DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment l(2)03659 and pgp-7

DIOPT Version :9

Sequence 1:NP_001260823.1 Gene:l(2)03659 / 47905 FlyBaseID:FBgn0010549 Length:1374 Species:Drosophila melanogaster
Sequence 2:NP_001361833.1 Gene:pgp-7 / 188697 WormBaseID:WBGene00004001 Length:1152 Species:Caenorhabditis elegans


Alignment Length:1250 Identity:268/1250 - (21%)
Similarity:490/1250 - (39%) Gaps:249/1250 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   104 YTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNRLC----------ASWERELKNDGRSPSLVRA 158
            ||.|:..:...|        :|||          ||          :.:|:.|...|...|||..
 Worm     8 YTTPLIAQSNEK--------KPLE----------LCSFIRVIFKCTSCFEKFLFLIGVFFSLVTG 54

  Fly   159 LLRVF-GWQLGFPGLAIFVV--ELGLRTLQPIFLVKLISYFSGEPDAANAGFYYAVAQIVISALT 220
            |.:.| .:.||.....:..:  .:..:|:.|..|.|....:       ..|.|..|....:....
 Worm    55 LCQPFVSYTLGETAQVLVTITNAINNKTIDPADLKKAYEQY-------ERGMYQVVLYFFLCGCA 112

  Fly   221 VMILTPTTFGIHHVCFK-------MRVAMGSMIFRKALRLTKGALGDTTSGHVVNLISNDIPRL- 277
            ..    |...|.|...|       .||.  .....:.||.......:.::||:..::::::.|. 
 Worm   113 YF----TFASIQHAIMKYVGDNTTYRVR--KQYISRLLRKDAEYFDNVSTGHLSTVLNDNLERFR 171

  Fly   278 DSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTD 342
            :.....:..::......:|.|.|.:......|.:|:.|.|..    .:.|...||..:|...:.:
 Worm   172 EVFNEKIALIFALLTDFVVGTALAFYTDWRLASYGIFFSLGI----AFSGFINSAGVMKTTGKQN 232

  Fly   343 NRIRMVNEIISAIQVLKMY-------AWEQPFEQMVTHAREKEMNTIRQG---QYIRGFDFARRI 397
            ........|  |.|.|..|       ......|:.....:..|...|.:.   ...|||.:....
 Worm   233 THYANAGSI--AFQTLGAYKTVCSLNGQNTEIERYTEELKAGEKYGIHRALMYSISRGFTYFFCN 295

  Fly   398 VLSRVAIFLSLVGYVILGKVFTPEIAFMITAYYNVLLAA--MSIYVP------SAIIQTAQFLTS 454
            .|:.|.:::. ...:..|.:   |.|.::..::.::..|  :|..:|      .||..||..   
 Worm   296 SLNTVILYVG-ANMIYSGSL---EPAVVVRIFHYMMFGAFCLSEALPHISRLAGAISSTAPI--- 353

  Fly   455 IRRVEQFMQSEELGSSDKSEGPSKDTVPGNPPSNNNEADLLKSAISIRDLKAKWDPNSPD-YTLS 518
               .|..::.:.:...|:::...:..|.||              ||.:::|..: |..|| ..|.
 Worm   354 ---AEMLIKEDNVIEKDETDYDVEVEVNGN--------------ISFKNVKFSY-PTRPDAQVLK 400

  Fly   519 GINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGS-------------LSYTSQE 570
            ||:.:::.|..:|::|.:|||||:::|.:|.....:||.:.::|.             :...|||
 Worm   401 GISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQE 465

  Fly   571 SWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLL---PLRDNTIVGERGATLSGGQKARI 632
            ..||:.|:.:||.||.|..|  ..|:.........:|.:   |....|||||||..||||||.||
 Worm   466 PVLFNTTIEENIRFGNPNVS--LPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRI 528

  Fly   633 SLARSVYRKASIYLLDDPLSAVDASVARHLFDQCVRGHLRGSTVVLVTHQEQFLPHVDQIVILAN 697
            ::||::.|...|.|||:..||:| :.:..:..:.:....:|.|.::|.|:...:.:..:|:::..
 Worm   529 AIARTLVRNPKILLLDEATSALD-NESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQK 592

