Protein Alignment l(2)03659 and pgp-11

DIOPT Version :9

• Sequence 1: NP_001260823.1
• Gene: l(2)03659 / 47905
• FlyBaseID: FBgn0010549
• Length: 1374
• Species: Drosophila melanogaster
• Sequence 2: NP_001364583.1
• Gene: pgp-11 / 183971
• WormBaseID: WBGene00004005
• Length: 1241
• Species: Caenorhabditis elegans
• Alignment Length: 1401
• Identity: 304/1401 - (21%)
• Similarity: 549/1401 - (39%)
• Gaps: 349/1401 - (24%)

  Fly   137 RLC---ASWERELKNDGRSPSLVRALLRVFGW----QLGFPGLAIFVVELGLRTLQPIFLVKLIS 194
            :||   :::..|.|....:||:.::|..:..:    .|.|...|:....|| .|:||:.|  ||.
 Worm     6 KLCRPVSAFGDESKVSDVTPSIRQSLNLMINFAKKSDLIFIITALICALLG-GTIQPVVL--LIG 67

  Fly   195 ------YFSGEPDAANAGFYYAVAQIVISALTVMILTPTTFGIHHVCFKMRVA----------MG 243
                  |.:....|.|..|.|:|..::.:.|...::......|..||.:...:          :|
 Worm    68 GWITDLYLTNGNTAGNDEFLYSVLTLIYAGLGFGVIILVLALIQGVCIQRGTSRILDSIRKEFLG 132

  Fly   244 SMIFRKALRLTKGALGDTTS--GHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIG 306
            :::.:.|..|.|.:.|..|.  ...:.:||:.:.              ....:||..:.|:....
 Worm   133 AVLRQDANWLDKHSSGSITCQLNENIEVISDGLG--------------NKCCMLVRGFAMFTSSI 183

  Fly   307 ISAVFGVLFMLLFMPIQM--------YLGTRTSAI---QLKAAERTDNRIRMVNEIISAIQVLKM 360
            |:..| :.:.|.|:...|        :|.|:.:.:   :|.:.....:.|  :.|.|..::.::.
 Worm   184 IACAF-INWQLTFITFTMGPVSAFVLHLLTKVNEVSNEELMSLSAQSHAI--IEESILNVRTVQS 245

  Fly   361 YAWEQPFEQMVTHAREKEMNTIRQGQYIRGFDFARRIVLSRVAIFLSLVGYVILGKVFTPEIAFM 425
            ...:......:....||......:..:..||       ...:|:|   |.|.|.|    ..:.|.
 Worm   246 CNGQNFMITKLNQVNEKIKKFYNKSTFWAGF-------FDGLALF---VIYFITG----ISLFFG 296

  Fly   426 ITAYYN--------VLLAAMSIYVP-----------SAIIQTA-QFLTSIRRVEQFMQSEELGSS 470
            ...|:|        |:|...:|.|.           |::.|.| .||...:.:|         |:
 Worm   297 CRLYFNQEIGKAGDVILIVNTICVTGYFLGLLGPHMSSLQQAATSFLLLYKTIE---------SA 352

  Fly   471 DKSEGPSKDTVPGNPPSNNNEADLLKSAISIRDLKAKWDPNSPDYTLSGINLEIKPGSVVAVIGL 535
            .||||...:....:...|          |..||::.|:.....: .|.|::|::.||..||::|.
 Worm   353 PKSEGKEGEIKISSTRGN----------IEFRDVRFKYFTRDNE-VLQGLSLQVLPGQTVALVGT 406

  Fly   536 TGSGKSSLIQAILGELKANSGQLQVNG-------------SLSYTSQESWLFSGTVRQNILFGQP 587
            :|.|||:.|..:....:|:.|::.::|             .:....||..||.||:.:||..|:.
 Worm   407 SGCGKSTSIGLLTKLYRASEGEILIDGKNIDMLDAKSLRQQIGIVQQEPKLFDGTIMENIKLGRN 471

  Fly   588 MDSQRYEEVVKKCA-----------LERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVYRK 641
            :|    ||.:|..|           ||..::       |.:|..|..||||||.||.:||::...
 Worm   472 VD----EETIKTAADIANASSFIEKLENGYE-------TRLGPGGVQLSGGQKQRICIARALVTS 525

  Fly   642 ASIYLLDDPLSAVDASVARHLFDQCVRGHLRGSTVVLVTHQEQFLPHVDQIVILANGQIKALGDY 706
            .||.|||:..||:| |...|:.::.:.....|.|.:::.|:...|..||:|.:|..|:.|.:|.:
 Worm   526 PSILLLDEATSALD-SHNEHIVNKALTKASEGRTTIIIAHRLSSLKSVDRIYVLDQGKTKEIGTH 589

