DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and mrp-7

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_507812.3	Gene:	mrp-7 / 180289	WormBaseID:	WBGene00003413	Length:	1525	Species:	Caenorhabditis elegans

Alignment Length:	1398	Identity:	455/1398 - (32%)
Similarity:	735/1398 - (52%)	Gaps:	201/1398 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 SENNSAQNEKEKVLPE---NPRARSNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDIL 134
            ::...|:.:.||...:   :|..:|:|::.|..|:...|...|.|:.|:..|::...|...::.|
Worm   188 ADPRGAKTDDEKASSKSAASPELQSSFLNRLTLWWFNSIPWTGARRDLEIDDIFELNERSGTEFL 252

  Fly   135 GNRLCASWERE-----------LKNDGRS--------PSLVRALLRVFGWQLGFPGLAIFVVELG 180
            .....:.||.:           .|.|...        ||:|.:|..:|.|:........||.:
Worm   253 SELWESFWEPKRLKYIHDTSIWAKKDPSEQEKDPVVIPSVVSSLFMMFRWEFLLASTLKFVSD-- 315

  Fly   181 LRTLQ---PIFLVKLISYFSGEPDAANAGFYYAVAQIV----ISALTVMILTPTTFGIHHVCFKM 238
              |:|   |..|.:|:::.|    |.||.|:..:|..:    :|.|..:||.    |..::.|:|
Worm   316 --TMQFASPFLLHELLNFIS----AKNAPFWKGMALSILMFSVSELRSLILN----GYFYIMFRM 370

  Fly   239 ----RVAMGSMIFRKALRLTKGALGDTTSGHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITY 299
                :.::.:.:::|.|.::..|..|.|.|.:|||::.|:.|.......:...|..|.|:.....
Worm   371 GTKIQTSLTAAVYKKTLLISNSARRDRTVGEIVNLMAIDVERFQMITPQIQQFWSCPYQITFALV 435

  Fly   300 LMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWE 364
            .::..:|.||:.||:.|::|:|:.:.........|::..:..|.|.:||||:::.|:|:|:||||
Worm   436 YLFITLGYSALPGVVIMVIFVPMNIISSMIVRKWQIEQMKLKDERTKMVNEVLNGIKVVKLYAWE 500

  Fly   365 QPFEQMVTHAREKEMNTIRQGQYIR----GFDFARRIVLSRVAIFLSLVGYVILGK---VFTPEI 422
            .|.|..:...|.||:..|::...:|    .|:.|...:   ||:|  ..|..:|..   :.||:|
Worm   501 VPMEAYIDEIRTKELALIKKSAMVRNILDSFNTASPFL---VALF--SFGTFVLSNPSHLLTPQI 560

  Fly   423 AFMITAYYNVLLAAMSIYVPSAIIQTAQFLTSIRRVEQFMQSEELGSS--DKSEGPSKDTVPGNP 485
            ||:..|.:|.|.:.|:: :...|.|..|.:.|.:|:::|:.:|||...  |:|....:
Worm   561 AFVSLALFNQLRSPMTM-IALLINQAVQAVVSNKRLKEFLVAEELDEKCVDRSVNIER------- 617

  Fly   486 PSNNNEADLLKSAISIRDLKAKWDPN--SPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAIL 548
             |:|        |:.:.:|.|.|||.  :.:.||..::|.....|::||:|..|||||||:||:|
Worm   618 -SHN--------AVRVENLTASWDPEEAAGEKTLQDVDLTAPRNSLIAVVGKVGSGKSSLLQALL 673

  Fly   549 GELKANSGQLQVNGSLSYTSQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRD 613
            ||:....|::.|||.::|..|:.|:.:.|:|.||.||:|.|.:||::|:..|||:.|..:||..|
Worm   674 GEMGKLRGRIGVNGRVAYVPQQPWIQNMTLRDNITFGRPFDRKRYDQVLYACALKADIKILPAGD 738

  Fly   614 NTIVGERGATLSGGQKARISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCV--RGHLRGSTV 676
            .|.:||:|..||||||||:||||:||:...:||||||||||||.|.||:|::.:  .|.||..|.
Worm   739 QTEIGEKGINLSGGQKARVSLARAVYQNLDVYLLDDPLSAVDAHVGRHIFEKVIGPNGLLREKTR 803

  Fly   677 VLVTHQEQFLPHVDQIVILANGQIKALGDYESLLK-TGLI--------TGLGSLSKTDKAKTEEQ 732
            :||||...:....|:|:::..|:|:..|.:|.|:| .||.        :|..:.|:...::.::.
Worm   804 ILVTHGLTYTKMADEILVMLEGKIEESGTFEHLIKRRGLFFDFMEEYKSGSDNSSEAGGSQDDDF 868

