Protein Alignment l(2)03659 and Abcc1

DIOPT Version :10

• Sequence 1: NP_610482.3
• Gene: l(2)03659 / 47905
• FlyBaseID: FBgn0010549
• Length: 1374
• Species: Drosophila melanogaster
• Sequence 2: NP_032602.1
• Gene: Abcc1 / 17250
• MGIID: 102676
• Length: 1528
• Species: Mus musculus
• Alignment Length: 1384
• Identity: 453/1384 - (32%)
• Similarity: 738/1384 - (53%)
• Gaps: 183/1384 - (13%)

  Fly    90 PRARSNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNRLCASWEREL-------- 146
            |.:.::|:|.:.||:...:...|||:.|:|:||:...:|..|:.:...|..:|::|.
Mouse   209 PESSASFLSRITFWWITGMMVHGYRQPLESSDLWSLNKEDTSEEVVPVLVNNWKKECDKSRKQPV 273

  Fly   147 -----------KNDG---------------------RSPSLVRALLRVFGWQLGFPGLAIFVVEL 179
                       |..|                     |.|||.:.|.:.||        ..|::..
Mouse   274 RIVYAPPKDPSKPKGSSQLDVNEEVEALIVKSPHKDREPSLFKVLYKTFG--------PYFLMSF 330

  Fly   180 GLRTLQPIF------LVKLISYFSGEPDAANAGFYYAVAQIVISALTVMILTPTTFGIH---HVC 235
            ..:.|..:.      :::||..|..:.:|.:...|:..|.:.:||..      .|..:|   |:|
Mouse   331 LYKALHDLMMFAGPKILELIINFVNDREAPDWQGYFYTALLFVSACL------QTLALHQYFHIC 389

  Fly   236 F----KMRVAMGSMIFRKALRLTKGALGDTTSGHVVNLISNDIPR-LDSAPYTVHYLWVGPLQVL 295
            |    :::.|:...::||||.:|..|...:|.|.:|||:|.|..| :|.|.| ::.:|..||||:
Mouse   390 FVSGMRIKTAVVGAVYRKALLITNAARKSSTVGEIVNLMSVDAQRFMDLATY-INMIWSAPLQVI 453

  Fly   296 VITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKM 360
            :..|.::..:|.|.:.||..|:|.:|:...:..:|...|:...:..||||:::|||::.|:|||:
Mouse   454 LALYFLWLSLGPSVLAGVAVMILMVPLNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKL 518

  Fly   361 YAWEQPFEQMVTHAREKEMNTIRQGQYIRG---FDFARR---IVLSRVAIFLSLVGYVILGKVFT 419
            ||||..|:..|...|::|:..:::..|:..   |.:...   :.||..|:|::    |....:..
Mouse   519 YAWELAFQDKVMSIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVFVT----VDERNILD 579

  Fly   420 PEIAFMITAYYNVLLAAMSIYVPSAIIQTAQFLTSIRRVEQFMQSEELGSSDKSEGPSKDTVPGN 484
            .:.||:..|.:|:|...::| :|..|....|...|::|:..|:..||| ..|..|..|..:..||
Mouse   580 AKKAFVSLALFNILRFPLNI-LPMVISSIVQASVSLKRLRIFLSHEEL-EPDSIERRSIKSGEGN 642

  Fly   485 PPSNNNEADLLKSAISIRDLKAKWDPNSPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILG 549
                         :|::::....|....|. ||:||...|..|::|||:|..|.|||||:.|:|.
Mouse   643 -------------SITVKNATFTWARGEPP-TLNGITFSIPEGALVAVVGQVGCGKSSLLSALLA 693

  Fly   550 ELKANSGQLQVNGSLSYTSQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDN 614
            |:....|.:.:.||::|..|::|:.:.::|:|||||.|:....|:.|::.|||..|.::||..|.
Mouse   694 EMDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGHPLQENYYKAVMEACALLPDLEILPSGDR 758

  Fly   615 TIVGERGATLSGGQKARISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCV--RGHLRGSTVV 677
            |.:||:|..||||||.|:||||:||..:.|||.|||||||||.|.:|:|::.|  .|.|:..|.:
Mouse   759 TEIGEKGVNLSGGQKQRVSLARAVYSNSDIYLFDDPLSAVDAHVGKHIFEKVVGPMGLLKNKTRI 823

