DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment l(2)03659 and mrp-5

DIOPT Version :9

Sequence 1:NP_001260823.1 Gene:l(2)03659 / 47905 FlyBaseID:FBgn0010549 Length:1374 Species:Drosophila melanogaster
Sequence 2:NP_510479.1 Gene:mrp-5 / 181587 WormBaseID:WBGene00003411 Length:1427 Species:Caenorhabditis elegans


Alignment Length:1395 Identity:439/1395 - (31%)
Similarity:701/1395 - (50%) Gaps:145/1395 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    68 KLTVNSENNSAQNEKEKVLPENPRARSNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSD 132
            :.|..::||......:          :...|.:.:.:..|...:..|..||...::.........
 Worm    57 RTTERNKNNGGSRIDD----------AGLFSFVTYSWVFPYLYQAVRGKLDRNQVWGCSFYDSCG 111

  Fly   133 ILGNRLCASWERELKNDGRSPSLVRALLRVFGWQLGFPGLAIFVVELGLRTLQPIFLVKLISYFS 197
            :...||...||.|.|.:.:||||.:.:.|....:|.| ..|:|...|....:.|...::.:..|:
 Worm   112 LNMARLEVLWEDEKKANAKSPSLFKVIYRFISTRLWF-SCAVFFFCLIFGFIGPTCFIRRLIAFA 175

  Fly   198 GEP---DAANAGFYYAVAQIVISALTVM----ILT-PTTFGI-HHVCFKMRVAMGSMIFRKALRL 253
            ..|   :.:...:.|.:|  :::|::|:    :|: ..|:.: :....::|.|:.:::::..|. 
 Worm   176 ENPERDEQSRIVYSYGIA--LVAAISVVEFARVLSYGATWAVSYRTGIRVRGAVLALLYKNVLN- 237

  Fly   254 TKGALGDTTSGHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLV--ITYLMYQEIGISAVFGVLFM 316
            :|...|.|.| .|:|:.:||..||..|......:.|||| |||  |.||: ..||..::.|:|..
 Worm   238 SKDLCGKTES-DVINIFANDGQRLFDAVTFAPLVLVGPL-VLVGGIGYLL-MVIGRWSLLGILVF 299

  Fly   317 LLFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNT 381
            .:|..||..||....|.:..|..:|:.||.|:.|||..|:::||..|||.|...:...|::|...
 Worm   300 FVFDVIQFGLGKSMVACRNLAIVKTEKRISMMAEIIKYIRIVKMNGWEQIFSAKIDQFRKEEKVQ 364

  Fly   382 IRQGQYIRGFDFARRIVLSRVAIFLSLVGYVILGKVFTPEIAFMITAYYNVLLAAMSIYVPSAII 446
            ||:..|.:....|...|:..||..|:.||.|:.|.......||.....|.|:|..:.: :|....
 Worm   365 IRKSGYAQSLAIACGPVVPVVAAILTFVGVVLAGNDLLASDAFSAITVYFVMLFGIRM-IPYGSR 428

  Fly   447 QTAQFLTSIRRVEQFMQSEELGSSDKSEGPSKDTVPGNPPSNNNEADLL--KSAISIRDLKAKWD 509
            ..|:.:.::||:::::..|:....               |..|.|..:|  :.|......||...
 Worm   429 YLAEAVVAMRRIQEYLLLEQYAPY---------------PVTNAEDVVLDCQGATYTYQPKAAKA 478

  Fly   510 P---------------NSPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQ 559
            |               .:|.:|.|...|.||.|..:||||..|.|||::::||.|.:......|.
 Worm   479 PVDETKEPTENEVIVVETPVFTCSFDKLSIKRGEHIAVIGAVGCGKSAILKAISGHMFTTDDALS 543

  Fly   560 VNGSLS-YTSQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGAT 623
            |:.|.: |..|::|:|:|||:.|||||..|:|:||.:.|..|.|..|...|.:.|.|.|||||||
 Worm   544 VDRSQTVYVPQKAWIFNGTVQDNILFGDKMNSERYYKAVNGCQLTEDLTTLSVGDRTEVGERGAT 608

  Fly   624 LSGGQKARISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCVRGHLRGSTVVLVTHQEQFLPH 688
            ||||||||::|||:|::..::||.||..:::|..||..:.::.::..|:...:::||:..:.|.|
 Worm   609 LSGGQKARVALARAVFQTKNLYLFDDIFASLDKKVANKIHEEIIQKLLKKKALMMVTNNMELLHH 673

  Fly   689 VDQIVILANGQIKALGDYESLLKTGLITGLGSLSKTDKAKT------EEQEPLNLNSPDNKNEVT 747
            .|:::.:..|.|.|.|:::.|.:           |.|..||      ..|......||.......
 Worm   674 FDRVLFVEGGNIVADGNHDILYE-----------KNDAYKTFVDACETYQATSGATSPCGDGPAQ 727

