DRSC/TRiP Functional Genomics Resources

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Protein Alignment l(2)03659 and pgp-8

DIOPT Version :9

Sequence 1:NP_001260823.1 Gene:l(2)03659 / 47905 FlyBaseID:FBgn0010549 Length:1374 Species:Drosophila melanogaster
Sequence 2:NP_509811.2 Gene:pgp-8 / 181277 WormBaseID:WBGene00004002 Length:1243 Species:Caenorhabditis elegans


Alignment Length:1374 Identity:313/1374 - (22%)
Similarity:562/1374 - (40%) Gaps:298/1374 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   121 DLYRPLEEQKSDILGNRL------CAS-WERELKNDGRSPSLVRALLRVF-GWQLGFPGLAIFVV 177
            |:..|:|.:|......:.      |.| ||:.|...|...::...|.:.| .:..|....|...:
 Worm     7 DVLIPVENEKKTTNWTKFVKVVWQCTSKWEKFLFVIGVVSAICTGLTQPFMSYTFGEVSQAFVRI 71

  Fly   178 ELGLR--TLQPIFLVKLISYFSGEPDAANAGFYYAVA-------QIVISALTVMILTPTTFGIHH 233
            ...:.  :|.|..|.|....|  ..|..|...::.:.       ..:..:|...|...||:.:.|
 Worm    72 TAAVNNASLDPSDLEKAYEMF--HADMNNVVIHFGLVGCAFMFFGFIQFSLFKYIGDNTTYRLRH 134

  Fly   234 VCFKMRVAMGSMIFRKALRLTK--GALGDTTS-GHVVNLISNDIPRLDSA-PYTVHYLWVGPLQV 294
                          :..|||.|  ....||.| |::..::::::.|...| ...:.::.......
 Worm   135 --------------KFILRLLKKDAKYFDTISTGYLSTVLNDNLERFREAFNEKIAFIICFSTDF 185

  Fly   295 LVITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLK 359
            .:.|.|.:......|.:|.:|....    :..|...|...:|:.|:..........|  |.|.| 
 Worm   186 AIGTALAFYTSWTLASYGSVFAFGI----VISGLLNSTSMMKSNEKQSMHYSNAGAI--AFQAL- 243

  Fly   360 MYAWEQPFEQMV-----THAREKEMNTIRQGQYIRGFDFARRIVLSRVAIFLS------------ 407
                 ..|:.::     |...||....:::|:...          ||.|.||:            
 Worm   244 -----CSFKTVISLNGQTQELEKYSAELKEGEKFG----------SRRAFFLATSRGLSHFFCNA 293

  Fly   408 ---LVGYVILGKVF--TPEIAFMITAYYNVLLAAMSIYVPSAIIQTAQFLTSIRRVEQFMQSEEL 467
               .:.||....::  |.....::|.::.:|.:|.|:  ..|.:..:..|.:|.......  :.|
 Worm   294 LNGTILYVGADLIYNKTMNTVAIVTLFHYMLFSAFSL--GEAFLHISYLLNAINSATPIF--DVL 354

  Fly   468 GSSDKSEGPSKDTVPGNPPSNNNEAD---LLKSAISIRDLKAKWDPNSPDY-TLSGINLEIKPGS 528
            .|.|       |.:..|  .:|.:.|   .::..:|..::|..: |:.||. .|.||:.::|.|.
 Worm   355 TSDD-------DMIENN--QDNEQTDSNKTIQGMLSFNNVKFAY-PSRPDVDILRGISFDVKQGE 409

  Fly   529 VVAVIGLTGSGKSSLIQAIL-------GELKANSGQL------QVNGSLSYTSQESWLFSGTVRQ 580
            .:|::|.:|||||:::|.:|       |.:|.....|      |:..::...|||..||:.|:.:
 Worm   410 CIALVGASGSGKSTIVQLLLHFYNIQSGTIKIGDSHLHDINLKQLRNAIGVVSQEPVLFNTTIEE 474

  Fly   581 NILFGQP--MDSQRYEEVVKKCALERDFDLLPLRD--NTIVGERGATLSGGQKARISLARSVYRK 641
            ||.||.|  ..|:.||.:.|..|.  || :..::|  .||||||||.||||||.||::||.:.:.
 Worm   475 NIRFGNPNATSSEIYEALRKANAY--DF-VCNIKDGLKTIVGERGAQLSGGQKQRIAIARVLVKN 536

  Fly   642 ASIYLLDDPLSAVDASVARHLFDQCVRGHLRGSTVVLVTHQEQFLPHVDQIVILANGQIKALGDY 706
            .:|.|||:..||:| |.:.......::....|.|.:::.|:...:.|.|:|::::||:|..:|.:
 Worm   537 PAILLLDEATSALD-SASERAVQLALKKASEGRTTIIIAHRLSTIRHCDKIMVMSNGKIAEVGSH 600

  Fly   707 ESLLK-----TGLITG--LGSLSKTDKAKTEEQEPLNLNSPDNKNEVTPIKENSEQTVGGSSSGK 764
            |.|:.     :.|:..  ..|.|..:....:..|.:...:|.|.|:..|::|..::|    ||..
 Worm   601 EELISMDREYSNLVRAQFFDSQSVEEDINGQGAEEVIQKTPPNLNDGEPLEELLKET----SSDI 661

