DRSC/TRiP Functional Genomics Resources

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Protein Alignment l(2)03659 and ABCC5

DIOPT Version :9

Sequence 1:NP_001260823.1 Gene:l(2)03659 / 47905 FlyBaseID:FBgn0010549 Length:1374 Species:Drosophila melanogaster
Sequence 2:NP_005679.2 Gene:ABCC5 / 10057 HGNCID:56 Length:1437 Species:Homo sapiens


Alignment Length:1493 Identity:456/1493 - (30%)
Similarity:736/1493 - (49%) Gaps:219/1493 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 SERENTSIEESSLLENNGFDHRNKDESLSVNTSPPLVCRKCFELGHQTENCKQKLTVNSENNSAQ 79
            |.||.||...:         ||::::| ....:.||.|:...|...:.|......:::|:.....
Human    19 SVRERTSTSGT---------HRDREDS-KFRRTRPLECQDALETAARAEGLSLDASMHSQLRILD 73

  Fly    80 NEKEK---------VLP-------ENPRARSNFISSLCFWYTIPIFRKGYRK-TLDSTDLYRPLE 127
            .|..|         :.|       ::|...:...|.:.|.:...:.|..::| .|...|::...:
Human    74 EEHPKGKYHHGLSALKPIRTTSKHQHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSK 138

  Fly   128 EQKSDILGNRLCASWERELKNDGRSPSLVRALLRVFGWQLGFPGLAIFVVELGLRTLQ----PIF 188
            .:.||:...||...|:.||...|...:.:|.::    |......|.:.:|.|.:..|.    |.|
Human   139 HESSDVNCRRLERLWQEELNEVGPDAASLRRVV----WIFCRTRLILSIVCLMITQLAGFSGPAF 199

  Fly   189 LVK-LISYFSGEPDAANAGFYYAVAQIVISALTVMILT---PTTFGIHH-VCFKMRVAMGSMIFR 248
            :|| |:.|    ..|..:...|::..::...||.::.:   ..|:.::: ...::|.|:.:|.|:
Human   200 MVKHLLEY----TQATESNLQYSLLLVLGLLLTEIVRSWSLALTWALNYRTGVRLRGAILTMAFK 260

  Fly   249 KALRLTKGALGDTTSGHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEI--GISAVF 311
            |.|:|..  :.:.:.|.::|:.|||..|:..|......|..||  |:.|..::|..|  |.:...
Human   261 KILKLKN--IKEKSLGELINICSNDGQRMFEAAAVGSLLAGGP--VVAILGMIYNVIILGPTGFL 321

  Fly   312 GVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHARE 376
            |....:||.|..|:....|:..:.|....||.|::.:||:::.|:.:|||||.:.|.|.|...||
Human   322 GSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIRE 386

  Fly   377 KEMNTIRQGQYIRGFDFARRIVLSRVAIFLSLVGYVILGKVFTPEIAFMITAYYNVLLAAMSIYV 441
            :|...:.:..|.:........::..:|..::...::.||...|...||.:...:|.:..|:.: .
Human   387 EERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTFALKV-T 450

  Fly   442 PSAIIQTAQFLTSIRRVEQFMQSEELGSSDKSEGPSKDTVPGNPPSNNNEADLLKSAISIRDLKA 506
            |.::...::...::.|.:.....||:           ..:...|.|.:.:.::..:.::      
Human   451 PFSVKSLSEASVAVDRFKSLFLMEEV-----------HMIKNKPASPHIKIEMKNATLA------ 498

  Fly   507 KWD------PNSP---------------------------------------------------- 513
             ||      .|||                                                    
Human   499 -WDSSHSSIQNSPKLTPKMKKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLLLDSDERPSPEEE 562

  Fly   514 ------------DYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGSLSY 566
                        ..||..|:|||:.|.:|.:.|..||||:|||.||||::....|.:.::|:.:|
Human   563 EGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAY 627

  Fly   567 TSQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKAR 631
            .:|::|:.:.|:|.|||||:..|.:||..|:..|.|..|..:||..|.|.:|||||.|||||:.|
Human   628 VAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQR 692

  Fly   632 ISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCVRGHLRGSTVVLVTHQEQFLPHVDQIVILA 696
            |||||::|...|||:|||||||:||.|..|:|:..:|.||:..||:.||||.|:|...|:::.:.
Human   693 ISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMK 757

