DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and abcc6

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	XP_002932264.3	Gene:	abcc6 / 100493037	XenbaseID:	XB-GENE-6465366	Length:	1500	Species:	Xenopus tropicalis

Alignment Length:	1377	Identity:	452/1377 - (32%)
Similarity:	722/1377 - (52%)	Gaps:	158/1377 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 TVNSENNSAQNEKEKVLPENPRARSNFISSLCF-WYTIPIFRKGYRKTLDSTDLYRPLEEQKSDI 133
            |.|.:.....|.|::..| .|.:.|:|:|.:.| |:|..:|| ||::.|.:.|::...:...::.
Frog   188 TFNDDPPFFSNLKKESNP-CPVSESSFLSKVTFSWFTEIMFR-GYKQPLKAEDVWSLRKSDTAEE 250

  Fly   134 LGNRLCASWERE------LKNDGR-SPS-------------------------------LVRALL 160
            :........|:|      ||...| |||                               |::.::
Frog   251 ILTLFSKGVEKECKKANLLKEPTRFSPSTLDNDMWISQTEKSEIELLLKNQHIQLSQKTLLKVIM 315

  Fly   161 RVFGWQLGFPGLAIFVVELGLRTLQPIF------LVKLISYFSGEPDAAN-AGFYYAVAQIVISA 218
            |.||        ..|::...|.|....|      ||:|:.....:|.|.: .||..||...:...
Frog   316 RSFG--------LYFLLSALLMTFYTAFLFISPLLVRLLLQLLKDPSAPSWQGFLVAVFLFICPC 372

  Fly   219 LTVMILTPTTFGIHHVCFKMRVAMGSMIFRKALRLTKGALGDTTSGHVVNLISNDIPRLDSAPYT 283
            ...:.|....:..:.:..::|.|:...:::|||.::.....::::|.:|||||.|:.:|......
Frog   373 CQSLFLHQHDYICYVIGMRLRAAIVGTVYKKALMISSAGRKESSAGEIVNLISTDVQKLMDLATC 437

  Fly   284 VHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIRMV 348
            |:|:|..|:.::|..|.::|.:||:.:.||...:|.:|...........:|.:..::.|.||:::
Frog   438 VNYMWSAPVTIIVAMYFLWQTLGIAVLAGVAVFILNLPFMTVFAVIIKRVQEQQMKQKDGRIKII 502

  Fly   349 NEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQYIRGFDFARRIV------LSRVAIFLS 407
            :||:..|:|||:||||..|.:.||..|..|:..::.|..:.....|..:.      |:...:||:
Frog   503 SEILQGIKVLKLYAWENAFMKKVTEFRLMELKAVKTGALLLSGALAVFVASPFWVSLTMFGVFLA 567

  Fly   408 LVGYVILGKVFTPEIAFMITAYYNVLLAAMSIYVPSAIIQTAQFLTSIRRVEQFMQSEELGSSDK 472
            |....||    ..|.||:.....|:|...:.:: |.||...||...|::|:.:|..:|||
Frog   568 LDEKNIL----DAEKAFVTIILLNILRIPLRMF-PMAITLFAQSSVSLKRMVKFFSAEEL----- 622

  Fly   473 SEGPSKDTVPGNPPSNNNEADLLKSAISIRDLKAKWDPNSPDYTLSGINLEIKPGSVVAVIGLTG 537
                       .|.|.:....|.|.||:||.....|..:.|. .|..||:.|..|::|||:|..|
Frog   623 -----------EPESVDINDSLSKHAITIRHGTFTWSSSEPP-CLQSINIGIPQGTLVAVVGQVG 675

  Fly   538 SGKSSLIQAILGELKANSGQLQVNGSLSYTSQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCAL 602
            .||:||:.|:|||::...||:.:..|::|..|::|:.:.|.::|:|||:.|:...|::||:.|||
Frog   676 CGKTSLLSALLGEMEKVEGQVSLMSSVAYVPQQTWIPNATFKENVLFGRKMEKCWYDQVVQACAL 740

  Fly   603 ERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCV 667
            ..|..:|...:||.:||:|..||||||.|||:||:|||...:||||||||||||.|.:|||:|.:
Frog   741 LPDLKILSGGENTEIGEKGVNLSGGQKQRISIARAVYRNCDVYLLDDPLSAVDAHVGQHLFEQVI 805

  Fly   668 --RGHLRGSTVVLVTHQEQFLPHVDQIVILANGQIKALGDYESLL-KTG----LITGLGSLSKTD 725
              .|.|:..|.|||||...|||.:|.|:::::|::..:|.|..|| |.|    .:......|...
Frog   806 GPSGLLKDKTRVLVTHGVSFLPQMDMIIVMSDGRVSEVGTYNELLQKNGAFSEFLNTYARKSVVF 870

