DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment l(2)03659 and CFTR

DIOPT Version :9

Sequence 1:NP_001260823.1 Gene:l(2)03659 / 47905 FlyBaseID:FBgn0010549 Length:1374 Species:Drosophila melanogaster
Sequence 2:NP_000483.3 Gene:CFTR / 1080 HGNCID:1884 Length:1480 Species:Homo sapiens


Alignment Length:1497 Identity:407/1497 - (27%)
Similarity:719/1497 - (48%) Gaps:276/1497 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    86 LPENPRARSNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNRLCASWERELKNDG 150
            :..:|..:::.:|.|.|.:|.||.|||||:.|:.:|:|:......:|.|..:|...|:|||.:. 
Human     1 MQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASK- 64

  Fly   151 RSPSLVRALLRVFGWQLGFPGLAIFVVELGLRTLQPIFLVKLI-SYFSGEPDAANAGFYYAVAQI 214
            ::|.|:.||.|.|.|:..|.|:.:::.|: .:.:||:.|.::| ||.....:..:...|..:...
Human    65 KNPKLINALRRCFFWRFMFYGIFLYLGEV-TKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLC 128

  Fly   215 VISALTVMILTPTTFGIHHVCFKMRVAMGSMIFRKALRLTKGALGDTTSGHVVNLISNDIPRLDS 279
            ::..:..::|.|..||:||:..:||:||.|:|::|.|:|:...|...:.|.:|:|:||::.:.|.
Human   129 LLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDE 193

  Fly   280 APYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNR 344
            .....|::|:.||||.::..|:::.:..||..|:.|:::....|..||......:.:.|.:...|
Human   194 GLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISER 258

  Fly   345 IRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQYIRGFDFARRIVLSRVAIFLSLV 409
            :.:.:|:|..||.:|.|.||:..|:|:.:.|:.|:...|:..|:|.|:.:.........:|||::
Human   259 LVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVL 323

  Fly   410 GY-----VILGKVFTPEIAFMITAYYNVLLAAMSIYVPSAIIQTAQFLTSIRRVEQFMQSEEL-- 467
            .|     :||.|:|| .|:|.|     ||..|::...|.|:......|.:|.:::.|:|.:|.  
Human   324 PYALIKGIILRKIFT-TISFCI-----VLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKT 382

  Fly   468 ---------------------GSSDKSEGPSKDTVPGNPPSNNNEADLLKSAISIRDLKAKWDPN 511
                                 |..:..|...::.  .|..::|.:..|..|..|:.        .
Human   383 LEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNN--NNRKTSNGDDSLFFSNFSLL--------G 437

  Fly   512 SPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGSLSYTSQESWLFSG 576
            :|  .|..||.:|:.|.::||.|.||:||:||:..|:|||:.:.|:::.:|.:|:.||.||:..|
Human   438 TP--VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPG 500

  Fly   577 TVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVYRK 641
            |:::||:||...|..||..|:|.|.||.|......:||.::||.|.||||||:|||||||:||:.
Human   501 TIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKD 565

  Fly   642 ASIYLLDDPLSAVDASVARHLFDQCVRGHLRGSTVVLVTHQEQFLPHVDQIVILANG-------- 698
            |.:||||.|...:|....:.:|:.||...:...|.:|||.:.:.|...|:|:||..|        
Human   566 ADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTF 630

  Fly   699 -------------------------------------------------------QIKALGDYES 708
                                                                   ..|..|::..
Human   631 SELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETLHRFSLEGDAPVSWTETKKQSFKQTGEFGE 695

  Fly   709 LLKTGLITGLGSLSKTDKAKTEEQEPLNLNSPDNKNE--------VTPIKENSE---QTVGGSSS 762
            ..|..::..:.|:.   |....::.||.:|..:..::        :.|..|..|   ..:...|:
Human   696 KRKNSILNPINSIR---KFSIVQKTPLQMNGIEEDSDEPLERRLSLVPDSEQGEAILPRISVIST 757