  Fly   765 EHVE---------RQESGGISLALYRKYFQAGGGLVAFLVMLSSSVLAQVAV-------TGGDYF 813
            |...         |.::..:|:|:.....|.          .:..:|:|:.|       ..|:..
 Worm   662 EIKSNIWEVLRECRPDAFLLSMAVIGSAIQG----------CNFPILSQIIVQTYKAYAMDGENI 716

  Fly   814 LTYWVKKESTAAGHGEMEDMESKSMDVYKYTLIIILSVI--MNLSSSFLLF-NIAKKASIRLHNT 875
            |||         ||             :...:.::|.||  :.|...|..| .:::|.|.||...
 Worm   717 LTY---------GH-------------FWAAMFLVLGVIRPITLYCQFFFFGKVSEKLSTRLRIK 759

  Fly   876 IFNRVTRADMHFFSINKHG--SILNRFTKDMSQ----VDEVLPVVLVDVMQIALWLAGIIIVIAN 934
            .|..:......|:...||.  .::||...|.|.    ||..|..:|:.::..:|    .|::...
 Worm   760 SFQHLLSLPCAFYDDPKHSPTRLVNRLNTDPSNIKAAVDARLGSLLMSMVSFSL----AILIACY 820

  Fly   935 VNPLLLVPTLMLSVIFYHLRNLYLKTS-----RDLKRVEAINRSPVYSHLAASLNGLTTIRALDA 994
            .:..|.:..::...:.|:.:.||.||:     .|....|..|:..:     ..|:.:.|::||:.
 Worm   821 YSWKLTLQVVLFFPVLYYAKFLYKKTTTISIKEDSVAFENSNKIAI-----EVLDNMKTVKALNM 880

  Fly   995 Q-RVLEKEFDSYQDAHSSAFFMYISTSQ---------AFGYCMNCICVIYISIITLSFFAFPPGN 1049
            : ||:....:         :...:.||.         |.|:...|..::|  .|:..|..:    
 Worm   881 EARVINLVME---------YLAVLKTSYPRRSVVMGLANGFSAGCSQIVY--AISFKFGTY---- 930

  Fly  1050 GADVGLVITQAMGLIDMVQWGVRQTAELENTMTAVERVVEYESIEPEGMLEAPDDKKP------- 1107
                 |::.:.:..:||    ......|..|.......:.|          .||.:|.       
 Worm   931 -----LILQKEVIPMDM----YLSLITLSYTSNMAGSAISY----------MPDFRKAIHSAGLI 976

  Fly  1108 ------PKTWP----------EQGEIIFKELNLRY--TPNAKAENVLKSLSFVIQPREKVGIVGR 1154
                  |.|.|          .:||:..:.:...|  .|:   ..||.|::..::..:.:.|||.
 Worm   977 FNLFTYPATMPFNSDTGSRSITKGEVNGENVKFHYHQRPD---YTVLDSVNLKVEAGKTLAIVGP 1038

  Fly  1155 TGAGKSSLINALFRLSYTD-GSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDE 1218
            :|:|||::|:.|......| |.:.||..:...:.|..||..:.::.|.||||:.::|.|:     
 Worm  1039 SGSGKSTIISLLEMFYRADQGFIKIDNDNVENINLDHLRSNLGLVSQGPVLFNCSIRDNI----- 1098

  Fly  1219 YSDEKLWGCLEEVKLKEV------------VSDLPDGLASKISEGGTNFSVGQRQLVCLARAILR 1271
                 |:|....:...|:            |..||.||.:.:.:.|...|.||:|.:.:.|||||
 Worm  1099 -----LYGLTRNISQTEIENALQIANAFNFVFQLPQGLDTIVGDRGAQLSGGQKQRIAITRAILR 1158

  Fly  1272 ENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSP 1336
            ..::|::||||:.:|.:::.::|..:.:.....:.:.:||||.|||::|.:.|:..|:|||.|:.
 Worm  1159 NPKLLLLDEATSALDTESEKIVQNALDTASERLSTIVVAHRLSTIINADSIAVLRNGKVVEQGTH 1223

  Fly  1337 YELM-TKSD 1344
            .:|: .|.|
 Worm  1224 NQLLAVKGD 1232

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)03659NP_001260823.1 CFTR_protein 89..1343 CDD:273530 311/1371 (23%)
ABC_membrane 171..437 CDD:294371 51/300 (17%)
ABCC_MRP_domain1 499..699 CDD:213217 75/217 (35%)
ABC_membrane 799..1045 CDD:294371 56/276 (20%)
ABCC_MRP_domain2 1115..1336 CDD:213211 69/235 (29%)
pgp-8NP_509811.2 PTZ00265 29..1241 CDD:240339 309/1352 (23%)
ABC_membrane 44..326 CDD:294371 54/319 (17%)
ABC_MTABC3_MDL1_MDL2 382..617 CDD:213216 80/239 (33%)
ABC_membrane 685..953 CDD:279056 61/332 (18%)
ABC_MTABC3_MDL1_MDL2 1005..1240 CDD:213216 70/241 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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