DRSC/TRiP Functional Genomics Resources

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Protein Alignment l(2)03659 and Abcc1

DIOPT Version :9

Sequence 1:NP_001260823.1 Gene:l(2)03659 / 47905 FlyBaseID:FBgn0010549 Length:1374 Species:Drosophila melanogaster
Sequence 2:NP_032602.1 Gene:Abcc1 / 17250 MGIID:102676 Length:1528 Species:Mus musculus


Alignment Length:1384 Identity:453/1384 - (32%)
Similarity:738/1384 - (53%) Gaps:183/1384 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    90 PRARSNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNRLCASWEREL-------- 146
            |.:.::|:|.:.||:...:...|||:.|:|:||:...:|..|:.:...|..:|::|.        
Mouse   209 PESSASFLSRITFWWITGMMVHGYRQPLESSDLWSLNKEDTSEEVVPVLVNNWKKECDKSRKQPV 273

  Fly   147 -----------KNDG---------------------RSPSLVRALLRVFGWQLGFPGLAIFVVEL 179
                       |..|                     |.|||.:.|.:.||        ..|::..
Mouse   274 RIVYAPPKDPSKPKGSSQLDVNEEVEALIVKSPHKDREPSLFKVLYKTFG--------PYFLMSF 330

  Fly   180 GLRTLQPIF------LVKLISYFSGEPDAANAGFYYAVAQIVISALTVMILTPTTFGIH---HVC 235
            ..:.|..:.      :::||..|..:.:|.:...|:..|.:.:||..      .|..:|   |:|
Mouse   331 LYKALHDLMMFAGPKILELIINFVNDREAPDWQGYFYTALLFVSACL------QTLALHQYFHIC 389

  Fly   236 F----KMRVAMGSMIFRKALRLTKGALGDTTSGHVVNLISNDIPR-LDSAPYTVHYLWVGPLQVL 295
            |    :::.|:...::||||.:|..|...:|.|.:|||:|.|..| :|.|.| ::.:|..||||:
Mouse   390 FVSGMRIKTAVVGAVYRKALLITNAARKSSTVGEIVNLMSVDAQRFMDLATY-INMIWSAPLQVI 453

  Fly   296 VITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKM 360
            :..|.::..:|.|.:.||..|:|.:|:...:..:|...|:...:..||||:::|||::.|:|||:
Mouse   454 LALYFLWLSLGPSVLAGVAVMILMVPLNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKL 518

  Fly   361 YAWEQPFEQMVTHAREKEMNTIRQGQYIRG---FDFARR---IVLSRVAIFLSLVGYVILGKVFT 419
            ||||..|:..|...|::|:..:::..|:..   |.:...   :.||..|:|::    |....:..
Mouse   519 YAWELAFQDKVMSIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVFVT----VDERNILD 579

  Fly   420 PEIAFMITAYYNVLLAAMSIYVPSAIIQTAQFLTSIRRVEQFMQSEELGSSDKSEGPSKDTVPGN 484
            .:.||:..|.:|:|...::| :|..|....|...|::|:..|:..||| ..|..|..|..:..||
Mouse   580 AKKAFVSLALFNILRFPLNI-LPMVISSIVQASVSLKRLRIFLSHEEL-EPDSIERRSIKSGEGN 642

  Fly   485 PPSNNNEADLLKSAISIRDLKAKWDPNSPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILG 549
                         :|::::....|....|. ||:||...|..|::|||:|..|.|||||:.|:|.
Mouse   643 -------------SITVKNATFTWARGEPP-TLNGITFSIPEGALVAVVGQVGCGKSSLLSALLA 693

  Fly   550 ELKANSGQLQVNGSLSYTSQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDN 614
            |:....|.:.:.||::|..|::|:.:.::|:|||||.|:....|:.|::.|||..|.::||..|.
Mouse   694 EMDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGHPLQENYYKAVMEACALLPDLEILPSGDR 758

  Fly   615 TIVGERGATLSGGQKARISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCV--RGHLRGSTVV 677
            |.:||:|..||||||.|:||||:||..:.|||.|||||||||.|.:|:|::.|  .|.|:..|.:
Mouse   759 TEIGEKGVNLSGGQKQRVSLARAVYSNSDIYLFDDPLSAVDAHVGKHIFEKVVGPMGLLKNKTRI 823

