DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment l(2)03659 and Abcc8

DIOPT Version :9

Sequence 1:NP_001260823.1 Gene:l(2)03659 / 47905 FlyBaseID:FBgn0010549 Length:1374 Species:Drosophila melanogaster
Sequence 2:XP_036008753.1 Gene:Abcc8 / 20927 MGIID:1352629 Length:1597 Species:Mus musculus


Alignment Length:1404 Identity:429/1404 - (30%)
Similarity:710/1404 - (50%) Gaps:179/1404 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    95 NFISSLCFWYTIPIFRKGYRKTLDSTDLYR-PLEEQKSDILGN--RLCASWERELKNDGRSP--- 153
            |.:|...:|:.....:..:||.:|...:.: |:..:   .|.|  ||||:::.:.:.|.:|.   
Mouse   223 NLLSKGTYWWMNAFIKTAHRKPIDLRAIGKLPIAMR---ALTNYQRLCAAFDAQARKDTQSQQGA 284

  Fly   154 -SLVRALLRVFGWQ-------------LGFPG-LAIF--VVELGL--RTLQPIFLVKLISYFSGE 199
             ::.|||...||.:             |||.| |.||  |..||.  ...||......:.:.|.:
Mouse   285 RAIWRALCHAFGRRLVLSSTFRILADLLGFAGPLCIFGIVDHLGKENHVFQPKTQFLGVYFVSSQ 349

  Fly   200 PDAANAGFYYAVAQIVISALTVMILTPTTF--GIHHVCFK----MRVAMGSMIFRKALRLTKG-- 256
            ....||   |.:|.::..||    |...||  ..::|..:    :|.|:.:.|:.|.:.|:..  
Mouse   350 EFLGNA---YVLAVLLFLAL----LLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNL 407

  Fly   257 ALGDTTSGHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMP 321
            ::|:.|:|.:.||::.|..:|....:....||..|:|::|...|:|..:|:||:.|...::|..|
Mouse   408 SMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAP 472

  Fly   322 IQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQ 386
            :|.::.|:.|..|....|.::.|::..||::..|::||:||||..|...|...|.|||.::|...
Mouse   473 VQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFCSRVEMTRRKEMTSLRAFA 537

  Fly   387 YIRGFDFARRIVLSRVAIFLSLVGYVILGKV--FTPEIAFMITAYYNVLLAAMSIYVPSAIIQTA 449
            ............:...|:.::.||:|...|.  |:|.:||...:.:::|:..:.: :.|.:..|.
Mouse   538 VYTSISIFMNTAIPIAAVLITFVGHVSFFKESDFSPSVAFASLSLFHILVTPLFL-LSSVVRSTV 601

  Fly   450 QFLTSIRRVEQFMQSEEL-------------GSSDKSEGPSKDTVPGNPPSNNNEADLLKSAISI 501
            :.|.|::::.:|:.|.|:             |.:.|.:......|....|:.....|||.   .:
Mouse   602 KALVSVQKLSEFLSSAEIREEQCAPREPAPQGQAGKYQAVPLKVVNRKRPAREEVRDLLG---PL 663

  Fly   502 RDLKAKWDPNSPDY-----------------TLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILG 549
            :.|....|.::.::                 |||.|.:.|..|.:..::|..|.|||||:.|.||
Mouse   664 QRLTPSMDGDADNFCVQIIGGFFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLATLG 728

  Fly   550 ELKANSGQLQVNGSL---------------------------------SYTSQESWLFSGTVRQN 581
            |::..||.:..|.||                                 :|.||:.||.:.||.:|
Mouse   729 EMQRVSGAVFWNSSLPDSEGEDPRYCLRTSNPERETAADSDARSRGPVAYASQKPWLLNATVEEN 793

  Fly   582 ILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVYRKASIYL 646
            |.|..|.:.|||:.|::.|:|:.|.|:||..|.|.:||||..|||||:.|||:||::|:..::..
Mouse   794 ITFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHTNVVF 858

  Fly   647 LDDPLSAVDASVARHLFDQCVRGHLRGS--TVVLVTHQEQFLPHVDQIVILANGQIKALGDYESL 709
            ||||.||:|..::.||....:...||..  |||||||:.|:|||.|.|:.:.:|.|:..|..:..
Mouse   859 LDDPFSALDVHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDF 923

