DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and ABCC2

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_000383.2	Gene:	ABCC2 / 1244	HGNCID:	53	Length:	1545	Species:	Homo sapiens

Alignment Length:	1399	Identity:	470/1399 - (33%)
Similarity:	735/1399 - (52%)	Gaps:	192/1399 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 SENNSAQNEKEKVLPENPRARSNFISSLCF-WYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGN 136
            ||||.:.|        ||.:.::|:||:.: ||. .|..|||::.|...|::...||.|:..|.:
Human   185 SENNESSN--------NPSSIASFLSSITYSWYD-SIILKGYKRPLTLEDVWEVDEEMKTKTLVS 240

  Fly   137 RLCASWEREL---------------------------KNDGRSPS-------------------- 154
            :.....:|||                           ||..:|..
Human   241 KFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDV 305

  Fly   155 ----LVRALLRVFGWQLGFPGLAIFVVELGLRTLQPIF------LVKLISYFSGEPDAANAGFY- 208
                |::||.:.|...|    |..|:::|    :..||      |:||:..|:.:.|.     |
Human   306 PKSWLMKALFKTFYMVL----LKSFLLKL----VNDIFTFVSPQLLKLLISFASDRDT-----YL 357

  Fly   209 ---YAVAQIVISALTVMILTPTTFGIHHVCFKM----RVAMGSMIFRKALRLTKGALGDTTSGHV 266
               |..|.::.:|..:.......:  ..:|||:    |.|:.:.:::|||.|:..|..:.|.|..
Human   358 WIGYLCAILLFTAALIQSFCLQCY--FQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGET 420

  Fly   267 VNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTS 331
            |||:|.|..:|......:|.||...||:::..:.:::|:|.|.:.||..|:|.:||...|.|::.
Human   421 VNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSK 485

  Fly   332 AIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTI---RQGQYIRGFDF 393
            .||:|..:..|.|::::|||:|.|::||.:|||..|...|.:.|:||:..:   .|.|.:..|.|
Human   486 TIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVF 550

  Fly   394 ARRIVLSRVAIFLSLVGYVILGKVFTPEIAFMITAYYNVLLAAMSIYVPSAIIQTAQFLTSIRRV 458
            ....||..|..| |:...|....:...:.||.....:|:|...:|: :|..|....|...|..|:
Human   551 QLTPVLVSVVTF-SVYVLVDSNNILDAQKAFTSITLFNILRFPLSM-LPMMISSMLQASVSTERL 613

  Fly   459 EQFMQSEELGSSDKSEGPSKDTVPGNPPSNNNEADLLKSAISIRDLKAKWDPNSPDYTLSGINLE 523
            |:::..::|.:|......:.|                 .|:...:....|:.:| :.|:..:||:
Human   614 EKYLGGDDLDTSAIRHDCNFD-----------------KAMQFSEASFTWEHDS-EATVRDVNLD 660

  Fly   524 IKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGSLSYTSQESWLFSGTVRQNILFGQPM 588
            |..|.:|||||..||||||||.|:|||::...|.:.:.|:.:|..|:||:.:||::.|||||...
Human   661 IMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNILFGTEF 725

  Fly   589 DSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVYRKASIYLLDDPLSA 653
            :.:||::|::.|||..|.::||..|...:||:|..||||||.||||||:.|:...||||||||||
Human   726 NEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSA 790

  Fly   654 VDASVARHLFDQCV--RGHLRGSTVVLVTHQEQFLPHVDQIVILANGQIKALGDYESL------- 709
            |||.|.:|:|::.:  .|.|:|.|.:||||...|||.||:||:|.||.|...|.|.:|
Human   791 VDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEF 855

  Fly   710 ---LKTGL-ITGLGSLSKTDKAKTEEQEPLNLNS-----PDNKNEVTPIKENS-EQTVGGSS--- 761
               |||.| .||....:.......||.:...|.|     |::...:|..:||| .:|:..||
Human   856 AKNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRSSRSN 920

  Fly   762 --------------------------SGKEHVERQ--ESGGISLALYRKYFQAGGGLVAFLVMLS 798
                                      .|::.::::  |:|.:..::|.:|.||.|....|.::|
Human   921 GRHLKSLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQAIGLFSIFFIIL- 984

  Fly   799 SSVLAQVAVTGGDYFLTYWVKKESTAAGHGEMEDMESKSMDVYKYTLIIILSVIMNLSSSFLLFN 863
            :.|:..||..|.:.:|:.|....................:.||. .|.:...:.:.::..:..|.
Human   985 AFVMNSVAFIGSNLWLSAWTSDSKIFNSTDYPASQRDMRVGVYG-ALGLAQGIFVFIAHFWSAFG 1048

  Fly   864 IAKKASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGI 928
            ....::| ||..:.|.:.||.|.||.....|.|:|||..|:|.||:.||..|...:...|.:...
Human  1049 FVHASNI-LHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGIIST 1112

  Fly   929 IIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALD 993
            :::|....|:..:..:.|.:|:..::..|:.|||.|:|::::.|||:|||.:.:::||..|||.:
Human  1113 LVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFE 1177

  Fly   994 AQRVLEKEFDSYQDAHSSAFFMYISTSQAFGYCMNCI--CVIYISII-------TLSFFAFPPGN 1049
            .|:...|..:...|.:....|.:|::::.....:..:  ..::.|.:       |||
Human  1178 HQQRFLKHNEVRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLS-------- 1234

  Fly  1050 GADVGLVITQAMGLIDMVQWGVRQTAELENTMTAVERVVEYESIEPEGMLEAP--DDKKPPKTWP 1112
            |..||.|::.|:.:...:.|.||.|:|:|..:.||||:.||..:|.    |||  .||:||..||
Human  1235 GDTVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVEN----EAPWVTDKRPPPDWP 1295

  Fly  1113 EQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFR-LSYTDGSV 1176
            .:|:|.|....:||.|  :.:.||:.::..|...||:|:|||||||||||.|.||| |....|.:
Human  1296 SKGKIQFNNYQVRYRP--ELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQI 1358

  Fly  1177 LIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLP 1241
            :||..|...:||||||.:::||||:|:||||::|.|||||:.||||::|..||...||..|:.|.
Human  1359 IIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQ 1423

  Fly  1242 DGLASKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQATIRSKFRDCTV 1306
            .||:.:::|.|.|.|:|||||:||.||:||:::|||:|||||.||.:||.|||.||:::|..|||
Human  1424 LGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTV 1488

  Fly  1307 LTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELM 1340
            :|||||||||:|||||||:|.|:::|.|||.||:
Human  1489 ITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELL 1522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	465/1383 (34%)
		ABC_membrane	171..437	CDD:294371	82/282 (29%)
		ABCC_MRP_domain1	499..699	CDD:213217	96/201 (48%)
		ABC_membrane	799..1045	CDD:294371	62/254 (24%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	122/221 (55%)
ABCC2	NP_000383.2	SunT	8..1537	CDD:331423	470/1399 (34%)
ABCC2	NP_000383.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	253..284		2/30 (7%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151617
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.760