DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Taf5 and TAF5

DIOPT Version :9

Sequence 1:	NP_476957.1	Gene:	Taf5 / 47900	FlyBaseID:	FBgn0010356	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	NP_009757.1	Gene:	TAF5 / 852497	SGDID:	S000000402	Length:	798	Species:	Saccharomyces cerevisiae

Alignment Length:	665	Identity:	207/665 - (31%)
Similarity:	346/665 - (52%)	Gaps:	92/665 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 QHYEQAYKELRTFVEDSLDIYKHELSMVLYPILVQIYFKILASGLREKAKEFIEKYKCDLDGYYI 178
            ::|.:||..|:.:|:.||:|||.|||.::|||.:.::..::|.. ...|:.|.:::..|...::.
Yeast   150 ENYIRAYSMLKNWVDSSLEIYKPELSYIMYPIFIYLFLNLVAKN-PVYARRFFDRFSPDFKDFHG 213

  Fly   179 EGLFNLLLLSKPEELLENDLVVAMEQDKFVIRMSRDSHSLFKRHIQDRRQ---EVVADIVSKYLH 240
            ..:..|..::..:.:.||::..|.:..|:.|.||:.:.:|....:.:...   .::..:::::|.
Yeast   214 SEINRLFSVNSIDHIKENEVASAFQSHKYRITMSKTTLNLLLYFLNENESIGGSLIISVINQHLD 278

  Fly   241 FDTYEGM-ARNKL----QCVATAGSHLGEAKRQDNKMRVYYG-------LLKEVDFQ-------- 285
            .:..|.: ||.||    :.::.:.:..|:...:.|.:.|..|       .:||::.:
Yeast   279 PNIVESVTAREKLADGIKVLSDSENGNGKQNLEMNSVPVKLGPFPKDEEFVKEIETELKIKDDQE 343

  Fly   286 ------------------TLTTPAPAPEEE-------DDDPD-APDRPKKKKPKKDPLL---SKK 321
                              ||.....|...|       |||.| ..|:..|.:.||:..|   .:|
Yeast   344 KQLNQQTAGDNYSGANNRTLLQEYKAMNNEKFKDNTGDDDKDKIKDKIAKDEEKKESELKVDGEK 408

  Fly   322 SKSDPNAPSIDRIPLPELKDSDKLLKLKALREASKRLALSKDQ--LPSAVFYTVLNSHQGVTCAE 384
            ..|:.::|:.|.:|||.....|..|:::.::|:...:.|...|  |||...||..|:::.::|.:
Yeast   409 KDSNLSSPARDILPLPPKTALDLKLEIQKVKESRDAIKLDNLQLALPSVCMYTFQNTNKDMSCLD 473

  Fly   385 ISDDSTMLACGFGDSSVRIWSLTPAKLRTLKDADSLRELDKESADINVRMLDDRSGEVTRSLMGH 449
            .|||..:.|.||.||.::||||         |..||     .:.:|.:...|.......::|:||
Yeast   474 FSDDCRIAAAGFQDSYIKIWSL---------DGSSL-----NNPNIALNNNDKDEDPTCKTLVGH 524

  Fly   450 TGPVYRCAFAPEMNLLLSCSEDSTIRLWSLLTWSCVVTYRGHVYPVWDVRFAPHGYYFVSCSYDK 514
            :|.||..:|:|:...|||.|||.|:||||:.|.:.:|:|:||.:|||||.|:|.|:||.:.|:|:
Yeast   525 SGTVYSTSFSPDNKYLLSGSEDKTVRLWSMDTHTALVSYKGHNHPVWDVSFSPLGHYFATASHDQ 589

  Fly   515 TARLWATDSNQALRVFVGHLSDVDCVQFHPNSNYVATGSSDRTVRLWDNMTGQSVRLMTGHKGSV 579
            |||||:.|....||:|.|||:|||||.||||..||.|||||:|.|:||..||.||||..||...|
Yeast   590 TARLWSCDHIYPLRIFAGHLNDVDCVSFHPNGCYVFTGSSDKTCRMWDVSTGDSVRLFLGHTAPV 654

  Fly   580 SSLAFSACGRYLASGSVDHNIIIWDLSNGSLVTTLLRH-TSTVTTITFSRDGTVLAAAGLDNNLT 643
            .|:|....||:|::||.|..|.:||:..|..:..:..| .:.:.::::|::|.||.:.|.|:.:.
Yeast   655 ISIAVCPDGRWLSTGSEDGIINVWDIGTGKRLKQMRGHGKNAIYSLSYSKEGNVLISGGADHTVR 719

  Fly   644 LWDFHKVT--------EDYIS--NHITVSHHQDEND----------EDVYLMRTFPSKNSPFVSL 688
            :||..|.|        |.:|.  ..:|.|.:||..:          .|  |:.:|.:|.:|...:
Yeast   720 VWDLKKATTEPSAEPDEPFIGYLGDVTASINQDIKEYGRRRTVIPTSD--LVASFYTKKTPVFKV 782

  Fly   689 HFTRRNLLMCVGLFK 703
            .|:|.||.:..|.|:
Yeast   783 KFSRSNLALAGGAFR 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Taf5	NP_476957.1	TAF5_NTD2	114..245	CDD:176269	30/133 (23%)
		WD40	319..674	CDD:225201	143/377 (38%)
		WD40	373..646	CDD:238121	115/273 (42%)
		WD40 repeat	380..448	CDD:293791	19/67 (28%)
		WD40 repeat	454..490	CDD:293791	17/35 (49%)
		WD40 repeat	495..531	CDD:293791	19/35 (54%)
		WD40 repeat	538..573	CDD:293791	24/34 (71%)
		WD40 repeat	579..615	CDD:293791	13/35 (37%)
TAF5	NP_009757.1	LisH	55..88	CDD:128913
		TFIID_NTD2	149..275	CDD:398277	29/125 (23%)
		WD40	458..722	CDD:238121	117/277 (42%)
		WD40 repeat	470..523	CDD:293791	19/66 (29%)
		WD40 repeat	529..565	CDD:293791	17/35 (49%)
		WD40 repeat	570..606	CDD:293791	19/35 (54%)
		WD40 repeat	613..648	CDD:293791	24/34 (71%)
		WD40 repeat	654..690	CDD:293791	13/35 (37%)
		WD40 repeat	697..732	CDD:293791	10/34 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346820
Domainoid	1	1.000	61	1.000	Domainoid score	I2534
eggNOG	1	0.900	-	-		E2759_KOG0263
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5064
Inparanoid	1	1.050	319	1.000	Inparanoid score	I455
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52000
OrthoFinder	1	1.000	-	-		FOG0003655
OrthoInspector	1	1.000	-	-		otm46886
orthoMCL	1	0.900	-	-		OOG6_102926
Panther	1	1.100	-	-	LDO	PTHR19879
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1472
SonicParanoid	1	1.000	-	-		X3022
TreeFam	1	0.960	-	-
	15	14.790