DRSC/TRiP Functional Genomics Resources

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Protein Alignment l(2)03659 and mrp-8

DIOPT Version :9

Sequence 1:NP_001260823.1 Gene:l(2)03659 / 47905 FlyBaseID:FBgn0010549 Length:1374 Species:Drosophila melanogaster
Sequence 2:NP_499598.2 Gene:mrp-8 / 190710 WormBaseID:WBGene00003414 Length:1461 Species:Caenorhabditis elegans


Alignment Length:1396 Identity:448/1396 - (32%)
Similarity:721/1396 - (51%) Gaps:159/1396 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 LVCRKCFELGHQTE----NCKQKLTVNSENNSAQNEKEKVLPENPRARSNFISSLCFWYTIPIFR 110
            ||....|:.|...|    ..:..|..:|.....::|::  :.:.|..:|:|:|.:.|.:..|:.|
 Worm   135 LVFESTFDAGVTAEFVLLMAETALLASSTKRLGEDEQK--IEQTPEEKSSFLSKIFFCWLNPLIR 197

  Fly   111 KGYRKTLDSTDLYRPLEEQKSDILGNRLCASWERELKNDGR---SPSLVRALLRVFGWQLGFPGL 172
            .|.::.|.:..|:...|...|:.|..|..|.:::|  ..||   ..|:|...:|:....:....|
 Worm   198 AGAKQPLTNESLHNLNENATSEWLYTRWRAEFDKE--KAGRKSGETSIVWPFIRIQRATIITLTL 260

  Fly   173 AIFVVELGLRTLQPIFLVKLISYFSGEPDAANAGFYYAVAQIVISALTVMILTPTTFGIHHVCFK 237
            |....:: :..|.||.|.:||.|.|......:.|.  |:|.|:.|..|...|. ..:.|..:|.:
 Worm   261 ARLTADI-VHYLNPILLKQLIDYVSLHDQPLSFGI--AIACIMFSCSTTRSLL-QNYQIAGMCRQ 321

  Fly   238 ---MRVAMGSMIFRKALRLTKGALGDTTSGHVVNLISNDIPRL-DSAPYTVHYLWVGPLQVLVIT 298
               .:..:.:.|..|.|||:..|..:.|:|.::|..:.||..: .|.|| :..:|..|.||.:..
 Worm   322 AVYYQTVLSNAILHKILRLSPSARSNRTAGEILNHAAVDIEIIVHSVPY-LQNMWSVPFQVTLAM 385

  Fly   299 YLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAW 363
            .::...:|.:|:.||..|:||:|:.:.........|.|..:..|.|.::.||:::.|:|:|:|||
 Worm   386 TMLAITLGWAAMAGVCIMILFIPLNLCTSRFIKLSQQKQMKIKDERTKLSNEMLNGIKVVKLYAW 450

  Fly   364 EQPFEQMVTHAREKEMNTIRQGQYIRGFDFARRIVLSRV-------AIFLSLVG----YVILG-- 415
            |:.||..:...|.||:..:|           ...:|||:       :.||..:|    ||:..  
 Worm   451 EESFEDQINRLRAKEVKMLR-----------NVCILSRIVDVANAASPFLVAIGSFTCYVLWSPD 504

  Fly   416 -KVFTPEIAFMITAYYNVLLAAMSIYVPSAIIQTAQFLTSIRRVEQFMQSEELGSSDKSEGPSKD 479
             ...||.:||:....:|.|...|.: |.:.|....|...|.:|:.||:..||:  ..|:|     
 Worm   505 ENGLTPSVAFVALTIFNQLRQPMRM-VANLINTLVQARVSNKRLRQFLNDEEM--ERKTE----- 561

  Fly   480 TVPGNPPSNNNEADLLKSAISIRDLKAKW-DPNSPDYTLSGINLEIKPGSVVAVIGLTGSGKSSL 543
            ...||             ||..::....| .|.:|. .|..::..||||.::|::|..|.|||||
 Worm   562 VALGN-------------AIVFKNASLNWKGPQNPP-VLKDLSATIKPGQLIAIVGSVGGGKSSL 612

  Fly   544 IQAILGELKANSGQLQVNGSLSYTSQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDL 608
            :.|:|.|:....|:::|.||::|..|.||:|:.|:::|||||..:.:..|::||..|.|:.||..
 Worm   613 LSAVLDEMVLLDGRVKVGGSIAYVPQHSWIFNKTIKENILFGNELSNYFYDQVVGSCQLKTDFRH 677

  Fly   609 LPLRDNTIVGERGATLSGGQKARISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCV--RGHL 671
            ....:||:|||.|.||||||||||||||:||:...|||||||||||||.|.|.|||:.:  .|.|
 Worm   678 FQQGENTMVGENGITLSGGQKARISLARAVYQDKDIYLLDDPLSAVDAHVGRALFDKVIGPDGLL 742

  Fly   672 RGSTVVLVTHQEQFLPHVDQIVILANGQIKALGDYESLLKTGLITG-LGSL------SKTDKAKT 729
            |..|.|||||..|:..:||.|.::.:|||...|.:|.:   ..:.| .|.|      |..|.|..
 Worm   743 RSKTRVLVTHNLQYTKYVDTIYVIEDGQIVQHGSFEDI---AYVDGPFGRLWSECENSDEDVADE 804