  Fly   698 GQIKALGDYESLL-KTGLITGLGSLSKTDKAKTEEQEPLNLNSPDNKNEVTP-----IKENSEQT 756
            |:|..:|:::.|: |.|:...|......:.....|:.| .|.:.....|::|     |:.::...
 Worm   593 GEIVEVGNHDELIAKRGVYNDLVQAQLLESHDDHEELP-PLAARQLSQELSPLHSYAIQRSTSND 656

  Fly   757 VGGSSSGKEHV--ERQESGG------------------ISLALYRKYFQAGGGLVAFLVMLSSSV 801
            .|......|.:  |..:.|.                  :.:|::....|.          :|..:
 Worm   657 AGVHDDDMERILDELSKEGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQG----------VSYPI 711

  Fly   802 LAQVAVTGGDYFLTYWVKKESTAAGHGEMEDMESKSMDVYKYTLIIILSVI-------MNLSSSF 859
            |||:.|.      ||              |.......|:..|:.:..||.:       :.|...:
 Worm   712 LAQLIVR------TY--------------EGFAMIGEDMLYYSHLWALSFMFLAVFRPLTLYCQY 756

  Fly   860 LLF-NIAKKASIRLHNTIFNRVTRADMHFFSINKHGS--ILNRFTKDMSQ----VDEVLPVVLVD 917
            ..| .::::.|.||....|:.:......|:....|.:  :.||...|.|.    ||:.|..|::.
 Worm   757 YYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMT 821

  Fly   918 V--MQIALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTS--RDLKRVEAINRSPVYSH 978
            |  :.||:..|.:......:..|:..|.|.|:...|   :...:||  .|....|..||:.:   
 Worm   822 VVAISIAITTASLYCWKMTLEVLIFFPLLYLAEYCY---DAATETSIQEDTIAFENSNRTAI--- 880

  Fly   979 LAASLNGLTTIRALDAQ-RVLEKEFDSYQDAHSSAFFMYISTSQAFGYCMNCICVIYISIITLSF 1042
              .:|..:.|:|||:.: :::....:..|..|.|.|...|....|.|..::|    |:.:.::||
 Worm   881 --EALENMRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSC----YLFVYSVSF 939

  Fly  1043 FAFPPGNGADVGLVITQAMGLIDMVQWGVRQTAELENTM--TAVERVVEY-ESIEPEGML----- 1099
                     ..|..:.....:..|..:.:.:|..:...|  :|...:.:| :::...|::     
 Worm   940 ---------KFGTYLALRKEVAPMDTYLILETLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFT 995

  Fly  1100 -------EAPDDKKPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGA 1157
                   .:.|.||.    .|:||||.:.:...|..... ..:|..::..:.|.:.:.:||.:|.
 Worm   996 YPATMPFSSSDGKKN----IEKGEIIGENVQFHYDQRPD-RMILNGVNLKVDPGKTLALVGPSGC 1055

  Fly  1158 GKSSLINALFRLSY-TDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSD 1221
            |||::|:.|.|..: .||.|.||:.:...:.|:.||..::::.|||.||:.::|.||        
 Worm  1056 GKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENL-------- 1112

  Fly  1222 EKLWGCLEEVKLKEV 1236
              |:|....|...|:
 Worm  1113 --LYGLTRSVPQLEL 1125

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)03659NP_001260823.1 CFTR_protein 89..1343 CDD:273530 268/1249 (21%)
ABC_membrane 171..437 CDD:294371 46/287 (16%)
ABCC_MRP_domain1 499..699 CDD:213217 67/216 (31%)
ABC_membrane 799..1045 CDD:294371 58/264 (22%)
ABCC_MRP_domain2 1115..1336 CDD:213211 36/122 (30%)
pgp-7NP_001361833.1 MdlB 42..621 CDD:224055 140/625 (22%)
ABC_MTABC3_MDL1_MDL2 381..618 CDD:213216 74/240 (31%)
ABC_6TM_Pgp_ABCB1_D2_like 686..994 CDD:350022 68/358 (19%)
TM helix 1 695..718 CDD:350022 6/32 (19%)
TM helix 2 733..781 CDD:350022 9/47 (19%)
TM helix 3 790..835 CDD:350022 13/44 (30%)
TM helix 4 836..885 CDD:350022 12/56 (21%)
TM helix 5 897..947 CDD:350022 12/62 (19%)
TM helix 6 956..989 CDD:350022 4/32 (13%)
P-loop_NTPase 1019..>1143 CDD:393306 32/117 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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