DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment l(2)03659 and Abcc5

DIOPT Version :9

Sequence 1:NP_001260823.1 Gene:l(2)03659 / 47905 FlyBaseID:FBgn0010549 Length:1374 Species:Drosophila melanogaster
Sequence 2:NP_446376.1 Gene:Abcc5 / 116721 RGDID:70913 Length:1436 Species:Rattus norvegicus


Alignment Length:1480 Identity:453/1480 - (30%)
Similarity:733/1480 - (49%) Gaps:200/1480 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 SIEESSLLENNGFDHRNKDESLSVNTSPPLVCRKCFELGHQTENCKQKLTVNSENNSAQNEKEK- 84
            |:.:.|.:..   .|.:::|.....|. .|.|:...|...:.|.....::|:|.......|..| 
  Rat    19 SVRDRSTIPG---QHGDREEPRFRRTR-SLECQDALETAARVEGLSLDISVHSHLQILDEEHTKG 79

  Fly    85 --------VLP-------ENPRARSNFISSLCFWYTIPIFRKGYRK-TLDSTDLYRPLEEQKSDI 133
                    :.|       ::|...:...|.:.|.:..|:.:..::| .|...|::...:.:.||:
  Rat    80 KYHHGLSALKPFRTTTKHQHPVDNAGLFSYMTFSWLSPLAQVVHKKGELLMEDVWPLSKYESSDV 144

  Fly   134 LGNRLCASWERELKNDGRSPSLVRALLRVFGWQLGFPGLAIFVVELGLRTLQ----PIFLVK-LI 193
            ...||...|:.||...|...:.:|.::    |......|.:.:|.|.:..|.    |.|:|| |:
  Rat   145 NCRRLERLWQEELNEVGPDAASLRRVV----WIFCRTRLILSIVCLMITQLAGFSGPAFVVKHLL 205

  Fly   194 SYFSGEPDAANAGFYYAVAQIVISALTVMILT---PTTFGIHH-VCFKMRVAMGSMIFRKALRLT 254
            .|    ..|..:...|::..::...||.::.:   ..|:.::: ...::|.|:.:|.|:|.|:|.
  Rat   206 EY----TQATESNLQYSLLLVLGLLLTEVVRSWSLALTWALNYRTGVRLRGAVLTMAFKKILKLK 266

  Fly   255 KGALGDTTSGHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEI--GISAVFGVLFML 317
            .  :.:.:.|.::|:.|||..|:..|......|..||  |:.|..::|..|  |.:...|....:
  Rat   267 N--IKEKSLGELINICSNDGQRMFEAAAVGSLLAGGP--VVAILGMIYNVIILGPTGFLGSAVFI 327

  Fly   318 LFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTI 382
            ||.|..|::...|:..:.|....||:|::.:||:::.|:.:|||||.:.|.|.|...||:|...:
  Rat   328 LFYPAMMFVSRLTAYFRRKCVAATDDRVQKMNEVLTYIKFIKMYAWVKAFSQCVQKIREEERRIL 392

  Fly   383 RQGQYIRGFDFARRIVLSRVAIFLSLVGYVILGKVFTPEIAFMITAYYNVLLAAMSIYVPSAIIQ 447
            .:..|.:........::..:|..::...::.||...|...||.:...:|.:..|:.: .|.::..
  Rat   393 EKAGYFQSITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTFALKV-TPFSVKS 456

  Fly   448 TAQFLTSIRRVEQFMQSEELGSSDKSEGPSKDTVPGNPPSNNNEADLLKSAISIRDL-------- 504
            .::...::.|.:.....||:           ..:...|.|.:.:.: :|:|....|.        
  Rat   457 LSEASVAVDRFKSLFLMEEV-----------HMIKNKPASPHIKIE-MKNATLAWDSSHSSTQSS 509

  Fly   505 -----KAKWDPNSP--------------------------------------------------- 513
                 |.|.|..:|                                                   
  Rat   510 PKLTPKVKKDKRAPKGKKEKSRQLQHTEHQAVLAEQKGHLLLDSDERPSPEEEEGKQIHAGSMRL 574

  Fly   514 DYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGSLSYTSQESWLFSGTV 578
            ..||..|:|||:.|.:|.:.|..||||:|||.||||::....|.:.|:|:.:|.:|::|:.:.|:
  Rat   575 QRTLYNIDLEIEEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAVSGTFAYVAQQAWILNATL 639

  Fly   579 RQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVYRKAS 643
            |.|||||:..|.:||..|:..|.|..|..:||..|.|.:|||||.|||||:.||||||::|...|
  Rat   640 RDNILFGKEFDEERYNSVLNSCCLRPDLAILPNSDLTEIGERGANLSGGQRQRISLARALYSDRS 704

