Protein Alignment l(2)03659 and cftr

DIOPT Version :9

• Sequence 1: NP_001260823.1
• Gene: l(2)03659 / 47905
• FlyBaseID: FBgn0010549
• Length: 1374
• Species: Drosophila melanogaster
• Sequence 2: XP_031754831.1
• Gene: cftr / 100486085
• XenbaseID: XB-GENE-853972
• Length: 1485
• Species: Xenopus tropicalis
• Alignment Length: 1494
• Identity: 407/1494 - (27%)
• Similarity: 713/1494 - (47%)
• Gaps: 267/1494 - (17%)

  Fly    86 LPENPRARSNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNRLCASWERELKNDG 150
            :..:|..:::..|.:.|.:|.||..||||:.|:.:|:|:......:|.|..||...|:||:....
 Frog     1 MQRSPLEKASIFSQIFFSWTKPILWKGYRQRLELSDIYQIHPGDSADNLSERLEREWDREVATSK 65

  Fly   151 RSPSLVRALLRVFGWQLGFPGLAIFVVELGLRTLQPIFLVKLI-SYFSGEPDAANAGFYYAVAQI 214
            ::|.|:.||.|.|.|:..|.|:.:::.|: .:.:||:.|.::| ||........:..:|.|:...
 Frog    66 KNPKLINALKRCFFWKFLFYGILLYLGEV-TKAVQPLLLGRIIASYDRDNEHERSIAYYLAIGLC 129

  Fly   215 VISALTVMILTPTTFGIHHVCFKMRVAMGSMIFRKALRLTKGALGDTTSGHVVNLISNDIPRLDS 279
            ::..:.:::|.|..||:||:..:||:||.|:|::|.|:|:...|...::|.:|:|:||::.:.|.
 Frog   130 LLFVVRMLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISTGQLVSLLSNNLNKFDE 194

  Fly   280 APYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNR 344
            .....|::|:.|||||::..|::..:..||..|:.|:::....|.:||......:.|.|.:.:.|
 Frog   195 GLALAHFVWIAPLQVLLLMGLLWDLLQASAFCGLGFLIILALFQAWLGRMMMKYRDKRAGKINER 259

  Fly   345 IRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQYIRGFDFARRIVLSRVAIFLSLV 409
            :.:.:|||..||.:|.|.||...|:::...||.|:...|:..|:|.|:.:.........:||.:|
 Frog   260 LVITSEIIENIQSVKAYCWESAMEKIIETIRETELKLTRKAAYVRYFNSSAFFFSGFFVVFLCIV 324

  Fly   410 GYVILG-----KVFTPEIAFMITAYYNVLLAAMSIYVPSAIIQTAQFLTSIRRVEQFMQSEELGS 469
            .:::|.     |:|| .|:|.|     ||..|::...|.|:......|..|.::::|:|.||..|
 Frog   325 PHLLLDGISLRKIFT-TISFSI-----VLRMAVTRQFPWAVQTWYDSLGVINKIQEFLQKEEYKS 383

  Fly   470 SDKSEGPSKDTVPGNPPSNNNEADLLKSAISIRDLKAKWDPN----------------------S 512
            .                    |.:|..:.:::.::.|.||..                      |
 Frog   384 L--------------------EYNLTTTEVAMENVSASWDEGIGEFFEKAKQEVNGGNISNEDPS 428

  Fly   513 PDYT---------LSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGSLSYTS 568
            |.::         |..||.:|:.|.::|:.|.||:||:||:..|:|||:.::|:::.:|.:|::.
 Frog   429 PFFSNFSLHVAPVLRNINFKIEKGQLLAIAGSTGAGKTSLLMMIMGELEPSAGKIKHSGRISFSP 493

  Fly   569 QESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARIS 633
            |.||:..||:::||:||...|..||..|:|.|.||.|....|.:|||::||.|.||||||:||||
 Frog   494 QVSWIMPGTIKENIIFGVSYDQYRYLSVIKACQLEEDISKFPEKDNTVLGEGGITLSGGQRARIS 558

  Fly   634 LARSVYRKASIYLLDDPLSAVDASVARHLFDQCVRGHLRGSTVVLVTHQEQFLPHVDQIVILANG 698
            |||:||:.|.:||:|.|.|.:|....:.:|:.||...:...|.:|||.:.:.|...|:::||..|
 Frog   559 LARAVYKDADLYLMDSPFSYLDLFTEKEIFESCVCKLMANKTRILVTSKVEQLKKADKVLILHEG 623

  Fly   699 ------------------------------------------------------------QIKAL 703
                                                                        ..|.:
 Frog   624 SCYFYGTFSELQDQRPEFSSHLTGFDHFNAERRNSIITETLRRCSIDSDPTAVRNEVKNKSFKQV 688

