DRSC/TRiP Functional Genomics Resources

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Protein Alignment l(2)03659 and mrp-1

DIOPT Version :9

Sequence 1:NP_001260823.1 Gene:l(2)03659 / 47905 FlyBaseID:FBgn0010549 Length:1374 Species:Drosophila melanogaster
Sequence 2:NP_001024719.2 Gene:mrp-1 / 180409 WormBaseID:WBGene00003407 Length:1534 Species:Caenorhabditis elegans


Alignment Length:1370 Identity:448/1370 - (32%)
Similarity:713/1370 - (52%) Gaps:150/1370 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    90 PRARSNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSD-----ILGNRL--CASWERELK 147
            |...::|::.|.|.:...:...|.:|:|:..||:...|..|::     .:.|.:  ...:.|::|
 Worm   208 PEYTASFLNQLTFQWFSGLAYLGNKKSLEKEDLWDLNERDKAENIIPSFIENLIPEVEGYRRKIK 272

  Fly   148 NDGRS------PSLVRALLRVFGWQLGFPGLAIFVVELGLRTLQPIFLVKLISYFSGEPDAANAG 206
            .:..:      ||::..:.:.:.:.|...|....:.:| |:.:.|..|.:|||:...:......|
 Worm   273 KNPEAAIPKNHPSILIPIFKTYKFTLLAGGCYKLMFDL-LQFVAPELLRQLISFIEDKNQPMWIG 336

  Fly   207 FYYAVAQIVISALTVMILTPTTFGIHHVCFKMRVAMGSMIFRKALRLTKGALGDTTSGHVVNLIS 271
            ...|:...:.|.|..|||......:..:...:|..:.|.::.|.|.|:..|....|:|.:|||:|
 Worm   337 VSIALLMFLSSLLQSMILHQYFHEMFRLGMNIRSVLTSAVYTKTLNLSNEARKGKTTGAIVNLMS 401

  Fly   272 NDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLK 336
            .||.|:......:...|..|||:|:..|.:::.:|:|.:.|.:.::|.:|...::..:....|::
 Worm   402 VDIQRIQDMTTFIMLFWSAPLQILLSLYFLWKLLGVSVLAGFVILILLIPFNSFISVKMRNCQME 466

  Fly   337 AAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQYIRGFDFARRIVLSR 401
            ..:..|.||:|::||::.::|||:|:||:..|:||...||||:..:::..|:.    |...:...
 Worm   467 QMKFKDERIKMMSEILNGMKVLKLYSWEKSMEKMVLEVREKEIRVLKKLSYLN----AATTLSWA 527

  Fly   402 VAIFLSLV---GYVIL----GKVFTPEIAFMITAYYNVLLAAMSIYVPSAIIQTAQFLTSIRRVE 459
            .|.||..|   |..:|    ..|.||:|.|:..|.:|:|...::::. ....|..|...|..|::
 Worm   528 CAPFLVAVLTFGLYVLWDPENNVLTPQITFVALALFNILRFPLAVFA-MVFSQAVQCSASNTRLK 591

  Fly   460 QFMQSEELGSSDKSEGPSKDTVPGNPPSNNNEADLLKSAISIRDLKAKWDPNSPDYTLSGINLEI 524
            :|..:||:       .|......|.          ..|||.:......|.....|..|..|...|
 Worm   592 EFFAAEEM-------SPQTSIAYGG----------TDSAIKMDGGSFAWGSKEEDRKLHDITFNI 639

  Fly   525 KPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGSLSYTSQESWLFSGTVRQNILFGQPMD 589
            |.|.:||::|..|||||||:.|:|||:...||.:|||||::|..|.:|:.:.::|.||||.:|.|
 Worm   640 KRGQLVAIVGRVGSGKSSLLHALLGEMNKLSGSVQVNGSVAYVPQLAWIQNLSLRNNILFNRPYD 704

  Fly   590 SQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVYRKASIYLLDDPLSAV 654
            ::.|:.|::.|||.:|.:.||..|.|.:||:|..||||||.|:||||:||:.|.|.|||||||||
 Worm   705 AKLYQNVIENCALVQDLESLPAEDRTEIGEKGINLSGGQKQRVSLARAVYQNAEIVLLDDPLSAV 769

  Fly   655 DASVARHLFDQCV---RGHLRGSTVVLVTHQEQFLPHVDQIVILANGQIKALGDYESLLKTG--- 713
            |:.|.:|:|:..:   .|.|...|.||:||...:|.|.||:::|.:..|..:|.|:.|:.:.   
 Worm   770 DSHVGKHIFENVISTATGCLGTKTRVLLTHGLTYLKHCDQVIVLKDETISEMGTYQELMNSNGAF 834

  Fly   714 ------------------------------LITGLGSLSKTDKAKTEEQEPLNLNSPDNKN---- 744
                                          |:..|..:|...:.:.:.|....:...|:||    
 Worm   835 SEFLEEFLLEESKHKGRSVSFGEDSKEVNELLRDLDQVSPAIRQRIQSQMSQEIEKTDDKNAEII 899

