Protein Alignment l(2)03659 and abcc9

DIOPT Version :9

• Sequence 1: NP_001260823.1
• Gene: l(2)03659 / 47905
• FlyBaseID: FBgn0010549
• Length: 1374
• Species: Drosophila melanogaster
• Sequence 2: XP_031754288.1
• Gene: abcc9 / 101733439
• XenbaseID: XB-GENE-6074535
• Length: 1577
• Species: Xenopus tropicalis
• Alignment Length: 1423
• Identity: 417/1423 - (29%)
• Similarity: 696/1423 - (48%)
• Gaps: 235/1423 - (16%)

  Fly    95 NFISSLCFWYTIPIFRKGYRKTLDSTDL------------YRPL----EEQKSDILGNRLCASWE 143
            |.:|...:|:..|:....:::.:|...:            |..|    ||||..::        :
 Frog   221 NLLSKATYWWMNPLIISAHKRPIDLKTIGKLPIAMRALTNYLSLKTAYEEQKKKLV--------D 277

  Fly   144 RELKNDGRSPSLVRALLRVFGWQLGFPGLAIFVVELGLRTLQPIFLVKLISY------FSGEP-- 200
            |..|:    ||:.:|:.|.||                    :||.|.....|      |:| |
 Frog   278 RPHKD----PSIWKAIYRAFG--------------------RPILLSSTFRYLADLLGFAG-PLC 317

  Fly   201 --------DAANAG------------------------FYYAVAQIVISALTVM--ILTPTTFGI 231
                    |:.|.|                        .||.:|.::..||.:.  .|..:.:..
 Frog   318 ISGIVQLLDSRNKGPTDQDFPKTNFSSVYFLSSKGLIENYYVLAVLLFLALILQRTFLQASYYVT 382

  Fly   232 HHVCFKMRVAMGSMIFRKALRLTKG--ALGDTTSGHVVNLISNDIPRLDSAPYTVHYLWVGPLQV 294
            ......:|.|:.|||:.|.|||:..  ::|:.|.|.:.||::.:..:|....:....||..|:|:
 Frog   383 IETGINLRGALLSMIYNKILRLSTSNMSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPIQI 447

  Fly   295 LVITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLK 359
            ::...|:::.:|:||:.|...::|..|:|.::.|:.:.:|....:.:..|::..|||:..|::||
 Frog   448 IMGVILLHKLVGVSALVGAAVIVLLAPMQYFIATKLAEVQKNTLDYSTERLKKTNEILKGIKLLK 512

  Fly   360 MYAWEQPFEQMVTHAREKEMNTIRQGQYIRGFDFARRIVLSRVAIFLSLVGYV-ILGKVFTPEIA 423
            :||||..|...|...|.||:.:::...............:...|:..:.|.:. :.....||..|
 Frog   513 LYAWENIFCNSVEETRIKELKSLKTFALHTSLSIFMNAAIPIAAVLATFVTHAYVSSSHLTPANA 577

  Fly   424 FMITAYYNVLLAAMSIYVPSAIIQTA-QFLTSIRRVEQFMQSEELGSSDKSEGPSKDTVP----- 482
            |...:.:::|:.  .:::.|.:::.| :.|.|::::.:|..|:|:.......|  :.|:|
 Frog   578 FASLSLFHILVT--PLFLLSTVVRFAVKALVSVQKLNEFFTSDEIREDGFRNG--ETTLPFESCR 638

  Fly   483 GNPPSNN---NEADLLKSAISIRDLKAKWDPNSPD-------------------YTLSGINLEIK 525
            .:|..::   |....|:..:...|...|....:.|                   .||:.|:::|.
 Frog   639 KHPGIHSRAFNRKQPLRYQMDKYDQAPKRQVRTSDTEDAALKVCGGFFSWGTGLATLANIDIQIP 703

  Fly   526 PGSVVAVIGLTGSGKSSLIQAILGELKANSGQL--------------QVNG-------------- 562
            .|.:..::|..|.|||||:.|||||::...|::              ..||
 Frog   704 TGELTMIVGQVGCGKSSLLLAILGEMQTLEGRVVWNKFGSQRRAPGSSANGWDSACGSERSKNRH 768

  Fly   563 SLSYTSQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGG 627
            |::|..|:.||.:.|:.:||.||.|.:.|||:.|...|:|:.|.||||..|.|.:||||..||||
 Frog   769 SVAYAGQKPWLLNATLEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGG 833

  Fly   628 QKARISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCVRGHLRGS--TVVLVTHQEQFLPHVD 690
            |:.||.:||::|:..:|..||||.||:|..::.||..:.:...||..  |||||||:.|:|||.|
 Frog   834 QRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLREDKRTVVLVTHKLQYLPHAD 898