  Fly   707 ESLLKTGLITGLGSLSKTDKAKTEEQEPLNLNSPDNKNEVTPIKENSEQTVGGSSSGKEHVERQE 771
            :.|:..|     |..::..|::..||                             |.|:..||:|
 Worm   590 DELILLG-----GIYARLAKSQEVEQ-----------------------------SSKKDWEREE 620

  Fly   772 SGGISLALYRKYFQAGGGLVAFLVMLSSSVLAQVAVTGGDYFLTYWVKKESTAAGHGEMEDMESK 836
                   |.|.......|....::..:|::|.:               .|....|....|:.|.|
 Worm   621 -------LRRAEKMKKKGRTVEIIEPNSTILQE---------------HEHNFVGSVITENEEQK 663

  Fly   837 -----------SMDVYKYTLIIILSVI-----------MNLSSSFLLFNIAKKASIRLHNTIFNR 879
                       .:..::.|||:|::::           :.:|.:|.....:|...:..:.....:
 Worm   664 ISFSGISKLFNYLPKHRKTLILIIALLIPRAIELCSYGIGMSFAFKTLQRSKDDYMTWNYITLAQ 728

  Fly   880 VTRADMHFFSINKH-----GSILNRFTKDMSQ--VDEVL--PVVLVD------------------ 917
            .|.|.:.|:.::..     |.:.|....::.|  :.|||  |:...|
 Worm   729 QTLAGITFWILHTSLMYLCGWLANEVMNEVKQEMLSEVLNKPIPYFDNPETSPSACVSRIISHAH 793

  Fly   918 ---------VMQIALWLAGIIIVIANVNPLL-------LVPTLMLSVIFYHLRNLYLKTSRDLKR 966
                     .::...::||.|..:....|.:       |..|::|::...|..::   ..|....
 Worm   794 NCYACLDHRAIRFVWFIAGTIFSLLLAFPFVWELGVLGLGITILLTIFSLHFVSV---AHRAHSE 855

  Fly   967 VEAINRS-----PVYSHLAASLNGLTTIRALDAQRVLEKEFDSYQDAHSSAFFMYISTSQAF--- 1023
            ...:::|     .:..|:.|       |:.|..:...|.:|..           |:.||:.:
 Worm   856 KSVMDKSGEFAVEIVEHIRA-------IKLLAVEGYFENKFSE-----------YLKTSEIYENK 902

  Fly  1024 -------------GYCMNC-ICVIYISIITL---------SFFAFPPGNGADVGLVITQAMGLID 1065
                         .|...| :.:.::..:.:         .|.||   |||.:     .|.|::.
 Worm   903 IGFVSSLNFAITQSYVFACDMLLFFVGTLLIYHGRYSPDKVFLAF---NGAQM-----SAWGVMY 959

  Fly  1066 MVQWG---VRQTAELENTMTAVERVVEYESIEPEGMLEAPDDKKPPKTWPE-QGEIIFKELNLRY 1126
            ...|.   ||.:|......:..::   ..:....|:.:           || .|::...::...|
 Worm   960 FSPWFPEIVRGSASANQIFSFFDK---NRTNSTSGLSK-----------PEINGKVEVSDVTFAY 1010

  Fly  1127 TPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFRL-SYTDGSVLIDTRDTRQMGLHD 1190
             |:....||.:..|..|.....:.:||.:|.|||::|:.|.|. |...|.:.:|..|...:.::.
 Worm  1011 -PSTPHRNVCEGFSLNIPKGHSIALVGASGCGKSTIISMLERFYSAKAGRISVDDNDIDGIDVNH 1074

  Fly  1191 LRRQISIIPQEPVLFSGTMRYNLD-PFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTN 1254
            ||..||::.||||||:.|:|.|:. ..||.|.|::....:.......:...|.|..:.:.|||.:
 Worm  1075 LRNNISVVGQEPVLFNATIRENITIGIDEVSVEEVQKACKAANAAGFIESFPLGYDTIVGEGGAS 1139

  Fly  1255 FSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDS 1319
            .|.||:|.:.:||||:|:.:||::||||:.:|.|::.::|..:||.....|.:.:||||.|:...
 Worm  1140 LSGGQKQRIAIARAIIRKPKILLLDEATSALDTQSEEIVQKALRSATTGRTSIIVAHRLSTVQHC 1204

  Fly  1320 DKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLVNQS 1355
            |.:..:..|.|.|:|:..||:. .|||....:..||
 Worm  1205 DTIYYISRGAVAEYGTHAELVA-MDSKYARLVAAQS 1239

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	299/1387 (22%)
		ABC_membrane	171..437	CDD:294371	56/302 (19%)
		ABCC_MRP_domain1	499..699	CDD:213217	67/223 (30%)
		ABC_membrane	799..1045	CDD:294371	47/341 (14%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	73/222 (33%)
pgp-11	NP_001364583.1	PTZ00265	38..1235	CDD:240339	295/1363 (22%)
		MdlB	46..607	CDD:224055	144/631 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910