Protein Alignment l(2)03659 and pgp-10

DIOPT Version :9

• Sequence 1: NP_001260823.1
• Gene: l(2)03659 / 47905
• FlyBaseID: FBgn0010549
• Length: 1374
• Species: Drosophila melanogaster
• Sequence 2: NP_509205.2
• Gene: pgp-10 / 180981
• WormBaseID: WBGene00004004
• Length: 1382
• Species: Caenorhabditis elegans
• Alignment Length: 1536
• Identity: 340/1536 - (22%)
• Similarity: 608/1536 - (39%)
• Gaps: 398/1536 - (25%)

  Fly    34 DHRNKDESLSVNTSPPLVCRKCFELGHQTENCKQKLTVNSENNSAQNEKEKVLPENPRARSNFIS 98
            :.:||:||.:          |..|:|    |.::|  ..:|....::.|..:.|..|
 Worm     3 NEKNKNESTN----------KTNEIG----NAEKK--EEAETEDKKSLKSMIYPIEP-------- 43

  Fly    99 SLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDI---LG-----NRLCA---SWERELKNDGRS 152
            |..:...:...:|.|..|:|.     || ::.||.   ||     .||.|   |.:.:|...|..
 Worm    44 STLYIDDLKNSKKAYDVTMDD-----PL-DKSSDSKPKLGFFEPYKRLYAFADSIDMQLMAMGLF 102

  Fly   153 PSLVRALLRVFGWQL--GFPGLAIFVVE--LGLRTLQPIFLVKLISYFSGEPDAANAGFYYAVAQ 213
            .:|:::.|..|.|.:  .|..::|...|  |||:.|...:.:             :..|.::...
 Worm   103 SALLQSALPPFVWLIMGNFVSISILREEGKLGLKNLTSDYPI-------------DDQFAHSATP 154

  Fly   214 IVISALTVMILTPTTFGIHHVCFKMRVAMGSMIFRKALRLTKGA-----------LGDTTSGHVV 267
            ..||.|.:.|      .:....|..|:|......|:..|:.|..           |....||||.
 Worm   155 AFISMLGLSI------AMFIAAFCQRIAWEISSIRQVFRIKKAYIRKLLLMDISWLESRQSGHVA 213

  Fly   268 NLISNDIPRLDSAPYTVHYLWVG-----PLQVLVITYLMYQEIGISAVFG---VLFMLLFMP--- 321
            .::...   .||       ::.|     |:.|.:::||:. .||:.....   .|||.|.:|
 Worm   214 AMLQES---ADS-------IYNGISDHLPMVVFILSYLLV-NIGVCLYIQWDVTLFMCLAIPLLI 267

  Fly   322 IQMYLGTRTSAIQLKAAERTDNRI-RMVNEIISAIQVLKMYAWEQ----PFEQM-VTHAREKEMN 380
            |...|.::..|..::...:..|:| .:|||..:.|..:..:|.::    .||:: ..|::..|..
 Worm   268 ISRILYSKWFANTMEEETKLQNKITNLVNETFNCITTVISFAAQKQKINKFEKLSAEHSKLTEER 332

  Fly   381 TIRQGQYIRGFDFARRIVLSRVAIFLSLVGYVILGKVFTPEIAFMITAYYN------VLLAAMSI 439
                              |....:|.||...::...:||..:.:.|....:      ..||...:
 Worm   333 ------------------LRSSVVFDSLTQILLTELIFTGALCYGIWRVADNSPGRLCALAINML 379

  Fly   440 YVPSAIIQTAQFLTSIRRV------------EQFMQSEELGSSDKSEGPSKDTVPGNPPSNNNEA 492
            |:....|.....:....|.            ||.....||.|.|.    :.|.||........::
 Worm   380 YMCVTSISIGFHMNGATRAKDNAKEICEVLNEQPKIEVELASIDN----NIDYVPVTRCKYRRQS 440

  Fly   493 --DLLKSAISIRDLKAKWDPNSPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANS 555
              .:.|.|:..||:...:........|.||:.:::.|..:|::|.:|||||:|...:|.......
 Worm   441 MKFMGKGALHFRDIHFSYPSRKETEVLRGISFKVEAGEKIAIVGSSGSGKSTLTALLLRFYDPTK 505

  Fly   556 GQL-------------QVNGSLSYTSQESWLFSGTVRQNILFGQPMDS--QRYEEVVKKCALERD 605
            |.:             .:.|..|..|||..||.||:..||.:|: :|:  |...:..:|....:.
 Worm   506 GAILLDGENIKTMCPDDLRGQCSLVSQEPVLFDGTISDNIRYGR-LDATQQEINDAARKVGAWKF 569

  Fly   606 FDLLPLRDNTIVGERGATLSGGQKARISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCVRGH 670
            .:.||....|.|||||..||||||.|:::||:|.||..:.:.|:..||:|     ::.::.|...
 Worm   570 INSLPDGMQTRVGERGHQLSGGQKQRVAIARAVIRKPIVLIFDEATSALD-----NIHEEEVNAA 629

  Fly   671 L----RGSTVVLVTHQEQFLPHVDQIVILANGQIKALGDYESLL--KTGLITGLGSLSKTDKAKT 729
            :    .|.|.:.:.|:...:.:.|:|::|..|:|...|..:.|:  ..|:...:.:..:.|:...
 Worm   630 IDLASEGLTTITIAHRLSTIKNSDRIIVLHEGKIVEEGVPDELIADANGIFHKMYNDQRLDQLTQ 694