  Fly   745 -------EVTPI----KENSEQTVGGSSSGKEH------------VERQ--ESGGISLALYRKYF 784
                   |.|..    |...::::.|:.|.||.            :|::  |:|.:...:|..||
 Worm   900 RNGLHKDEQTAHSSIGKSEEKESLLGAISPKEKTPEPPKQTKTQLIEKEAVETGKVKFEVYMSYF 964

  Fly   785 QAGG---GLVAFLVMLSSSVLAQVAVTGGDYFLTYWV--KKESTAAGHGEMEDMESKSMDVY--- 841
            :|.|   .||.|||.::||:|...:    :.:|..|.  .||...:|:|...:.:.: :.:|   
 Worm   965 RAIGIKIALVFFLVYVASSMLGVFS----NLYLARWSDDAKEIALSGNGSSSETQIR-LGIYAVL 1024

  Fly   842 ---KYTLIIILSVIMNLSSSFLLFNIAKKASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKD 903
               :.|.:...|:||.|....        ||..||.|:...:.|:.|.||.:...|.|||||.||
 Worm  1025 GMGQATSVCAASIIMALGMVC--------ASRLLHATLLENIMRSPMAFFDVTPLGRILNRFGKD 1081

  Fly   904 MSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVE 968
            :..||..:|..:...::.|:....||.:|....||.:...|.|.::::.:...|:.|||.|||:|
 Worm  1082 VDGVDTDIPRTMSMFIRTAVSSIEIIAIILWATPLAISLLLPLFIVYFVVLRFYVSTSRQLKRLE 1146

  Fly   969 AINRSPVYSHLAASLNGLTTIRALDAQRVLEKEFDSYQDAHSSAFFMYISTSQAFGYCMNCICVI 1033
            :.:|||:|||...|:.|.::|||........:|.....|.:.:.::..|..::.....:..:.  
 Worm  1147 SASRSPIYSHFQESIQGASSIRAYGVVDKFIRESQHRVDENLATYYPSIVANRWLAVRLEMVG-- 1209

  Fly  1034 YISIITLS------FFAFPPGNGAD-VGLVITQAMGLIDMVQWGVRQTAELENTMTAVERVVEYE 1091
              ::|.||      :|...||..|. |||.::.|:.:...:.|.||.|:|||..:.||||:.||.
 Worm  1210 --NLIVLSSAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVRMTSELETNIVAVERINEYT 1272

  Fly  1092 SIEPEGMLEAPDDKKPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTG 1156
            ....||   .......||:|||.|||..|..::||.|.  .:.||..::..|.|.||:|||||||
 Worm  1273 ITPTEG---NNSQSLAPKSWPENGEISIKNFSVRYRPG--LDLVLHGVTAHISPCEKIGIVGRTG 1332

  Fly  1157 AGKSSLINALFRLSYTDGSVL-IDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYS 1220
            ||||||..||||:...||..: ||..:...:.|..||.:::|:||:|||||||||.|||||..:|
 Worm  1333 AGKSSLTLALFRIIEADGGCIEIDGTNIADLLLEQLRSRLTIVPQDPVLFSGTMRMNLDPFFAFS 1397

  Fly  1221 DEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANV 1285
            |:::|..|....|...|..|.:||...|||||.|.|||||||:|||||:||:.::||:|||.|.|
 Worm  1398 DDQIWEALRNAHLDSFVKSLQEGLHHHISEGGENLSVGQRQLICLARALLRKTKVLVLDEAAAAV 1462

  Fly  1286 DPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHN 1350
            |.:||.|:|.|||.:|:|||||||||||:|::|||:::|:|.|.|.||.:|.:|::..|. :|::
 Worm  1463 DVETDSLLQKTIREQFKDCTVLTIAHRLNTVMDSDRLLVLDKGCVAEFDTPKKLLSNPDG-IFYS 1526

  Fly  1351 LVNQS 1355
            :...:
 Worm  1527 MAKDA 1531

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)03659NP_001260823.1 CFTR_protein 89..1343 CDD:273530 446/1356 (33%)
ABC_membrane 171..437 CDD:294371 77/272 (28%)
ABCC_MRP_domain1 499..699 CDD:213217 92/202 (46%)
ABC_membrane 799..1045 CDD:294371 69/259 (27%)
ABCC_MRP_domain2 1115..1336 CDD:213211 120/221 (54%)
mrp-1NP_001024719.2 MRP_assoc_pro 23..1531 CDD:188098 448/1368 (33%)
ABC_membrane 309..570 CDD:294371 76/265 (29%)
ABCC_MRP_domain1 614..815 CDD:213217 92/200 (46%)
ABC_membrane 976..1248 CDD:279056 79/288 (27%)
ABCC_MRP_domain2 1293..1513 CDD:213211 120/221 (54%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.830

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