DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and abcc3

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_001107301.1	Gene:	abcc3 / 100135090	XenbaseID:	XB-GENE-1003737	Length:	1531	Species:	Xenopus tropicalis

Alignment Length:	1388	Identity:	473/1388 - (34%)
Similarity:	739/1388 - (53%)	Gaps:	183/1388 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 PRARSNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNRLCASWERELKN------ 148
            |.:.:.|:|.|.||:...:...||::.|:..||:...|:..|:::...|...||:|..|
Frog   208 PESDAGFLSRLTFWWFTKMAILGYKRPLEDKDLWSLNEDDTSNVVVTNLIKEWEKEKSNLAQMQV 272

  Fly   149 ----------------------------DGRSPSLVRALLRVFG--WQLG-----FPGLAIFVVE 178
                                        ..:.||.::.|||.||  :.:|     |..|..||
Frog   273 SYSKKPEAVLNHTDEKAYESDVLIVDNKKPKEPSFLKVLLRTFGPYFLIGSFFKLFQDLLSFV-- 335

  Fly   179 LGLRTLQPIFLVKLISYFSGEPDAANAGFYYAVAQIVISALTVMILTPTTFGIH---HVCF---- 236
                  .|..|..||::...:...:..||..||...:.|.:..:||       |   ..||
Frog   336 ------NPQLLSILITFIKNKDAPSWWGFCIAVLMFLTSLVQTLIL-------HQHFQYCFVTGM 387

  Fly   237 KMRVAMGSMIFRKALRLTKGALGDTTSGHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLM 301
            ::|.|:..:|:||:|.:|..|...:|.|.||||:|.|..|.......::.||..|||:.:..|.:
Frog   388 RLRSAITGIIYRKSLVITNSAKRSSTVGEVVNLMSVDAQRFQDLTTFLNMLWSAPLQICLALYFL 452

  Fly   302 YQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQP 366
            :|.:|.|.:.||..|:|.:||..::..:|.|.|::..:..|:||:::|||::.|:|||:||||..
Frog   453 WQALGPSVLAGVAVMVLLIPINAFIAMKTRAFQVEQMQYKDSRIKLMNEILNGIKVLKLYAWEPS 517

  Fly   367 FEQMVTHAREKEMNTIRQGQYIRGFD-FARR-----IVLSRVAIFLSLVGYVILGKVFTPEIAFM 425
            |.|.|...|.||:|.:::..|:.... ||..     :.|:..|::::    |....:...|.||:
Frog   518 FAQKVLEIRNKELNILKKAAYLNALSTFAWTSAPFLVALTTFAVYVT----VDEKNILDAEKAFV 578

  Fly   426 ITAYYNVLLAAMSIYVPSAIIQTAQFLTSIRRVEQFMQSEELGSSDKSEGPSKDTVPGNPPSNNN 490
            ..:.:|:|...::: :|..|...||...||:|::.|:.::||   |.:......|:|||
Frog   579 SLSLFNILRFPLNM-LPQVISNLAQASVSIKRIQNFLANDEL---DLNAVTKDKTLPGN------ 633

  Fly   491 EADLLKSAISIRDLKAKWDPNSPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANS 555
                   ||::.:....|..|. ...|..|||.:..||:|||:|..|.|||||:.|:|||::...
Frog   634 -------AITVHNGTFSWAKNG-GAILQNINLLVPSGSLVAVVGQVGCGKSSLVSALLGEMEKEE 690

  Fly   556 GQLQVNGSLSYTSQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGER 620
            |::.|.||::|..|::|:.:.|::.|||||:..:.:.|::|::.|||..|.::||..|.|.:||:
Frog   691 GEVSVRGSVAYVPQQAWIQNCTLKDNILFGRAANEKNYKKVLEACALVTDLEVLPGGDQTEIGEK 755

  Fly   621 GATLSGGQKARISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCV--RGHLRGSTVVLVTHQE 683
            |..||||||.|:||||:|:..|.:||||||||||||.||:|:||..:  .|.|||.|.|||||..
Frog   756 GINLSGGQKQRVSLARAVFSNADVYLLDDPLSAVDAHVAKHIFDNVIGPDGLLRGKTRVLVTHGI 820

  Fly   684 QFLPHVDQIVILANGQIKALGDYESLLKTGLITGLGSLSK--TDKAKTEEQEPLNLNSPDNK--- 743
            .|||.||.||:|.:|::..:|.|:.|||..     |:.|:  .:.|..:|.|..::..||.:
Frog   821 SFLPQVDHIVVLVDGRVTEMGSYQELLKQN-----GAFSEFLRNYAFDDEVEEEDITIPDEEEVL 880

