DRSC/TRiP Functional Genomics Resources

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Protein Alignment l(2)03659 and mrp-2

DIOPT Version :9

Sequence 1:NP_001260823.1 Gene:l(2)03659 / 47905 FlyBaseID:FBgn0010549 Length:1374 Species:Drosophila melanogaster
Sequence 2:NP_508121.1 Gene:mrp-2 / 180408 WormBaseID:WBGene00003408 Length:1525 Species:Caenorhabditis elegans


Alignment Length:1391 Identity:468/1391 - (33%)
Similarity:725/1391 - (52%) Gaps:201/1391 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    90 PRARSNFISSLCF-WYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNRLCAS-------WEREL 146
            |...::||:.|.| |:| .:...|.:|:|::.||:...|..|::.|......:       :.:.:
 Worm   208 PEYTASFINRLTFQWFT-GLAYLGNKKSLENEDLWDLNEIDKAENLIPSFMQNLKPRIDEYHQNI 271

  Fly   147 KNDGRS------PSLVRALLRVFGWQLGFPGLAIFVVEL---GLRTLQPIFLVKLISYFSGEPDA 202
            |.|..:      ||.|..:.:.:.:.|    ||.|..:|   .|:.|.|..|.:||.:...:...
 Worm   272 KKDPSAALPKNHPSFVIPIFKTYKYTL----LAGFFYKLCFDMLQFLAPQLLKQLIGFIEDKNQP 332

  Fly   203 ANAGFYYAVAQIVISALTVMILTPTTFGIHHVCFKMRVAMGSMIFRKALRLTKGALGDTTSGHVV 267
            ...|..........|.|..|.|......:..:...:|..:.|.::.|||.|:..|....|.|.:|
 Worm   333 VWIGCSIVGIMFFSSFLQSMFLHQYYHSMFRLGMHVRSVLTSAVYSKALNLSNEARKGKTIGAIV 397

  Fly   268 NLISNDIPRL-DSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTS 331
            ||:|.||.:: |.|| |:...|..|||:.:..|.:::.:|::|:.|::.::|.:|:...:..:..
 Worm   398 NLMSVDIQKIQDMAP-TIMLFWSAPLQIFLSIYFLWKFLGVAALAGLVVLILALPVNGLIAIQMR 461

  Fly   332 AIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQYIRGFDFARR 396
            ..|.:..:..|.||:|::||::.::|||:|:||:..|.||...||:|::.:::..|     |...
 Worm   462 KCQTEQMKLKDERIKMMSEILNGMKVLKLYSWERSMENMVLKIRERELHILKKLSY-----FMAA 521

  Fly   397 IVLSRV-----AIFLSLVGYVIL---GKVFTPEIAFMITAYYNVL---LAAMSIYVPSAIIQTAQ 450
            ||.|.:     |..:|.|.||.|   ..|.||||.|:..:.:::|   ||.:::....|:    |
 Worm   522 IVFSWICAPFLASVISFVVYVYLDPENNVLTPEITFVALSLFDILRMPLAMVAMVYGEAV----Q 582

  Fly   451 FLTSIRRVEQFMQSEELGSSDKSEGPSKDTVPGNPPS--NNNEADLLKSAISIRDLKAKWDPNSP 513
            ...|..|:::|..:||:                :|.:  ::.|.|   |||.:.:....|. :..
 Worm   583 CSVSNTRLKEFFAAEEM----------------SPQTSISHGETD---SAIEVENGLFSWS-SDE 627

  Fly   514 DYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGSLSYTSQESWLFSGTV 578
            |.||..|:.:|:.|.:||::|..|||||||:.|:|||:...||.:|:||:::|..|::|:.:.::
 Worm   628 DPTLREISFKIQKGQLVAIVGKVGSGKSSLLHALLGEMNKLSGSVQINGNIAYVPQQAWIQNMSL 692

  Fly   579 RQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVYRKAS 643
            |.||||.:|.|.:.||:|||.|||:.|...||..|.|.:||:|..||||||.|:||||:||:...
 Worm   693 RNNILFNKPYDLENYEDVVKNCALKEDLANLPAGDRTEIGEKGINLSGGQKQRVSLARAVYQNPD 757

  Fly   644 IYLLDDPLSAVDASVARHLFDQCV---RGHLRGSTVVLVTHQEQFLPHVDQIVILANGQIKALGD 705
            |.||||||||||:.|.:|:|:..:   .|.|...|.|||||...:|.|.||:::|..|.|..||.
 Worm   758 IILLDDPLSAVDSHVGKHIFENVISSSTGCLASKTRVLVTHGLTYLKHCDQLIVLKEGTISELGT 822

  Fly   706 YESLL--------------------------------------------KTGLITGLGS-LS-KT 724
            |:.||                                            |.|::..|.| || ::
 Worm   823 YQELLNNSGAFAEFLEEFLIEESKTRGRVASIGDGSGEVDEILRDLGQVKPGILKRLESHLSQES 887

