Protein Alignment l(2)03659 and Abcc8

DIOPT Version :10

• Sequence 1: NP_610482.3
• Gene: l(2)03659 / 47905
• FlyBaseID: FBgn0010549
• Length: 1374
• Species: Drosophila melanogaster
• Sequence 2: XP_036008753.1
• Gene: Abcc8 / 20927
• MGIID: 1352629
• Length: 1597
• Species: Mus musculus
• Alignment Length: 1404
• Identity: 429/1404 - (30%)
• Similarity: 710/1404 - (50%)
• Gaps: 179/1404 - (12%)

  Fly    95 NFISSLCFWYTIPIFRKGYRKTLDSTDLYR-PLEEQKSDILGN--RLCASWERELKNDGRSP--- 153
            |.:|...:|:.....:..:||.:|...:.: |:..:   .|.|  ||||:::.:.:.|.:|.
Mouse   223 NLLSKGTYWWMNAFIKTAHRKPIDLRAIGKLPIAMR---ALTNYQRLCAAFDAQARKDTQSQQGA 284

  Fly   154 -SLVRALLRVFGWQ-------------LGFPG-LAIF--VVELGL--RTLQPIFLVKLISYFSGE 199
             ::.|||...||.:             |||.| |.||  |..||.  ...||......:.:.|.:
Mouse   285 RAIWRALCHAFGRRLVLSSTFRILADLLGFAGPLCIFGIVDHLGKENHVFQPKTQFLGVYFVSSQ 349

  Fly   200 PDAANAGFYYAVAQIVISALTVMILTPTTF--GIHHVCFK----MRVAMGSMIFRKALRLTKG-- 256
            ....||   |.:|.::..||    |...||  ..::|..:    :|.|:.:.|:.|.:.|:..
Mouse   350 EFLGNA---YVLAVLLFLAL----LLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNL 407

  Fly   257 ALGDTTSGHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMP 321
            ::|:.|:|.:.||::.|..:|....:....||..|:|::|...|:|..:|:||:.|...::|..|
Mouse   408 SMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAP 472

  Fly   322 IQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQ 386
            :|.::.|:.|..|....|.::.|::..||::..|::||:||||..|...|...|.|||.::|...
Mouse   473 VQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFCSRVEMTRRKEMTSLRAFA 537

  Fly   387 YIRGFDFARRIVLSRVAIFLSLVGYVILGKV--FTPEIAFMITAYYNVLLAAMSIYVPSAIIQTA 449
            ............:...|:.::.||:|...|.  |:|.:||...:.:::|:..:.: :.|.:..|.
Mouse   538 VYTSISIFMNTAIPIAAVLITFVGHVSFFKESDFSPSVAFASLSLFHILVTPLFL-LSSVVRSTV 601

  Fly   450 QFLTSIRRVEQFMQSEEL-------------GSSDKSEGPSKDTVPGNPPSNNNEADLLKSAISI 501
            :.|.|::::.:|:.|.|:             |.:.|.:......|....|:.....|||.   .:
Mouse   602 KALVSVQKLSEFLSSAEIREEQCAPREPAPQGQAGKYQAVPLKVVNRKRPAREEVRDLLG---PL 663

  Fly   502 RDLKAKWDPNSPDY-----------------TLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILG 549
            :.|....|.::.::                 |||.|.:.|..|.:..::|..|.|||||:.|.||
Mouse   664 QRLTPSMDGDADNFCVQIIGGFFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLATLG 728

  Fly   550 ELKANSGQLQVNGSL---------------------------------SYTSQESWLFSGTVRQN 581
            |::..||.:..|.||                                 :|.||:.||.:.||.:|
Mouse   729 EMQRVSGAVFWNSSLPDSEGEDPRYCLRTSNPERETAADSDARSRGPVAYASQKPWLLNATVEEN 793

  Fly   582 ILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVYRKASIYL 646
            |.|..|.:.|||:.|::.|:|:.|.|:||..|.|.:||||..|||||:.|||:||::|:..::..
Mouse   794 ITFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHTNVVF 858