  Fly   730 EEQE-------------------PLNL--------------------------NSPDNKNEVTPI 749
            :.|:                   |.|:                          ||.:.:....|:
 Worm   695 QHQQLHQQQAKPPSLQQQMSFSPPPNMDPDQQRRAWARSSLGGNKKLGKSYSVNSMEKEKLKLPV 759

  Fly   750 --KENSEQ-----TVGGSSSGKEHVERQE-----------------------------SGGISLA 778
              |:.||:     :...|...|:|.:...                             :|.|...
 Worm   760 MSKKKSERLDYKYSKVHSMDVKQHTDSMHDDDDLPGKETNFTVLKDLIYSYRTGLPLLAGAIPTT 824

  Fly   779 LYRKYFQAGGGLVAFLVMLSSSVLAQVAVTGGDYFLTYWVKKESTAAGHGEMEDMESKSMDVY-- 841
            :.|..|..   |:.|.|   :||| ::::...                       |.:::.::
 Worm   825 IVRAVFYL---LICFQV---ASVL-EISIAPD-----------------------EERALQIFIV 859

  Fly   842 --KYTLIIILSVIMNLSSSFLLFNIAKKASIRLHNTIFNRVTRADMHFF--SINKHGSILNRFTK 902
              .||.:||:..|........:..........:.|.:|.:|.|....:|  ..|..|.::::...
 Worm   860 AAIYTALIIVKTIFEALGRIFIALYGHGFCKFMRNEMFRKVLRHGAAYFDEERNSPGRLVHKVIN 924

  Fly   903 DMSQVDEV--------LPVVLVDVMQI--ALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRNLY 957
            :.|.::|:        :|.|:..:..|  |||:...:.::.:..    .|.      ::.:|.|.
 Worm   925 ESSTLNEIMEQKLDMLIPGVVCSLFSIVCALWINWKMALLCSFQ----FPA------YFVIRILQ 979

  Fly   958 LK--TSRDLKRVEAINRSPVYSHLAA-SLNGLTTIRALDAQRVLEKEFDSYQDAHSSAFFMYIST 1019
            ::  |.|..:.|:...::   ::||: .|..::||:|.:.|              |..:.::...
 Worm   980 IREGTKRQRQMVDEEKKA---ANLASVVLANMSTIKAYNLQ--------------SHFYNVFCDA 1027

  Fly  1020 SQAFGYCMNCICVI------------YISI-ITLSFFAFPPGNGADVGLVITQA--------MGL 1063
            .:....||....:|            ||.| |||.|           |.|:..|        |.:
 Worm  1028 LKPVSQCMQKQSLISALVFACQYSFTYILIAITLHF-----------GKVMMLANEISVFDYMRV 1081

  Fly  1064 IDMVQWGVRQTAEL--------------ENTMTAV-ERVVEYESIEPEGMLEAPDDKKPPKTWPE 1113
            :.:.|:|....::|              ||.|..: |..|:.:::..||:        .||.
 Worm  1082 VLLTQFGANFFSQLIASVSDFTKAQIAAENVMRVIREPPVDMDNLSEEGL--------RPKL--- 1135

  Fly  1114 QGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFRLSY--TDGSV 1176
            :|.:..|:::.|| |:.....||.:|:..::..|.:.:||.:|:||||:| :||:..|  |||.|
 Worm  1136 EGNLCLKDVSFRY-PSRPIVPVLTNLNLKVRGGESIALVGPSGSGKSSVI-SLFQRMYNATDGVV 1198

  Fly  1177 LIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEV---VS 1238
            :||..:.:.:....|||.|..:.|||.|||.|::.|:......|:..:...:|..|:.::   ::
 Worm  1199 IIDKYNIKSINPAYLRRCIVQVGQEPDLFSFTIKENIAFGMMESEATIDKVIEAAKIADIHNFIT 1263

  Fly  1239 DLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQATI----RS 1299
            .||.|..:::.|.|...|.||:|.:.:||||:|:..:|::||||:.:|..::..:|...    ||
 Worm  1264 SLPQGYDTEVGEFGAQLSGGQKQRIAIARAIIRKPTVLLLDEATSALDSASEREVQNAFERVKRS 1328

  Fly  1300 KFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELM 1340
            ....||.:.|||||.||.:.||:.|:..|.:.|.||..:|:
 Worm  1329 TKTQCTCIQIAHRLSTIRNVDKIYVIVHGEIAEEGSHEQLI 1369

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	328/1481 (22%)
		ABC_membrane	171..437	CDD:294371	59/301 (20%)
		ABCC_MRP_domain1	499..699	CDD:213217	62/218 (28%)
		ABC_membrane	799..1045	CDD:294371	48/277 (17%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	79/229 (34%)
pgp-10	NP_509205.2	MdlB	73..687	CDD:224055	153/671 (23%)
		ABC_membrane	156..381	CDD:294371	52/259 (20%)
		ABC_MTABC3_MDL1_MDL2	450..687	CDD:213216	67/242 (28%)
		ABC_membrane	823..1099	CDD:294371	60/343 (17%)
		MdlB	825..1382	CDD:224055	150/626 (24%)
		P-loop_NTPase	1141..1381	CDD:304359	80/231 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1734
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.860