DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment l(2)03659 and abcc8

DIOPT Version :9

Sequence 1:NP_001260823.1 Gene:l(2)03659 / 47905 FlyBaseID:FBgn0010549 Length:1374 Species:Drosophila melanogaster
Sequence 2:XP_031756190.1 Gene:abcc8 / 101730668 -ID:- Length:1580 Species:Xenopus tropicalis


Alignment Length:1383 Identity:414/1383 - (29%)
Similarity:694/1383 - (50%) Gaps:154/1383 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    95 NFISSLCFWYTIPIFRKGYRKTLDSTD----------------LYRPLEEQKS---------DIL 134
            |.:|...:|:.....:..::|.:|...                |.:....|||         ..:
 Frog   223 NLLSKGTYWWMNTFIKTAHKKPIDLKAIGKLPIAMRAVTNYLLLNKAFHSQKSKSSPCPAGPKSI 287

  Fly   135 GNRLCASWERELKNDGRSPSLVRALLRVFGWQLGFPG-LAIFVVELGL----RTL--QPIFLVKL 192
            ...||.::.|        |.::.::.|:....|||.| |.|..:...|    :|.  |||||.  
 Frog   288 WFALCQAFGR--------PLILSSIFRIMADMLGFAGPLCISGIVHHLSQENKTFHPQPIFLG-- 342

  Fly   193 ISYFSGEPDAANAGFYYAVAQIVISALTVM--ILTPTTFGIHHVCFKMRVAMGSMIFRKALRLTK 255
            :.:.|.:...|||   |.:|.::..||.:.  .|..:.:........:|.|:.:.|:.|.:.|:.
 Frog   343 VFFISSQEFLANA---YVLAVLLFFALLLQRSFLQASYYVAIETGINLRGAIQTKIYNKIMHLST 404

  Fly   256 G--ALGDTTSGHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLL 318
            .  ::|:.:||.:.||::.|..:|....:....||..|:|::|...|:|..:||||:.|.:.:::
 Frog   405 SNMSMGEMSSGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGISALIGAVVIIV 469

  Fly   319 FMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIR 383
            ..|||.::.|:.|..|....|.::.|::..||::..|::||:|:||..|...|...|:||||:::
 Frog   470 LAPIQYFVATKLSQAQRSTLEYSNERLKKTNEMLRGIKLLKLYSWEHIFHSSVEETRQKEMNSLK 534

  Fly   384 QGQYIRGFDFARRIVLSRVAIFLSLVGYVIL--GKVFTPEIAFMITAYYNVLLAAMSIYVPSAII 446
            ...............:...|:.::.|.:|.|  .:.|:|.:||...:.:::|:..:.: :.|.:.
 Frog   535 AFALYTSISIFMNAAIPIAAVLITFVVHVHLLHREQFSPAVAFASLSLFHILVTPLFL-LSSVVR 598

  Fly   447 QTAQFLTSIRRVEQFMQSEELGSSDKSEGPSKDTVPGNP-------------------------- 485
            .|.:.|.|::::.:|..|||:|...:...||..:||.|.                          
 Frog   599 STVKALVSVQKLSEFFSSEEIGEEVEKCPPSNKSVPQNKYQAVPLKVVNRKRPIRDDWNHFNSRQ 663

  Fly   486 -----PSNNNEADLLKSAISIRDLKAKWDPNSPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQ 545
                 |:..||     ..|.:......|.|:.|. .||.|::.|..|.:..::|..|.|||||:.
 Frog   664 RGAPNPTEGNE-----FCIKVTSGFFTWTPDGPP-ALSSIDIRIPQGQLTMIVGQVGCGKSSLLL 722

  Fly   546 AILGELKANSGQLQVN---------------------------GSLSYTSQESWLFSGTVRQNIL 583
            |.|||:...||.:..|                           |:::|.||:.||.:.||.:||.
 Frog   723 ATLGEMHKISGDVSWNSTVPDSETGEDVNPDKETAIDVETRRRGAVAYASQKPWLLNATVEENIT 787

  Fly   584 FGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVYRKASIYLLD 648
            |..|.:.|:|:.::..|:|:.|.|:||..|.|.:||||..|||||:.|||:||.:|::.|:..||
 Frog   788 FESPFNKQKYKAIIDACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARVLYQQTSVVFLD 852

  Fly   649 DPLSAVDASVARHLFDQCVRGHLRGS--TVVLVTHQEQFLPHVDQIVILANGQIKALGDYESLLK 711
            ||.||:|..::.||..:.:...||.:  |.|||||:.|:|||.|.|:.:.:|.|:..|..:.:.|
 Frog   853 DPFSALDIHLSDHLMHEGILKMLRDNKRTTVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDIQK 917