  Fly   744 --------------NEVTPI--------------------------------KENSEQTVGGSSS 762
                          ||  |:                                |:.||..|.....
Frog   881 LAEETLSTHTDLADNE--PVANEARKKFIRQISILSDGEPSHAMSTRRRFTEKKPSENLVAKQPP 943

  Fly   763 GKE--HVERQESGGISLALYRKYFQAGG-GLVAFLVMLSSSVLAQVAVTGGDYFLTYWVKKESTA 824
            .::  ..|..|:|.:.:.::.:|.:|.| .:..|:..|.|  ....|..|.:.:|:.|..:...
Frog   944 TEKLIQTETTETGRVKMTVFWQYMKAVGLAISVFICFLYS--CQNAAAIGANVWLSDWTNEPVI- 1005

  Fly   825 AGHGEMEDMESKSMDVYKYTLIIILSVIMNLSSSFLLFNIAKKASIRLHNTIFNRVTRADMHFFS 889
                 .:..::..|.|..|..:.||..::.::|||.|......|:.:||:.:.:........|:.
Frog  1006 -----NQTQQNTQMRVGVYAALGILQGLLVMTSSFSLAIAGIGAARKLHSALLDNKMHTPQSFYD 1065

  Fly   890 INKHGSILNRFTKDMSQVDEVLP-VVLVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFYHL 953
            ....|.|:|||:||:..:|||:| .:|:.:......|:.:|:::|: .||..|..:.|::.:..:
Frog  1066 TTPIGRIINRFSKDIYVIDEVIPGTILMFLATFFTSLSTMIVIVAS-TPLFAVVIIPLAIAYIFV 1129

  Fly   954 RNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQRVLEKEFDSYQDAHSSAFFMYIS 1018
            :..|:.|||.|||:|:::|||:|||.:.::.|.:.|||...|.......|:..|.:..:::..|.
Frog  1130 QRFYVATSRQLKRLESVSRSPIYSHFSETITGASIIRAYGRQNSFIVLSDNKVDENQKSYYPGIV 1194

  Fly  1019 TSQAFG----YCMNCICVIYISIITLSFFAFPPGNGADVGLVITQAMGLIDMVQWGVRQTAELEN 1079
            :::..|    :..||:.:.......|......||.   |||.::.|:.:...:.|.||.|::||.
Frog  1195 SNRWLGVRVEFVGNCVVLFAALFAVLGREHLSPGL---VGLSVSYALQVTMSLNWMVRMTSDLET 1256

  Fly  1080 TMTAVERVVEYESIEPEGMLEAP---DDKKPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSF 1141
            .:.|||||.||    .|...|||   :|.|||:.||.:||:.....::||  .|..:.|||:|:.
Frog  1257 NIVAVERVKEY----AENETEAPWHIEDTKPPEDWPSKGEVELSNYSVRY--RAGLDLVLKNLNL 1315

  Fly  1142 VIQPREKVGIVGRTGAGKSSLINALFR-LSYTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLF 1205
            .:...|||||||||||||||:...||| |...:|.|.||..:..::||.|||.:::||||:||||
Frog  1316 KVNGGEKVGIVGRTGAGKSSMTLCLFRILEPAEGIVKIDNVNISEIGLQDLRSRLTIIPQDPVLF 1380

  Fly  1206 SGTMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAIL 1270
            |||:|.|||||::|||:::|..||...||:.|:..|..|..:.||||.|.|||||||||||||:|
Frog  1381 SGTLRMNLDPFNKYSDDEIWKALELSNLKKFVAGQPSQLEYECSEGGENLSVGQRQLVCLARALL 1445

  Fly  1271 RENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGS 1335
            |:.|||::|||||.:|.:||.|||.|||::|.|||||||||||:||:|..:|:|:|.||:.||.:
Frog  1446 RKTRILILDEATAAIDLETDDLIQMTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGRIAEFDT 1510

  Fly  1336 PYELMTKSDSKVFHNLVNQSGRA 1358
            |..|:....  :|:.:...:|.|
Frog  1511 PTNLIALKG--IFYGMAKDAGLA 1531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	470/1371 (34%)
		ABC_membrane	171..437	CDD:294371	84/278 (30%)
		ABCC_MRP_domain1	499..699	CDD:213217	97/201 (48%)
		ABC_membrane	799..1045	CDD:294371	63/250 (25%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	124/221 (56%)
abcc3	NP_001107301.1	MRP_assoc_pro	7..1530	CDD:188098	471/1385 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010