DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and mrp-3

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_001359552.1	Gene:	mrp-3 / 181677	WormBaseID:	WBGene00003409	Length:	1505	Species:	Caenorhabditis elegans

Alignment Length:	1361	Identity:	416/1361 - (30%)
Similarity:	689/1361 - (50%)	Gaps:	148/1361 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 PRARSNFIS-SLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNRLCASW--------ERE 145
            |...:|||| .|..|:| .|...||.:||.:.|::....:...:.|..|....|        |::
Worm   194 PEENANFISRQLLLWFT-QIISLGYERTLVADDVFEMDSQMDQEYLKARWKTEWLKQTEKAREKQ 257

  Fly   146 LKNDGR---------------------------------SPSLVRALLRVFGWQLGFPGLAIFVV 177
            :|.|.:                                 .||::..|.::..|::.......|:.
Worm   258 VKLDDKRERARTGSEKAPLLGTFNNYGAVNLDDKDRVIVQPSVIVTLWQIMKWEILGGSFIKFLS 322

  Fly   178 ELGLRTLQPIFLVKLISYFSGEPDAANA----GFYYAVAQIVISALTVMILTPTTFGIHHVCFKM 238
            :| |:...|.||..||.:.    :..||    |...||...:...:..:.:......:..|..|:
Worm   323 DL-LQFANPTFLNYLILFI----ETPNAPLINGIGLAVGLFLAGQIKSLFMNTYFIAMTRVGAKI 382

  Fly   239 RVAMGSMIFRKALRLTKGALGDTTSGHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQ 303
            :..:...::.|:|.|:..|..:.|.|.:||::|.|:.|.......:...|..|.|:::...|:.|
Worm   383 QTMLSCAVYEKSLLLSNTARRERTVGEMVNILSIDVDRFRMITPQIQQYWSSPFQIIICMVLLSQ 447

  Fly   304 EIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFE 368
            .||::...|::.|:..:||.:.:...|...||:..:..|.|||::||:::.|:|:|:.|||...|
Worm   448 TIGVAVWAGIVVMISIVPINICVSMITKRWQLRLMKYKDERIRLINEVLNGIKVVKLSAWETAME 512

  Fly   369 QMVTHAREKEMNTIRQGQYIRGFDFARRIVLSRVAIFLSLVGYVIL-----GKVFTPEIAFMITA 428
            :.:...|:||:..|:|...::.|.....:   ...:|::|..:.:.     ..|.||.|||:..:
Worm   513 ETIERVRDKELKMIKQSALLKTFADCLNV---GAPVFVALSSFTVFVLIDPKNVLTPNIAFVSLS 574

  Fly   429 YYNVLLAAMSIYVPSAIIQTAQFLTSIRRVEQFMQSEELGSS--DKSEGPSKDTVPGNPPSNNNE 491
            .:|:|...: :.....:.||.|.:.|.:||..|:..:|:.::  ||.       :.|
Worm   575 LFNLLRGPL-MMAAELVAQTVQLVVSNKRVRTFLCEKEVDTAAIDKE-------IRG-------- 623

  Fly   492 ADLLKSAISIRDLKAKWDPNSPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSG 556
             :|..:.:.|......|| ::....||.|........:|.|:|..|||||||:.|.|||::...|
Worm   624 -ELYTNTVEIHSGSFAWD-SAEARILSDIEFLAGSKELVTVVGSVGSGKSSLLLAALGEMEKVCG 686

  Fly   557 QLQVNGSLSYTSQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERG 621
            .:.|.||::|.||:.|:.:.::::|:|....::...|::|::.|||:.|...||..|:|.:||:|
Worm   687 YVGVRGSVAYLSQQPWILNQSLKKNVLMQADLNDVLYKKVIESCALKEDLKQLPDGDDTEIGEKG 751

  Fly   622 ATLSGGQKARISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCV--RGHLRGSTVVLVTHQEQ 684
            ..|||||||||:|||:||:...:|.||||||||||.|.:|:||..:  .|.|..:|.:|||:...
Worm   752 INLSGGQKARIALARAVYQSKDVYFLDDPLSAVDAHVGKHIFDNVIGPNGMLSHTTRILVTNCTS 816

  Fly   685 FLPHVDQIVILANGQIKALGDYESLLKTGLITGLGSLSKTDKAKTEEQEPLNLNSPDNKNEVTPI 749
            ||....:|:::.:|:||..|.|..||..  :.....|.:.|....:.||        :..|.:..
Worm   817 FLQESGKIIVMKDGRIKHCGTYNELLTD--VEAREYLQEVDNEYAQAQE--------SSGEESGG 871

