DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment betaTry and PRSS53

DIOPT Version :9

Sequence 1:	NP_001286314.1	Gene:	betaTry / 47901	FlyBaseID:	FBgn0010357	Length:	253	Species:	Drosophila melanogaster
Sequence 2:	XP_011544118.1	Gene:	PRSS53 / 339105	HGNCID:	34407	Length:	623	Species:	Homo sapiens

Alignment Length:	308	Identity:	73/308 - (23%)
Similarity:	119/308 - (38%)	Gaps:	79/308 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LSAVACALGGTIPEGLLPQLDGRIVGGTATTISSFPWQISLQRSGSHSCGGSIYSARVIVTAAHC 72
            |.|...|.|...|....|| :|..|.|      .:|||.|::|.|:|.|.||:.:...::|||||
Human    21 LQAAQRACGQRGPGPPKPQ-EGNTVPG------EWPWQASVRRQGAHICSGSLVADTWVLTAAHC 78

  Fly    73 LQSVSASSL---QIRAGS---SYWSSGGVVAKVSSFKNHEGYNANTMVNDIAVLHLSSSLSFSST 131
            .:..:|:.|   .:..||   ...|.|.....|::.:....||..:..:|:|:|.|:...:.:.
Human    79 FEKAAATELNSWSVVLGSLQREGLSPGAEEVGVAALQLPRAYNHYSQGSDLALLQLAHPTTHTP- 142

  Fly   132 IKAIGLASSNPAN----GAAASVSGWGTESSGS-------------------------------- 160
                 |....||:    ||:...:||..::|..
Human   143 -----LCLPQPAHRFPFGASCWATGWDQDTSDGKCWPRLKLGEALCLPSVTVSAPNCPGFQSPLL 202

  Fly   161 ------------SSIPSQLRYVNVNIVSQSRCSS-----SSYGYGNQIKSSMICAFASG--KDSC 206
                        |..|..||.:.:.::|:..|:.     ......|..:..|:|.....  :..|
Human   203 PRSQTLAPAPSLSPAPGTLRNLRLRLISRPTCNCIYNQLHQRHLSNPARPGMLCGGPQPGVQGPC 267

  Fly   207 QGDSGGPLV-----SGGVLVGVVSWGYGCAAANYPGVYADVAALRSWV 249
            |||||||::     ...|..|::|:...||..:.|.:..:.||..||:
Human   268 QGDSGGPVLCLEPDGHWVQAGIISFASSCAQEDAPVLLTNTAAHSSWL 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
betaTry	NP_001286314.1	Tryp_SPc	30..249	CDD:214473	64/284 (23%)
betaTry	NP_001286314.1	Tryp_SPc	31..252	CDD:238113	65/285 (23%)
PRSS53	XP_011544118.1	Tryp_SPc	42..316	CDD:238113	65/286 (23%)
		Tryp_SPc	43..314	CDD:214473	63/282 (22%)
		Tryp_SPc	359..>512	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149440
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24276
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030