  Fly   644 IYLLDDPLSAVDASVARHLFDQCVRGHLRGSTVVLVTHQEQFLPHVDQIVILANGQIKALGDYES 708
            ||:|||||||:||.|..|:|:..:|..|:..||:.||||.|:|...|:::.:..|.|...|.:|.
  Rat   705 IYILDDPLSALDAHVGNHIFNSAIRKRLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEE 769

  Fly   709 LLK---------TGLITGLGSLSKTDKAKTEEQEPLNLNSPDNKNEVTPIKENSEQTVGGSSSGK 764
            |:.         ..|:.|             |..|:.:||   |.|.:..:::.::.....|..|
  Rat   770 LMNLNGDYATIFNNLLLG-------------ETPPVEINS---KKEASGSQKSQDKGPKPGSVKK 818

  Fly   765 E-----------HVERQESGGISLALYRKYFQAGGGLVAFLVMLSSSVLAQVAVTGGDYFLTYWV 818
            |           .||.:..|.:..::|..|.||.||.:||||::...:|...:.....::|:||:
  Rat   819 EKAVKSEEGQLVQVEEKGQGSVPWSVYWVYIQAAGGPLAFLVIMVLFMLNVGSTAFSTWWLSYWI 883

  Fly   819 KKES--TAAGHGEMEDMESKSMD---------VYKYTLIIILSVIMNLSSSFLLFNIAKKASIRL 872
            |:.|  :....|....:.....|         :|..::.::|  |:......:......:||.||
  Rat   884 KQGSGNSTVFEGNRSSVSDSMRDNPFLQYYASIYALSMAVML--ILKAIRGVVFVKGTLRASSRL 946

  Fly   873 HNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIV------ 931
            |:.:|.|:.|:.|.||.....|.|||||:|||.:||..||      .|..:::..:|:|      
  Rat   947 HDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLP------FQAEMFIQNVILVFFCVGM 1005

  Fly   932 IANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQR 996
            ||.|.|..||....|.::|..|..:.....|:|||::.|.:||..||:.:|:.||.||.|.:.::
  Rat  1006 IAGVFPWFLVAVGPLLILFSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKRQ 1070

  Fly   997 VLEKEFDSYQDAHSSAFFMYISTSQAFGYCMNCICVIYIS----IITLSFFAFPPGNGADVGLVI 1057
            .....:....|.:.:.||::....:.....::.|.:..|:    :|.|.....|   .|..||.|
  Rat  1071 EFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIP---SAYAGLAI 1132

  Fly  1058 TQAMGLIDMVQWGVRQTAELENTMTAVERVVEY-ESIEPEGMLEAP---DDKKPPKTWPEQGEII 1118
            :.|:.|..:.|:.||..:|.|...|:|||:..| :::.    ||||   .:|.||..||::|||.
  Rat  1133 SYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLS----LEAPARIKNKAPPHDWPQEGEIT 1193

  Fly  1119 FKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFRL-SYTDGSVLIDTRD 1182
            |:...:||..|...  |||.:||.|:|:||:|||||||:|||||..||||| ..:.|.:.||...
  Rat  1194 FENAEMRYRENLPL--VLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVR 1256

  Fly  1183 TRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASK 1247
            ...:||.|||.:::||||||||||||:|.|||||::|::|::|..||...:||.::.||..|.|:
  Rat  1257 ISDIGLADLRSKLTIIPQEPVLFSGTVRSNLDPFNQYTEEQIWDALERTHMKECIAQLPLKLESE 1321

  Fly  1248 ISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHR 1312
            :.|.|.|||||:|||:|:|||:||..:||::|||||.:|.:||.|||.|||..|.|||:||||||
  Rat  1322 VMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHR 1386

  Fly  1313 LHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLVNQSGRASYEG 1362
            |||::.||::||:..|:||||.:|..|::...|:.:........:.:.:|
  Rat  1387 LHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMCAAAENKVAVKG 1436

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)03659NP_001260823.1 CFTR_protein 89..1343 CDD:273530 437/1375 (32%)
ABC_membrane 171..437 CDD:294371 69/276 (25%)
ABCC_MRP_domain1 499..699 CDD:213217 92/263 (35%)
ABC_membrane 799..1045 CDD:294371 69/266 (26%)
ABCC_MRP_domain2 1115..1336 CDD:213211 124/221 (56%)
Abcc5NP_446376.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 12..38 4/21 (19%)
PLN03130 100..1424 CDD:215595 438/1381 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 499..569 5/69 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 795..822 7/29 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166345037
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
76.660

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