DRSC/TRiP Functional Genomics Resources

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Protein Alignment l(2)03659 and cft-1

DIOPT Version :9

Sequence 1:NP_001260823.1 Gene:l(2)03659 / 47905 FlyBaseID:FBgn0010549 Length:1374 Species:Drosophila melanogaster
Sequence 2:NP_504463.1 Gene:cft-1 / 178939 WormBaseID:WBGene00000477 Length:1247 Species:Caenorhabditis elegans


Alignment Length:1367 Identity:338/1367 - (24%)
Similarity:609/1367 - (44%) Gaps:224/1367 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 LTVNSENNSAQNEKEKVLPENPRARSNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDI 133
            ::||...|:.|.:.|   .||.:|:|:|.|.|.......:.:|....|:...||  |:.|:|.  
 Worm     5 VSVNLSKNARQIQNE---TENEQAKSSFASKLLELPVSKLLQKCRSSTITVDDL--PILEEKQ-- 62

  Fly   134 LGNRLCA--SWERELKNDGRSPSLVRALLRVFGWQLGFPGLAIFVVELGLRTLQPIFLVK-LISY 195
            ..||:.:  .|::.:     ..|::....:.|.....|...|||.      ....|.|:| ||. 
 Worm    63 CSNRVMSGFKWKKRV-----IFSILMKFWKSFAGAFAFRMCAIFA------DYASILLLKYLID- 115

  Fly   196 FSGEPDAANAGFY-YAVAQIVISALTVMILTPTTFGIHHVCFKMRVAMGSMIFRKALRLTKGALG 259
             |.|..|....|: .||..:....|..::|...|:.:.....:|...:.::|.:|||.||.... 
 Worm   116 -SAEISATLFNFFIIAVLILFFMQLKSLLLGVHTYLVGEDSVEMVTVLNNIIVKKALHLTSENT- 178

  Fly   260 DTTSGHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLL----FM 320
            |.....:..|::.....:.:....||:.....:::.:..:.:::.:|...:..||.:.|    |.
 Worm   179 DWNRSKISKLLTTHSEAVSNGLAYVHHSCSALIELTIALFWIWETLGTRTIIVVLIVALVYAVFN 243

  Fly   321 PIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQG 385
            .|..|:..::..:|||.   .|.|:.....::::::.:||::||..|.:.:...|.||::..|:.
 Worm   244 IIDSYVYKKSLKVQLKC---RDERVEFEKTVLNSMETIKMFSWEPHFWKKLKSMRGKELSVFRKT 305

  Fly   386 QYIRGFDFARRIVLSRVAIFLSLVGYVILGKV--FTPEIAFMITAYYNVLLAAMSIYVPS-AIIQ 447
            ..|..|..:..:....|..|:|...|.:..::  ...|.||::.|.:|.:...:.:.:|| .|:.
 Worm   306 LSINSFMHSLNVTSPFVITFVSFAVYGLQYEISALRFEDAFVLIAIFNYMRRPLHVIIPSLEIVD 370

  Fly   448 TAQFLTSIRRVEQFM---QSEELGSSDKSEGPSKDTVPGNPPSNNNEADLLKSAISIRDLKAKWD 509
            .|  |.|...:.||:   ||.::.:.         |.| .||.   |.||     .|:.|.|.:.
 Worm   371 KA--LHSATIINQFLIVKQSPKINTK---------TAP-QPPV---EPDL-----DIKILNANFS 415

  Fly   510 PNSPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGSLSYTSQESWLF 574
            .|..|.||:.:.:.:|.|...|.||....|||||:.:|.||||...|.:.|:..:|:.....::|
 Worm   416 WNGKDDTLNDVCVHVKKGEKHAFIGFPLCGKSSLLFSITGELKMTKGNMWVSKGISFAPASPYIF 480

  Fly   575 SGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVY 639
            |.::::|||||......:|::|:..|.|::|...||..:.|::|::|..|:..|||:|||||.:|
 Worm   481 SQSLKENILFGNDYVKSKYDKVIMACDLKKDIFSLPRCEATVLGDKGYVLTSTQKAQISLARCLY 545

  Fly   640 RKASIYLLDDPLSAVDASVARHLFDQCV--RGHLRGSTVVLVTHQEQFLPHVDQIVILANGQIKA 702
            ..|.||.||.....:|.:.:..:|.:.:  .|:||..||:|.|:..:.:.....:.:|.||:|:.
 Worm   546 EDADIYALDKAFGPMDRTTSNKIFTRVLGENGYLRDKTVILATNNIELIKTFTMVHVLKNGKIET 610

  Fly   703 LGDYESLLK-TGLITGLGSLSKTDK----AKTEEQEPLNLNSPDNK-----------NEVTPIKE 751
            .|.|:.:|: :.:::.|.:.|:.||    ..::|:.|......|:|           .:..|:.|
 Worm   611 SGSYDQILECSEIMSDLLNQSRIDKIIEEKYSDEKPPRKTVMFDDKVLKKRKKKQSMEDTAPVFE 675