  Fly   748 P------IKENSEQTVGGSSSGKEHVERQESGGISLA--LYRKYFQAGGG-------LVAFLVML 797
            |      |..||.:.:.|.:. |...:.::.|..::|  :|::|..|.||       ::.|:|.:
 Worm   728 PAPLDAEILRNSSEDLKGDAD-KLISDEEDMGNSTIAWRIYKQYIHAAGGWPIWTCLVIGFIVNV 791

  Fly   798 SSSVLAQVAVTGGDYFLTYWVKK---ESTAAGHG-EMEDMESKSMD---------VYKYTLIIIL 849
            .|::.:       .|:|:.|:||   |:|...:| |..:|::...|         ||...|::: 
 Worm   792 VSNIFS-------TYWLSRWLKKGHDETTTITNGTEFLEMKTSLADSPVTGFYAAVYLVALVVL- 848

  Fly   850 SVIMNLSSSFLLFNIAKKASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVV 914
             .|..|..:.:...::..|:.|||:.:|..|......||.....|.|||||:|||.::|..||..
 Worm   849 -TISGLFKACVFVKVSLTAATRLHDRMFQAVIHGATSFFDSTPTGRILNRFSKDMDEIDVKLPFT 912

  Fly   915 LVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHL 979
            ....:|..:...|.::||.:|.|..|:..:.|.|:|....:.:....|:|||.|.|:|||:|.|:
 Worm   913 AEVFLQNMITCLGFLVVITSVFPYFLLFAIPLFVVFVVFVSCFRAGIRNLKRSEHISRSPLYDHV 977

  Fly   980 AASLNGLTTIRALDAQRVLEKEFDSYQDAHSSAFFMYISTSQAFGYCMNCICVIYISIIT-LSFF 1043
            :|||.|:|||..........:....:.|.:|.|.||:.|..:.....::.:.|:..:|:. |:..
 Worm   978 SASLEGITTIHTFQQSNRFLEVLKKHLDCNSGAIFMFQSAMRWLAVWLDLLVVVMTAIVALLTVM 1042

  Fly  1044 AFPPGNGADVGLVITQAMGLIDMVQWGVRQTAELENTMTAVERVVEY-ESIEPEGMLEAPDDKKP 1107
            .....:.||.|:.|..|:.:..:.|:.||...|||..||:||||..| ::|..:|..........
 Worm  1043 LTGTVSPADAGMAIAFAVQMSGIFQFAVRTQTELEAKMTSVERVSYYADNIPEDGEWNTRQGLDI 1107

  Fly  1108 PKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFRL-SY 1171
            ..:||..|:|.|.|:||||..:...  .|..::|.|:..|||||:||||:|||||.|.:||| ..
 Worm  1108 ESSWPANGQINFSEVNLRYRKSHPL--ALNDITFEIKGGEKVGIIGRTGSGKSSLANLIFRLYPV 1170

  Fly  1172 TDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEV 1236
            |:|::.||..|.|.:||..|||.||.|.|:|.|||||:|:||||..||||..:|..||:..||.:
 Worm  1171 TNGTIYIDGVDIRTVGLVKLRRGISAIAQDPSLFSGTVRFNLDPSLEYSDSMIWEALEKCHLKTL 1235

  Fly  1237 VSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQATIRSKF 1301
            |..|...|.:.:|.||.|||||:|||.|||||:|.::||:::|||||:||..||.|||..|::.|
 Worm  1236 VQSLDKKLEADVSHGGNNFSVGERQLFCLARALLMKSRIVILDEATASVDAGTDKLIQEVIKTVF 1300

  Fly  1302 RDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVF------------------ 1348
            .|.||:.|||||..:.:.|::|.:..|:::.|.:|.| |.|.|..|:                  
 Worm  1301 ADATVIIIAHRLDNVRNMDRIMHLKNGKLINFTTPQE-MFKDDWSVYKLEDKDDDQHSAVVVGEN 1364

  Fly  1349 --HNLVNQSGRASYEG--LLKIAQETFESS 1374
              |::...|..:|.|.  ::|:..|..:||
 Worm  1365 SEHSMEKSSQGSSQESDDIVKVENEQKDSS 1394

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)03659NP_001260823.1 CFTR_protein 89..1343 CDD:273530 425/1319 (32%)
ABC_membrane 171..437 CDD:294371 80/276 (29%)
ABCC_MRP_domain1 499..699 CDD:213217 79/215 (37%)
ABC_membrane 799..1045 CDD:294371 74/259 (29%)
ABCC_MRP_domain2 1115..1336 CDD:213211 112/221 (51%)
mrp-5NP_510479.1 MRP_assoc_pro 90..1340 CDD:188098 423/1296 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 142 1.000 Domainoid score I2904
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.830

Return to query results.
Submit another query.