  Fly   763 GK---------------------EHVERQESGG---ISLA------------------------- 778
            |.                     :::.|:.:..   :|||                         
Human   758 GPTLQARRRQSVLNLMTHSVNQGQNIHRKTTASTRKVSLAPQANLTELDIYSRRLSQETGLEISE 822

  Fly   779 -------------------------LYRKYFQAGGGLVAFLVMLSSSVLAQVAVTGGDYFLTYWV 818
                                     .|.:|......|:..|:......||:||.:    .:..|:
Human   823 EINEEDLKECFFDDMESIPAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEVAAS----LVVLWL 883

  Fly   819 KKESTAAGHGEMEDMESKSMDVYKYTLIIILSVIMNLSSSFLLFNI------------------- 864
            ...:.....|......:.|           .:||:..:||:.:|.|                   
Human   884 LGNTPLQDKGNSTHSRNNS-----------YAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPL 937

  Fly   865 ---AKKASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLA 926
               ....|..||:.:.:.|.:|.|...:..|.|.|||||:||::.:|::||:.:.|.:|:.|.:.
Human   938 VHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVI 1002

  Fly   927 GIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRA 991
            |.|.|:|.:.|.:.|.|:.:.|.|..||..:|:||:.||::|:..|||:::||..||.||.|:||
Human  1003 GAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRA 1067

  Fly   992 LDAQRVLEKEFDSYQDAHSSAFFMYISTSQAFGYCMNCICVI-YISIITLSFFAFPPGNGADVGL 1055
            ...|...|..|....:.|::.:|:|:||.:.|...:..|.|| :|::..:|......|.|. ||:
Human  1068 FGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGR-VGI 1131

  Fly  1056 VITQAMGLIDMVQWGVRQTAELENTMTAVERVVEYESIEPEGMLEAPDDKKPPKT---------- 1110
            ::|.||.::..:||.|..:.::::.|.:|.||.::        ::.|.:.||.|:          
Human  1132 ILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKF--------IDMPTEGKPTKSTKPYKNGQLS 1188

  Fly  1111 ---------------WPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKS 1160
                           ||..|::..|:|..:||....|  :|:::||.|.|.::||::||||:|||
Human  1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNA--ILENISFSISPGQRVGLLGRTGSGKS 1251

  Fly  1161 SLINALFRLSYTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLW 1225
            :|::|..||..|:|.:.||......:.|...|:...:|||:..:||||.|.||||::::||:::|
Human  1252 TLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIW 1316

  Fly  1226 GCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTD 1290
            ...:||.|:.|:...|..|...:.:||...|.|.:||:||||::|.:.:||::||.:|::||.|.
Human  1317 KVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTY 1381

  Fly  1291 GLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLVNQS 1355
            .:|:.|::..|.||||:...||:..:::..:.:|::..:|.::.|..:|:  ::..:|...::.|
Human  1382 QIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLL--NERSLFRQAISPS 1444

  Fly  1356 GR 1357
            .|
Human  1445 DR 1446

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)03659NP_001260823.1 CFTR_protein 89..1343 CDD:273530 404/1478 (27%)
ABC_membrane 171..437 CDD:294371 77/271 (28%)
ABCC_MRP_domain1 499..699 CDD:213217 82/262 (31%)
ABC_membrane 799..1045 CDD:294371 77/268 (29%)
ABCC_MRP_domain2 1115..1336 CDD:213211 81/220 (37%)
CFTRNP_000483.3 CFTR_protein 1..1480 CDD:273530 407/1497 (27%)
ABC_membrane 85..303 CDD:279056 61/218 (28%)
ABCC_CFTR1 389..670 CDD:213258 88/292 (30%)
CFTR_R 639..849 CDD:291094 17/212 (8%)
Disordered R region. /evidence=ECO:0000269|PubMed:10792060 654..831 17/179 (9%)
ABC_membrane 866..1147 CDD:279056 86/296 (29%)
ABCC_CFTR2 1208..1480 CDD:213256 86/243 (35%)
Interaction with GORASP2. /evidence=ECO:0000269|PubMed:21884936 1386..1480 15/63 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1452..1480
PDZ-binding. /evidence=ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:16331976 1478..1480
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151597
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24223
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.850

Return to query results.
Submit another query.