  Fly   725 DKAKT----------EEQEPLNLNSPDNKNEV-----------TPIKENSEQTVGGSSSGKEHVE 768
            ||..|          ..:..:.|:||.:::|.           .|.:||::.           :|
 Worm   888 DKEDTSARAIEYSRDSSRRSVLLHSPRSQHEENEALLGAISEDVPAQENTQL-----------IE 941

  Fly   769 RQ--ESGGISLALYRKYFQAGG---GLVAFLVMLSSSVLAQVAVTGGDYFLTYWVKKESTAAGHG 828
            ::  |:|.:...:|..||||..   .|:.|.:.:.||.|..::        .:::.|.|..|..|
 Worm   942 KETVETGKVKFEVYIAYFQAISIPITLLFFFLYVGSSGLGILS--------NFYLAKLSDHAKSG 998

  Fly   829 EMEDMESK-SMDVY------KYTLIIILSVIMNLSSSFLLFNIAKKASIRLHNTIFNRVTRADMH 886
            .....::| .:.:|      :..:::|.|:|:.:.        ..:||..||..:...:.|:.|.
 Worm   999 NRTSSDAKMELGIYAVLGMGQSFVVLIASIILTIG--------VLRASRILHAGLLGNIMRSPMA 1055

  Fly   887 FFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFY 951
            ||.:...|.||||..||:..:|..||.|:..:......:...::||....|...:...:||||::
 Worm  1056 FFDVTPIGRILNRIGKDIEAIDRTLPDVIRHMSMTIFNVVATLVVIMWATPWAGIAFAILSVIYF 1120

  Fly   952 HLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQRVLEKEFDSYQDAHSSAFFMY 1016
            .:...|:.|||.|||:|:.:|||:|||...|:.|.::|||........|:.....|.|..|::..
 Worm  1121 IVLRFYISTSRQLKRLESASRSPIYSHFQESIQGASSIRAFGVVDNFIKQSQQRVDDHLIAYYPS 1185

  Fly  1017 ISTSQAFGYCMNCICVIYISIITLS------FFAFPPGNGAD-VGLVITQAMGLIDMVQWGVRQT 1074
            |..::.....:..:.    ::|.||      :|...||..|. |||.::.|:.:...:.|.||.|
 Worm  1186 IVANRWLAVRLEMVG----NLIVLSAAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVRMT 1246

  Fly  1075 AELENTMTAVERVVEYESIEPEG----MLEAPDDKKPPKTWPEQGEIIFKELNLRYTPNAKAENV 1135
            :|||..:.:|||:.||.....||    .|.|       |:|||:|||..|..::||.|.  .:.|
 Worm  1247 SELETNIVSVERIKEYTVTPTEGNNSRRLAA-------KSWPEKGEISIKNFSVRYRPG--LDLV 1302

  Fly  1136 LKSLSFVIQPREKVGIVGRTGAGKSSLINALFRLSYTD-GSVLIDTRDTRQMGLHDLRRQISIIP 1199
            |..:|..|.|.||||||||||||||||..||||:...| ||:.||..:...:.|..||..::|:|
 Worm  1303 LHGISAHIAPSEKVGIVGRTGAGKSSLTLALFRIIEADGGSIEIDGINIANLQLEQLRSCLTIVP 1367

  Fly  1200 QEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVC 1264
            |:||||||||:.|||||..|||.::|..||...||..|..|.|||..||||||.|.|||||||:|
 Worm  1368 QDPVLFSGTMKMNLDPFSAYSDSQVWEALENAHLKPFVKSLQDGLEHKISEGGENLSVGQRQLIC 1432

  Fly  1265 LARAILRENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGR 1329
            ||||:||:.::||:|||.|.||.:||.|||.|||.:|::||||||||||:|::|||:::|:|.||
 Worm  1433 LARALLRKTKVLVLDEAAAAVDVETDSLIQKTIREQFKECTVLTIAHRLNTVMDSDRLLVLDKGR 1497

  Fly  1330 VVEFGSPYELMTKSDSKVFHNLVNQS 1355
            |.||.||..|:...|. :|:::...:
 Worm  1498 VAEFDSPKNLLANPDG-IFYSMAKDA 1522

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)03659NP_001260823.1 CFTR_protein 89..1343 CDD:273530 466/1377 (34%)
ABC_membrane 171..437 CDD:294371 83/280 (30%)
ABCC_MRP_domain1 499..699 CDD:213217 93/202 (46%)
ABC_membrane 799..1045 CDD:294371 66/258 (26%)
ABCC_MRP_domain2 1115..1336 CDD:213211 128/221 (58%)
mrp-2NP_508121.1 MRP_assoc_pro 25..1522 CDD:188098 468/1389 (34%)
ABC_membrane 309..570 CDD:294371 77/266 (29%)
ABCC_MRP_domain1 614..816 CDD:213217 93/202 (46%)
ABC_membrane 971..1239 CDD:279056 74/287 (26%)
ABCC_MRP_domain2 1284..1504 CDD:213211 128/221 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S1734
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.680

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