DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and abcc8b

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	XP_021323602.1	Gene:	abcc8b / 100329706	ZFINID:	ZDB-GENE-120215-45	Length:	1607	Species:	Danio rerio

Alignment Length:	1397	Identity:	407/1397 - (29%)
Similarity:	684/1397 - (48%)	Gaps:	191/1397 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 LPENPRARSNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNRLCASWE-RELKND 149
            ||::.||.|||              :..||..||     .:|.....:.|    :.|. |.|:..
Zfish   268 LPKSMRALSNF--------------QQLRKAFDS-----QMESGCVHLQG----SGWMWRALRQA 309

  Fly   150 GRSPSLVRALLRVFGWQLGFPGLAIFVVELGLRTLQPIFLVKLISYFSGEPDAA----------- 203
            ..:|.|:....|.....|||.|              |:.:..::.:.|.:...|
Zfish   310 FGAPLLLSICFRFISDLLGFAG--------------PLCISGILQHISRDNHTAPPPVKLLGVHF 360

  Fly   204 -NAGFYYAVAQIVISALTVMILTPTTF--GIHHVCFK----MRVAMGSMIFRKALRL--TKGALG 259
             ::..::|.|.::...|.:.:|...||  ..::|..:    :|.|:.:.|:.|.:||  :..::|
Zfish   361 ISSEVFFANAYVLAVLLFLALLLQRTFLQASYYVAIENGINLRGAVQTKIYNKIMRLCTSNMSMG 425

  Fly   260 DTTSGHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMPIQM 324
            |.|:..:.||::.|..:|....:....||..|:|:::...|:|..:|.||:.|...:.:..|:|.
Zfish   426 DMTTAQICNLVARDTNQLMWFFFLCPNLWAMPVQIVIGVLLLYYLLGASALIGATVITVLAPLQY 490

  Fly   325 YLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQYIR 389
            ::.||.|..|....|.|..|::..||::..|::||:||||..|...|...|.:|:.::|......
Zfish   491 FVATRLSRAQKSTLEYTSERLKKTNELLRGIKLLKLYAWEHIFRSSVEETRRQELTSLRTFALYT 555

  Fly   390 GFDFARRIVLSRVAIFLSLVGYVILGK----VFTPEIAFMITAYYNVLLAAMSIYVPSAIIQTAQ 450
            .........:...|:....|.:|.|..    ..:|.:||...:.:::|:..:.: :.|.:..|.:
Zfish   556 SLSIFMNAAIPIAAVLTIFVVHVHLQSSSDFALSPAVAFGSLSLFHILVTPLFL-LSSVLHSTVK 619

  Fly   451 FLTSIRRVEQFMQSEELGSSDKSEGPSKDTVPGNPPSNNN------EADLLKSAISIRDLKAK-- 507
            .|.|::::.:|:.|.|:   :..:.|...|     |:|||      .|..|::.:..|..|||
Zfish   620 ALVSVQKLSEFLSSAEI---ETDQDPIAQT-----PANNNGNIKSVYALQLQAKLVNRKNKAKQD 676

  Fly   508 --------------------------------WDPNSPDYTLSGINLEIKPGSVVAVIGLTGSGK 540
                                            |....|  ||:.|::::..|.:..::|..||||
Zfish   677 VNRNFEQQDQELRASAQHEDNICIKIVNGYFSWTQGCP--TLTNIDIKVPFGQLTMIVGQVGSGK 739

  Fly   541 SSLIQAILGELKANSGQLQVN-------------------------GSLSYTSQESWLFSGTVRQ 580
            |||:.|.|||::..||.:..|                         ||::|.||..||.:.||.:
Zfish   740 SSLLLAALGEMQKISGSITWNSLPRSDSDENIRAHDMSGRQSFTRRGSVAYASQRPWLLNATVEE 804

  Fly   581 NILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGER----GATLSGGQKARISLARSVYRK 641
            ||||....:.:||::|::.|.|..|.|.||..|.|::|||    |..|||||:.|||:||::|::
Zfish   805 NILFDTAPNVKRYKDVIEVCQLGPDIDTLPQGDQTVIGERVRHLGIILSGGQRQRISVARALYQQ 869

  Fly   642 ASIYLLDDPLSAVDASVARHLFDQCVRGHLRGS--TVVLVTHQEQFLPHVDQIVILANGQIKALG 704
            .::..||||.||:|..::.||..:.:...||..  :||||||:.|:|||.|.|:.:.:|.::..|
Zfish   870 TNVVFLDDPFSALDIHLSDHLMHEGILKFLRQEKRSVVLVTHKLQYLPHADWIIAMRDGTVQTQG 934

