DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and abcc6b.2

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	XP_003198194.2	Gene:	abcc6b.2 / 100002917	ZFINID:	ZDB-GENE-110208-2	Length:	1502	Species:	Danio rerio

Alignment Length:	1357	Identity:	453/1357 - (33%)
Similarity:	721/1357 - (53%)	Gaps:	153/1357 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 PRARSNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNRLCASWERE-LKNDGRSP 153
            |...::|:|.|.||:...:..||||..|.:.||:...||..|:.:...|...|.:: .|...:..
Zfish   207 PVEDASFLSKLLFWWYGRLVVKGYRSPLKAEDLWSLREEDTSEKIICDLEKEWAKQWAKLQQKKS 271

  Fly   154 SLVRALLRVFGWQL-----------------GF---------------PGLAIFVVELGLRTLQP 186
            ||..|  :..|::|                 ||               .|....|::..|....|
Zfish   272 SLNEA--QTLGFKLSSCVKQLFRKLFKEQCTGFVLFRTLAKIFSPYFLTGTLFLVIQDALMFSIP 334

  Fly   187 IFLVKLISYFSGEPDAANAGFYYAVAQIVISALTVM-----ILTPTTFGIHHVCFKMRVAMGSMI 246
            ..|..|:.|...|......|:.:|.:..::|.|..:     :.|..|.|:     :::.|:..::
Zfish   335 QVLSLLLGYVRDEDAPLWKGYLFAFSLFLLSCLQSLFNHQYMYTCLTVGM-----RVKTAVMGLV 394

  Fly   247 FRKALRLTKGALGDTTSGHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVF 311
            :||:|.:...|....|.|.:|||:|.|..:|.......:.||:.|:::.:..:.::|.:|.|.:.
Zfish   395 YRKSLVINSAARKTCTVGEIVNLVSADTQKLVDFVMYFNALWLAPIEIALCLFFLWQHLGPSTLA 459

  Fly   312 GVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHARE 376
            |:..::|..|:..::....|.:|....:..|.||:::|||:|.|::||.||||:.|.:.|...||
Zfish   460 GITTVILIFPLNGFIAKMRSKLQEVQMKHKDERIKLMNEILSGIKILKFYAWEKAFRERVLGYRE 524

  Fly   377 KEMNTIRQGQYIRGFDFARRIVLSRVAIFLSLVG-YVILG--KVFTPEIAFMITAYYNVLLAAMS 438
            ||:|.:::.|.:.....| ....|.:.|..::.| ||::.  .|...:..|:..|..|:|.|.:|
Zfish   525 KELNALKKSQILYSVSIA-SFNSSTLLIAFAMFGVYVLIDDKHVLDAQKIFVSMALINILKAPLS 588

  Fly   439 IYVPSAIIQTAQFLTSIRRVEQFMQSEELGSSDKSEGPSKDTVPGNPPSNNNEADLLKSAISIRD 503
             .:|.|:..|.|.:.|::|:..|:..:||      :..|...||.||   |.|      ::.|.:
Zfish   589 -QLPIAMSTTMQVVVSLKRLGTFLDQDEL------KLDSVQRVPYNP---NIE------SVVINN 637

  Fly   504 LKAKWDPNSPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGSLSYTS 568
            ....|..:|.. .|..||::::.||:|||:|..|||||||:.|:|||::..||.:.:.||:.|..
Zfish   638 GTFSWSKDSTP-CLRRINVKVQRGSLVAVVGHVGSGKSSLLSAMLGEMEKKSGHITITGSVGYVP 701

  Fly   569 QESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARIS 633
            |::|:.:.|::.|||||.......|::|::.|||..|.::||.||.|.:||:|..||||||.|:|
Zfish   702 QQAWIQNATLKDNILFGCEKKDSLYQKVLEACALLPDLEILPARDATEIGEKGLNLSGGQKQRVS 766

  Fly   634 LARSVYRKASIYLLDDPLSAVDASVARHLFDQCV--RGHLRGSTVVLVTHQEQFLPHVDQIVILA 696
            |||:|||.:.|||||||||||||.|.:|:|::.:  .|.|:..|.|||||...|||..|.|:::|
Zfish   767 LARAVYRNSDIYLLDDPLSAVDAHVGQHIFEKVIGPNGSLKNKTRVLVTHGLSFLPQADLILVMA 831

  Fly   697 NGQIKALGDYESLL-KTGLITGLGSLSKTDKAKTEEQEPLNLNSPDNKNEVTPIKENSE------ 754
            :|:||.:|.|..|| :......|.:.|     .:|.:|...|...........||:.|.
Zfish   832 DGEIKEMGSYAELLSRKNAFAELKAFS-----VSERKESATLKGTRKSVSFLSIKDFSTDLIRGD 891