  Fly   691 QIVILANGQIKALGDYESLLKTGLITGLGSLSKTDKAKTEEQEPL------NLNSPDNKNEVTPI 749
            .|:.:.:|         |:|:.|.   |..:...|....|..:.|      .|....:.::||..
 Frog   899 WIIAMKDG---------SVLREGT---LKDIQNNDNELYEHWKTLMNRQDQELEKDSDADQVTME 951

  Fly   750 KE-------NSEQTVGGSSSGKEHVERQESGGISLAL-------YR---KYFQAGGGLVAFLVML 797
            ::       :.|..|......:|..|..|...:|.|:       :|   :|..:||.|:.|| |:
 Frog   952 RKTLRRAMYSREAKVQAEEEEEEEEEEDEDETMSTAMRLRTKFPWRTCWRYLTSGGYLLLFL-MI 1015

  Fly   798 SSSVLAQVAVTGGDYFLTYWVKKESTAAGHGEMEDMESKS--MDVYKYTLI---------IILSV 851
            .|.:|....:...||:|..|. .|::...:.:.:::.|.|  ..:..|.:.         |:|.:
 Frog  1016 FSKLLKHSVIVAIDYWLASWT-SETSNISYAQSDNVTSASELSSIQSYYVTGFSVLSATGIVLCL 1079

  Fly   852 IMNLSSSFLLFNIAKKASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLV 916
            |.:|:..::..|.||    .||:.:..::..|.:.||.....|.|||||:.|.:.:|:.:|..|.
 Frog  1080 IASLTVEWMGLNAAK----NLHHNLLKKIILAPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLE 1140

  Fly   917 DVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAA 981
            .:.:..|.....|.||:...|:.:|..|.|.|.||.::..:...|:||:.::...:.|:..|.:.
 Frog  1141 SLTRSTLLCLSAIGVISYATPISMVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSE 1205

  Fly   982 SLNGLTTIRALD-----AQRVLEKEFDSYQDAHSSAFFMYISTSQAF-----GYCMNCICVIYIS 1036
            :..|||||||..     .||:||     ..|.::.| ::::|.:..:     .|...||
 Frog  1206 TAEGLTTIRAFRHEARFKQRMLE-----LTDTNNLA-YLFLSAANRWLEVRTDYLGACI------ 1258

  Fly  1037 IITLSFFAFPPG-NGADVGLVITQAMGLIDMVQWGVRQTAELENTMTAVERVVEYESIEPEGMLE 1100
            ::|.:.|:...| :...|||.:|.|:.:.:.:.|.||..|:||..:.||::|..:.:||.|....
 Frog  1259 VLTAAVFSITYGLDSGIVGLGLTYALTVTNYLNWVVRNLADLEVQIGAVKKVNSFLNIESECYEG 1323

  Fly  1101 APDDKKPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINA 1165
            :.:.::.|:.||:.|||...:|.:||..|.|.  |||.|...|:|.:||||.||||:|||||..|
 Frog  1324 SMEQQQVPEDWPQSGEIRISDLCVRYENNHKP--VLKHLKAYIKPGQKVGICGRTGSGKSSLSLA 1386

  Fly  1166 LFRL-SYTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLE 1229
            .||: ...||.::||..|..::.|:.||.::|||.|:|:||||::|:||||..:.|||:||..|:
 Frog  1387 FFRMVDIFDGKIVIDGIDISKLPLNTLRSRLSIILQDPILFSGSIRFNLDPECKCSDERLWEGLD 1451

  Fly  1230 EVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQ 1294
            ..:||.:|..||.||.:.::|||.|||||||||.|||||.:|.:.||:||||||::|..|:.::|
 Frog  1452 IAQLKNLVKALPGGLDAMVTEGGENFSVGQRQLFCLARAFVRNSSILIMDEATASIDMATENILQ 1516

  Fly  1295 ATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLV 1352
            ..:.:.|.|.||:|||||:|||:..|..:||..|.::|..:|..|:.:.|| :|.:.|
 Frog  1517 KVVMTAFADRTVVTIAHRVHTILTGDVAIVMRRGNILEHDTPGNLLAQEDS-IFASFV 1573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	413/1412 (29%)
		ABC_membrane	171..437	CDD:294371	68/310 (22%)
		ABCC_MRP_domain1	499..699	CDD:213217	86/248 (35%)
		ABC_membrane	799..1045	CDD:294371	67/266 (25%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	111/221 (50%)
abcc9	XP_031754288.1	MRP_assoc_pro	222..1574	CDD:188098	416/1422 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9436
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010