Protein Alignment l(2)03659 and mrp-4

DIOPT Version :10

• Sequence 1: NP_610482.3
• Gene: l(2)03659 / 47905
• FlyBaseID: FBgn0010549
• Length: 1374
• Species: Drosophila melanogaster
• Sequence 2: NP_509658.1
• Gene: mrp-4 / 181202
• WormBaseID: WBGene00003410
• Length: 1573
• Species: Caenorhabditis elegans
• Alignment Length: 1394
• Identity: 468/1394 - (33%)
• Similarity: 726/1394 - (52%)
• Gaps: 165/1394 - (11%)

  Fly    89 NPRARSNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNRLCASWERELK------ 147
            :|...|:|::.:..|:...:...|.:|.|:.:|||...|...|::|..:....|:::.|
 Worm   217 SPETTSSFLNRITMWWFNSLCSLGVKKPLEVSDLYSLNEADTSNLLVPKWYNLWDKQSKKFEETA 281

  Fly   148 --------------------------ND-----------GRS----PSLVRALLRVFGWQLGFPG 171
                                      ||           |:|    ||::..|..:|.|.:   .
 Worm   282 ARRRIGSNASRTNRRRTSSNDTTPLLNDQSTDDYGSVPAGQSTQKMPSIIWTLFLMFKWDV---I 343

  Fly   172 LAIFVVELG--LRTLQPIFLVKLISYFSGEPDAANAGFYYAVAQIVISALTVMILTPTTFGIHHV 234
            .|:||..|.  |....|:.|..||.:..........|...|......:.|:.::|:...:.::.|
 Worm   344 TAMFVKLLSDVLLFCNPLLLKSLIRFTEELERPMWQGVVLAFTMFFSAELSSILLSHYFYLMYRV 408

  Fly   235 CFKMRVAMGSMIFRKALRLTKGALGDTTSGHVVNLISNDIPRLDS-APYTVHYLWVGPLQVLVIT 298
            ..:::..:.:.::||.|||:..|..:.|.|.:|||::.|:.|... .|.|:.| |..|.|:.:..
 Worm   409 GTRVQTCLTAAVYRKTLRLSNAARREKTVGEIVNLMAIDVDRFQQITPQTMQY-WSNPFQIGLAL 472

  Fly   299 YLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAW 363
            :|::|::|:|...||..|:|..||...:.......|:......|.|.:||||:::.|:|:|:|||
 Worm   473 FLLFQQLGVSVFSGVAVMVLLFPINFVITMIIRKWQIAQMYYKDERTKMVNEVLNGIKVIKLYAW 537

  Fly   364 EQPFEQMVTHAREKEMNTIRQGQYIRGF-DFARR-----IVLSRVAIFLSLVGYVILGKVFTPEI 422
            |.|.||::...||:|:..|::..::|.| |....     :.||..|.|:    |:....|.||||
 Worm   538 EPPMEQVIEDLREQELGLIKKAAFLRTFSDMLNTASPFLVALSTFATFI----YIDPKNVLTPEI 598

  Fly   423 AFMITAYYNVLLAAMSIYVPSAIIQTAQFLTSIRRVEQFMQSEELGSSDKSEGPSKDTVPGNPPS 487
            ||:....:|.|.:.|| .|...|.||.|.:.|.||:::|:.|||| :.:..:..::|
 Worm   599 AFVSLTLFNQLRSPMS-QVAELITQTVQVVVSNRRLKEFLVSEEL-NVEAIDHRARD-------- 653

  Fly   488 NNNEADLLKSAISIRDLKAKWD--PNSPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGE 550
             ||:...||.|.      ..|:  .:.|..||:.|:..:..|.:|.::|..|:||||::||::||
 Worm   654 -NNDVICLKEAC------LSWESAEHQPVPTLTNISFSVNRGQLVTIVGRVGAGKSSMLQALMGE 711

  Fly   551 LKANSGQLQVNGSLSYTSQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNT 615
            ::..||.:.::|.|.|..|:.|:.:.|:||||.||:..|...|..|:..|||.||..:|||.|||
 Worm   712 MEKLSGSISMHGRLCYVPQQPWMQNNTLRQNITFGKQFDEYFYSRVLDACALYRDLQILPLGDNT 776

  Fly   616 IVGERGATLSGGQKARISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCV--RGHLRGSTVVL 678
            .:||:|..|||||||||||||:||:...|||||||:|||||.|...||...:  .|.||..|.:|
 Worm   777 EIGEKGINLSGGQKARISLARAVYQNHDIYLLDDPMSAVDAHVGSQLFGSVIGPEGMLRNKTRIL 841

