Protein Alignment l(2)03659 and pgp-9

DIOPT Version :9

• Sequence 1: NP_001260823.1
• Gene: l(2)03659 / 47905
• FlyBaseID: FBgn0010549
• Length: 1374
• Species: Drosophila melanogaster
• Sequence 2: NP_507487.1
• Gene: pgp-9 / 180165
• WormBaseID: WBGene00004003
• Length: 1294
• Species: Caenorhabditis elegans
• Alignment Length: 1330
• Identity: 313/1330 - (23%)
• Similarity: 579/1330 - (43%)
• Gaps: 248/1330 - (18%)

  Fly   167 LGFPGLAIFV--VELGLRTLQPIFLVKLISYFSGEPDAANAGFYYAVAQ-------IVISALTVM 222
            :|.|.::|.:  |.....||..|||..  :..:.|..||.|.|.:.|.|       :........
 Worm    58 VGLPLMSIIMGNVSQNFVTLGTIFLDP--NSTASEKAAARAEFSHEVIQNCLKYVYLGCGIFAAG 120

  Fly   223 ILTPTTFGIHHVCFKMRVAMGSMIFRKALRLTKGALGDTTSGHVVNLISNDIPRLDSAPYTVHYL 287
            .|..:.|.:  :|.|:........|...:|.........|||.:.|.:.:::.|:...
 Worm   121 FLQASCFMV--ICEKLSNRFRRQFFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREG------- 176

  Fly   288 WVGPLQVLVITYLMYQEIGISAV------FGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIR 346
             .|. :|.:...:|.|.||..||      ...|.|:...|..|..|...:.:...||.:...:..
 Worm   177 -TGD-KVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFLAKLLATAATKEAKQYA 239

  Fly   347 ----MVNEIISAIQVLKMYAWEQ----PFEQMVTHAREKEMNTIRQGQYIRGFDFARRIVLSRVA 403
                :..|::::|:.:..:..::    .:|..:.|.::    |..:..::.|...|...|:...:
 Worm   240 VAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKK----TGIKKSFLIGAGLASFFVIIYAS 300

  Fly   404 IFLSL-VG--YVILGKVFTPEIAFMITAYYNVLLAAMSI--------YVPSAIIQTAQFLTSIRR 457
            ..|:. ||  :|..|::   |...::|.:::|::.:|::        .:.:|:...|.....|.|
 Worm   301 YCLAFWVGTNFVYSGRL---ESGTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDR 362

  Fly   458 VEQFMQSEELGSSDKSEGPSKDTVPGNPPSNNNEADLLKSAISIRDLKAKWDPNSPDYTLSGINL 522
            :.:..     ..|.:.:.|||                :...||:..::..:...:....|.|::|
 Worm   363 IPEID-----AYSTEGQTPSK----------------ISGRISVNKVEFTYPTRADVKILKGVSL 406

  Fly   523 EIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNG------SLSY-------TSQESWLF 574
            :.:||..||::|.:|.|||::||.:......::||:.::.      ::.|       .|||..||
 Worm   407 DAQPGQTVALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLF 471

  Fly   575 SGTVRQNILFGQPMDSQRYEEVVK--KCALERDF-DLLPLRDNTIVGERGATLSGGQKARISLAR 636
            :.::.|||.:|:...|.  |::.:  |.|...|| ...|...||:||:||..:|||||.||::||
 Worm   472 NTSIEQNIRYGRSDVSD--EDIARALKEANAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIAR 534

  Fly   637 SVYRKASIYLLDDPLSAVDASVARHLFDQCVRGHLRGSTVVLVTHQEQFLPHVDQIVILANGQIK 701
            ::.|...|.|||:..||:||. :..:....:....||.|.:::.|:...:.:.|:|:::..||:.
 Worm   535 ALVRNPKILLLDEATSALDAE-SESIVQSALENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVM 598

  Fly   702 ALGDYESLLKT-----GLITGLGSLSKTDKAKTEEQE------------PLNLNSP----DNKNE 745
            .:|.:|:|::.     .|:.........||.|.:|.|            .:|..:.    |.|..
 Worm   599 EVGTHETLIEQKGLYHELVHAQVFADVDDKPKKKEAERRMSRQTSQRKGSVNFKTQESQVDEKPG 663

