DRSC/TRiP Functional Genomics Resources

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Protein Alignment l(2)03659 and mrp-6

DIOPT Version :9

Sequence 1:NP_001260823.1 Gene:l(2)03659 / 47905 FlyBaseID:FBgn0010549 Length:1374 Species:Drosophila melanogaster
Sequence 2:NP_001362008.1 Gene:mrp-6 / 180691 WormBaseID:WBGene00003412 Length:1415 Species:Caenorhabditis elegans


Alignment Length:1426 Identity:445/1426 - (31%)
Similarity:722/1426 - (50%) Gaps:173/1426 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    72 NSENNS---AQNEKEKVLPENPRARSN----------------FISSLCF-------WYTIPIFR 110
            |.||.:   .|.|..|..|:..:...|                .|||:.|       |.|     
 Worm    10 NKENETLLIEQKEDLKKTPDETKPDVNLESVEGYHPSSEDSAGLISSILFSFVGFYWWRT----- 69

  Fly   111 KGYRKTLDSTDLYRPLEEQKSDILGNRLCASWERELKNDGRSPSLVRALLRVFGWQLGFPGLAIF 175
               |.....|||   ||:....|.........|.:..:.|  |.....|:.|  |......:...
 Worm    70 ---RNAQTDTDL---LEKPSKGISAKYAAQKLESKWISSG--PKRTHFLVGV--WHCTKVSVMAH 124

  Fly   176 VVELGL----RTLQPIFLVKLISYFSGE-----PDAANAGFYYAVAQIVISALTVMILTPTTFGI 231
            .:.|.|    |..||:.|.:|:||:..|     |       |:...|:   ||.:.:|:..|..|
 Worm   125 AISLCLEELTRVAQPLLLRELMSYYDIEEGQEFP-------YWPAMQV---ALIISLLSFVTVCI 179

  Fly   232 HHVCF--------KMRVAMGSMIFRKALRLTKGALGDTTSGHVVNLISNDIPRLDSAPYTVHYLW 288
            ||..|        ..|||.|.:::||:||::..:|.:|.||.::.|::.|..:|:.|....||:|
 Worm   180 HHPYFHGLLKVGNHARVATGVLLYRKSLRISLTSLFETNSGQIIQLLNTDAAKLEQAFLFAHYVW 244

  Fly   289 VGPLQVLVITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIIS 353
            :.||.:....|:::...|...:.|.|.|:..:..|::...:....:....::.|:|:::::|||:
 Worm   245 LCPLLMFFYAYILWSMFGFCCLLGFLVMMAIVSFQVHYSYQLGVNRRNIGDKMDSRLKVMSEIIN 309

  Fly   354 AIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQYIRGFDFARRIVLSRVAIFLSLVGYVILGKVF 418
            .|:|:||:.||..|.:.:...||.|:..:....:..........:.:::.:|:.:.......::.
 Worm   310 GIKVIKMHGWENAFAEKIRILREDEIKAVGTSAFYSSMVMGIYFISAKIGLFVYIFACDYFDEIL 374

  Fly   419 TPEIAFMITAYYNVLLAAMSIYVPSAIIQTAQFLTSIRRVEQFMQSEEL--------------GS 469
            |....|..:|.:|.:....::::|..::...:..::.||::.|...||.              ||
 Worm   375 TTRGVFASSALFNSVRLPFALFLPLGLLFGRELFSTSRRIDLFFCLEEYSRITLELDSTDTEDGS 439

  Fly   470 SDKSEGPSKDTVPGNPPSNNNEADLL-KSAISIRDLKAKW-DPNSPD------------------ 514
            .::.||.:...: |..||...:.|.. |:::.:..:.|.| |.:..|                  
 Worm   440 KNEKEGLTLKKI-GEKPSWTLKCDKAEKTSVFLNKVTAVWYDKDEHDQKKKKKNFKALSDNDATV 503

  Fly   515 -------------YTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGSLSY 566
                         |.:..::.|...|:...:||..|||||||:..||.|.:...|.|.||||.:|
 Worm   504 IAGEKKDEPLHVVYAVQDLSFEFVAGTCYGIIGSVGSGKSSLLLTILSESRMTRGNLSVNGSFAY 568

  Fly   567 TSQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKAR 631
            .:||.|:|:|:::.||:||...:.:|||..::.|.|..|.......|.||||:.|:||||||:||
 Worm   569 CAQEPWIFTGSIQDNIVFGSEFNKERYENALELCLLTPDLRQFANGDMTIVGDNGSTLSGGQRAR 633

  Fly   632 ISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCVRGHLRGSTVVLVTHQEQFLPHVDQIVILA 696
            ::|||:||..|.|||||||||||||.|.:.|::..:||.|....|:|||||..||..:|.::::.
 Worm   634 VALARAVYADADIYLLDDPLSAVDAHVGKKLYENLIRGFLSDKLVILVTHQIHFLSELDSVILMK 698

