDG---------SVLREGTLKDI----Q 897

  Fly   724 TDKAKTEEQEPLNLNSPDNKNE------VTPIKENSEQTVGGSSSGK---------EHVERQESG 773
            |...:..|.....:|..|.:.|      .|.::..:.:....|...|         |..|..|..
Mouse   898 TKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEED 962

  Fly   774 GISLALYRK----------YFQAGGGLVAFLVMLSSSVLAQVAVTGGDYFLTYWVKKESTAAGHG 828
            .:|..:..:          |..:||..:.|| |:.|.:|....:...||:|..|..:.|  ..|.
Mouse   963 NMSTVMRLRTKMPWKTCWWYLTSGGFFLLFL-MIFSKLLKHSVIVAIDYWLATWTSEYS--INHP 1024

  Fly   829 EMEDMESKSMDVYKYTLI----IILSVIMNLSSSFLLFNIAKKASIRLHNTIFNRVTRADMHFFS 889
            ...|   ::..|..::::    |.|.::.:|:..::....||    .||:.:.|::....:.||.
Mouse  1025 GKAD---QTFYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAK----NLHHNLLNKIILGPIRFFD 1082

  Fly   890 INKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLR 954
            ....|.|||||:.|.:.:|:.:|..|..:.:..|.....|.:|:...|:.||....|.|.||.::
Mouse  1083 TTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALAPLGVAFYFIQ 1147

  Fly   955 NLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALD-----AQRVLEKEFDSYQDAHSSAFF 1014
            ..:...|:||:.::...:.|:..|.:.:..|||||||..     .||:||     ..|.::.| :
Mouse  1148 KYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLE-----LTDTNNIA-Y 1206

  Fly  1015 MYISTSQAF-----GYCMNCICVIYISIITLSFFAFPPGNGADVGLVITQAMGLIDMVQWGVRQT 1074
            :::|.:..:     .|...|| |:..||.::|    ...|...|||.:..|:.:.:.:.|.||..
Mouse  1207 LFLSAANRWLEVRTDYLGACI-VLTASIASIS----GSSNSGLVGLGLLYALTITNYLNWVVRNL 1266

  Fly  1075 AELENTMTAVERVVEYESIEPEGMLEAPDDKKPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSL 1139
            |:||..|.||::|..:.::|.|......|..:.|:.||::|||...:|.:||..|.|.  |||.:
Mouse  1267 ADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKP--VLKHV 1329

  Fly  1140 SFVIQPREKVGIVGRTGAGKSSLINALFRL-SYTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPV 1203
            ...|:|.:||||.||||:|||||..|.||: ...||.::||..|..::.||.||.::|||.|:|:
Mouse  1330 KAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPI 1394

  Fly  1204 LFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARA 1268
            ||||::|:||||..:.:|::||..||..:||.:|..||.||.:.::|||.|||||||||.|||||
Mouse  1395 LFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDATVTEGGENFSVGQRQLFCLARA 1459

  Fly  1269 ILRENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEF 1333
            .:|::.||:||||||::|..|:.::|..:.:.|.|.||:|||||:|||:.:|.|:||..|.::|:
Mouse  1460 FVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEY 1524

  Fly  1334 GSPYELMTKSDSKVFHNLV 1352
            .:|..|:.:.|. ||.:.|
Mouse  1525 DTPESLLAQEDG-VFASFV 1542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	405/1373 (29%)
		ABC_membrane	171..437	CDD:294371	65/301 (22%)
		ABCC_MRP_domain1	499..699	CDD:213217	85/218 (39%)
		ABC_membrane	799..1045	CDD:294371	66/259 (25%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	111/221 (50%)
Abcc9	NP_035641.1	MRP_assoc_pro	23..1543	CDD:188098	409/1384 (30%)
Abcc9	NP_035641.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	941..964		4/22 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841673
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.640