  Fly   679 VTHQEQFLPHVDQIVILANGQIKALGDYESLLKTGLITGLGSLSKTDKAKTEEQEPLNLNSPDNK 743
            ||::..||...|.|:::..|:|:..|.|:.|::.|....|  |.:.:|.:.|.:|.......|::
 Worm   842 VTNELSFLEKSDLIIVMNEGKIEYSGKYDDLMQQGAFEQL--LIECEKEERERREAEASADEDDE 904

  Fly   744 NE--------------------VTPIKE-----NSEQTVGG-----------------SSSGKEH 766
            |.                    .:||.:     :...||.|                 .|:.|.|
 Worm   905 NSEPGGIMIGGDSDFEYDDDVMASPIIDHVLGTSHMSTVSGIINRRRISTSTHKQRRRLSTTKSH 969

  Fly   767 ----------------VERQESGGISLALYRKYFQAGGGLVAFLVMLSSSVLAQVAVTGGDYFLT 815
                            .||.|:|.:.:..|.|||.|.|..:|.|.:|..:. :.:...|.:.:||
 Worm   970 THSITSASTQTRQLTGTERVETGRVKMDTYYKYFGAMGMSIAVLFVLGMTT-STIFSMGRNLWLT 1033

  Fly   816 YWVKKESTAAGHGEMEDMESKSMDVYK---YTLIIILSVIMNLSSSFLLFNIAKKASIRLHNTIF 877
            .|....:..:|........:..:.||.   ::.||:|.:.| ||   ||:. ...||..||..:.
 Worm  1034 DWSNDNAARSGSNTTGQPIAIRLGVYAGLGFSEIILLFIGM-LS---LLYG-GVSASRNLHAPLM 1093

  Fly   878 NRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNPLLLVP 942
            ..:.|..|.|:.....|.||||..||:..||.:||..:....|..|.:...:|:|....|:..:.
 Worm  1094 RNLFRVPMAFYDTTPFGRILNRIGKDIETVDVLLPFNVQFFAQCLLQVVSTLIIIMISTPVFGIV 1158

  Fly   943 TLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQRVLEKEFDSYQD 1007
            .:.|||::..:...|:.|||.|||:|:|.|||:||||:.|:.|..||||........|..::..|
 Worm  1159 IIPLSVMYLMVMRYYIATSRQLKRLESITRSPIYSHLSESIQGSATIRAYHLVDRFCKLSETKVD 1223

  Fly  1008 AHSSAFFM-YIST---SQAFGYCMNCICVIYISIITLSFFAFPPGNGADVGLVITQAMGLIDMVQ 1068
            :|....:: |::.   |....:..|||  :..|.:..:.......:|. :||.::.|:.:..::.
 Worm  1224 SHVQCRYLNYVANRWLSVRLEFIGNCI--VLFSALFAALTRTTTTSGV-IGLSVSYALNITTVLN 1285

  Fly  1069 WGVRQTAELENTMTAVERVVEYESIEPEGMLEAPDDKKPPKTWPEQGEIIFKELNLRYTPNAKAE 1133
            :.|||..:||..:.:||||.||...|.|...::...|:||:.||.:|.|:....:.||.|....
 Worm  1286 FAVRQITKLETNIVSVERVKEYAETETEAEWKSEPGKEPPQNWPSEGRIVMNNYSARYRPGLNL- 1349

  Fly  1134 NVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFR-LSYTDGSVLIDTRDTRQMGLHDLRRQISI 1197
             |:|.|:..|:|.|||||||||||||||:..:||| :...:|.:::|..:..::||||||..::|
 Worm  1350 -VVKQLNVEIKPHEKVGIVGRTGAGKSSVTLSLFRIIEAAEGQIVVDGINLAEIGLHDLRSNLTI 1413

  Fly  1198 IPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQL 1262
            |||:|||||||:|:|||||:.|||..:|..||...|||..:...:.|...|:|||.|.|||||||
 Worm  1414 IPQDPVLFSGTLRFNLDPFNHYSDGDIWKTLEMANLKEFATAHNEQLNYIITEGGDNISVGQRQL 1478

  Fly  1263 VCLARAILRENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDA 1327
            ||||||:||:.|:|::|||||.||..||.|||.|||.:|.:.|||||||||:||:|.|:::|::.
 Worm  1479 VCLARALLRKTRVLILDEATAAVDVSTDALIQKTIREEFANATVLTIAHRLNTIMDYDRIIVLND 1543

  Fly  1328 GRVVEFGSPYELMTKSDSKVFHNLVNQSG 1356
            |:|.||.||..|::..:|: |:::..::|
 Worm  1544 GKVGEFDSPANLLSNRNSE-FYSMAKRAG 1571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_610482.3	PLN03130	83..1369	CDD:215595	468/1394 (34%)
mrp-4	NP_509658.1	MRP_assoc_pro	17..1572	CDD:188098	468/1394 (34%)