  Fly   726 KAKTEEQEPLNLNSP-----------DNKNEVTPIKENSEQTVGGSSSGKEHVERQESGGISLAL 779
            :...|||.|.::...           |..||...:....|...|..:.....:    :|.:.|::
Frog   871 EESYEEQTPNSIQGAMKMKGKHSARNDTDNETDDVANEIEADAGKLTEADVAL----TGRVKLSV 931

  Fly   780 YRKYFQAGGGLVAFLVMLSS--SVLAQVAVTGGDYFLTYWVKKESTAAGHGEMEDMESKSMDVYK 842
            |.:|.:..|   .:.:::|:  .::.|.|....:|::..|......   :|..:. .|..:.||.
Frog   932 YLEYCKIMG---KWYLLISALFFIVQQAASLSYNYWIGLWADDPPV---NGTQQH-TSLRLGVYS 989

  Fly   843 YTLIIILSVIMNLSSSFLLFNIAKKASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQV 907
            :..::....|...||:.::..::  .|.:||:.:...:.|..:.||.....|::.|||.|:|..:
Frog   990 FLGVMQALSIFAASSTIIVGGVS--VSRQLHSRLLYSILRCPLSFFERTPSGNLTNRFAKEMDII 1052

  Fly   908 DEVLPVVLVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINR 972
            |..:|.||:..:.:.|.:|.|::||:...||..|..:.|.::::.|:..|:.:||.|||::|:::
Frog  1053 DNTVPQVLMLFIIMMLTIAEILLVISIATPLAAVAFIPLGLLYFFLQRFYVASSRQLKRLDAVSK 1117

  Fly   973 SPVYSHLAASLNGLTTIRALDAQRVLEKEFDSYQDAHSSAFFMYISTSQAFGYC---------MN 1028
            ||:|:|...||.|:..|||...|    :.|  .||.:     |.::.:|.|.:|         :.
Frog  1118 SPLYTHFNESLQGVYVIRAFREQ----ERF--IQDNN-----MRLNMNQRFYFCSFVANRWLSVR 1171

  Fly  1029 C-----ICVIYISIITLSF-FAFPPGNGADVGLVITQAMGLIDMVQWGVRQTAELENTMTAVERV 1087
            |     ..|..::|:.:.| ....||.   |||.:..::.|..:::..|....::|....:||||
Frog  1172 CDFLSNFIVFTVAIVGVLFRDNITPGL---VGLAVVNSLRLTGVLKEAVHVATDMETNSVSVERV 1233

  Fly  1088 VEYESIEPEGMLEAP---DDKKPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKV 1149
            .||...||    |||   |:......||.:|:|.|:...|||.|:  .:..||:::..||..|||
Frog  1234 KEYCDAEP----EAPWTSDNASDLSNWPSKGKIEFQNYGLRYRPD--LDLALKNVTASIQQGEKV 1292

  Fly  1150 GIVGRTGAGKSSLINALFR-LSYTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNL 1213
            |||||||||||||...||| |....|.:.||.:|..::|||:||.:|:||||:|||||||:|.||
Frog  1293 GIVGRTGAGKSSLTLGLFRILEPATGRICIDEKDISELGLHELRSKITIIPQDPVLFSGTLRMNL 1357

  Fly  1214 DPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVM 1278
            ||||.|||..:|..|:...||...|.||:||:...:|||.|.|||||||||||||:||:.:|||:
Frog  1358 DPFDNYSDNDIWVALQLAHLKVFASGLPEGLSYICTEGGENLSVGQRQLVCLARALLRKTKILVL 1422

  Fly  1279 DEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKS 1343
            |||||.||.:||.|||.|||.:|.|||::||||||:||:|..:|:|.|.|.:|||.:|..|:  .
Frog  1423 DEATAAVDLETDDLIQNTIRKEFEDCTIITIAHRLNTIMDYTRVVVFDKGEIVEFDTPATLL--E 1485

  Fly  1344 DSKVFHNLVNQS 1355
            :..:|:::...:
Frog  1486 NKGLFYSMARDA 1497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	446/1344 (33%)
		ABC_membrane	171..437	CDD:294371	72/278 (26%)
		ABCC_MRP_domain1	499..699	CDD:213217	92/201 (46%)
		ABC_membrane	799..1045	CDD:294371	66/262 (25%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	128/221 (58%)
abcc6	XP_002932264.3	MRP_assoc_pro	5..1499	CDD:188098	452/1377 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010