DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and Abcc4

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	XP_038948894.1	Gene:	Abcc4 / 170924	RGDID:	620266	Length:	1382	Species:	Rattus norvegicus

Alignment Length:	1379	Identity:	548/1379 - (39%)
Similarity:	827/1379 - (59%)	Gaps:	136/1379 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 NPRARSNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNRLCASWEREL---KNDG 150
            ||...:|..|.|.||:..|:|:.|:::.|:..|::..|.|.:|..||..|...|::|:   |.|.
  Rat    11 NPLQDANLCSRLFFWWLNPLFKAGHKRRLEEDDMFSVLPEDRSKHLGEELQGYWDKEVLRAKKDA 75

  Fly   151 RSPSLVRALLRVFGWQLGFPGLAIF-VVELGLRTLQPIFLVKLISYFSGEPDAANAGFYYAVAQI 214
            |.|||.:|:::.: |: .:..|.|| ::|...|.:|||||.|:|.||.......:|..:.|....
  Rat    76 RKPSLTKAIVKCY-WK-SYLILGIFTLIEETTRVVQPIFLGKIIDYFEKYDSDDSAALHTAYGYA 138

  Fly   215 VISALTVMILTPTTFGIHHVCF--------KMRVAMGSMIFRKALRLTKGALGDTTSGHVVNLIS 271
            .:.:|..:||..    :||:.|        ::||||..||:||||||:..|:|.||:|.:|||:|
  Rat   139 AVLSLCTLILAI----LHHLYFYHVQCAGMRIRVAMCHMIYRKALRLSNSAMGKTTTGQIVNLLS 199

  Fly   272 NDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLK 336
            ||:.:.|.....:|:||.||||.:.:|.|::.|||||.:.|:..:::.:|:|..:|...|:::.|
  Rat   200 NDVNKFDQVTIFLHFLWAGPLQAIGVTILLWVEIGISCLAGLAILVILLPLQSCIGKLFSSLRSK 264

  Fly   337 AAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQYIRGFDFARRIVLSR 401
            .|..||.|||.:||:|:.::::||||||:.|..::|:.|:||::.|....|:||.:.|...:.::
  Rat   265 TAAFTDARIRTMNEVITGMRIIKMYAWEKSFADLITNLRKKEISKILGSSYLRGMNMASFFIANK 329

  Fly   402 VAIFLSLVGYVILGKVFTPEIAFMITAYYNVLLAAMSIYVPSAIIQTAQFLTSIRRVEQFMQSEE 466
            |.:|::...||:||...|....|:....|..:...::::.||||.:.::.:.|:||::.|:..:|
  Rat   330 VILFVTFTTYVLLGNKITASHVFVAMTLYGAVRLTVTLFFPSAIERVSEAVVSVRRIKNFLLLDE 394

  Fly   467 LGSSDKSEGPSKDTVPGNPPSNNNEADLLKSAISIRDLKAKWDPNSPDYTLSGINLEIKPGSVVA 531
            |......|           ||:.      |:.:.::|..|.||......||.|::...:||.::|
  Rat   395 LPERKAQE-----------PSDG------KAIVHVQDFTAFWDKALDTPTLQGLSFTARPGELLA 442

  Fly   532 VIGLTGSGKSSLIQAILGELKANSGQLQVNGSLSYTSQESWLFSGTVRQNILFGQPMDSQRYEEV 596
            |:|..|:|||||:.|:||||...||.:.|:|.::|.||:.|:||||||.|||||:..:.:|||:|
  Rat   443 VVGPVGAGKSSLLSAVLGELPPTSGLVSVHGRIAYVSQQPWVFSGTVRSNILFGRKYEKERYEKV 507

  Fly   597 VKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVYRKASIYLLDDPLSAVDASVARH 661
            :|.|||::|..||...|.|::|:||||||||||||::|||:||:.|.|||||||||||||.|.:|
  Rat   508 IKACALKKDLQLLEDGDLTVIGDRGATLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVGKH 572

  Fly   662 LFDQCVRGHLRGSTVVLVTHQEQFLPHVDQIVILANGQIKALGDYESLLKTGLITGLGSLSKTDK 726
            ||..|:...|.....:|||||.|:|.....|:||.:|::...|.|...||:|:  ..|||.|.:
  Rat   573 LFQLCICQTLHEKITILVTHQLQYLKAASHILILKDGEMVQKGTYTEFLKSGV--DFGSLLKKE- 634