  Fly   746 VTPIKENSEQTVGGSSSGKEHVERQESGGISLALYR--KYFQAGGGLVAFLVMLSSSVLAQVAVT 808
            ..|..|.:|:.:     .:...|.:|.|.:...|::  :|.:.....:.|.::   :.|.|.||.
 Worm   664 APPAPEAAEKEI-----KRLKKELEEEGAVKANLFKILRYARPEWIYIFFAII---AALIQGAVM 720

  Fly   809 GG-DYFLTYWVKKESTAAGHGEMEDMESKSMDVYKYTLI-IILSVIMNLSSSF--LLFNI-AKKA 868
            .. ..|.:..:...|.       .|.:....|.:.:.|: ::|:.:...|..|  .||.: |::.
 Worm   721 PAFSLFFSQIINVFSN-------PDRDQMKKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERL 778

  Fly   869 SIRLHNTIFNRVTRADMHFFSINKH--GSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAG---- 927
            ::|:.:.::..|.|.|..:|.:.||  |.|..|...|...:...:...|..:......:.|
 Worm   779 TMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGI 843

  Fly   928 -------IIIVIANVNPLLLV-PTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLN 984
                   :..::..:.|.:.| ..||:.   ||..:    .:.|.|.:|...::.:     .::.
 Worm   844 AFYYGWQMAFLVMAIFPFMAVGQALMMK---YHGGS----ATSDAKEMENAGKTAM-----EAIE 896

  Fly   985 GLTTIRALDAQRVLEKEFDSYQD-------------------AHSSAFFMYISTSQAFGYCM--- 1027
            .:.|::||..|..|...|.|:.|                   |:|..||.|.:..: ||..:
 Worm   897 NIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFR-FGLFLIFD 960

  Fly  1028 --------NCICVIY---ISIITLSFFA--FPPGNGADVGLVITQAMGLIDMVQWGVRQTAELEN 1079
                    |.:.|::   .|..|:.|.|  ||.      .:..|.|.|||
 Worm   961 KNVLMEPENVLRVLFAISFSFGTIGFAASYFPE------YIKATFAAGLI--------------- 1004

  Fly  1080 TMTAVERVVEYESIEPEGMLEAPDDKKPPKTWPE-QGEIIFKELNLRYTPNAKAENVLKSLSFVI 1143
                      :..:|.|..:   |......|:|: .||:...::..|| |...|..:|:.|:..:
 Worm  1005 ----------FNMLEEEPRI---DGMTSSGTYPQLSGEVKLNKVFFRY-PERPAVPILQGLNVHV 1055

  Fly  1144 QPREKVGIVGRTGAGKSSLINALFRL-SYTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSG 1207
            :|.:.:.:||.:|.|||::|:.|.|| ...:|:|.:|..|.|||....||:.|:::.|||:||..
 Worm  1056 KPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDT 1120

  Fly  1208 TMR----YNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARA 1268
            ::|    |.|.| .||:.|::.....:..:.:.:.:||||..:::.|.||..|.||:|.:.:|||
 Worm  1121 SIRENIVYGLQP-GEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARA 1184

  Fly  1269 ILRENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEF 1333
            ::|..:||::||||:.:|.:::..:|..:.:..:|.|.:.:||||.||:::..:||:..|:|||.
 Worm  1185 LIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQ 1249

  Fly  1334 GSPYELMTKSDSKVFHNLV-----NQSGRA 1358
            |:..||:.|..:  :..|.     ||||.|
 Worm  1250 GTHNELIAKRGA--YFALTQKQSSNQSGGA 1277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	306/1308 (23%)
		ABC_membrane	171..437	CDD:294371	56/291 (19%)
		ABCC_MRP_domain1	499..699	CDD:213217	65/215 (30%)
		ABC_membrane	799..1045	CDD:294371	58/299 (19%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	79/225 (35%)
pgp-9	NP_507487.1	PTZ00265	28..1262	CDD:240339	307/1313 (23%)
		ABC_membrane	50..334	CDD:279056	58/295 (20%)
		ABC_MTABC3_MDL1_MDL2	383..620	CDD:213216	71/239 (30%)
		ABC_membrane	710..977	CDD:279056	54/289 (19%)
		ABC_MTABC3_MDL1_MDL2	1030..1269	CDD:213216	81/242 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000