  Fly   678 LVTHQEQFLPHVDQIVILANGQIKALGDYESLL----------------------KTGLITGLGS 720
            ||||...:||.||.|::::.|:|..:|.|:.||                      :...::|.|.
Mouse   824 LVTHGISYLPQVDVIIVMSGGKISEMGSYQELLDRDGAFAEFLRTYANAEQDLASEDDSVSGSGK 888

  Fly   721 LSK--------TDKAKTEEQEPLNLNSPDNKNEVTPIKENSEQTVGGSSSGKE------HVERQE 771
            .||        ||......|..|: ||..:..:.:  :::|.......:..||      ..::.:
Mouse   889 ESKPVENGMLVTDTVGKHLQRHLS-NSSSHSGDTS--QQHSSIAELQKAGAKEETWKLMEADKAQ 950

  Fly   772 SGGISLALYRKYFQAGGGLVAFLVMLSSSVLAQVAVTGGDYFLTYWVKKESTAAG---------- 826
            :|.:.|::|..|.:|.|..:.|| .:...:...|:....:|:|:.|........|          
Mouse   951 TGQVQLSVYWNYMKAIGLFITFL-SIFLFLCNHVSALASNYWLSLWTDDPPVVNGTQANRNFRLS 1014

  Fly   827 -HGEMEDMESKSMDVYKYTLIIILSVIMNLSSSFLLFNIAKKASIRLHNTIFNRVTRADMHFFSI 890
             :|.:..::..:  ::.|::.:.:..|.              ||.|||..:...|.|:.|.||..
Mouse  1015 VYGALGILQGAA--IFGYSMAVSIGGIF--------------ASRRLHLDLLYNVLRSPMSFFER 1063

  Fly   891 NKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRN 955
            ...|:::|||:|::..||.::|.|:...|.....:.|.:|:|....|:..|....|.::::.::.
Mouse  1064 TPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIILLATPIAAVIIPPLGLVYFFVQR 1128

  Fly   956 LYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQRVLEKEFDSYQDAHSSAFFMYISTS 1020
            .|:.:||.|||:|:::|||||||...:|.|::.|||.:.|.....:.|...|.:..|::..|..:
Mouse  1129 FYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVAN 1193

  Fly  1021 QAFGYCMNCI--CVIYISII--TLSFFAFPPGNGADVGLVITQAMGLIDMVQWGVRQTAELENTM 1081
            :.....:.|:  |::..:.:  .:|..:...|.   |||.::.::.:...:.|.||.::|:|..:
Mouse  1194 RWLAVRLECVGNCIVLFAALFAVISRHSLSAGL---VGLSVSYSLQITAYLNWLVRMSSEMETNI 1255

  Fly  1082 TAVERVVEYESIEPEGMLEAP---DDKKPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVI 1143
            .||||:.||...|.    |||   .:..||.|||..|.:.|::..|||..:  .:.|||.::..|
Mouse  1256 VAVERLKEYSETEK----EAPWQIQETAPPSTWPHSGRVEFRDYCLRYRED--LDLVLKHINVTI 1314

  Fly  1144 QPREKVGIVGRTGAGKSSLINALFRLSYT-DGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSG 1207
            :..||||||||||||||||...|||::.: :|.::||..:..::|||:||.:|:||||:||||||
Mouse  1315 EGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGVNIAKIGLHNLRFKITIIPQDPVLFSG 1379

  Fly  1208 TMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRE 1272
            ::|.|||||.:||||::|..||...||..||.|||.|..:.:|||.|.|||||||||||||:||:
Mouse  1380 SLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCLARALLRK 1444

  Fly  1273 NRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPY 1337
            .:|||:|||||.||.:||.|||:|||::|.|||||||||||:||:|..:|:|:|.|.|.|.|:|.
Mouse  1445 TKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEVRECGAPS 1509

  Fly  1338 ELMTKSDSKVFHNLVNQSG 1356
            ||:.:..  :|:::...:|
Mouse  1510 ELLQQRG--IFYSMAKDAG 1526

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)03659NP_001260823.1 CFTR_protein 89..1343 CDD:273530 451/1369 (33%)
ABC_membrane 171..437 CDD:294371 79/285 (28%)
ABCC_MRP_domain1 499..699 CDD:213217 89/201 (44%)
ABC_membrane 799..1045 CDD:294371 61/260 (23%)
ABCC_MRP_domain2 1115..1336 CDD:213211 127/221 (57%)
Abcc1NP_032602.1 MRP_assoc_pro 7..1527 CDD:188098 453/1384 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 876..895 4/18 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 909..929 4/22 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167841653
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.660

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