  Fly   752 NSEQTVGGSSSGKEHVERQESGGISLALYRKYFQAGGGLVA--FLVMLSSSVLAQVAVTGGDYFL 814
            |.                        ::|..||::|..:..  ::|:|....:.|....   ::|
 Worm   676 NR------------------------SVYPFYFRSGSFIFTAFYIVLLICRFVFQALAF---FWL 713

  Fly   815 TYWV----KKESTAAGHGEMEDMESKSMDVYKY----TLIIILSVIMNLSS--SFLLFNIAKKAS 869
            ::|:    ||            :|.::...|.:    :...|.::|..:.|  .|:|.|:  :.|
 Worm   714 SFWLDPVWKK------------VECENCPQYVFIQTMSFFAISAIISTMLSYTFFVLTNV--QTS 764

  Fly   870 IRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLP------------------VVLV 916
            .:|:..|.:.:....|.|.|.....|::|..|.|:..||...|                  :|.|
 Worm   765 RKLYQHITSAIFAVPMIFLSPTNKESLMNMITSDLDIVDTQFPLFFKFSFECTLHILMIFAIVCV 829

  Fly   917 DVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRNLYL-----------------KTSRDL 964
            :|...|:::...:|.:..:....|.....:|.:....|:|:|                 ||.:.|
 Worm   830 NVPVFAIFVVAFLIFLVGLLRYFLPALHKISSLEEQKRDLFLCGSIEDFEARIMVRTFGKTRQTL 894

  Fly   965 KRVEAIN-------RSPVYSHLAASLNGLTTIRALDAQRVLEKEFDSYQDAHSSAFFMYISTSQA 1022
            .:. ::|       |...||          |:|.:.    |..||.|                  
 Worm   895 AKT-SVNADILTRCRMARYS----------TLRWIS----LRTEFIS------------------ 926

  Fly  1023 FGYCMNCICVIYISI-ITLSFFAFPPGNGADVGLVITQAMGLIDMVQWGVRQTAELENTMTAVER 1086
              ..|.|:|....|| :.:.:.    || |...|.:...:.:.::|...:|.|..||:....|:|
 Worm   927 --NLMICMCFFIASICLKVDYI----GN-AQFALSVASILCISELVSTFIRTTCILESLTPHVQR 984

  Fly  1087 VVEYESIEPEGMLEAPDDKKPPK-TWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVG 1150
            :........|.|:    ||...: :||:.|:|..|.||:...   |..:|:|.:|.||:.|||:|
 Worm   985 ISNVREYPKEPMI----DKCTIRDSWPDDGKIEIKNLNVFAN---KYRHVIKDVSLVIEEREKLG 1042

  Fly  1151 IVGRTGAGKSSLINALFRLSYTD--GSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNL 1213
            |:|:.|:|||.|...|..:|..|  ..:::|..|..:|.:..||.:|::|||:..:||.|:|.|:
 Worm  1043 IIGKVGSGKSQLAKTLVMMSSADKESHIVVDDLDIFEMSVKTLRSRITVIPQKAKIFSDTLRSNI 1107

  Fly  1214 DPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVM 1278
            ||..:::|..:|..:|..:|:|.|..|||||...:|.  ...|..|:..|.:.||:|:..:|.|:
 Worm  1108 DPCCQFADSDIWLAIEACQLREYVKSLPDGLHQMVSP--EKMSNEQKCQVNVCRALLKGGQIFVI 1170

  Fly  1279 DEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKS 1343
            |::|..:......|:...||:..:..|.:.|......:...|:|:|::.|.::...:|..|:::.
 Worm  1171 DQSTKMMKEPIKSLVNEAIRNSLKQSTTIWIGEDFSDVEHCDRVVVIENGVILTTDTPQNLISEF 1235

  Fly  1344 DS 1345
            .|
 Worm  1236 GS 1237

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)03659NP_001260823.1 CFTR_protein 89..1343 CDD:273530 331/1343 (25%)
ABC_membrane 171..437 CDD:294371 60/273 (22%)
ABCC_MRP_domain1 499..699 CDD:213217 68/201 (34%)
ABC_membrane 799..1045 CDD:294371 54/298 (18%)
ABCC_MRP_domain2 1115..1336 CDD:213211 72/222 (32%)
cft-1NP_504463.1 MdlB 76..631 CDD:224055 154/591 (26%)
ABC_membrane 93..359 CDD:294371 61/277 (22%)
P-loop_NTPase 407..607 CDD:304359 68/199 (34%)
ABC_membrane 696..938 CDD:294371 54/293 (18%)
P-loop_NTPase 1010..1228 CDD:304359 72/222 (32%)
EcfA2 1012..1234 CDD:224047 73/226 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160157424
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24223
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.850

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