DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment l(2)03659 and Cftr

DIOPT Version :9

Sequence 1:NP_001260823.1 Gene:l(2)03659 / 47905 FlyBaseID:FBgn0010549 Length:1374 Species:Drosophila melanogaster
Sequence 2:NP_066388.1 Gene:Cftr / 12638 MGIID:88388 Length:1476 Species:Mus musculus


Alignment Length:1487 Identity:403/1487 - (27%)
Similarity:714/1487 - (48%) Gaps:254/1487 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    86 LPENPRARSNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNRLCASWERELKNDG 150
            :.::|..:::|||.|.|.:|.||.|||||..|:.:|:|:......:|.|..:|...|:|| :...
Mouse     1 MQKSPLEKASFISKLFFSWTTPILRKGYRHHLELSDIYQAPSADSADHLSEKLEREWDRE-QASK 64

  Fly   151 RSPSLVRALLRVFGWQLGFPGLAIFVVELGLRTLQPIFLVKLISYFSGEPDAANA-GFYYAVAQI 214
            ::|.|:.||.|.|.|:..|.|:.:::.|: .:.:||:.|.::|:.:..|.....: ..|..:...
Mouse    65 KNPQLIHALRRCFFWRFLFYGILLYLGEV-TKAVQPVLLGRIIASYDPENKVERSIAIYLGIGLC 128

  Fly   215 VISALTVMILTPTTFGIHHVCFKMRVAMGSMIFRKALRLTKGALGDTTSGHVVNLISNDIPRLDS 279
            ::..:..::|.|..||:|.:..:||.||.|:|::|.|:|:...|...:.|.:|:|:||::.:.|.
Mouse   129 LLFIVRTLLLHPAIFGLHRIGMQMRTAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDE 193

  Fly   280 APYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNR 344
            .....|::|:.||||.::..|::..:..||..|:..:::.:..|..||......:.:.|.:.:.|
Mouse   194 GLALAHFIWIAPLQVTLLMGLLWDLLQFSAFCGLGLLIILVIFQAILGKMMVKYRDQRAAKINER 258

  Fly   345 IRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQYIRGFDFARRIVLSRVAIFLSLV 409
            :.:.:|||..|..:|.|.||...|:|:.:.||.|:...|:..|:|.|..:.........:|||::
Mouse   259 LVITSEIIDNIYSVKAYCWESAMEKMIENLREVELKMTRKAAYMRFFTSSAFFFSGFFVVFLSVL 323

  Fly   410 GY-----VILGKVFTPEIAFMITAYYNVLLAAMSIYVPSAIIQTAQFLTSIRRVEQFMQSEELGS 469
            .|     ::|.|:|| .|:|.|     ||..:::...|:|:.........||:::.|:|.:|.  
Mouse   324 PYTVINGIVLRKIFT-TISFCI-----VLRMSVTRQFPTAVQIWYDSFGMIRKIQDFLQKQEY-- 380

  Fly   470 SDKSEGPSKDTVPGNPPSNNNEADLLKSAISIRDLKAKW----------------------DPNS 512
                              ...|.:|:.:.|.:.::.|.|                      |.|:
Mouse   381 ------------------KVLEYNLMTTGIIMENVTAFWEEGFGELLEKVQQSNGDRKHSSDENN 427

  Fly   513 PDYT---------LSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGSLSYTS 568
            ..::         |..|||.|:.|.::|:.|.|||||:||:..|||||:|:.|.::.:|.:|:.|
Mouse   428 VSFSHLCLVGNPVLKNINLNIEKGEMLAITGSTGSGKTSLLMLILGELEASEGIIKHSGRVSFCS 492

  Fly   569 QESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARIS 633
            |.||:..||:::||:||...|..||:.|||.|.|::|......:|||::||.|.||||||:||||
Mouse   493 QFSWIMPGTIKENIIFGVSYDEYRYKSVVKACQLQQDITKFAEQDNTVLGEGGVTLSGGQRARIS 557

  Fly   634 LARSVYRKASIYLLDDPLSAVDASVARHLFDQCVRGHLRGSTVVLVTHQEQFLPHVDQIVILANG 698
            |||:||:.|.:||||.|...:|......:|:.||...:...|.:|||.:.:.|...|:|:||..|
Mouse   558 LARAVYKDADLYLLDSPFGYLDVFTEEQVFESCVCKLMANKTRILVTSKMEHLRKADKILILHQG 622

  Fly   699 QIKALG----------DYESLL-------------KTGLITG----------------------- 717
            .....|          |:.|.|             ::.::|.                       
Mouse   623 SSYFYGTFSELQSLRPDFSSKLMGYDTFDQFTEERRSSILTETLRRFSVDDSSAPWSKPKQSFRQ 687

  Fly   718 ------------LGSLSKTDKAKTEEQEPLNLNS-----PDNKNEVTPIKENSEQTVGGS----- 760
                        |.|.|...|....::.||.::.     .:.:..:.|..|..|..:..|     
Mouse   688 TGEVGEKRKNSILNSFSSVRKISIVQKTPLCIDGESDDLQEKRLSLVPDSEQGEAALPRSNMIAT 752