  Fly   705 DYESL--LKTGLITGLGSL-SKTDKAKTEEQEPLNLN----------SPDNKNE-----VTPIKE 751
            ..:.:  .:..|.....:| ::.||..:.|.:..:..          :.|:::|     |:.:|:
Zfish   935 TLKDIQCAEPELFEQWRTLMNRQDKENSTELKRKSFRRAMMYSRDTVATDDEDEVADVAVSEVKD 999

  Fly   752 NSEQTVGGSSSGKEHVERQESGGISLALYRKYFQAGGGLVAFLVMLSSSVLAQVAVTGGDYFLTY 816
            :|..| ...|.|.|...|......|.|.|.|    ..||....:::.|.:.....:...|::|.:
Zfish  1000 SSTST-DEDSLGAELRHRTTIPWSSFATYLK----AAGLFLLPLLIVSQLAKHSLMVAIDFWLAH 1059

  Fly   817 WVKKESTAAGHGEMEDME---------SKSMDVYKYTLIIILSVIMNLSSSFLLFNIAKKASIRL 872
            |.  ....|...|..:..         |.|..:..:.|:..|.:::.|.:|..:.....:.:..|
Zfish  1060 WT--SDVIAAQSESAERNCTFTKDCVFSHSWYLQVFCLLCALGIVLCLVTSLAVEWTGLRVAKEL 1122

  Fly   873 HNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNP 937
            |.::...:..|.|..|.....|:|||||:.|.:.:|:.:||.:..:.:..|.....:.||:.|.|
Zfish  1123 HCSLLRIIVLAPMRLFETTPLGNILNRFSTDTNTIDQHIPVTMECLSRSTLLCVSAVGVISYVTP 1187

  Fly   938 LLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQRVLEKEF 1002
            :.|:..|.|:|..|.::..:...||||:::|.....|:.||.:.::.|||||||...::..:|:.
Zfish  1188 VFLIALLPLTVACYFIQKYFRVASRDLQQLEDSTEMPLLSHYSQTIEGLTTIRAFRHEQRFKKKL 1252

  Fly  1003 DSYQDAHS-SAFFM-----YISTSQAFGYCMNCICVIYISIITLSFFAFPPGNGADVGLVITQAM 1061
            ..:.||:: |:.|:     ::.....:   :..:.|:..::.:::...:...:...|||.:|.|:
Zfish  1253 LEHTDANNISSLFLTAANRWLEVRMEY---IGALVVLIAAVASITNALYRQLSAGLVGLGLTYAL 1314

  Fly  1062 GLIDMVQWGVRQTAELENTMTAVERVVEYESIEPEGMLEAPDDKKPPKTWPEQGEIIFKELNLRY 1126
            .:.:.:.|.||..|::|..:..|:||......:||.........:.|..||:.|||..:.|::||
Zfish  1315 MVSNYLNWIVRNLADMEVQLGCVKRVSGLIHTQPESYDNIMTPAQVPAGWPKYGEIQIQNLSVRY 1379

  Fly  1127 TPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFRLSYT-DGSVLIDTRDTRQMGLHD 1190
            ..:.|.  |||.:|..|:|.:||||.||||:||||...||||:..| :|.:.||..|..::.|..
Zfish  1380 DSSLKP--VLKHVSAHIRPGQKVGICGRTGSGKSSFSLALFRMVDTFEGQISIDGIDISKLPLQT 1442

  Fly  1191 LRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNF 1255
            ||.:.|||.|:|:|||||:|:||||..:.:||.||..||..:|..||..||.||.:.::|||.||
Zfish  1443 LRSKFSIILQDPILFSGTIRFNLDPERKATDEMLWEALEIAQLMPVVKALPGGLDAVVTEGGENF 1507

  Fly  1256 SVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSD 1320
            |.|||||.|||||.:|::.||:||||||::|..|:.::|..:.:.|.|.||:|||||:|||:.||
Zfish  1508 SQGQRQLFCLARAFVRKSSILIMDEATASIDMATESILQKVVMTAFADRTVVTIAHRVHTILGSD 1572

  Fly  1321 KVMVMDAGRVVEFGSPYELMTKSDSKVFHNLV 1352
            .|:||..|.::|:..|..|:.:.|| ||...|
Zfish  1573 VVIVMKHGGIIEYDEPDVLLEQKDS-VFSAFV 1603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	400/1383 (29%)
		ABC_membrane	171..437	CDD:294371	65/289 (22%)
		ABCC_MRP_domain1	499..699	CDD:213217	87/264 (33%)
		ABC_membrane	799..1045	CDD:294371	58/260 (22%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	112/221 (51%)
abcc8b	XP_021323602.1	SunT	239..1600	CDD:331423	405/1392 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586045
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.650