  Fly   678 LVTHQEQFLPHVDQIVILANGQIKALGDYESLL----------------------KTGLITGLGS 720
            ||||...:||.||.|::::.|:|..:|.|:.||                      :...::|.|.
Mouse   824 LVTHGISYLPQVDVIIVMSGGKISEMGSYQELLDRDGAFAEFLRTYANAEQDLASEDDSVSGSGK 888

  Fly   721 LSK--------TDKAKTEEQEPLNLNSPDNKNEVTPIKENSEQTVGGSSSGKE------HVERQE 771
            .||        ||......|..|: ||..:..:.:  :::|.......:..||      ..::.:
Mouse   889 ESKPVENGMLVTDTVGKHLQRHLS-NSSSHSGDTS--QQHSSIAELQKAGAKEETWKLMEADKAQ 950

  Fly   772 SGGISLALYRKYFQAGGGLVAFLVMLSSSVLAQVAVTGGDYFLTYWVKKESTAAG---------- 826
            :|.:.|::|..|.:|.|..:.|| .:...:...|:....:|:|:.|........|
Mouse   951 TGQVQLSVYWNYMKAIGLFITFL-SIFLFLCNHVSALASNYWLSLWTDDPPVVNGTQANRNFRLS 1014

  Fly   827 -HGEMEDMESKSMDVYKYTLIIILSVIMNLSSSFLLFNIAKKASIRLHNTIFNRVTRADMHFFSI 890
             :|.:..::..:  ::.|::.:.:..|.              ||.|||..:...|.|:.|.||..
Mouse  1015 VYGALGILQGAA--IFGYSMAVSIGGIF--------------ASRRLHLDLLYNVLRSPMSFFER 1063

  Fly   891 NKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRN 955
            ...|:::|||:|::..||.::|.|:...|.....:.|.:|:|....|:..|....|.::::.::.
Mouse  1064 TPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIILLATPIAAVIIPPLGLVYFFVQR 1128

  Fly   956 LYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQRVLEKEFDSYQDAHSSAFFMYISTS 1020
            .|:.:||.|||:|:::|||||||...:|.|::.|||.:.|.....:.|...|.:..|::..|..:
Mouse  1129 FYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVAN 1193

  Fly  1021 QAFGYCMNCI--CVIYISII--TLSFFAFPPGNGADVGLVITQAMGLIDMVQWGVRQTAELENTM 1081
            :.....:.|:  |::..:.:  .:|..:...|.   |||.::.::.:...:.|.||.::|:|..:
Mouse  1194 RWLAVRLECVGNCIVLFAALFAVISRHSLSAGL---VGLSVSYSLQITAYLNWLVRMSSEMETNI 1255

  Fly  1082 TAVERVVEYESIEPEGMLEAP---DDKKPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVI 1143
            .||||:.||...|.    |||   .:..||.|||..|.:.|::..|||..:  .:.|||.::..|
Mouse  1256 VAVERLKEYSETEK----EAPWQIQETAPPSTWPHSGRVEFRDYCLRYRED--LDLVLKHINVTI 1314

  Fly  1144 QPREKVGIVGRTGAGKSSLINALFRLSYT-DGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSG 1207
            :..||||||||||||||||...|||::.: :|.::||..:..::|||:||.:|:||||:||||||
Mouse  1315 EGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGVNIAKIGLHNLRFKITIIPQDPVLFSG 1379

  Fly  1208 TMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRE 1272
            ::|.|||||.:||||::|..||...||..||.|||.|..:.:|||.|.|||||||||||||:||:
Mouse  1380 SLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCLARALLRK 1444

  Fly  1273 NRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPY 1337
            .:|||:|||||.||.:||.|||:|||::|.|||||||||||:||:|..:|:|:|.|.|.|.|:|.
Mouse  1445 TKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEVRECGAPS 1509

  Fly  1338 ELMTKSDSKVFHNLVNQSG 1356
            ||:.:..  :|:::...:|
Mouse  1510 ELLQQRG--IFYSMAKDAG 1526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_610482.3	PLN03130	83..1369	CDD:215595	453/1384 (33%)
Abcc1	NP_032602.1	MRP_assoc_pro	7..1527	CDD:188098	453/1384 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	876..895		4/18 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	909..929		4/22 (18%)