  Fly   761 --------------------SSGKEHVERQESGGISLAL-------------------------- 779
                                :||..:::|..:....::|                          
Mouse   753 GPTFPGRRRQSVLDLMTFTPNSGSSNLQRTRTSIRKISLVPQISLNEVDVYSRRLSQDSTLNITE 817

  Fly   780 --------------------------YRKYFQAGGGLVAFLVMLSSSVLAQVAVTGGDYFLTYWV 818
                                      |.:||....||:..|:......|.:||.:   .|:.:.:
Mouse   818 EINEEDLKECFLDDVIKIPPVTTWNTYLRYFTLHKGLLLVLIWCVLVFLVEVAAS---LFVLWLL 879

  Fly   819 KKESTAAGHGEMEDMESKSMDVYKYTLII-------ILSVIMNLSSSFLLFNIAK---------K 867
            |.....:|:...:...|      .|.:||       |..:.:.::.:.|..::.:         .
Mouse   880 KNNPVNSGNNGTKISNS------SYVVIITSTSFYYIFYIYVGVADTLLALSLFRGLPLVHTLIT 938

  Fly   868 ASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVI 932
            ||..||..:.:.:..|.|...|..|.|.|||||:||::.:|:.||:.:.|.:|:...:.|.|||:
Mouse   939 ASKILHRKMLHSILHAPMSTISKLKAGGILNRFSKDIAILDDFLPLTIFDFIQLVFIVIGAIIVV 1003

  Fly   933 ANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQRV 997
            :.:.|.:.:.|:...|:|..||..:|.|::.||::|:..|||:::||..||.||.|:||...|..
Mouse  1004 SALQPYIFLATVPGLVVFILLRAYFLHTAQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFRRQTY 1068

  Fly   998 LEKEFDSYQDAHSSAFFMYISTSQAFGYCMNCICVIYISIIT-LSFFAFPPGNGADVGLVITQAM 1061
            .|..|....:.|::.:|||::|.:.|...::.|.|::..::| :|......|.|. .|:::|.||
Mouse  1069 FETLFHKALNLHTANWFMYLATLRWFQMRIDMIFVLFFIVVTFISILTTGEGEGT-AGIILTLAM 1132

  Fly  1062 GLIDMVQWGVRQTAELENTMTAVERVVEYESIEPEGMLEAPDDKKPPK----------------- 1109
            .::..:||.|..:.:.::.|.:|.||.::..|:.|..:.....|:.|:                 
Mouse  1133 NIMSTLQWAVNSSIDTDSLMRSVSRVFKFIDIQTEESMYTQIIKELPREGSSDVLVIKNEHVKKS 1197

  Fly  1110 -TWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFRLSYTD 1173
             .||..||::.|:|.::|..:..|  ||:::||.|.|.::||::||||:|||:|::|..|:....
Mouse  1198 DIWPSGGEMVVKDLTVKYMDDGNA--VLENISFSISPGQRVGLLGRTGSGKSTLLSAFLRMLNIK 1260

  Fly  1174 GSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEVVS 1238
            |.:.||......:.|.:.|:...:|.|:..:||||.|.||||..::.||::|...:||.||.|:.
Mouse  1261 GDIEIDGVSWNSVTLQEWRKAFGVITQKVFIFSGTFRQNLDPNGKWKDEEIWKVADEVGLKSVIE 1325

  Fly  1239 DLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQATIRSKFRD 1303
            ..|..|...:.:||...|.|.:||:||||::|.:.:|:::||.:|::||.|..:|:..::..|..
Mouse  1326 QFPGQLNFTLVDGGYVLSHGHKQLMCLARSVLSKAKIILLDEPSAHLDPITYQVIRRVLKQAFAG 1390

  Fly  1304 CTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLVNQSGRASY 1360
            |||:...||:..::|..:.:|::...|.::.|...|:  |:..:|...::.|.:..:
Mouse  1391 CTVILCEHRIEAMLDCQRFLVIEESNVWQYDSLQALL--SEKSIFQQAISSSEKMRF 1445

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)03659NP_001260823.1 CFTR_protein 89..1343 CDD:273530 400/1465 (27%)
ABC_membrane 171..437 CDD:294371 74/271 (27%)
ABCC_MRP_domain1 499..699 CDD:213217 88/230 (38%)
ABC_membrane 799..1045 CDD:294371 73/262 (28%)
ABCC_MRP_domain2 1115..1336 CDD:213211 78/220 (35%)
CftrNP_066388.1 CFTR_protein 1..1464 CDD:273530 403/1487 (27%)
ABC_membrane 85..303 CDD:294371 59/218 (27%)
ABCC_CFTR1 389..670 CDD:213258 94/280 (34%)
CFTR_R 639..844 CDD:291094 18/204 (9%)
Disordered R region. /evidence=ECO:0000250|UniProtKB:P13569 654..826 15/171 (9%)
ABC_membrane 861..1142 CDD:279056 81/290 (28%)
ABCC_CFTR2 1204..1464 CDD:213256 83/246 (34%)
Interaction with GORASP2. /evidence=ECO:0000250|UniProtKB:P13569 1382..1476 14/66 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1446..1476 403/1487 (27%)
PDZ-binding. /evidence=ECO:0000250|UniProtKB:P13569 1474..1476
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167841715
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24223
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.850

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