  Fly   727 AKTEEQEPLNL-NSPDNKNEV-------------------TPIKENSEQTVGGSSSGKEHVERQE 771
              .||.||..: .:|..:|..                   .|..:::|.|     ...:..|.:.
  Rat   635 --NEEAEPSPVPGTPTLRNRTFSEASIWSQQSSRPSLKDGVPDAQDAENT-----QAAQPEESRS 692

  Fly   772 SGGISLALYRKYFQAGGG--LVAFLVMLSSSVLAQVAVTGGDYFLTYWVKKE----STAAGHGEM 830
            .|.|....|:.||.||..  .:.|||:|  :::.||.....|::|::|..::    .|...:|.:
  Rat   693 EGRIGFKAYKNYFSAGASWFFIIFLVLL--NLMGQVFYVLQDWWLSHWANRQGALNDTKNANGNV 755

  Fly   831 EDMESKSMDVYKYTLIIILSVIMNLSSSFLLFNIAKKASIRLHNTIFNRVTRADMHFFSIN---- 891
            ......|..:..||.:..::|:..::.|.|:|.:...||..|||.:|..:.:|.:.||..|
  Rat   756 TGTLDLSWYLGIYTGLTAVTVLFGIARSLLVFYVLVNASQTLHNRMFESILKAPVLFFDRNPIEL 820

  Fly   892 ----------------KH-------------------------------------GSILNRFTKD 903
                            :|                                     |.|||||:||
  Rat   821 TQLEVFRVVDGALDSHRHLSHPHPWPQNGSLQASVTSVTGSDVIRFPEVLLLALPGRILNRFSKD 885

  Fly   904 MSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVE 968
            :..:|::||:..:|.:|..|.:..:|.|.|.|.|.:|:|.:.||:||..||..:|:||||:||:|
  Rat   886 IGHMDDLLPLTFLDFIQTLLLVVSVIAVAAAVIPWILIPLVPLSIIFVVLRRYFLETSRDVKRLE 950

  Fly   969 AINRSPVYSHLAASLNGLTTIRALDAQRVLEKEFDSYQDAHSSAFFMYISTSQAFGYCMNCICVI 1033
            :..||||:|||::||.||.||||..|:...::.||::||.||.|:|::::||:.|...::.||.:
  Rat   951 STTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAV 1015

  Fly  1034 YISIITL-SFFAFPPGNGADVGLVITQAMGLIDMVQWGVRQTAELENTMTAVERVVEYESIEPEG 1097
            ::.::.. |.......:...|||.::.::.|:.|.||.|||:||:||.|.:||||:||..:|.|.
  Rat  1016 FVIVVAFGSLVLAKTLDAGQVGLALSYSLTLMGMFQWSVRQSAEVENMMISVERVIEYTDLEKEA 1080

  Fly  1098 MLEAPDDKKPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSL 1162
            ..|.  .|:||..||.:|.|:|..:|..|:.:...  |||.|:.:|:.|||||||||||||||||
  Rat  1081 PWEC--RKRPPPGWPHEGVIVFDNVNFTYSLDGPL--VLKHLTALIKSREKVGIVGRTGAGKSSL 1141

  Fly  1163 INALFRLSYTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGC 1227
            |:||||||..:|.:.||...|.::||||||:::||||||||||:||||.|||||:|:|||:||..
  Rat  1142 ISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHSDEELWKA 1206

  Fly  1228 LEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGL 1292
            ||||:|||.:.|||..:.::::|.|:|||||||||||||||||::||||::|||||||||:||.|
  Rat  1207 LEEVQLKEAIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILKKNRILIIDEATANVDPRTDEL 1271

  Fly  1293 IQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLVNQSGR 1357
            ||..||.||..||||||||||:|||||||:||:|:||:.|:..||.|:...:| :|:.:|.|.|:
  Rat  1272 IQQKIREKFAQCTVLTIAHRLNTIIDSDKIMVLDSGRLREYDEPYVLLQNPES-LFYKMVQQLGK 1335

  Fly  1358 ASYEGLLKIAQETF 1371
            .....|.:.|::.:
  Rat  1336 GEAAALTETAKQVY 1349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	541/1349 (40%)
		ABC_membrane	171..437	CDD:294371	100/274 (36%)
		ABCC_MRP_domain1	499..699	CDD:213217	103/199 (52%)
		ABC_membrane	799..1045	CDD:294371	90/307 (29%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	143/220 (65%)
Abcc4	XP_038948894.1	MRP_assoc_pro	6..1334	CDD:188098	545/1362 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345057
Domainoid	1	1.000	229	1.000	Domainoid score	I2384
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74563
Inparanoid	1	1.050	1102	1.000	Inparanoid score	I217
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm44390
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X771
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.810