  Fly   750 KENSEQTVGGSSSGK--------EHVERQES---------------------GGISLALYRKYFQ 785
            :|||:...|..:||.        ..:.|::|                     |.::..:|..||:
Worm   872 EENSDILPGSIASGSRMSRLSRLSKISRKKSKSSIVEKKKPDALITKEEAAIGRVNPGVYLLYFK 936

  Fly   786 AGGGLVAFLVMLSSSVLAQVA-VTGGDYFLTYWVKKESTAAGHGEMEDMESKSMDVYKYTLIIIL 849
            | .|:|.:::..:.:|:..|: ..|...:||.|    |.|.......|..|....:..|....|.
Worm   937 A-MGIVTYVLPYAIAVVLNVSFALGRSLWLTAW----SDANIDINHPDTMSVGARLGVYAGFGIT 996

  Fly   850 SVIMNLSSSFLLFNIAKKASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVD------ 908
            .||....|..||......||..||..:.:.|.|..:.:|.|...|.|:||..|||..||
Worm   997 EVIFLFFSLVLLLIGGVAASKNLHKPLLHNVLRNPLSYFDITPIGRIINRLAKDMEVVDLRLSSS 1061

  Fly   909 -EVLPVVLVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINR 972
             ..|.:.|::::|       .:::::...||.:...:.:.:|::.:....:|::|.|:|:.::.|
Worm  1062 FRFLVMALINMVQ-------TVLIVSYTTPLFIAIIIPVFIIYFFVLKYSIKSTRQLQRIASLTR 1119

  Fly   973 SPVYSHLAASLNGLTTIRALDAQRVLEKEFDSYQDAHSSAFFMYISTSQAFGYCMNCI-CVIYIS 1036
            ||::|:.:.:|.|::|:||........:..|.:.:.|....:.....::.....:..: .::..|
Worm  1120 SPIFSNFSETLQGISTVRAFQWSDEFVRRNDEHLNTHVKCSYYSQMANRWLSIRLELLGNIVIFS 1184

  Fly  1037 IITLSFFAFPPGNGAD-VGLVITQAMGLIDMVQWGVRQTAELENTMTAVERVVEYESIEPEGMLE 1100
            ...|:......|..|. :||.::.::.:..|:...|||..|:|..:.:|||:.||...:.|....
Worm  1185 AAILAIIGKESGITAGMLGLSVSYSLNITFMLNMFVRQINEVETNVVSVERIDEYSKTKSEAEWR 1249

  Fly  1101 APDDKKPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINA 1165
            . |:...|..||..|.:..::.:.||  ..:.:.|||.:|..|.|.:|||:.||||||||||..|
Worm  1250 L-DNNNLPSNWPTGGAVNIEDYSCRY--RDELDLVLKQISLNILPGQKVGVCGRTGAGKSSLALA 1311

  Fly  1166 LFRL-SYTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLE 1229
            |||: ...||::.||...|..:||||||.:::|||||.|||:.|:|:|:||..:::|::||..||
Worm  1312 LFRIVEAADGNISIDQTITSHIGLHDLREKLTIIPQENVLFANTLRFNIDPKGQFTDQQLWLALE 1376

  Fly  1230 EVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQ 1294
            ...||..|..||..|.|.::|||.|||||||||:||.||:||::::||:|||||.:|.:||.::|
Worm  1377 NSNLKAHVELLPHKLESPVAEGGENFSVGQRQLLCLTRALLRKSKVLVLDEATAGIDNRTDTMVQ 1441

  Fly  1295 ATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLVNQS 1355
            ||||.||.|.|::|||||||||||.|:::||||||:||.|.|.||:...:|: |:.|...:
Worm  1442 ATIREKFADSTIITIAHRLHTIIDYDRIIVMDAGRIVEDGIPGELLKNRNSQ-FYGLAKSA 1501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	413/1347 (31%)
		ABC_membrane	171..437	CDD:294371	69/274 (25%)
		ABCC_MRP_domain1	499..699	CDD:213217	81/201 (40%)
		ABC_membrane	799..1045	CDD:294371	57/254 (22%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	120/221 (54%)
mrp-3	NP_001359552.1	MRP_assoc_pro	25..1501	CDD:188098	416/1359 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I5384
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1734
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.670