  Fly   733 EPL-----------------------NLNSPDNKNEVTPIKENSEQTVGGSSSG----------K 764
            |.:                       .:.:|:...:::.:....:...|.|.:.          |
Worm   869 EAIGGEIQDYMNPEDVVLTVTNDLDETIRTPELTTQISTMSSPEKPPTGTSPAAATESQNKLIKK 933

  Fly   765 EHVERQESGGISLALYRKYFQAGGGLVA------FLVMLSSSVLAQVAVTGGDYFLTYWVKKEST 823
            |.:.:   |.:.:|.|:.|.:|.|.|::      |:|.::..:|.       .::|:.|
Worm   934 EGIAQ---GKVEIATYQLYVKAAGYLLSIAFIGFFIVYMTLQILR-------SFWLSAW------ 982

  Fly   824 AAGHGEMEDMESKS---------MDVY-----KYTLIIILSVIMNLSSSFLLFNIAKKASIRLHN 874
                .:..|.:|.|         :.||     ..|....::::.      |:| :.::||..||.
Worm   983 ----SDEYDPDSPSAHPMAKGWRLGVYGALGFSETACFFVALLA------LVF-VGQRASKNLHG 1036

  Fly   875 TIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPV----VLVDVMQIALWLAGIIIVIANV 935
            .:.:.:.|:.|.|:.....|.||||..||:..:|.:||:    :::.|:|:|..|  |:|:|:
Worm  1037 PLIHNLMRSPMSFYDTTPLGRILNRCAKDIETIDMMLPMNFRYLVMCVLQVAFTL--IVIIIS-- 1097

  Fly   936 NPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRAL-------- 992
            .||..|..|.|::|:......|:.|||.|||:|:::|||:|||...::.|..:|||.
Worm  1098 TPLFAVVILPLALIYLIFLRYYVPTSRQLKRLESVHRSPIYSHFGETIQGAASIRAFGKVDEFRQ 1162

  Fly   993 DAQRVLEKEFDSYQDAHSSAFFMYISTSQAFGYCMNCICVIYISIITLS-FFAFPPGNGADVGLV 1056
            |:.|:|    |::.....|:.......:....:..|||.........|| .|.:....|. :|:.
Worm  1163 DSGRIL----DTFIRCRYSSLVSNRWLAVRLEFVGNCIIFFAALFAVLSKEFGWITSPGV-IGVS 1222

  Fly  1057 ITQAMGLIDMVQWGVRQTAELENTMTAVERVVEYESIEPEGMLEAP---DDKKPPKTWPEQGEII 1118
            ::.|:.:.:::.:.|||.:|:|..:.:||||.||.: .|.   |||   :.::|...||.:|.:.
Worm  1223 VSYALNITEVLNFAVRQVSEIEANIVSVERVNEYTN-TPN---EAPWRIEGREPAPGWPSRGVVK 1283

  Fly  1119 FKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFR-LSYTDGSVLIDTRD 1182
            |...:.||...  .:.||..:|..:...||:||||||||||||...|||| :....|.::||..:
Worm  1284 FDGYSTRYREG--LDLVLHDISADVAAGEKIGIVGRTGAGKSSFALALFRMIEAAGGRIVIDDVE 1346

  Fly  1183 TRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASK 1247
            ..|:||||||..|:||||:|||||||:|:|||||..|||:::|..||...||...:.|||||..|
Worm  1347 VSQIGLHDLRSNITIIPQDPVLFSGTLRFNLDPFFTYSDDQIWRALELAHLKHFAAGLPDGLLYK 1411

  Fly  1248 ISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHR 1312
            |||.|.|.||||||||.||||:||..|:||:|||||.||..||.|||.|||.:|::|||.|||||
Worm  1412 ISEAGENLSVGQRQLVALARALLRHTRVLVLDEATAAVDVATDALIQETIREEFKECTVFTIAHR 1476

  Fly  1313 LHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDS 1345
            |:||:|.|::||:|.|.::||.:|..||...:|
Worm  1477 LNTIMDYDRIMVLDKGSILEFDTPDALMADKNS 1509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	451/1375 (33%)
		ABC_membrane	171..437	CDD:294371	78/283 (28%)
		ABCC_MRP_domain1	499..699	CDD:213217	93/203 (46%)
		ABC_membrane	799..1045	CDD:294371	70/272 (26%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	124/221 (56%)
mrp-7	NP_507812.3	MRP_assoc_pro	14..1518	CDD:188098	455/1398 (33%)
		ABC_membrane	310..575	CDD:294371	78/281 (28%)
		ABCC_MRP_domain1	622..826	CDD:213217	93/203 (46%)
		ABC_membrane	976..1227	CDD:279056	71/276 (26%)
		ABCC_MRP_domain2	1280..1500	CDD:213211	124/221 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.730