DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment l(2)03659 and abcc2

DIOPT Version :9

Sequence 1:NP_001260823.1 Gene:l(2)03659 / 47905 FlyBaseID:FBgn0010549 Length:1374 Species:Drosophila melanogaster
Sequence 2:XP_004915926.1 Gene:abcc2 / 100485020 XenbaseID:XB-GENE-1012796 Length:1552 Species:Xenopus tropicalis


Alignment Length:1420 Identity:479/1420 - (33%)
Similarity:746/1420 - (52%) Gaps:206/1420 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    77 SAQNEKEKVLPENPRARSNFISSLCF-WYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNRLCA 140
            ||.:||.:...|||...::|:|.:.| ||. .|..|||:|.|:..||:...||.|:    ..:..
 Frog   190 SAISEKNESTKENPELTASFLSRITFNWYN-SIVVKGYKKPLEMEDLWELNEEDKT----KNMYE 249

  Fly   141 SWERELKNDGRSPS--------------------------------------------------- 154
            .:|:.:|:|.|...                                                   
 Frog   250 IFEKHMKHDVRKAKKDLEKRKNKRKQKESGIEMNGISKAQSQDILVMEEKKKEKKKKEKSIDGTA 314

  Fly   155 -------LVRALLRVFGWQLGFPGL----AIFVVELGLRTLQPIFLVKLISYFSGEPDAAN-AGF 207
                   |::.|::.      ||..    |||.:...|.......::|::..|:.:|.... .||
 Frog   315 KDYPKRWLIKTLIKT------FPSTLLTSAIFKLLHDLLAFVSPQILKVMVTFTADPSQHQWQGF 373

  Fly   208 YYAVAQIVISALTVMILTPTTFGIHHVCF----KMRVAMGSMIFRKALRLTKGALGDTTSGHVVN 268
            :|||. ::::||....|....|   |.||    ::|..:.:.:::|||.::.....::|.|..||
 Frog   374 FYAVL-LLVTALLQSFLLQQYF---HGCFVLGMRVRSLLMAAVYKKALTVSNAIRKESTVGETVN 434

  Fly   269 LISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAI 333
            |:|.|..|.......:|.||..|||:.:....:::|:|.|.:.|:..|:|.:||...|.|.:..:
 Frog   435 LMSADAQRFMDLTNFIHLLWSSPLQIAISIVFLWEELGPSVLAGLGVMILLIPINAVLATVSRKL 499

  Fly   334 QLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQYIRG---FDFAR 395
            |:|..:..|.|::::|||::.|::||:||||..||..|...||||:..:....|:..   |.|..
 Frog   500 QMKNMKNKDKRMKIMNEILNGIKILKLYAWEPSFENQVQEIREKELKDMLHFTYLHSVSLFVFTC 564

  Fly   396 RIVLSRVAIFLSLVGYVILGKVFTPEIAFMITAYYNVL---LAAMSIYVPSAIIQTAQFLTSIRR 457
            ...|..||.|...|. |....|...|.||...:.:|:|   ||.:.:.: |:::||:   .|..|
 Frog   565 APFLVSVATFAVYVA-VDPSNVLNAEKAFTSISLFNILRFPLAMLPMLI-SSMVQTS---VSSAR 624

  Fly   458 VEQFMQSEELGSSDKSEGPSKDTVPGNPPSNNNEADLLKSAISIRDLKAKWDPNSPDYTLSGINL 522
            :|:::..:.|.:|.....|:.|                 :|:...|....|:.:: :..::.:||
 Frog   625 LEKYLGGDNLDTSAIRCDPNID-----------------AAVQFSDATFSWEEDA-NPAVNNVNL 671

  Fly   523 EIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGSLSYTSQESWLFSGTVRQNILFGQP 587
            :||.|::|||:|..|||||||:.|:|||:....|.:.:.||::|..|::|:.:.|::.|||||..
 Frog   672 DIKEGNLVAVVGGVGSGKSSLVSAMLGEMDHVGGYINIKGSIAYVPQQAWIQNATLKNNILFGSK 736

  Fly   588 MDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVYRKASIYLLDDPLS 652
            ||.:||::|::.|||..|.::||..|.:.:||:|..||||||.|:||||:||..|.||:||||||
 Frog   737 MDEERYQKVLEACALLPDLEMLPGHDESEIGEKGINLSGGQKQRVSLARAVYNDADIYILDDPLS 801

  Fly   653 AVDASVARHLFDQCV--RGHLRGSTVVLVTHQEQFLPHVDQIVILANGQIKALGDYESLL----- 710
            ||||.|.:|:|::.|  .|.|:..|.:||||...||.|.|.||:|.|.::...|.|::|.     
 Frog   802 AVDAHVGKHIFEKVVGPNGLLKNKTRILVTHGVSFLKHADDIVVLVNSRVTETGSYKTLQANNGA 866