  Fly   704 GDYESLLKTGLITGLGSLSK---TDKAKTE----EQEPLNLNSPDNKNEVTPIKENSEQTV---- 757
            .|:....|..:|....|..|   ..|::.:    |:|.:..|..:.|..:.|..|..|.::
 Frog   689 ADFSEKRKNSVINPRKSSRKFSIMQKSQPQMSGIEEEDIPPNQGERKLSLVPESEQGEASLPRSN 753

  Fly   758 ----GGSSSGKEH-------------------------VERQESGGISLA--------------- 778
                |.:..|:..                         |.:...|..|.:
 Frog   754 VLNTGPTFQGRRRQSVLNLMTRTSVSQGSNAFATRNTSVRKMSVGSFSNSSFEVDIYNRRLSQDS 818

  Fly   779 -------------------------------LYRKYFQAGGGLVAFLVMLSSSVLAQVAVTGGDY 812
                                           .|.::..|....:..||......||:|..:...
 Frog   819 ILEVSEEINEEDLKECFLDDTDSPSPTTTWNTYIRFLTAHKNFIFILVFCIVIFLAEVIASSAG- 882

  Fly   813 FLTYWVKKESTAAGHGEMEDMESKSMDVYKYTLIIILSVIMNLSSSFLLFNI------------- 864
               .|:.|.:....:....:..|::.|        |||||:..:|.:.:|.|
 Frog   883 ---LWIIKRNAPVSNMTSNENISEASD--------ILSVIVTHTSFYYVFYIYVGVADSLLALGI 936

  Fly   865 ---------AKKASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQ 920
                     ....|..||..:.:.:..|.|..|:..:.|.|||||:||.:.:|::||:.:.|..|
 Frog   937 FRGLPLVHSLISVSRVLHKKMLHSILHAPMSTFNTMRAGRILNRFSKDTAILDDILPLSIFDFTQ 1001

  Fly   921 IALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNG 985
            :.|.:.|.|.|::.:.|.:.:.|:.:...|..||:.:|.||:.||::|:..|||:::||..||.|
 Frog  1002 LVLIVIGAITVVSLLEPYIFLATVPVIAAFILLRSYFLHTSQQLKQLESEARSPIFAHLITSLKG 1066

  Fly   986 LTTIRALDAQRVLEKEFDSYQDAHSSAFFMYISTSQAFGYCMNCICVIYISIITLSFFAFPPGNG 1050
            |.|:||...|...|..|....:.|::.:|:|:||.:.|...:..|.||:  .|.:||.:......
 Frog  1067 LWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMTIEMIFVIF--FIAVSFISIATSGA 1129

  Fly  1051 AD--VGLVITQAMGLIDMVQWGVRQTAELENTMTAVERVVEYESIEPEGMLEAPDDK-------- 1105
            .:  ||:|:|.||.:::.:||.|..:.::::.|.:|.|:..:..:..|.::...:.|
 Frog  1130 GEEKVGIVLTLAMNIMNTLQWAVNASIDVDSLMRSVSRIFRFIDMPREELIHDNNHKDDQLSEVL 1194

  Fly  1106 -------KPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLI 1163
                   |..:.||..|::..|.|:.:|...  ...||:::||.:.|.::||::||||:|||:|:
 Frog  1195 IYENDYIKKNQVWPSGGQMTVKNLSAKYKDG--GHTVLENISFSLNPGQRVGLLGRTGSGKSTLL 1257

  Fly  1164 NALFRLSYTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCL 1228
            :|..||..|.|.:.||....:.:.|...|:...::||:..:||||:|.||||:.::|||:|....
 Frog  1258 SAFLRLLSTQGDIQIDGVSWQTIPLQKWRKAFGVVPQKVFIFSGTIRKNLDPYGKWSDEELLKVT 1322

  Fly  1229 EEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLI 1293
            |||.||.::...|..|...:.:||...|.|.:|||||||::|.:.:||::||.:|::||.|..:|
 Frog  1323 EEVGLKSIIDQFPGQLDFVLLDGGCVLSHGHKQLVCLARSVLSKAKILLLDEPSAHLDPITFQII 1387

  Fly  1294 QATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLVNQSGR 1357
            :.|::..|.:|||:...|||..:::....:|::...|.::.|..:||  ::...|...::||.|
 Frog  1388 RKTLKHAFANCTVILSEHRLEAMLECQHFLVIEDNTVRQYDSIQKLM--NEKSFFKQAISQSDR 1449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	403/1475 (27%)
		ABC_membrane	171..437	CDD:294371	79/271 (29%)
		ABCC_MRP_domain1	499..699	CDD:213217	84/290 (29%)
		ABC_membrane	799..1045	CDD:294371	76/267 (28%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	81/220 (37%)
cftr	XP_031754831.1	CFTR_protein	1..1472	CDD:273530	407/1494 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.110