  Fly   755 ------QTVGGSSSGKEHVERQE-----------SGGISLALYRKYFQAGGGLVAFLV-MLSSSV 801
                  ||:...|..|.:.:|.|           :|.:.|.:|.:||:..|  :||:: ::....
Zfish   892 LGSASIQTMEAISDPKLNQDRDEVGRLTQADKAHTGRVKLEMYVEYFRTIG--LAFIIPIIFLYA 954

  Fly   802 LAQVAVTGGDYFLTYWVKKESTAAGHGEMEDME---------SKSMDVYKYTLIIILSVIMNLSS 857
            ..|||....:|:|:.|. .:....|.....|::         ::.:.::..|:.|.|..|:
Zfish   955 FQQVASLAYNYWLSLWA-DDPVINGTQVNTDLKLGVYGALGFAQGIAIFGTTVAISLGGII---- 1014

  Fly   858 SFLLFNIAKKASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIA 922
                      ||.:||..:.|.|..:.|.||.....|::||||:|::..:|.::|..|..::...
Zfish  1015 ----------ASRQLHLDLLNNVLHSPMSFFESTPSGNLLNRFSKEIDAIDCMIPHGLKIMLGYV 1069

  Fly   923 LWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLT 987
            ..|..:.|::....|...|..|.|::::..:::.|:.||..|:|:|:::|||:|:|...::.|.:
Zfish  1070 FKLLEVCIIVLMATPFAGVIILPLTLLYAFIQSFYVATSCQLRRLESVSRSPIYTHFNETVQGAS 1134

  Fly   988 TIRALDAQRVLEKEFDSYQDAHSSAFF------MYISTSQAFGYCMNCICVIYISII---TLSFF 1043
            .|||...|.....:.:...|.:.:::|      .:::.:..|...:..:....:|::   |||
Zfish  1135 VIRAFGEQPRFILQANCRVDLNQTSYFPRFVASRWLAVNLEFLGNLLVLAAAILSVMGRATLS-- 1197

  Fly  1044 AFPPGNGADVGLVITQAMGLIDMVQWGVRQTAELENTMTAVERVVEYESIEPEGMLEAP---DDK 1105
               ||.   |||.::.::.:..::.|.||...::||.:.:||||.||    .|...|||   :|.
Zfish  1198 ---PGT---VGLAVSHSLQVTGILSWIVRSWTDVENNIVSVERVKEY----AETAKEAPWTFEDS 1252

  Fly  1106 KPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFR-L 1169
            ..|..||..|.|.|:...|:|...  .:..||.:|..:..|||||||||||||||||...:|| |
Zfish  1253 PLPSDWPRSGSIGFQAYGLQYRKG--LDWALKEISLSVNEREKVGIVGRTGAGKSSLALGIFRIL 1315

  Fly  1170 SYTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLK 1234
            ....|.:.||..:..::|||:||.:|:||||:||||||::|.||||||.|:||::|..||...||
Zfish  1316 EAAKGKIFIDGINIAEIGLHELRSRITIIPQDPVLFSGSLRINLDPFDRYTDEEVWRSLELAHLK 1380

  Fly  1235 EVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQATIRS 1299
            ..||||||.|..:.||||.|.|:|||||:|||||:||:.:|||:|||||.||.:||.|||:|||:
Zfish  1381 TFVSDLPDKLNHECSEGGENLSLGQRQLICLARALLRKTKILVLDEATAAVDLKTDNLIQSTIRT 1445

  Fly  1300 KFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLVNQSG 1356
            :|.|||||||||||:||:|..:|:|||.|.:.|..||..|:::...  |:.:..::|
Zfish  1446 QFEDCTVLTIAHRLNTIMDYTRVIVMDRGNITEIDSPSNLISQHGQ--FYRMCREAG 1500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	451/1342 (34%)
		ABC_membrane	171..437	CDD:294371	73/273 (27%)
		ABCC_MRP_domain1	499..699	CDD:213217	94/201 (47%)
		ABC_membrane	799..1045	CDD:294371	59/263 (22%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	126/221 (57%)
abcc6b.2	XP_003198194.2	MRP_assoc_pro	5..1501	CDD:188098	453/1357 (33%)
		ABC_membrane	320..587	CDD:294371	72/272 (26%)
		ABCC_MRP_domain1	633..834	CDD:213217	94/201 (47%)
		ABC_membrane	950..1215	CDD:279056	64/287 (22%)
		ABCC_MRP_domain2	1262..1482	CDD:213211	126/221 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586068
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.760