  Fly   647 LDDPLSAVDASVARHLFDQCVRGHLRGS--TVVLVTHQEQFLPHVDQIVILANGQIKALGDYESL 709
            ||||.||:|..::.||....:...||..  |||||||:.|:|||.|.|:.:.:|.|:..|..:..
Mouse   859 LDDPFSALDVHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDF 923

  Fly   710 LKT--GLITGLGSLSKTDKAKTEEQEPLNLNSPD---------NKNEVTPIKENSEQTVGGSSSG 763
            .::  .|.....:|......:.|::..:...:|:         :..:...:.|:.|:
Mouse   924 QRSECQLFEHWKTLMNRQDQELEKETVMERKAPEPSQGLPRAMSSRDGLLLDEDEEE-------- 980

  Fly   764 KEHVERQESGGISLALYR----------KYFQAGGGLVAFLVMLSSSVLAQVAVTGGDYFLTYWV 818
            :|..|.:|...:|..|::          ||..:.|.|:..|::. |.:|..:.:...||:|..|.
Mouse   981 EEAAESEEDDNLSSVLHQRAKIPWRACTKYLSSAGVLLLSLLVF-SQLLKHMVLVAIDYWLAKWT 1044

  Fly   819 KKE---STAAGHGEMEDMESKSMDVYK--YTLIIILSVIMNLSSSFLLFNIAKKASIRLHNTIFN 878
            ...   |.||.:..:....:....||.  :|::..|.:.:.|.:|..:.....|.:.|||.::.|
Mouse  1045 DSALVLSPAARNCSLSQECALDQSVYAMVFTVLCSLGIALCLVTSVTVEWTGLKVAKRLHRSLLN 1109

  Fly   879 RVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNPLLLVPT 943
            |:..|.|.||.....|||||||:.|.:.:|:.:|..|..:.:..|.....:.||:.|.|:.||..
Mouse  1110 RIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALTVISYVTPVFLVAL 1174

  Fly   944 LMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQRVLEKEFDSYQDA 1008
            |.|:|:.|.::..:...||||::::...:.|:.||.|.::.|||||||...:...:::...|.|:
Mouse  1175 LPLAVVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDS 1239

  Fly  1009 HSSAFFMYISTS----------------QAFGYCMNCICVIYISIITLSFFAFPPGNGADVGLVI 1057
            ::.|.....:.:                :..|.|:    |:..:..::|.......:...|||.:
Mouse  1240 NNIASLFLTAANRWLEVRMPGPAAVLPQEYIGACV----VLIAAATSISNSLHRELSAGLVGLGL 1300

  Fly  1058 TQAMGLIDMVQWGVRQTAELENTMTAVERV---VEYESIEPEGMLEAPDDKKPPKTWPEQGEIIF 1119
            |.|:.:.:.:.|.||..|::|..:.||:|:   ::.|:...||:| ||  ...||.||:||:|..
Mouse  1301 TYALMVSNYLNWMVRNLADMEIQLGAVKRIHTLLKTEAESYEGLL-AP--SLIPKNWPDQGKIQI 1362

  Fly  1120 KELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFRL-SYTDGSVLIDTRDT 1183
            :.|::||..:.|.  |||.::.:|.|.:|:||.||||:||||...|.||: ...:|.::||..|.
Mouse  1363 QNLSVRYDSSLKP--VLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDMFEGRIIIDGIDI 1425

  Fly  1184 RQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKI 1248
            .::.||.||.::|||.|:|||||||:|:||||..:.||..||..||..:||.||..||.||.:.|
Mouse  1426 AKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTLWEALEIAQLKLVVKALPGGLDAII 1490

  Fly  1249 SEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRL 1313
            :|||.|||.|||||.|||||.:|:..|.:||||||::|..|:.::|..:.:.|.|.||:|||||:
Mouse  1491 TEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRV 1555

  Fly  1314 HTIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLV 1352
            |||:.:|.|||:..|.::||..|.:|:::.|| ||.:.|
Mouse  1556 HTILSADLVMVLKRGAILEFDKPEKLLSQKDS-VFASFV 1593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_610482.3	PLN03130	83..1369	CDD:215595	429/1404 (31%)
Abcc8	XP_036008753.1	MRP_assoc_pro	224..1594	CDD:188098	428/1403 (31%)