DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment betaTry and PRSS1

DIOPT Version :9

Sequence 1:	NP_001286314.1	Gene:	betaTry / 47901	FlyBaseID:	FBgn0010357	Length:	253	Species:	Drosophila melanogaster
Sequence 2:	XP_011514713.1	Gene:	PRSS1 / 5644	HGNCID:	9475	Length:	472	Species:	Homo sapiens

Alignment Length:	254	Identity:	91/254 - (35%)
Similarity:	140/254 - (55%)	Gaps:	23/254 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LILLSAVACALGGTIPEGLLPQLDGRIVGGTATTISSFPWQISLQRSGSHSCGGSIYSARVIVTA 69
            |::|:.||.||.....:      |.:||||.....:|.|:|:|| .||.|.||||:.:.:.:|:|
Human   229 LLILTFVAAALAAPFDD------DDKIVGGYNCEENSVPYQVSL-NSGYHFCGGSLINEQWVVSA 286

  Fly    70 AHCLQS-----VSASSLQIRAGSSYWSSGGVVAKVSSFKNHEGYNANTMVNDIAVLHLSSSLSFS 129
            .||.:|     :...::::..|:..:.:...:.:      |..|:..|:.|||.::.|||....:
Human   287 GHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIR------HPQYDRKTLNNDIMLIKLSSRAVIN 345

  Fly   130 STIKAIGLASSNPANGAAASVSGWGTESSGSSSIPSQLRYVNVNIVSQSRCSSSSYGYGNQIKSS 194
            :.:..|.|.::.||.|....:||||..:|..:..|.:|:.::..::||::|.:|   |..:|.|:
Human   346 ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEAS---YPGKITSN 407

  Fly   195 MICA--FASGKDSCQGDSGGPLVSGGVLVGVVSWGYGCAAANYPGVYADVAALRSWVIN 251
            |.|.  ...||||||||||||:|..|.|.||||||.|||..|.||||..|.....|:.|
Human   408 MFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKN 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
betaTry	NP_001286314.1	Tryp_SPc	30..249	CDD:214473	82/225 (36%)
betaTry	NP_001286314.1	Tryp_SPc	31..252	CDD:238113	84/228 (37%)
PRSS1	XP_011514713.1	Ig	19..119	CDD:299845
		IG_like	29..113	CDD:214653
		Tryp_SPc	248..464	CDD:214473	82/225 (36%)
		Tryp_SPc	249..467	CDD:238113	84/228 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBP0
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469244at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X21
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820