  Fly   697 NGQIKALGDYESLLK---------TGLITGLGSLSKTDKAKTEEQEPLNLNSPDNKNEVTPIKEN 752
            .|.|...|.:|.|:.         ..|:.|             |..|:.:||   |.|.:..::.
Human   758 EGCITERGTHEELMNLNGDYATIFNNLLLG-------------ETPPVEINS---KKETSGSQKK 806

  Fly   753 SEQTVGGSSSG---KE-----------HVERQESGGISLALYRKYFQAGGGLVAFLVMLSSSVLA 803
            |:..  |..:|   ||           .:|.:..|.:..::|..|.||.||.:||||:::..:|.
Human   807 SQDK--GPKTGSVKKEKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLN 869

  Fly   804 QVAVTGGDYFLTYWVKKES-----TAAGHGEMED--MESKSMDVYK--YTLIIILSVIMNLSSSF 859
            ..:.....::|:||:|:.|     |......:.|  .::..|..|.  |.|.:.:.:|:......
Human   870 VGSTAFSTWWLSYWIKQGSGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVMLILKAIRGV 934

  Fly   860 LLFNIAKKASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALW 924
            :......:||.|||:.:|.|:.|:.|.||.....|.|||||:|||.:||..||      .|..::
Human   935 VFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLP------FQAEMF 993

  Fly   925 LAGIIIV------IANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASL 983
            :..:|:|      ||.|.|..||....|.::|..|..:.....|:|||::.|.:||..||:.:|:
Human   994 IQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSRVLIRELKRLDNITQSPFLSHITSSI 1058

  Fly   984 NGLTTIRALDAQRVLEKEFDSYQDAHSSAFFMYISTSQAFGYCMNCICVIYIS----IITLSFFA 1044
            .||.||.|.:..:.....:....|.:.:.||::....:.....::.|.:..|:    :|.|....
Human  1059 QGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQ 1123

  Fly  1045 FPPGNGADVGLVITQAMGLIDMVQWGVRQTAELENTMTAVERVVEY-ESIEPEGMLEAP---DDK 1105
            .||   |..||.|:.|:.|..:.|:.||..:|.|...|:|||:..| :::.    ||||   .:|
Human  1124 IPP---AYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLS----LEAPARIKNK 1181

  Fly  1106 KPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFRL- 1169
            .|...||::||:.|:...:||..|...  |||.:||.|:|:||:|||||||:|||||..||||| 
Human  1182 APSPDWPQEGEVTFENAEMRYRENLPL--VLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLV 1244

  Fly  1170 SYTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLK 1234
            ..:.|.:.||......:||.|||.::|||||||||||||:|.|||||::|:::::|..||...:|
Human  1245 ELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMK 1309

  Fly  1235 EVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQATIRS 1299
            |.::.||..|.|::.|.|.|||||:|||:|:|||:||..:||::|||||.:|.:||.|||.|||.
Human  1310 ECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIRE 1374

  Fly  1300 KFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLVNQSGRASYEG 1362
            .|.|||:|||||||||::.||::||:..|:||||.:|..|::...|:.:........:.:.:|
Human  1375 AFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAENKVAVKG 1437

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)03659NP_001260823.1 CFTR_protein 89..1343 CDD:273530 437/1382 (32%)
ABC_membrane 171..437 CDD:294371 69/276 (25%)
ABCC_MRP_domain1 499..699 CDD:213217 92/269 (34%)
ABC_membrane 799..1045 CDD:294371 71/264 (27%)
ABCC_MRP_domain2 1115..1336 CDD:213211 123/221 (56%)
ABCC5NP_005679.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 15..41 8/31 (26%)
CFTR_protein 100..1430 CDD:273530 438/1393 (31%)
ABC_membrane <271..447 CDD:294371 47/177 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 501..538 3/36 (8%)
ABCC_MRP_domain1 577..759 CDD:213217 87/181 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 794..827 9/37 (24%)
ABC_membrane 863..1143 CDD:294371 79/288 (27%)
ABCC_MRP_domain2 1191..1411 CDD:213211 123/221 (56%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151534
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.660

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