  Fly   712 TG--LITGLGSLSKTDKAKTEEQEPLNLNSPDNKNEVTPIKENSEQTVGGSSSGKEHVERQE--S 772
            :.  |.....:|......:.|::..|:..:...:..:|......:..:|.....:|.:...|  .
 Frog   918 SDPELYEHWKTLMNRQDQELEKEIILDRKAGGERMNLTRTIYPRDALLGDDEEDEEEISESEEDD 982

  Fly   773 GGISLALYR----------KYFQAGGGLVAFLVMLSSSVLAQVAVTGGDYFLTYWVKKESTAAGH 827
            ..:|..|::          ||..:.|.|:..|::| |.:|....:...|::|..|.....|....
 Frog   983 DNLSSVLHQRAKMPWRACGKYLSSAGILLLPLLVL-SQLLKHSVMVAIDFWLAKWTSAAITNLSV 1046

  Fly   828 GEMEDMESKSMDVYKYTLII-ILS---VIMNLSSSFLL----FNIAKKASIRLHNTIFNRVTRAD 884
            .......:...|...|::.. |||   :||.|::|..:    ..:|||    ||:::.|.:..|.
 Frog  1047 ANCSGRPTCRFDHSPYSMAFSILSCVGIIMCLATSIAVEWTGLRVAKK----LHSSLLNAIILAP 1107

  Fly   885 MHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSVI 949
            |.||.....|||||||:.|.:.:|:.:|..|..:.:..|.....:.||:.|.|:.|:..:.|::|
 Frog  1108 MRFFETTPLGSILNRFSADFNTIDQHIPATLECLSRSTLLCVSALAVISYVTPVFLISLVPLAII 1172

  Fly   950 FYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQRVLEKEFDSYQDAHSSAFF 1014
            .|.::..:...||||:::|...:.|:.||.|.::.|||||||...:....::...:.|:::.|..
 Frog  1173 CYFIQKYFRVASRDLQQLEDSTQLPLLSHFAETVEGLTTIRAFRYEPRFRQKLLEHTDSNNIASL 1237

  Fly  1015 MYISTSQAFGYCMNCI--CVIYISIIT--LSFFAFPPGNGADVGLVITQAMGLIDMVQWGVRQTA 1075
            ...:.::.....|..|  ||:.|:.:.  .:...:...:|. |||.:|.|:.:.:.:.|.||..:
 Frog  1238 FLTAANRWLEVRMEYIGACVVLIAAVASITNSLHYNLSSGL-VGLGLTYALMVSNYLNWMVRNLS 1301

  Fly  1076 ELENTMTAVERVVEYESIEPEGMLEAPDDKKPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLS 1140
            ::|..:.||:|:......|||.........:.|..|||.|||..:.|::||..:.|.  |||.::
 Frog  1302 DMEIQLGAVKRINGLLKTEPENYKGLLSPTQIPPNWPENGEIQIQNLSVRYDSSLKP--VLKHVN 1364

  Fly  1141 FVIQPREKVGIVGRTGAGKSSLINALFRLSYT-DGSVLIDTRDTRQMGLHDLRRQISIIPQEPVL 1204
            ..|.|.:|:||.||||:||||...|.||:..| .|.::||..|..::.|..||.::|||.|:|:|
 Frog  1365 AHITPGQKIGICGRTGSGKSSFSLAFFRMVDTFQGRIIIDGIDIAKLPLQTLRSRLSIILQDPIL 1429

  Fly  1205 FSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAI 1269
            ||||:|:||||.::.:|..||..||..:||.||..||.||.:.::|||.|||||||||.|||||.
 Frog  1430 FSGTIRFNLDPENKCTDAMLWEALEIAQLKHVVKVLPGGLDALVTEGGENFSVGQRQLFCLARAF 1494

  Fly  1270 LRENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFG 1334
            :|::.||:||||||::|..|:.::|..:.:.|.|.||:|||||:|||:::|.|:||..|.::|:.
 Frog  1495 VRKSSILIMDEATASIDMATENILQKVVMTAFDDRTVVTIAHRVHTILNADLVIVMKRGAIMEYD 1559

  Fly  1335 SPYELMTKSDSKVFHNLV 1352
            .| |.:.:....:|.:.|
 Frog  1560 KP-EALLEGGGSMFASYV 1576

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)03659NP_001260823.1 CFTR_protein 89..1343 CDD:273530 412/1372 (30%)
ABC_membrane 171..437 CDD:294371 75/278 (27%)
ABCC_MRP_domain1 499..699 CDD:213217 84/228 (37%)
ABC_membrane 799..1045 CDD:294371 68/257 (26%)
ABCC_MRP_domain2 1115..1336 CDD:213211 109/221 (49%)
abcc8XP_031756190.1 MRP_assoc_pro 224..1573 CDD:188098 411/1377 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 69 1.000 Domainoid score I9436
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.010

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