  Fly   710 LKT--GLITGLGSLSKTDKAKTEEQEPLNLNSPD---------NKNEVTPIKENSEQTVGGSSSG 763
            .::  .|.....:|......:.|::..:...:|:         :..:...:.|:.|:        
Mouse   924 QRSECQLFEHWKTLMNRQDQELEKETVMERKAPEPSQGLPRAMSSRDGLLLDEDEEE-------- 980

  Fly   764 KEHVERQESGGISLALYR----------KYFQAGGGLVAFLVMLSSSVLAQVAVTGGDYFLTYWV 818
            :|..|.:|...:|..|::          ||..:.|.|:..|::. |.:|..:.:...||:|..|.
Mouse   981 EEAAESEEDDNLSSVLHQRAKIPWRACTKYLSSAGVLLLSLLVF-SQLLKHMVLVAIDYWLAKWT 1044

  Fly   819 KKE---STAAGHGEMEDMESKSMDVYK--YTLIIILSVIMNLSSSFLLFNIAKKASIRLHNTIFN 878
            ...   |.||.:..:....:....||.  :|::..|.:.:.|.:|..:.....|.:.|||.::.|
Mouse  1045 DSALVLSPAARNCSLSQECALDQSVYAMVFTVLCSLGIALCLVTSVTVEWTGLKVAKRLHRSLLN 1109

  Fly   879 RVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNPLLLVPT 943
            |:..|.|.||.....|||||||:.|.:.:|:.:|..|..:.:..|.....:.||:.|.|:.||..
Mouse  1110 RIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALTVISYVTPVFLVAL 1174

  Fly   944 LMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQRVLEKEFDSYQDA 1008
            |.|:|:.|.::..:...||||::::...:.|:.||.|.::.|||||||...:...:::...|.|:
Mouse  1175 LPLAVVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDS 1239

  Fly  1009 HSSAFFMYISTS----------------QAFGYCMNCICVIYISIITLSFFAFPPGNGADVGLVI 1057
            ::.|.....:.:                :..|.|:    |:..:..::|.......:...|||.:
Mouse  1240 NNIASLFLTAANRWLEVRMPGPAAVLPQEYIGACV----VLIAAATSISNSLHRELSAGLVGLGL 1300

  Fly  1058 TQAMGLIDMVQWGVRQTAELENTMTAVERV---VEYESIEPEGMLEAPDDKKPPKTWPEQGEIIF 1119
            |.|:.:.:.:.|.||..|::|..:.||:|:   ::.|:...||:| ||  ...||.||:||:|..
Mouse  1301 TYALMVSNYLNWMVRNLADMEIQLGAVKRIHTLLKTEAESYEGLL-AP--SLIPKNWPDQGKIQI 1362

  Fly  1120 KELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFRL-SYTDGSVLIDTRDT 1183
            :.|::||..:.|.  |||.::.:|.|.:|:||.||||:||||...|.||: ...:|.::||..|.
Mouse  1363 QNLSVRYDSSLKP--VLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDMFEGRIIIDGIDI 1425

  Fly  1184 RQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKI 1248
            .::.||.||.::|||.|:|||||||:|:||||..:.||..||..||..:||.||..||.||.:.|
Mouse  1426 AKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTLWEALEIAQLKLVVKALPGGLDAII 1490

  Fly  1249 SEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRL 1313
            :|||.|||.|||||.|||||.:|:..|.:||||||::|..|:.::|..:.:.|.|.||:|||||:
Mouse  1491 TEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRV 1555

  Fly  1314 HTIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLV 1352
            |||:.:|.|||:..|.::||..|.:|:::.|| ||.:.|
Mouse  1556 HTILSADLVMVLKRGAILEFDKPEKLLSQKDS-VFASFV 1593

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)03659NP_001260823.1 CFTR_protein 89..1343 CDD:273530 424/1393 (30%)
ABC_membrane 171..437 CDD:294371 77/280 (28%)
ABCC_MRP_domain1 499..699 CDD:213217 86/251 (34%)
ABC_membrane 799..1045 CDD:294371 69/266 (26%)
ABCC_MRP_domain2 1115..1336 CDD:213211 110/221 (50%)
Abcc8XP_036008753.1 MRP_assoc_pro 224..1594 CDD:188098 428/1403 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167841693
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.650

Return to query results.
Submit another query.