  Fly   730 E-EQEPLNLNSPDNKNEVTPIKENSEQTVGGSSSG----------------------KEHVERQE 771
            | |....::..|      .|:.||.:......||.                      :::||..:
 Worm   805 EAESSEASVTPP------VPVLENGDNGAIEKSSQIDRTNSHFSEKSRKSEEKPQKVEKNVENVQ 863

  Fly   772 SGGISLALYRKY------FQAGGGLVAFLVMLSSSVLAQVAVTGGDYFLTYWVK-----KESTAA 825
            .|.:..::|:.|      |.:...|:.|:...:..::..:       :|:.|..     |::|.:
 Worm   864 LGRVKKSVYQLYIKTMGIFNSSAFLIFFIAHFTVMIMRSL-------WLSDWSNENAAIKKATLS 921

  Fly   826 GHGEMEDMESKSMDVYKYTLIII------LSVIMNLSSSFLLFNIAK-KASIRLHNTIFNRVTRA 883
            ....:....|....|...|.:|:      |.::: |:.:|.:..|.. :||..||:.:.:.:..|
 Worm   922 SVDYLNSTSSVDGPVSVETRLIVYAGFGGLEMLL-LALAFTVLTIGSLRASYGLHSPLIHALLVA 985

  Fly   884 DMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSV 948
            .:.||.....|.|:||.::|:..:|::...:.: ..|..|....|:::|:...|:.||....|.:
 Worm   986 PISFFDTTPTGRIINRLSRDLDVIDKLQDNIRM-CTQTLLNACMILVLISISTPIFLVCAAPLIL 1049

  Fly   949 IFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALD----AQRVLEKEFDSYQD-- 1007
            |:|.:...|:.|||.|||:|:.||||:.|.:|.|::|.::|||.|    ....|....|.:..  
 Worm  1050 IYYFVMIYYIPTSRQLKRLESANRSPILSTIAESIHGASSIRAFDKTERTTTALSTNVDKFAQCR 1114

  Fly  1008 --AHSSAFFMYISTSQAFGYCMNCICVIYISI-ITLS--FFAFPPGNGADVGLVITQAMGLIDMV 1067
              :|.|.  .:::|....   :...||::.|: .|||  :|...||.   .||.::.|:.:.:::
 Worm  1115 YLSHMSN--RWLATRLEL---LGNTCVLFASLSATLSTKYFGLTPGM---AGLSVSYALTITEVL 1171

  Fly  1068 QWGVRQTAELENTMTAVERVVEYESIEPEGMLEAPDDKKPPKTWPEQGEIIFKELNLRYTPNAKA 1132
            ...||..:|:|:.:.:||||.||:.:|||.........:..:.||.:|:|.....::||..|...
 Worm  1172 NICVRSVSEIESNIVSVERVNEYQKLEPEAPWRIEKSLENEEKWPVKGKIELDGFSMRYRKNLPL 1236

  Fly  1133 ENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFR-LSYTDGSVLIDTRDTRQMGLHDLRRQIS 1196
              |||::...|:..|::|::||||:|||||..||:| :....|::.||..:...:|||.||.::.
 Worm  1237 --VLKNIDLKIEGGERIGVIGRTGSGKSSLTMALYRMIEGESGTIKIDDVEIDTIGLHQLRSKLI 1299

  Fly  1197 IIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQ 1261
            |||||||:||||:|:|||||::|||:::|.|||..:||:...:....|...|:|||.|.|||:||
 Worm  1300 IIPQEPVVFSGTLRFNLDPFNQYSDDQIWNCLEICQLKQFAQEDDKTLDRYIAEGGKNMSVGERQ 1364

  Fly  1262 LVCLARAILRENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMD 1326
            |:||.||:||..||:::|||||:||..|||::|..||..|...|.::|||||.||:|||:::|:|
 Worm  1365 LLCLCRALLRGARIVILDEATASVDTVTDGIVQRAIRQHFPQSTTISIAHRLDTIVDSDRIVVLD 1429

  Fly  1327 AGRVVEFGSPYELMTKSDSKVFHNLVNQSGR 1357
            ||||.||.:|..|:...|| ::..|:|:..|
 Worm  1430 AGRVAEFDTPSNLLLNPDS-LYSQLLNEKNR 1459

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)03659NP_001260823.1 CFTR_protein 89..1343 CDD:273530 435/1337 (33%)
ABC_membrane 171..437 CDD:294371 78/283 (28%)
ABCC_MRP_domain1 499..699 CDD:213217 95/202 (47%)
ABC_membrane 799..1045 CDD:294371 67/268 (25%)
ABCC_MRP_domain2 1115..1336 CDD:213211 110/221 (50%)
mrp-8NP_499598.2 CFTR_protein 173..1459 CDD:273530 439/1354 (32%)
ABC_membrane 259..527 CDD:294371 78/283 (28%)
ABCC_MRP_domain1 568..770 CDD:213217 95/202 (47%)
ABC_membrane 887..1168 CDD:294371 74/297 (25%)
ABCC_MRP_domain2 1219..1439 CDD:213211 110/221 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.720

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