  Fly   697 NGQIKALGDYESLLKTGLITGLGSLSKTDKAKTEEQ---------------EPLNLNSPDNKNEV 746
            |.::...|..:.|..    |......|....:||.|               .|:|:.|.:..|:.
 Worm   699 NNKMVGNGSLDELKS----TFTDDFIKLQAVETEVQSDELFVDGPPSSPPPSPVNIESMEKINKE 759

  Fly   747 TPIKENSEQTVGGSSSGKEHV-----ERQESGGISLALYRKYFQAGGGLVAFLVMLSSSVL-AQV 805
            :..:..:....|...|..|:|     |.::||.||.::|.:|.:.....:.:.:.|...|| .|:
 Worm   760 SIFQRANSVLSGSKMSETEYVKEIVYESRKSGTISWSVYWEYTRGVINPLKYGIWLVVCVLITQL 824

  Fly   806 AVTGGDYFLTYW-VKKESTAAGHGEMEDMESKSMDVYKYTL----------IIILSVIMNLSS-- 857
            .....|::|..| |..:...|.:...::..::::||..||.          .||.:|||::..  
 Worm   825 MNNFVDWWLNKWLVDLDMNNADNSTSKEEFNRNVDVLGYTFNVTFQTYELTFIISTVIMSILGVV 889

  Fly   858 -SFLLFNIAKKASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQI 921
             |....|....||..|||::|:.|.:.:..||..|..|.|||||:||:...|::|.....:.:..
 Worm   890 RSVWFRNAQLMASRILHNSMFDCVLKTESEFFDKNSEGMILNRFSKDIGLTDDLLAFTYFEFVFG 954

  Fly   922 ALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGL 986
            .|...||:.:::.|.|::::....::..||..|.:|:..||:|||:||..|||:.:.:.::::||
 Worm   955 TLTFVGIVGLVSMVRPIVILACAFITAGFYFCRKMYVHRSRELKRIEAAARSPLNTTITSTVHGL 1019

  Fly   987 TTIRALDAQRVLEKEFDSYQDAHSSAFFMYISTSQAFGYCMNCICVIYISI----ITLSFFAFPP 1047
            :||||...:..:.::|.:..|.:.:|:.|.:.:::.||.|::.:..:::||    :.|.:.....
 Worm  1020 STIRAYRKENEMIEKFCALHDVYMAAYNMGLLSARWFGICIDFLVSVFVSIVAIVVVLQYETLTV 1084

  Fly  1048 GNGADVGLVITQAMGLIDMVQWGVRQTAELENTMTAVERVVEYESIEPEGMLEAPD----DKKPP 1108
            |   :|||.:..|:.|.....|.:||:|||||.|.:||||:||..::.|.....|.    ||:..
 Worm  1085 G---EVGLCLVCAVQLSGFFSWIMRQSAELENGMVSVERVLEYTKLKSEEEARRPHDAYLDKQLL 1146

  Fly  1109 KTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFRL-SYT 1172
            .:||.:|||.|:.:::.|...    .|||:||||:...:|:|:|||||||||:||..:|.| .|.
 Worm  1147 NSWPTKGEIEFENVSVNYGET----KVLKNLSFVVLGGQKIGVVGRTGAGKSTLIKIIFGLKEYC 1207

  Fly  1173 DGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEVV 1237
            .|.|.||..|...:.|:..|..:||||||||:||||:|.||||||||.|..:|..||:.:||..:
 Worm  1208 SGRVTIDGVDLDHISLNFRRGGMSIIPQEPVIFSGTVRENLDPFDEYDDATIWFALEQCELKRSI 1272

  Fly  1238 SDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQATIRSKFR 1302
            :. ..||..::.:.|.:.|||||||.|||||::..::|||:||||||||..||..||.|||..|:
 Worm  1273 TK-EKGLNVELGQRGVSLSVGQRQLFCLARAMIHRSKILVIDEATANVDGVTDACIQKTIRDFFK 1336

  Fly  1303 DCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLVNQSGRASYEGL 1363
            :.|::|:|||||||::||.|||.:.|.:|||..|..|: ...|.:|..:..|||..:::.|
 Worm  1337 NATIITVAHRLHTIMNSDNVMVFEKGELVEFDKPITLL-DDQSSLFSRMAAQSGAENFDSL 1396

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)03659NP_001260823.1 CFTR_protein 89..1343 CDD:273530 432/1384 (31%)
ABC_membrane 171..437 CDD:294371 68/282 (24%)
ABCC_MRP_domain1 499..699 CDD:213217 89/231 (39%)
ABC_membrane 799..1045 CDD:294371 74/264 (28%)
ABCC_MRP_domain2 1115..1336 CDD:213211 114/221 (52%)
mrp-6NP_001362008.1 MRP_assoc_pro <126..1389 CDD:188098 415/1286 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 148 1.000 Domainoid score I2739
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H74563
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 1 1.000 - - FOG0001028
OrthoInspector 1 1.000 - - otm14754
orthoMCL 1 0.900 - - OOG6_100026
Panther 1 1.100 - - O PTHR24223
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X771
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1211.830

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