  Fly   711 -----------------KTGLITGLGSLSKTDKAKTEEQ-EPLNLNSPDNKNEVTPIKENS---- 753
                             :..:.||.......|:.:|.|. |.:..::...:|.:...|.:|    
 Frog   867 FAEFLRLYAKQNDQTDNEATVFTGEDDEDDGDQVETAEVIEDIVASTVKRENSMRQRKRSSVSMN 931

  Fly   754 ------------EQTVGGS--SSGKEHVERQ--ESGGISLALYRKYFQAGGGLVAFLVMLSSSVL 802
                        ::|..||  :.|::.:|::  |:|.:...||.||.:|.|...:|.:.: |.:|
 Frog   932 GTLRRSVKDVTKKKTGIGSNDTKGQKLIEKETVETGKVKFKLYLKYLRAVGWGFSFWIFV-SYIL 995

  Fly   803 AQVAVTGGDYFLTYWVKKESTAAGHGEME-------DMESKSMDVYKYTLIIILSVIMNLSSSFL 860
            ...|..|.:.:|:.|.         |:.|       ....:.|.|..:..:.:...:..|..:||
 Frog   996 QNAAFVGQNIWLSDWT---------GDAEKYYNITYPASQRDMRVGVFGALGVAQALFVLLGAFL 1051

  Fly   861 LFNIAKKASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWL 925
            :...|.:||..||..:.:.:.|..|.||.....|.|:|||.||:..|||.:|      |....|:
 Frog  1052 VSGGAVRASRMLHTQLLHNILRVPMRFFDTTPTGRIVNRFAKDILTVDETIP------MSFRSWI 1110

  Fly   926 A------GIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLN 984
            |      |.:.:|....|:.....:.|::.:|.::..|:.|||.|:|::::.|||:|||...:::
 Frog  1111 ACFLGVIGTLFIICLATPIFAAVIVPLAIFYYFVQRFYVTTSRQLRRLDSVTRSPIYSHFGETVS 1175

  Fly   985 GLTTIRALDAQ-RVLEKEFDSYQDAHSSAFFMYISTSQAFGYCMNCICVIYISIITLSFFAF--P 1046
            ||:.|||...| |.|:...|:..:...|.:...:|....      .|.:.::..:|:.|.|.  .
 Frog  1176 GLSVIRAYGHQDRFLQHNEDTIDNNQKSVYSWIVSNRWL------AIRLEFVGNLTVFFAALFAV 1234

  Fly  1047 PGNG----ADVGLVITQAMGLIDMVQWGVRQTAELENTMTAVERVVEYESIEPEGMLEAPDDKKP 1107
            .|.|    ..|||.|:.|:.:...:.|.||.|:|||..:.|||||.||..:|.|.  :..:|.:|
 Frog  1235 LGRGTVDSGTVGLSISSALNITQTLNWLVRMTSELETNIVAVERVDEYIKVEREA--QWVEDHRP 1297

  Fly  1108 PKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFR-LSY 1171
            ||.|||:|.:.|.:..:||.|  :.:.||:.:|..|...||||||||||||||||.|.:|| :..
 Frog  1298 PKDWPEKGVVQFVDYKVRYRP--ELDLVLQGISCTINSMEKVGIVGRTGAGKSSLTNCIFRIIES 1360

  Fly  1172 TDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEV 1236
            ..|.::||..|...:||||||::::||||:||||||.:|.|||||::|:||.:|..||...||..
 Frog  1361 AGGKIMIDGLDIASIGLHDLRQKLTIIPQDPVLFSGNLRMNLDPFNQYTDEDIWKALELSHLKPF 1425

  Fly  1237 VSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQATIRSKF 1301
            |..|.:.|..::||||.|.|||||||||||||:||:::||::|||||.||.:||.|||.||||:|
 Frog  1426 VEGLQEKLFHEVSEGGENLSVGQRQLVCLARALLRKSKILILDEATAAVDLETDNLIQRTIRSEF 1490

  Fly  1302 RDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLVNQSG 1356
            .||||||||||||||:||.::||:|||:::|||||.||:.:...  |.::...:|
 Frog  1491 ADCTVLTIAHRLHTIMDSSRLMVLDAGKIIEFGSPDELLQRQGH--FFSMAKDAG 1543

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)03659NP_001260823.1 CFTR_protein 89..1343 CDD:273530 472/1393 (34%)
ABC_membrane 171..437 CDD:294371 85/280 (30%)
ABCC_MRP_domain1 499..699 CDD:213217 94/201 (47%)
ABC_membrane 799..1045 CDD:294371 67/259 (26%)
ABCC_MRP_domain2 1115..1336 CDD:213211 128/221 (58%)
abcc2XP_004915926.1 MRP_assoc_pro 10..1544 CDD:188098 479/1420 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.930

Return to query results.
Submit another query.