DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Taf5 and can

DIOPT Version :9

Sequence 1:	NP_476957.1	Gene:	Taf5 / 47900	FlyBaseID:	FBgn0010356	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	NP_524827.1	Gene:	can / 45432	FlyBaseID:	FBgn0011569	Length:	942	Species:	Drosophila melanogaster

Alignment Length:	741	Identity:	229/741 - (30%)
Similarity:	359/741 - (48%)	Gaps:	128/741 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 IKKYQLKSTEELLCQEANV-SSVELSEISESDVQQVLGAVLGAGDANRERKHVQSPAQGHKQSAV 93
            ::|.:||:.|:....::|. ||..||.:.:.|.          |:.:.:.:|.::.....::.::
  Fly   197 LEKEKLKADEDDNFSDSNTSSSFSLSSLDDYDY----------GETDLDEQHNENKCTYWEEMSL 251

  Fly    94 TEAN----AAEELAKFIDDDSFDAQH--------------------------------------- 115
            ...:    :.|||...:::|.....|
  Fly   252 RPVDKGEVSQEELMAILNEDESSPDHRSECDIDEAIRTRDGSDFYEDSAQFLENMENVSLLVIKE 316

  Fly   116 ------YEQAYKELRTFVEDSLDIYKHELSMVLYPILVQIYFKILASGLREKAKEFIEKYKCDLD 174
                  ||.|.|:|...::.:...||:|:.::|||:||..|.:::||...:||:..:.:::..||
  Fly   317 DSVFADYEFAVKKLIKLIQSTPSHYKYEIYILLYPLLVLTYLQMMASDKIQKARMLLVRFQDHLD 381

  Fly   175 GYYIEGLFNLLLLSKPEELLENDLVVAMEQDKFVIRMSRDSHSLFKRHIQDRRQEVVADIVSKYL 239
            ..||..:..|..:|||.|:......:....:|..|.||
  Fly   382 DSYISRIIKLREISKPAEVPNKARKLLAGLEKVKIEMS--------------------------- 419

  Fly   240 HFDTYEGMARNKLQCVA--TAG------SHLG-EAKRQDNKMRVYYGLLKEVDFQTLTTP----A 291
                 ||..|..|.|..  |.|      ||.. :...:|:|.:..:.:     .|.|..|    |
  Fly   420 -----EGAFRQLLLCTEEWTRGQQEKLLSHFQIQPYSEDDKPQQRFAI-----GQPLLEPIWYGA 474

  Fly   292 PAPEEEDDDPDAPDRPKKKKPKKDPLLSKKSKSDPNAPSIDRI--PLPELKDSDKLLKLKALREA 354
            |.|..:.|....|...|::|.:.:|.||    .:.:.|.::|:  |:|...|   ||.:|:  :.
  Fly   475 PEPLHKKDFAARPFFQKRRKKRSEPQLS----DNLHLPPVNRVYNPIPNKMD---LLHMKS--DE 530

  Fly   355 SKRLALSKDQLPSAVFYTVLNSHQGVTCAEISDDSTMLACGFGDSSVRIWSLTPAKLRTLKDADS 419
            ..|:.|.::.|||...||...|.:.|.||..|:.::|||.|...|.|.::||.|:||..:|.|..
  Fly   531 QYRMKLDRNNLPSTYLYTTSPSDEVVICATFSEGNSMLALGTVSSKVYVFSLKPSKLVQVKAAQW 595

  Fly   420 LRELDKESADINVRMLDDRSGEVTRSLMGHTGPVYRCAFAPEMNLLLSCSEDSTIRLWSLLTWSC 484
            |:.||...|.::..|:|.......|:|.||.||||.|:|.||...|::||||.::|||.||:|||
  Fly   596 LKNLDTGMAGVDKDMIDPIKKFTRRTLYGHQGPVYGCSFNPEDRFLITCSEDFSVRLWCLLSWSC 660

  Fly   485 VVTYRGHVYPVWDVRFAPHGYYFVSCSYDKTARLWATDSNQALRVFVGHLSDVDCVQFHPNSNYV 549
            ||.:.||:.||..|.|||.||||.:.|.|.|||:|..|:.:..|:..|||:::....||||.:|:
  Fly   661 VVIFSGHLAPVCFVVFAPRGYYFATASDDCTARVWMQDNTKPARILQGHLAELGVCLFHPNRHYM 725

  Fly   550 ATGSSDRTVRLWDNMTGQSVRLMTGHKGSVSSLAFSACGRYLASGSVDHNIIIWDLSNGSLVTTL 614
            ||||:|.|||:||.:....||:..|||..:::|.:|.|||||.||..|:.|:|||.:|..|:...
  Fly   726 ATGSADCTVRIWDIVKAVQVRIFRGHKSRITALIYSICGRYLVSGGDDNLIMIWDTANEILMQFF 790

  Fly   615 LRHTSTVTTITFSRDGTVLAAAGLDNNLTLWDFHKVTEDYISNHITVSHHQ----DENDEDVYLM 675
            ..|.:::.|:..|.|..:|...|.|..||||||.:|.::|: |...:|...    .|:..:..|:
  Fly   791 DHHKASINTMEISLDNNILVVGGQDCQLTLWDFEQVIKNYL-NRAKISMKNQAGTQESSANNLLV 854

  Fly   676 RTFPSKNSPFVSLHFTRRNLLM--CV 699
            .:|.:|..||..:.|||||||:  ||
  Fly   855 SSFFTKGEPFYMIRFTRRNLLLGFCV 880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Taf5	NP_476957.1	TAF5_NTD2	114..245	CDD:176269	32/175 (18%)
		WD40	319..674	CDD:225201	144/360 (40%)
		WD40	373..646	CDD:238121	120/272 (44%)
		WD40 repeat	380..448	CDD:293791	25/67 (37%)
		WD40 repeat	454..490	CDD:293791	20/35 (57%)
		WD40 repeat	495..531	CDD:293791	17/35 (49%)
		WD40 repeat	538..573	CDD:293791	17/34 (50%)
		WD40 repeat	579..615	CDD:293791	16/35 (46%)
can	NP_524827.1	TAF5_NTD2	320..453	CDD:176269	40/164 (24%)
		WD40	<503..829	CDD:225201	139/330 (42%)
		WD40 repeat	591..624	CDD:293791	10/32 (31%)
		WD40	619..>823	CDD:238121	97/203 (48%)
		WD40 repeat	629..666	CDD:293791	21/36 (58%)
		WD40 repeat	672..708	CDD:293791	16/35 (46%)
		WD40 repeat	713..749	CDD:293791	17/35 (49%)
		WD40 repeat	760..790	CDD:293791	15/29 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45473213
Domainoid	1	1.000	43	1.000	Domainoid score	I8401
eggNOG	1	0.900	-	-		E2759_KOG0263
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D230914at33208
OrthoFinder	1	1.000	-	-		FOG0003655
OrthoInspector	1	1.000	-	-		otm14181
orthoMCL	1	0.900	-	-		OOG6_102926
Panther	1	1.100	-	-	P	PTHR19879
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.750